메뉴 건너뛰기




Volumn 9, Issue 2, 2009, Pages 202-213

Lipoamino acid prodrugs of paclitaxel: Synthesis and cytotoxicity evaluation on human anaplastic thyroid carcinoma cells

Author keywords

Aro cells; Cell accumulation; Lipoamino acids; Lipophilicity; Paclitaxel; Prodrugs; Taxol

Indexed keywords

2 AMINODECANOIC ACID; 2' O HEMISUCCINATE DERIVATIVE; 2' O SUCCINYL DERIVATIVE; DECANOIC ACID DERIVATIVE; LIPOAMINO ACID DERIVATIVE; NORLEUCINE; PACLITAXEL DERIVATIVE; PRODRUG; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

EID: 62549126476     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800909787580944     Document Type: Article
Times cited : (20)

References (76)
  • 1
    • 0028708678 scopus 로고
    • Clinical pharmacology and metabolism of Taxol (paclitaxel): Update 1993
    • Rowinsky, E. K.; Wright, M.; Monsarrat, B.; Donehower, R. C. Clinical pharmacology and metabolism of Taxol (paclitaxel): update 1993. Ann. Oncol. 1994, 5(Suppl. 6), S7-S16.
    • (1994) Ann. Oncol , vol.5 , Issue.SUPPL. 6
    • Rowinsky, E.K.1    Wright, M.2    Monsarrat, B.3    Donehower, R.C.4
  • 2
    • 0027950826 scopus 로고
    • Taxol (paclitaxel): A novel anti-microtubule agent with remarkable anti-neoplastic activity
    • Foa, R.; Norton, L.; Seidman, A. D. Taxol (paclitaxel): a novel anti-microtubule agent with remarkable anti-neoplastic activity. Int. J. Clin. Lab. Res. 1994, 24, 6-14.
    • (1994) Int. J. Clin. Lab. Res , vol.24 , pp. 6-14
    • Foa, R.1    Norton, L.2    Seidman, A.D.3
  • 3
    • 0031040149 scopus 로고    scopus 로고
    • The development and clinical utility of the taxane class on antimicrotubule chemotherapy agents
    • Rowinsky, E. K. The development and clinical utility of the taxane class on antimicrotubule chemotherapy agents. Annu. Rev. Med. 1997, 48, 353-374.
    • (1997) Annu. Rev. Med , vol.48 , pp. 353-374
    • Rowinsky, E.K.1
  • 6
    • 33644977631 scopus 로고    scopus 로고
    • Anaplastic thyroid carcinoma: Biology, pathogenesis, prognostic factors, and treatment approaches
    • Are, C.; Shaha, A. R. Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches. Ann. Surg. Oncol. 2006, 13, 453-464.
    • (2006) Ann. Surg. Oncol , vol.13 , pp. 453-464
    • Are, C.1    Shaha, A.R.2
  • 7
    • 33751247035 scopus 로고    scopus 로고
    • Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins
    • Hamada, H.; Ishihara, K.; Masuoka, N.; Mikuni, K.; Nakajima, N. Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins. J. Biosci. Bioeng. 2006, 102, 369-371.
    • (2006) J. Biosci. Bioeng , vol.102 , pp. 369-371
    • Hamada, H.1    Ishihara, K.2    Masuoka, N.3    Mikuni, K.4    Nakajima, N.5
  • 9
    • 0028335032 scopus 로고
    • Pharmacology and toxicology of Cremophor EL diluent
    • Dorr, R. T. Pharmacology and toxicology of Cremophor EL diluent. Ann. Pharmacother. 1994, 28, S11-S14.
    • (1994) Ann. Pharmacother , vol.28
    • Dorr, R.T.1
  • 11
    • 38949108587 scopus 로고    scopus 로고
    • Recent Developments in Taxane Drug Delivery
    • Safavy, A. Recent Developments in Taxane Drug Delivery. Curr. Drug Deliv. 2008, 5, 42-54.
    • (2008) Curr. Drug Deliv , vol.5 , pp. 42-54
    • Safavy, A.1
  • 12
    • 34447545904 scopus 로고    scopus 로고
    • Novel enhanced delivery taxanes: An update
    • Perez, E. A. Novel enhanced delivery taxanes: an update. Semin. Oncol. 2007, 34(Suppl.), 1-5.
