-
1
-
-
2442494895
-
The common and distinct target genes of the p53 family transcription factors
-
Harms K, Nozell S, Chen X (2004) The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci 61:822-842.
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 822-842
-
-
Harms, K.1
Nozell, S.2
Chen, X.3
-
2
-
-
0037119631
-
ΔNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors
-
Zaika AI, et al. (2002) ΔNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J Exp Med 196:765-780.
-
(2002)
J Exp Med
, vol.196
, pp. 765-780
-
-
Zaika, A.I.1
-
3
-
-
2942731545
-
DNA damage induces the rapid and selective degradation of the ΔNp73 isoform, allowing apoptosis to occur
-
Maisse C, Munarriz E, Barcaroli D, Melino G, De Laurenzi V (2004) DNA damage induces the rapid and selective degradation of the ΔNp73 isoform, allowing apoptosis to occur. Cell Death Differ 11:685-687.
-
(2004)
Cell Death Differ
, vol.11
, pp. 685-687
-
-
Maisse, C.1
Munarriz, E.2
Barcaroli, D.3
Melino, G.4
De Laurenzi, V.5
-
4
-
-
17544363909
-
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
-
YangA
-
YangA, et al. (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404:99-103.
-
(2000)
Nature
, vol.404
, pp. 99-103
-
-
-
6
-
-
18144368557
-
p73 induces apoptosis by different mechanisms
-
Ramadan S, et al. (2005) p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun 331:713-717.
-
(2005)
Biochem Biophys Res Commun
, vol.331
, pp. 713-717
-
-
Ramadan, S.1
-
7
-
-
0034234237
-
CBP/p300 in cell growth, transformation, and development
-
Goodman RH, Smolik S (2000) CBP/p300 in cell growth, transformation, and development. Genes Dev 14:1553-1577.
-
(2000)
Genes Dev
, vol.14
, pp. 1553-1577
-
-
Goodman, R.H.1
Smolik, S.2
-
8
-
-
0032076229
-
Conjunction dysfunction: CBP/p300 in human disease
-
Giles RH, Peters DJ, Breuning MH (1998) Conjunction dysfunction: CBP/p300 in human disease. Trends Genet 14:178-183.
-
(1998)
Trends Genet
, vol.14
, pp. 178-183
-
-
Giles, R.H.1
Peters, D.J.2
Breuning, M.H.3
-
9
-
-
0033979402
-
The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis
-
Zeng XY, et al. (2000) The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis. Mol Cell Biol 20:1299-1310.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1299-1310
-
-
Zeng, X.Y.1
-
10
-
-
0035808390
-
p300 does not require its acetylase activity to stimulate p73 function
-
Zeng X, Lee H, Zhang Q, Lu H (2001) p300 does not require its acetylase activity to stimulate p73 function. J Biol Chem 276:48-52.
-
(2001)
J Biol Chem
, vol.276
, pp. 48-52
-
-
Zeng, X.1
Lee, H.2
Zhang, Q.3
Lu, H.4
-
11
-
-
34249863018
-
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53
-
Teufel DP, Freund SM, Bycroft M, Fersht AR (2007) Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci USA 104:7009-7014.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7009-7014
-
-
Teufel, D.P.1
Freund, S.M.2
Bycroft, M.3
Fersht, A.R.4
-
12
-
-
0032557649
-
Identification of a novel p53 functional domain that is necessary for mediating apoptosis
-
Zhu J, Zhou W, Jiang J, Chen X (1998) Identification of a novel p53 functional domain that is necessary for mediating apoptosis. J Biol Chem 273:13030-13036.
-
(1998)
J Biol Chem
, vol.273
, pp. 13030-13036
-
-
Zhu, J.1
Zhou, W.2
Jiang, J.3
Chen, X.4
-
13
-
-
0038269028
-
The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein
-
Liu G, Xia T, Chen X (2003) The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. J Biol Chem 278:17557-17565.
-
(2003)
J Biol Chem
, vol.278
, pp. 17557-17565
-
-
Liu, G.1
Xia, T.2
Chen, X.3
-
14
-
-
0034704151
-
Definition of the p53 functional domains necessary for inducing apoptosis
-
Zhu J, Zhang S, Jiang J, Chen X (2000) Definition of the p53 functional domains necessary for inducing apoptosis. J Biol Chem 275:39927-39934.
-
(2000)
J Biol Chem
, vol.275
, pp. 39927-39934
-
-
Zhu, J.1
Zhang, S.2
Jiang, J.3
Chen, X.4
-
15
-
-
0034692876
-
Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP
-
De Guzman RN, Liu HY, Martinez-Yamout M, Dyson HJ, Wright PE (2000) Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP. J Mol Biol 303:243-253.
-
(2000)
J Mol Biol
, vol.303
, pp. 243-253
-
-
De Guzman, R.N.1
Liu, H.Y.2
Martinez-Yamout, M.3
Dyson, H.J.4
Wright, P.E.5
-
16
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
Kussie PH, et al. (1996) Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274:948-953.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
-
17
-
-
0037180374
-
Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB
-
Campbell KM, Lumb KJ (2002) Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB. Biochemistry 41:13956-13964.
