Lipophilic methotrexate conjugates with antitumor activity

European Journal of Pharmaceutical Sciences

Volumn 10, Issue 3, 2000, Pages 237-245

  Pignatello, Rosario ^a,b   Spampinato, Giuseppina ^b   Sorrenti, Valeria ^b   Di Giacomo, Claudia ^b   Vicari, Luisa ^b   McGuire, John J ^c   Russell, Cynthia A ^c   Puglisi, Giovanni ^b   Toth, Istvan ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF CATANIA   (Italy)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Antitumor agents; CCRF CEM cells; CEM MTX cells; Lipoamino acids; Lipophilicity; Methotrexate conjugates

Indexed keywords

DIHYDROFOLATE REDUCTASE; LIPOAMINO ACID CONJUGATE; LIVER ENZYME; METHOTREXATE; METHOTREXATE DERIVATIVE; METHOTREXATE GAMMA ETHYL ESTER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CATTLE; CELL SUBPOPULATION; CONCENTRATION RESPONSE; CONJUGATE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CONJUGATION; DRUG DEGRADATION; DRUG POTENCY; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG SYNTHESIS; DRUG TRANSPORT; ENZYME INHIBITION; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIPOPHILICITY; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CATTLE; CELL DIVISION; CHEMISTRY, PHYSICAL; EXCIPIENTS; FOLIC ACID ANTAGONISTS; HUMANS; LEUKEMIA, T-CELL, ACUTE; LIPIDS; LIVER; MASS SPECTROMETRY; METHOTREXATE; SPECTROPHOTOMETRY, INFRARED; TETRAHYDROFOLATE DEHYDROGENASE; TUMOR CELLS, CULTURED;

EID: 0034126277     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00062-2     Document Type: Article

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