    • (2007) Semin. Oncol , vol.34 , Issue.SUPPL. , pp. 1-5
    • Perez, E.A.1
  • 14
    • 33745386420 scopus 로고    scopus 로고
    • Enhanced oral paclitaxel bioavailability after administration of pacli- taxel-loaded lipid nanocapsules
    • Peltier, S.; Oger, J. M.; Lagarce, F.; Couet, W.; Benoit, J. P. Enhanced oral paclitaxel bioavailability after administration of pacli- taxel-loaded lipid nanocapsules. Pharm. Res. 2006, 23, 1243-1250.
    • (2006) Pharm. Res , vol.23 , pp. 1243-1250
    • Peltier, S.1    Oger, J.M.2    Lagarce, F.3    Couet, W.4    Benoit, J.P.5
  • 15
    • 0028280464 scopus 로고
    • A mixed micellar formulation suitable for parenteral administration of taxol
    • Onyuksel, H.; Ramakrishanan, S.; Chai, H. B.; Pezzuto, J. M. A mixed micellar formulation suitable for parenteral administration of taxol. Pharm. Res. 1994, 11, 206-212.
    • (1994) Pharm. Res , vol.11 , pp. 206-212
    • Onyuksel, H.1    Ramakrishanan, S.2    Chai, H.B.3    Pezzuto, J.M.4
  • 16
    • 0033964804 scopus 로고    scopus 로고
    • Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes
    • Crosasso, P.; Ceruti, M.; Brusa, P.; Arpicco, S.; Dosio, F.; Cattel, L. Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes. J. Control. Release 2000, 63, 19-30.
    • (2000) J. Control. Release , vol.63 , pp. 19-30
    • Crosasso, P.1    Ceruti, M.2    Brusa, P.3    Arpicco, S.4    Dosio, F.5    Cattel, L.6
  • 18
    • 0030947239 scopus 로고    scopus 로고
    • Preparation, characterization and properties in vitro and in vivo of pacli- taxel-albumin conjugate
    • Dosio, F.; Brusa, P.; Crosasso, P.; Arpicco, S.; Cattel, L. Preparation, characterization and properties in vitro and in vivo of pacli- taxel-albumin conjugate. J. Contr. Release 1997, 47, 293-304.
    • (1997) J. Contr. Release , vol.47 , pp. 293-304
    • Dosio, F.1    Brusa, P.2    Crosasso, P.3    Arpicco, S.4    Cattel, L.5
  • 19
    • 0028896964 scopus 로고    scopus 로고
    • Burt, H.; Jackson, J. K.; Sarvjeet, B. K.; Liggins, R. T.; Oktaba, A. M.; Arsenault, L. A; Hunter, W. L. Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (D,L-lactic acid). Cancer Lett. 1995, 88, 73-79.
    • Burt, H.; Jackson, J. K.; Sarvjeet, B. K.; Liggins, R. T.; Oktaba, A. M.; Arsenault, L. A; Hunter, W. L. Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (D,L-lactic acid). Cancer Lett. 1995, 88, 73-79.
  • 20
    • 0023165070 scopus 로고
    • A new parenteral emulsion for administration of taxol
    • Tarr, B.; Sambandan, T. G.; Yalkowsky, S. H. A new parenteral emulsion for administration of taxol. Pharm. Res. 1987, 4, 162-165.
    • (1987) Pharm. Res , vol.4 , pp. 162-165
    • Tarr, B.1    Sambandan, T.G.2    Yalkowsky, S.H.3
  • 21
    • 0031033405 scopus 로고    scopus 로고
    • A submicron lipid emulsion coated with amphi- patic polyethylene glycol for parenteral administration of paclitaxel (taxol)
    • Lundberg, B. B. A submicron lipid emulsion coated with amphi- patic polyethylene glycol for parenteral administration of paclitaxel (taxol). J. Pharm. Pharmacol. 1997, 49, 16-21.
    • (1997) J. Pharm. Pharmacol , vol.49 , pp. 16-21
    • Lundberg, B.B.1
  • 22
    • 1542291181 scopus 로고    scopus 로고
    • Nanoparticles of biodegradable polymers for clinical administration of paclitaxel
    • Feng, S. S.; Mu, L.; Win, K. Y.; Huang, G. Nanoparticles of biodegradable polymers for clinical administration of paclitaxel. Curr. Med. Chem. 2004, 11, 413-424.
