Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 Å crystal structure

Journal of Molecular Biology

Volumn 312, Issue 4, 2001, Pages 731-742

  Lang, Rupert ^a   Kocourek, Andreas ^b   Braun, Marianne ^a   Tschesche, Harald ^b   Huber, Robert ^a   Bode, Wolfram ^a   Maskos, Klaus ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

Author keywords

Crystal structure; Elastase; Emphysema; Matrix metalloproteinase; 1 proteinase inhibitor

Indexed keywords

BATIMASTAT; MACROPHAGE ELASTASE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN TISSUE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0035965125     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4954     Document Type: Article

References (58)

1. Matrix metalloproteinases
2. Insights into MMP-TIMP interactions
3. Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII
4. The serpin alpha 1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
5. Structural properties of matrix metalloproteinases
6. Structure and promoter characterization of the human membrane-typed matrix metalloproteinase (mt1-mmp) gene
7. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors
8. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms
9. Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice
10. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase
11. Animal models for chronic obstructive pulmonary disease - Age of klotho and marlboro mice
12. Human collagenase (matrix metalloproteinase-1) expression in lungs of patients with emphysema
13. Diverse roles of macrophage matrix metalloproteinases in tissue destruction and tumor growth
14. Alpha 1-proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase
15. Human plasma proteinase inhibitors
16. Matrix metalloproteinases generate angiostatin - Effects on neovascularization
17. Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein
18. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
19. Structural studies on MMPs and TIMPs
20. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages
21. Structural implications for the role of the N terminus in the "superactivation" of collagenases. A crystallographic study
22. Structure of human pro-matrix metalloproteinase-2: Activation mechanism revealed
23. Matrilysin-inhibitor complexes - Common themes among metalloproteases
24. 3D search and research using the Cambridge Structural Database
25. Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor
26. X-Ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors - Implications for substrate binding and rational drug design
27. Characterization of zinc-binding sites in human stromelysin-1: Stoichiometry of the catalytic domain and identification of a cysteine ligand in the proenzyme
28. The second zinc atom in the matrix metalloproteinase catalytic domain is absent in the full-length enzymes: A possible role for the C-terminal domain
29. Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils
30. The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity
31. Calcium-binding sites in proteins: A structural perspective
32. Elastin degradation by matrix metalloproteinases - Cleavage site specificity and mechanisms of elastolysis
33. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by Timp-1
34. Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin
35. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma
36. Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)
37. Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12) in actinic damage
38. Interferon gamma induction of pulmonary emphysema in the adult murine lung
39. A general method of in vitro preparation and specific mutagenesis of DNA fragments: Study of protein and DNA interactions
40. Purification of human collagenases with a hydroxamic acid affinity column
41. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3
42. Solvent content of protein crystals
43. Processing of X-ray diffraction data collected in oscillations mode
44. AMoRe: An automated package for molecular replacement
45. Accurate bond and angle parameters for X-ray protein structure refinement
46. Crystallography and NMR systems (CNS): A new software system for macromolecular structure determination
47. Improved methods for building protein models in electron density maps and the location of errors in these models
48. SHELXL: High resolution refinement
49. The CCP4 suiteprograms for protein crystallography
50. PROCHECK: A program to check the stereochemical quality of protein structures
51. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities
52. Raster3D version 2.0. A program for photorealistic molecular graphics
53. ALSCRIPT. A tool to format multiple sequence alignments
54. Swiss-PDBViewer: A fast and easy-to-use PDB viewer for Macintosh and PC