Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 strain

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 294, Issue 2, 2008, Pages

  Mori, Hiroaki ^a   Nose, Takashi ^b   Ishitani, Kouki ^b   Kasagi, Satoshi ^a   Souma, Sanae ^a   Akiyoshi, Taeko ^a   Kodama, Yuzo ^a   Mori, Takanori ^a   Kondo, Miwa ^b   Sasaki, Shinichi ^c   Iwase, Akihiko ^d   Takahashi, Kazuhisa ^a   Fukuchi, Yoshinosuke ^a   Seyama, Kuniaki ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Grelan Pharmaceutical Co Ltd   (Japan)

^c JUNTENDO UNIVERSITY URAYASU HOSPITAL   (Japan)

^d JUNTENDO TOKYO KOTO GERIATRIC MEDICAL CENTER   (Japan)

Author keywords

Aging; Apoptosis; Oxidative stress; Protease; Vascular endothelial growth factor

Indexed keywords

3 BENZYL 5 PHENYL 1H PYRAZOLO[4,3 C][1,8]NAPHTHYRIDIN 4(H) ONE; CIGARETTE SMOKE; CYCLIC AMP; GPD 1116; MACROPHAGE ELASTASE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; INFLAMMATORY CELL; LUNG ALVEOLUS CELL; LUNG EMPHYSEMA; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER;

AEROSOLS; AGING; ANIMALS; APOPTOSIS; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ENZYME INHIBITORS; LEUKOCYTES; LIPOPOLYSACCHARIDES; LUNG; MATRIX METALLOPROTEINASE 12; MICE; MICE, INBRED STRAINS; NAPHTHYRIDINES; PULMONARY EMPHYSEMA; SMOKING; SUBCELLULAR FRACTIONS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 39149104982     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00173.2007     Document Type: Article

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