    • (2004) Curr. Med. Chem , vol.11 , pp. 413-424
    • Feng, S.S.1    Mu, L.2    Win, K.Y.3    Huang, G.4
  • 25
    • 33745423724 scopus 로고    scopus 로고
    • Phar- macokinetics and biodistribution of polymeric micelles of pacli- taxel with Pluronic P123
    • Han, L. M.; Guo, J.; Zhang, L. J.; Wang, Q. S.; Fang, X. L. Phar- macokinetics and biodistribution of polymeric micelles of pacli- taxel with Pluronic P123. Acta Pharmacol. Sin. 2006, 27, 747-753.
    • (2006) Acta Pharmacol. Sin , vol.27 , pp. 747-753
    • Han, L.M.1    Guo, J.2    Zhang, L.J.3    Wang, Q.S.4    Fang, X.L.5
  • 26
    • 56949084877 scopus 로고    scopus 로고
    • Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
    • Epub ahead of print
    • Kratz, F. Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles. J. Control. Release 2008 [Epub ahead of print].
    • (2008) J. Control. Release
    • Kratz, F.1
  • 27
    • 33745458519 scopus 로고    scopus 로고
    • Albumin-bound paclitaxel: A next-generation taxane
    • Gradishar, W. J. Albumin-bound paclitaxel: a next-generation taxane. Expert Opin. Pharmacother. 2006, 7, 1041-1053.
    • (2006) Expert Opin. Pharmacother , vol.7 , pp. 1041-1053
    • Gradishar, W.J.1
  • 28
    • 34548563733 scopus 로고    scopus 로고
    • Using nanotechnology to improve the characteristics of antineoplastic drugs: Improved characteristics of nab-paclitaxel compared with solvent-based paclitaxel
    • Foote, M. Using nanotechnology to improve the characteristics of antineoplastic drugs: improved characteristics of nab-paclitaxel compared with solvent-based paclitaxel. Biotechnol. Annu. Rev. 2007, 13, 345-357.
    • (2007) Biotechnol. Annu. Rev , vol.13 , pp. 345-357
    • Foote, M.1
  • 29
    • 0037619168 scopus 로고    scopus 로고
    • Poly-(L)-glutamic acid- paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: Characterization, preclinical pharmacology, and preliminary clinical data
    • Singer, J. W.; Baker, B.; De Vries, P.; Kumar, A.; Shaffer, S.; Vawter, E.; Bolton, M.; Garzone, P. Poly-(L)-glutamic acid- paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data. Adv. Exp. Med. Biol. 2003, 519, 81-99.
    • (2003) Adv. Exp. Med. Biol , vol.519 , pp. 81-99
    • Singer, J.W.1    Baker, B.2    De Vries, P.3    Kumar, A.4    Shaffer, S.5    Vawter, E.6    Bolton, M.7    Garzone, P.8
  • 30
    • 34548626932 scopus 로고    scopus 로고
    • Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate
    • Chipman, S. D.; Oldham, F. B.; Pezzoni, G.; Singer, J. W. Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate. Int. J. Nanomed. 2006, 1, 375-383.
    • (2006) Int. J. Nanomed , vol.1 , pp. 375-383
    • Chipman, S.D.1    Oldham, F.B.2    Pezzoni, G.3    Singer, J.W.4
  • 31
    • 34247629652 scopus 로고    scopus 로고
    • Paclitaxel poliglumex (PPX, CT-2103): Macromolecu- lar medicine for advanced non-small-cell lung cancer
    • Bonomi, P. Paclitaxel poliglumex (PPX, CT-2103): macromolecu- lar medicine for advanced non-small-cell lung cancer. Expert Rev. Anticancer Ther. 2007, 7, 415-422.
    • (2007) Expert Rev. Anticancer Ther , vol.7 , pp. 415-422
    • Bonomi, P.1
  • 33
    • 50149116962 scopus 로고    scopus 로고
    • Gynecologic Oncology Group. Paclitaxel poliglumex and carboplatin as first-line therapy in ovarian, peritoneal or fallopian tube cancer: A phase I and feasibility trial of the Gynecologic Oncology Group
    • Morgan, M. A.; Darcy, K. M.; Rose, P. G.; DeGeest, K.; Bookman, M.A.; Aikins, J. K.; Sill, M. W.; Mannel, R. S.; Allievi, C.; Egorin, M. J.; Gynecologic Oncology Group. Paclitaxel poliglumex and carboplatin as first-line therapy in ovarian, peritoneal or fallopian tube cancer: a phase I and feasibility trial of the Gynecologic Oncology Group. Gynecol. Oncol. 2008, 110, 329-335.
