Animal models of cigarette smoke-induced chronic obstructive lung disease

Contributions to Microbiology

Volumn 14, Issue , 2007, Pages 113-125

  Churg, A ^a   Wright, J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MUS;

ANIMAL; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE MODEL; GUINEA PIG; HUMAN; LUNG ALVEOLUS; MOUSE; PATHOLOGY; REVIEW; SMOKING;

ANIMALS; DISEASE MODELS, ANIMAL; GUINEA PIGS; HUMANS; MICE; PULMONARY ALVEOLI; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 35848937351     PISSN: 14209519     EISSN: 1662291X     Source Type: Book Series    
DOI: 10.1159/000107058     Document Type: Review

References (35)

1. Wright JL, Churg A: Cigarette smoke causes physiological and morphological changes of emphysema in the guinea pig. Am Rev Respir Dis 1990;142:1422-1428.
2. Pauwels RA, Buist AS, Ma P, Jenkins CR, Hurd SS; GOLD Scientific Committee: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary. Respir Care 2001;46:798-825.
3. Wright JL: The importance of ultramicroscopic emphysema in cigarette smoke induced lung disease. Lung 2001;179:71-81.
4. Cosio MG, Shiner RJ, Saetta M, Wang N-S, King M, Ghezzo H, Angus E: Alveolar fenestrae in smokers. Am Rev Respir Dis 1986;133:126-131.
5. Kuhn C, Tavassoli F: The scanning electron microscopy of elastase-induced emphysema. Lab Invest 1976;34:2-9.
6. Wright JL, Churg A: Smoke-induced emphysema in the guinea pig is associated with morphometric evidence of collagen breakdown and repair. Am J Physiol 1995;268:L17-L20.
7. Thurlbeck WM: Christie Lecture: emphysema then and now. Can Respir J 1994;1:21-39.
8. Churg A, Wang RD, Tai H, Wang X, Xie C, Wright JL: Tumor necrosis factor-α drives 70% of cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2004;170:492-498.
9. Guerassimov A, Hoshino Y, Takubo Y, Turcotte A, Yamamoto M, Ghezzo H, Triantafillopoulos A, Whittaker K, Hoidal JR, Cosio MG: The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am J Respir Crit Care Med 2004;170:974-980.
10. Takubo Y, Guerassimov A, Ghezzo H, Triantafillopoulos A, Bates JH, Hoidal JR, Cosio MG: Alpha1-antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice: parallels with human disease. Am J Respir Crit Care Med 2002;166:1596-1603.
11. Cavarra E, Bartalesi B, Lucattelli M, Fineschi S, Lunghi B, Gambelli F, Ortiz LA, Martorana PA, Lungarella G: Effects of cigarette smoke in mice with different levels of alpha(1)-proteinase inhibitor and sensitivity to oxidants. Am J Respir Crit Care Med 2001;164:886-890.
12. Tuder RM, McGrath S, Neptune E: The pathobiological mechanisms of emphysema models: what do they have in common? Pulm Pharmacol Ther 2003;16:67-78.
13. Churg A, Wang RD, Xie C, Wright JL: α-1-Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2003;168:199-207.
14. Pemberton PA, Kobayashi D, Wilk BJ, Henstrand JM, Shapiro SD, Barr PJ: Inhaled recombinant alpha-1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. COPD 2006;3:101-108.
15. Wright JL, Farmer S, Churg A: A synthetic serine elastase inhibitor reduces cigarette smoke induced emphysema in guinea pigs. Am J Respir Crit Care Med 2002;166:954-960.
16. Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A: Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol 2003;163:2329-2335.
17. Churg A, Wright J: Proteases and emphysema. Curr Opin Pulm Med 2005;11:153-159.
18. Hautamaki R, Kobayashi D, Senior R, Shapiro S: Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997;277:2002-2004.
19. Selman M, Cisneros-Lira J, Gaxiola M, Ramirez R, Kudlacz EM, Mitchell PG, Pardo A: Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in guinea pigs. Chest 2003;123:1633-1641.
20. Martin RL, Shapiro SD, Tong SE, Van Wart H: Macrophage metalloelastase inhibitors; in Hansel TT, Barnes PJ (eds): New Drugs for Asthma, Allergy and COPD. Prog Respir Res. Basel, Karger, 2001, vol 31, pp 177-180.
21. MacNee W: Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005;2:50-60.
22. Foronjy RF, Mirochnitchenko O, Propokenko O, Lemaitre V, Jia Y, Inouye M, Okada Y, D'Armiento JM: Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Am J Respir Crit Care Med 2006;173:623-631.
23. Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S: Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004;114:1248-1259.
24. Iizuka T, Ishii Y, Itoh K, Kiwamoto T, Kimura T, Matsuno Y, Morishima Y, Hegab AE, Homma S, Nomura A, Sakamoto T, Shimura M, Yoshida A, Yamamoto M, Sekizawa K: Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells 2005;10:1113-1125.
25. Martorana PA, Beume R, Lucattelli M, Wollin L, Lungarella G: Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. Am J Respir Crit Care Med 2005;172:848-853.
26. Lee J-H, Lee D-S, Kim E-K, Choe K-H, Oh Y-M, Shim T-S, Kim S-E, Lee Y-S, Lee S-D: Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med 2005;172:987-993.
27. van der Strate BW, Postma DS, Brandsma CA, Melgert BN, Luinge MA, Geerlings M, Hylkema MN, van den Berg A, Timens W, Kerstjens HA: Cigarette smoke-induced emphysema: a role for the B cell? Am J Respir Crit Care Med 2006;173:751-758.
28. Wright JL, Churg A: Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig. Exp Lung Res 1991;17:997-1009.
29. Yamato H, Sun J-P, Churg A, Wright JL: Guinea pig pulmonary hypertension caused by cigarette smoke cannot be explained by capillary bed destruction. J Appl Physiol 1997;82:1644-1653.
30. Wright JL, Tai H, Churg A: Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig. J Appl Physiol 2006;100:672-678.
31. Wright JL, Tai H, Wang R, Wang X, Churg A: Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNFα signaling. Am J Physiol 2007;292:L125-L133. DOI: 10.1152/ajplung.00539.2005.
32. Wright JL, Farmer S, Churg A: A neutrophil elastase inhibitor reduces cigarette smoke-induced remodeling of lung vessels. Eur Respir J 2003;22:77-81.
33. Wright JL, Ngai T, Churg A: Effect of long-term exposure to cigarette smoke on the small airways of the guinea pig. Exp Lung Res 1992;18:105-114.
34. Wright JL, Churg A: Smoking cessation decreases the number of metaplastic secretory cells in the small airways of the guinea pig. Inhal Toxicol 2002;14:101-107.
35. Pemberton P, Cantwell JS, Kim K, Sundin DJ, Kobayashi D, Fink JB, Shapiro SD, Barr PJ: An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD 2005;3:303-310.