A mathematical model of protease-antiprotease homeostasis failure in chronic obstructive pulmonary disease (COPD)

Risk Analysis

Volumn 29, Issue 4, 2009, Pages 576-586

  Cox Jr , Louis Anthony ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b NONE   (United States)

Author keywords

Bistable equilibrium; COPD risk; Homeostasis; Nonlinear network dynamics

Indexed keywords

ALVEOLAR MACROPHAGES; ANTITRYPSIN; BISTABLE EQUILIBRIUM; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CIGARETTE SMOKING; CONCEPTUAL MODELS; COPD RISK; DISEASE MARKERS; ELASTASE; ELEVATED LEVELS; EQUILIBRIUM BEHAVIORS; HOMEOSTASIS; HOMEOSTATIC PROCESS; HUMAN DATUM; LUNG TISSUES; METALLOPROTEINASE; QUADRATIC EQUATIONS; TISSUE INHIBITORS; TWO PARAMETERS;

BIOLOGICAL ORGANS; BODY FLUIDS; COMPUTER SIMULATION; DYNAMICS; ENZYME ACTIVITY; MACROPHAGES; NONLINEAR NETWORKS; ORDINARY DIFFERENTIAL EQUATIONS; ULSI CIRCUITS;

MATHEMATICAL MODELS;

ALPHA 1 ANTITRYPSIN; LEUKOCYTE ELASTASE; MACROPHAGE ELASTASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

CAUSE OF DEATH; DIGESTION; ENZYME ACTIVITY; ETIOLOGY; HEALTH RISK; HOMEOSTASIS; NUMERICAL MODEL; RESPIRATORY DISEASE; RISK ASSESSMENT; SMOKING;

ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; HOMEOSTASIS; HUMAN; LUNG ALVEOLUS MACROPHAGE; MATHEMATICAL MODEL; NEUTROPHIL; ORDINARY DIFFERENTIAL EQUATION; PARAMETER; PROTEIN DEGRADATION;

HOMEOSTASIS; HUMANS; MODELS, THEORETICAL; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 62749167005     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2008.01152.x     Document Type: Article

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