    • (2008) Gynecol. Oncol , vol.110 , pp. 329-335
    • Morgan, M.A.1    Darcy, K.M.2    Rose, P.G.3    DeGeest, K.4    Bookman, M.A.5    Aikins, J.K.6    Sill, M.W.7    Mannel, R.S.8    Allievi, C.9    Egorin, M.J.10
  • 34
    • 44349123949 scopus 로고    scopus 로고
    • Synthesis and evaluation of water-soluble poly(vinyl alcohol)-paclitaxel conjugate as a macromolecular prodrug
    • Kakinoki, A.; Kaneo, Y.; Tanaka, T.; Hosokawa, Y. Synthesis and evaluation of water-soluble poly(vinyl alcohol)-paclitaxel conjugate as a macromolecular prodrug. Biol. Pharm. Bull. 2008, 31, 963-996.
    • (2008) Biol. Pharm. Bull , vol.31 , pp. 963-996
    • Kakinoki, A.1    Kaneo, Y.2    Tanaka, T.3    Hosokawa, Y.4
  • 35
    • 0030071043 scopus 로고    scopus 로고
    • Drug delivery systems: Water soluble taxol 2'- poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness
    • Greenwald, R. B.; Gilbert, C. W.; Pendri, A.; Conover, C. D.; Xia, J.; Martinez, A. Drug delivery systems: water soluble taxol 2'- poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness. J. Med. Chem. 1996, 39, 424-431.
    • (1996) J. Med. Chem , vol.39 , pp. 424-431
    • Greenwald, R.B.1    Gilbert, C.W.2    Pendri, A.3    Conover, C.D.4    Xia, J.5    Martinez, A.6
  • 36
    • 0031857631 scopus 로고    scopus 로고
    • Antitumor activity of paclitaxel-2'-glycinate conjugated to poly(ethylene glycol): A water- soluble prodrug
    • Pendri, A.; Conover, C. D.; Greenwald, R. B. Antitumor activity of paclitaxel-2'-glycinate conjugated to poly(ethylene glycol): a water- soluble prodrug. Anticancer Drug Des. 1998, 13, 387-395.
    • (1998) Anticancer Drug Des , vol.13 , pp. 387-395
    • Pendri, A.1    Conover, C.D.2    Greenwald, R.B.3
  • 37
    • 3242736466 scopus 로고    scopus 로고
    • Enhanced paclitaxel bioavailability after oral administration of pegylated paclitaxel prodrug for oral delivery in rats
    • Choi, J. -S.; Jo, B. -W. Enhanced paclitaxel bioavailability after oral administration of pegylated paclitaxel prodrug for oral delivery in rats. Int. J. Pharm. 2004, 280, 221-227.
    • (2004) Int. J. Pharm , vol.280 , pp. 221-227
    • Choi, J.-S.1    Jo, B.-W.2
  • 38
    • 1442359716 scopus 로고    scopus 로고
    • Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pre- treated with quercetin
    • Choi, J. -S.; Jo, B. -W.; Kim, Y. -C. Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pre- treated with quercetin. Eur. J. Pharm. Biopharm. 2004, 57, 313-318.
    • (2004) Eur. J. Pharm. Biopharm , vol.57 , pp. 313-318
    • Choi, J.-S.1    Jo, B.-W.2    Kim, Y.-C.3
  • 39
    • 23744480026 scopus 로고    scopus 로고
    • Anti-tumor activity of paclitaxel prodrug conjugated with polyethylene glycol
    • Lee, K. H.; Chung, Y. J.; Kim, Y. -C.; Song, S. J. Anti-tumor activity of paclitaxel prodrug conjugated with polyethylene glycol. Bull. Korean Chem. Soc. 2005, 26, 1079-1082.
    • (2005) Bull. Korean Chem. Soc , vol.26 , pp. 1079-1082
    • Lee, K.H.1    Chung, Y.J.2    Kim, Y.-C.3    Song, S.J.4
  • 40
    • 33845508580 scopus 로고    scopus 로고
    • Paclitaxel Prodrugs: Toward Smarter Delivery of Anticancer Agents
    • Skwarczynski, M.; Hayashi, Y.; Kiso, Y. Paclitaxel Prodrugs: Toward Smarter Delivery of Anticancer Agents. J. Med. Chem. 2006, 49, 7253-7269.
    • (2006) J. Med. Chem , vol.49 , pp. 7253-7269
    • Skwarczynski, M.1    Hayashi, Y.2    Kiso, Y.3
  • 41
    • 0033253860 scopus 로고    scopus 로고
    • Growth inhibition of a human ovarian tumor by a novel paclitaxel derivative in SCID mice
    • Ahmad, I.; Masters, G. R.; Schupsky, J. J.; Nguyen, J.; Ali, S.; Janoff, A. S.; Mayhew, E. Growth inhibition of a human ovarian tumor by a novel paclitaxel derivative in SCID mice. Oncol. Res. 1999, 11, 273-280.
    • (1999) Oncol. Res , vol.11 , pp. 273-280
    • Ahmad, I.1    Masters, G.R.2    Schupsky, J.J.3    Nguyen, J.4    Ali, S.5    Janoff, A.S.6    Mayhew, E.7
  • 44
    • 38049110236 scopus 로고    scopus 로고
    • Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(epsilon- caprolactone) micelle nanocarriers: Pharmacokinetic disposition, tolerability, and cytotoxicity
    • Forrest, M. L.; Yanez, J. A.; Remsberg, C. M.; Ohgami, Y.; Kwon, G. S.; Davies, N. M. Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(epsilon- caprolactone) micelle nanocarriers: pharmacokinetic disposition, tolerability, and cytotoxicity. Pharm. Res. 2008, 25, 194-206.
    • (2008) Pharm. Res , vol.25 , pp. 194-206
    • Forrest, M.L.1    Yanez, J.A.2    Remsberg, C.M.3    Ohgami, Y.4    Kwon, G.S.5    Davies, N.M.6
  • 45
    • 17644366858 scopus 로고    scopus 로고
    • A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug
    • Stevens, P. J.; Sekido, M.; Lee, R. J. A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug. Pharm. Res. 2004, 21, 2153-2157.
    • (2004) Pharm. Res , vol.21 , pp. 2153-2157
    • Stevens, P.J.1    Sekido, M.2    Lee, R.J.3
  • 46
    • 36049049858 scopus 로고    scopus 로고
    • Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme
    • Nikanjam, M.; Gibbs, A. R.; Hunt, C. A.; Budinger, T. F.; Forte, T. M. Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme. J. Control. Release 2007, 124, 163-171.
    • (2007) J. Control. Release , vol.124 , pp. 163-171
    • Nikanjam, M.1    Gibbs, A.R.2    Hunt, C.A.3    Budinger, T.F.4    Forte, T.M.5
  • 47
    • 0028067744 scopus 로고
    • A novel chemical approach to drug delivery: Lipid amino acid conjugates
    • Toth, I. A novel chemical approach to drug delivery: lipid amino acid conjugates. J. Drug Target 1994, 2, 217-239.
    • (1994) J. Drug Target , vol.2 , pp. 217-239
    • Toth, I.1
  • 48
    • 0034935071 scopus 로고    scopus 로고
    • Lipid, sugar and liposaccharide based delivery systems
    • Wong, A.; Toth, I. Lipid, sugar and liposaccharide based delivery systems. Curr. Med. Chem. 2001, 8, 1123-1136.
    • (2001) Curr. Med. Chem , vol.8 , pp. 1123-1136
    • Wong, A.1    Toth, I.2
  • 49
    • 4444244953 scopus 로고    scopus 로고
    • Lipid, sugar and liposaccharide based delivery systems 2
    • Blanchfield, J.; Toth, I. Lipid, sugar and liposaccharide based delivery systems 2. Curr. Med. Chem. 2004, 11, 2375-2382.
    • (2004) Curr. Med. Chem , vol.11 , pp. 2375-2382
    • Blanchfield, J.1    Toth, I.2
  • 50
    • 0026564126 scopus 로고    scopus 로고
    • Wood, I. P.; Toth, I.; Halley, J. L.; Gibbons, W. A. Lipidic peptides. XIII. Synthesis, structure elucidation, and in vitro toxicity assessment of chlorambucil conjugates with lipidic acids, lipidic amino acids and their oligomers. Int. J. Pharm. 1992, 87, 141-147.
    • Wood, I. P.; Toth, I.; Halley, J. L.; Gibbons, W. A. Lipidic peptides. XIII. Synthesis, structure elucidation, and in vitro toxicity assessment of chlorambucil conjugates with lipidic acids, lipidic amino acids and their oligomers. Int. J. Pharm. 1992, 87, 141-147.
  • 51
    • 0031900337 scopus 로고    scopus 로고
    • Lipoamino acid conjugates of methotrexate with antitumor activity
    • Pignatello, R.; Jansen, G.; Kathmann, I.; Puglisi, G.; Toth, I. Lipoamino acid conjugates of methotrexate with antitumor activity. J. Pharm. Sci. 1998, 87, 367-371.
    • (1998) J. Pharm. Sci , vol.87 , pp. 367-371
    • Pignatello, R.1    Jansen, G.2    Kathmann, I.3    Puglisi, G.4    Toth, I.5
  • 52
    • 0034126277 scopus 로고    scopus 로고
    • Pignatello, R.; Spampinato, G.; Sorrenti, V.; Di Giacomo, C.; Vi- cari, L.; McGuire, J. J.; Russell, C. A.; Puglisi, G.; Toth, I. Lipo- philic methotrexate conjugates with antitumor activity. Eur. J. Pharm. Sci. 2000, 10, 237-245.
    • Pignatello, R.; Spampinato, G.; Sorrenti, V.; Di Giacomo, C.; Vi- cari, L.; McGuire, J. J.; Russell, C. A.; Puglisi, G.; Toth, I. Lipo- philic methotrexate conjugates with antitumor activity. Eur. J. Pharm. Sci. 2000, 10, 237-245.
  • 53
    • 0034969204 scopus 로고    scopus 로고
    • Lipophilic methotrexate conjugates with glucose-lipoamino acid moieties: Synthesis and in vitro anti- tumor activity
    • Pignatello, R.; Vicari, L.; Sorrenti, V.; Di Giacomo, C.; Spampi- nato, G.; Puglisi, G.; Toth, I. Lipophilic methotrexate conjugates with glucose-lipoamino acid moieties: synthesis and in vitro anti- tumor activity. Drug Dev. Res. 2001, 52, 454-464.
    • (2001) Drug Dev. Res , vol.52 , pp. 454-464
    • Pignatello, R.1    Vicari, L.2    Sorrenti, V.3    Di Giacomo, C.4    Spampi- nato, G.5    Puglisi, G.6    Toth, I.7
  • 54
    • 2442549560 scopus 로고    scopus 로고
    • Lipo- philic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling
    • Pignatello, R.; Guccione, S.; Forte, S.; Di Giacomo, C.; Sorrenti, V.; Vicari, L.; Uccello Barretta, G.; Balzano, F.; Puglisi, G. Lipo- philic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling. Bioorg. Med. Chem. 2004, 12, 2951-2964.
    • (2004) Bioorg. Med. Chem , vol.12 , pp. 2951-2964
    • Pignatello, R.1    Guccione, S.2    Forte, S.3    Di Giacomo, C.4    Sorrenti, V.5    Vicari, L.6    Uccello Barretta, G.7    Balzano, F.8    Puglisi, G.9
  • 55
    • 2942685195 scopus 로고    scopus 로고
    • Synthesis, physico-chemical and biological characterization of a paclitaxel macromolecular prodrug
    • Cavallaro, G.; Licciardi, M.; Caliceti, P.; Salmaso, S.; Giammona, G. Synthesis, physico-chemical and biological characterization of a paclitaxel macromolecular prodrug. Eur. J. Pharm. Biopharm. 2004, 58, 151-159.
    • (2004) Eur. J. Pharm. Biopharm , vol.58 , pp. 151-159
    • Cavallaro, G.1    Licciardi, M.2    Caliceti, P.3    Salmaso, S.4    Giammona, G.5
  • 56
    • 0027455042 scopus 로고
    • High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas
    • Fagin, J. A.; Matsuo, K.; Karmakar, A.; Chen, D. L.; Tang, S. H.; Koeffler, H. P. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J. Clin. Invest. 1993, 91, 179-184.
    • (1993) J. Clin. Invest , vol.91 , pp. 179-184
    • Fagin, J.A.1    Matsuo, K.2    Karmakar, A.3    Chen, D.L.4    Tang, S.H.5    Koeffler, H.P.6
  • 57
    • 0031752682 scopus 로고    scopus 로고
    • Anaplastic thyroid carcinoma: Behavior, biology, and therapeutic approaches
    • Ain, K. B. Anaplastic thyroid carcinoma: behavior, biology, and therapeutic approaches. Thyroid 1998, 8, 715-726.
    • (1998) Thyroid , vol.8 , pp. 715-726
    • Ain, K.B.1
  • 58
    • 0037249255 scopus 로고    scopus 로고
    • Anaplastic thyroid cancer
    • Pasieka, J. L. Anaplastic thyroid cancer. Curr. Opin. Oncol. 2003, 75, 78-83.
    • (2003) Curr. Opin. Oncol , vol.75 , pp. 78-83
    • Pasieka, J.L.1
  • 59
    • 0029823530 scopus 로고    scopus 로고
    • Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo
    • Ain, K. B.; Tofiq, S.; Taylor, K. D. Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo. J. Clin. Endocrinol. Metab. 1996, 87, 3650-3653.
    • (1996) J. Clin. Endocrinol. Metab , vol.87 , pp. 3650-3653
    • Ain, K.B.1    Tofiq, S.2    Taylor, K.D.3
  • 60
    • 0033840233 scopus 로고    scopus 로고
    • Treatment of anaplastic thyroid carcinoma with paclitaxel: Phase 2 trial using ninety-six- hour infusion. Collaborative Anaplastic Thyroid Cancer Health Intervention Trials (CATCHIT) Group
    • Ain, K. B.; Egorin, M. J.; De Simone, P. A. Treatment of anaplastic thyroid carcinoma with paclitaxel: phase 2 trial using ninety-six- hour infusion. Collaborative Anaplastic Thyroid Cancer Health Intervention Trials (CATCHIT) Group. Thyroid2000, 10, 587-594.
    • (2000) Thyroid , vol.10 , pp. 587-594
    • Ain, K.B.1    Egorin, M.J.2    De Simone, P.A.3
  • 61
    • 34547730849 scopus 로고    scopus 로고
    • Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model
    • Yeung, S. C.; She, M.; Yang, H.; Pan, J.; Sun, L.; Chaplin, D. Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model. J. Clin. Endocrinol. Metab. 2007, 92, 2902-2909.
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 2902-2909
    • Yeung, S.C.1    She, M.2    Yang, H.3    Pan, J.4    Sun, L.5    Chaplin, D.6
  • 62
    • 0035040127 scopus 로고    scopus 로고
    • Angiogenesis inhibition in the in vivo antineoplastic effect of manumycin and paclitaxel against anaplastic thyroid carcinoma
    • Xu, G.; Pan, J.; Martin, C.; Yeung, S. C. Angiogenesis inhibition in the in vivo antineoplastic effect of manumycin and paclitaxel against anaplastic thyroid carcinoma. J. Clin. Endocrinol. Metab. 2001, 86, 1769-1777.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 1769-1777
    • Xu, G.1    Pan, J.2    Martin, C.3    Yeung, S.C.4
  • 63
    • 33646149656 scopus 로고    scopus 로고
    • Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1
    • Copland, J. A.; Marlow, L. A.; Kurakata, S.; Fujiwara, K.; Wong, A. K.; Kreinest, P. A.; Williams, S. F.; Haugen, B. R.; Klopper, J. P.; Smallridge, R. C. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene 2006, 25, 2304-2317.
    • (2006) Oncogene , vol.25 , pp. 2304-2317
    • Copland, J.A.1    Marlow, L.A.2    Kurakata, S.3    Fujiwara, K.4    Wong, A.K.5    Kreinest, P.A.6    Williams, S.F.7    Haugen, B.R.8    Klopper, J.P.9    Smallridge, R.C.10
  • 64
    • 0141786825 scopus 로고    scopus 로고
    • Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the of chemotherapeutics agents in vitro
    • Mahoney, B. P.; Raghunand, N.; Baggett, B.; Gillies, R. J. Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the of chemotherapeutics agents in vitro. Biochem. Pharmacol. 2003, 66, 1207-1218.
    • (2003) Biochem. Pharmacol , vol.66 , pp. 1207-1218
    • Mahoney, B.P.1    Raghunand, N.2    Baggett, B.3    Gillies, R.J.4
  • 65
    • 0032789521 scopus 로고    scopus 로고
    • Determinants of paclitaxel penetration and accumulation in human solid tumor
    • Kuh, H. J.; Jang, S. H.; Wientjes, M. G.; Weaver, J. R.; Au, J. L. Determinants of paclitaxel penetration and accumulation in human solid tumor. J. Pharmacol. Exp. Ther. 1999, 290, 871-880.
    • (1999) J. Pharmacol. Exp. Ther , vol.290 , pp. 871-880
    • Kuh, H.J.1    Jang, S.H.2    Wientjes, M.G.3    Weaver, J.R.4    Au, J.L.5
  • 66
    • 0036351238 scopus 로고    scopus 로고
    • Multidrug resistance gene-1 is a useful predictor of Paclitaxel-based chemotherapy for patients with ovarian cancer
    • Kamazawa, S.; Kigawa, J.; Kanamori, Y.; Itamochi, H.; Sato, S.; Iba, T.; Terakawa, N. Multidrug resistance gene-1 is a useful predictor of Paclitaxel-based chemotherapy for patients with ovarian cancer. Gynecol. Oncol. 2002, 86, 171-176.
    • (2002) Gynecol. Oncol , vol.86 , pp. 171-176
    • Kamazawa, S.1    Kigawa, J.2    Kanamori, Y.3    Itamochi, H.4    Sato, S.5    Iba, T.6    Terakawa, N.7
  • 67
    • 34247237746 scopus 로고    scopus 로고
    • Parry, S.; Zhang, J. Multidrug resistance proteins affect drug transmission across the placenta. Am. J. Obstet. Gynecol. 2007, 196, 476.e1-e6.
    • Parry, S.; Zhang, J. Multidrug resistance proteins affect drug transmission across the placenta. Am. J. Obstet. Gynecol. 2007, 196, 476.e1-e6.
  • 68
    • 1542346470 scopus 로고    scopus 로고
    • The influence of enaminones on the transport and oral bioavailability of P- glycoprotein substrate therapeutic agents
    • Salama, N. N.; Scott, K. R.; Eddington, N. D. The influence of enaminones on the transport and oral bioavailability of P- glycoprotein substrate therapeutic agents. Int. J. Pharm. 2004, 273, 135-147.
    • (2004) Int. J. Pharm , vol.273 , pp. 135-147
    • Salama, N.N.1    Scott, K.R.2    Eddington, N.D.3
  • 69
    • 18144399975 scopus 로고    scopus 로고
    • Clinical pharmacogenetics of immuno- suppressive drugs in organ transplantation
    • Szekeres, T.; Haushofer, A. Clinical pharmacogenetics of immuno- suppressive drugs in organ transplantation. Pharmacogenomics 2005, 6, 163-168.
    • (2005) Pharmacogenomics , vol.6 , pp. 163-168
    • Szekeres, T.1    Haushofer, A.2
  • 71
    • 35348930627 scopus 로고    scopus 로고
    • Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport
    • Amioka, K.; Kuzuya, T.; Kushihara, H.; Ejiri, M.; Nitta, A.; Na- beshima, T. Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport. J. Pharm. Pharmacol. 2007, 59, 1383-1387.
    • (2007) J. Pharm. Pharmacol , vol.59 , pp. 1383-1387
    • Amioka, K.1    Kuzuya, T.2    Kushihara, H.3    Ejiri, M.4    Nitta, A.5    Na- beshima, T.6
  • 72
    • 33846105372 scopus 로고    scopus 로고
    • Assessment of the first and second generation antihistamines brain penetration and role of P-glycoprotein
    • Obradovic, T.; Dobson, G. G.; Shingaki, T.; Kungu, T.; Hidalgo, I. J. Assessment of the first and second generation antihistamines brain penetration and role of P-glycoprotein. Pharm. Res. 2007, 24, 318-327.
    • (2007) Pharm. Res , vol.24 , pp. 318-327
    • Obradovic, T.1    Dobson, G.G.2    Shingaki, T.3    Kungu, T.4    Hidalgo, I.J.5
  • 73
    • 33747891036 scopus 로고    scopus 로고
    • Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells
    • Manov, I.; Bashenko, Y.; Hirsh, M.; Iancu, T. C. Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells. Basic Clin. Pharmacol. Toxicol. 2006, 99, 213-224.
    • (2006) Basic Clin. Pharmacol. Toxicol , vol.99 , pp. 213-224
    • Manov, I.1    Bashenko, Y.2    Hirsh, M.3    Iancu, T.C.4
  • 74
    • 0035032962 scopus 로고    scopus 로고
    • P-glycoprotein efflux pump expression and activity in Calu-3 cells
    • Hamilton, K. O.; Backstrom, G.; Yazdanian, M. A.; Audus, K. L. P-glycoprotein efflux pump expression and activity in Calu-3 cells. J. Pharm. Sci. 2001, 90, 647-658.
    • (2001) J. Pharm. Sci , vol.90 , pp. 647-658
    • Hamilton, K.O.1    Backstrom, G.2    Yazdanian, M.A.3    Audus, K.L.4
  • 75
    • 33745746815 scopus 로고    scopus 로고
    • Pharmacological strategies for overcoming multidrug resistance
    • Nobili, S.; Landini, I.; Giglioni, B.; Mini, E. Pharmacological strategies for overcoming multidrug resistance. Curr. Drug Targets 2006, 7, 861-879.
    • (2006) Curr. Drug Targets , vol.7 , pp. 861-879
    • Nobili, S.1    Landini, I.2    Giglioni, B.3    Mini, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.