-
(2002)
Biochemistry
, vol.41
, pp. 13956-13964
-
-
Campbell, K.M.1
Lumb, K.J.2
-
18
-
-
0027166048
-
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
-
Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
-
(1993)
Cell
, vol.74
, pp. 609-619
-
-
Oltvai, Z.N.1
Milliman, C.L.2
Korsmeyer, S.J.3
-
19
-
-
1542379662
-
p73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
-
Melino G, et al. (2004) p73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem 279:8076-8083.
-
(2004)
J Biol Chem
, vol.279
, pp. 8076-8083
-
-
Melino, G.1
-
20
-
-
0041997348
-
Chemosensitivity linked to p73 function
-
Irwin MS, et al. (2003) Chemosensitivity linked to p73 function. Cancer Cell 3:403-410.
-
(2003)
Cancer Cell
, vol.3
, pp. 403-410
-
-
Irwin, M.S.1
-
21
-
-
0025853776
-
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
-
Fakharzadeh SS, Trusko SP, George DL (1991) Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J 10:1565-1569.
-
(1991)
EMBO J
, vol.10
, pp. 1565-1569
-
-
Fakharzadeh, S.S.1
Trusko, S.P.2
George, D.L.3
-
22
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand J, Zambetti GP, Olson DC, George D, Levine AJ (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
24
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
25
-
-
0032961828
-
MDM2 suppresses p73 function without promoting p73 degradation
-
Zeng X, et al. (1999) MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol 19:3257-3266.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3257-3266
-
-
Zeng, X.1
-
26
-
-
33845270990
-
Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
-
Toledo F, Wahl GM (2006) Regulating the p53 pathway: In vitro hypotheses, in vivo veritas. Nat Rev Cancer 6:909-923.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
27
-
-
4944255743
-
Post-translational modification of p53 in tumorigenesis
-
Bode AM, Dong Z (2004) Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 4:793-805.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 793-805
-
-
Bode, A.M.1
Dong, Z.2
-
28
-
-
34547119277
-
Regulation of p73 by Hck through kinase-dependent and -independent mechanisms
-
Paliwal P, Radha V, Swarup G (2007) Regulation of p73 by Hck through kinase-dependent and -independent mechanisms. BMC Mol Biol 8:45.
-
(2007)
BMC Mol Biol
, vol.8
, pp. 45
-
-
Paliwal, P.1
Radha, V.2
Swarup, G.3
-
29
-
-
34547453816
-
Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase
-
Jones EV, Dickman MJ, Whitmarsh AJ (2007) Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase. Biochem J 405:617-623.
-
(2007)
Biochem J
, vol.405
, pp. 617-623
-
-
Jones, E.V.1
Dickman, M.J.2
Whitmarsh, A.J.3
-
30
-
-
18244408596
-
DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
-
Costanzo A, et al. (2002) DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell 9:175-186.
-
(2002)
Mol Cell
, vol.9
, pp. 175-186
-
-
Costanzo, A.1
-
31
-
-
1542572304
-
2/M transition
-
2/M transition. J Biol Chem 278:49196-49202.
-
(2003)
J Biol Chem
, vol.278
, pp. 49196-49202
-
-
Fulco, M.1
-
32
-
-
0042347445
-
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73
-
Gaiddon C, et al. (2003) Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem 278:27421-27431.
-
(2003)
J Biol Chem
, vol.278
, pp. 27421-27431
-
-
Gaiddon, C.1
-
33
-
-
0033600234
-
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
-
Gong JG, et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399:806-809.
-
(1999)
Nature
, vol.399
, pp. 806-809
-
-
Gong, J.G.1
-
34
-
-
0033600240
-
Interaction of c-Abl and p73 α and their collaboration to induce apoptosis
-
Agami R, Blandino G, Oren M, Shaul Y (1999) Interaction of c-Abl and p73 α and their collaboration to induce apoptosis. Nature 399:809-813.
-
(1999)
Nature
, vol.399
, pp. 809-813
-
-
Agami, R.1
Blandino, G.2
Oren, M.3
Shaul, Y.4
-
35
-
-
33845920314
-
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
-
Watson IR, Blanch A, Lin DC, Ohh M, Irwin MS (2006) Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J Biol Chem 281:34096-34103.
-
(2006)
J Biol Chem
, vol.281
, pp. 34096-34103
-
-
Watson, I.R.1
Blanch, A.2
Lin, D.C.3
Ohh, M.4
Irwin, M.S.5
-
36
-
-
0033429271
-
Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15
-
Dumaz N, Milne DM, Meek DW (1999) Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. FEBS Lett 463:312-316.
-
(1999)
FEBS Lett
, vol.463
, pp. 312-316
-
-
Dumaz, N.1
Milne, D.M.2
Meek, D.W.3
-
37
-
-
0034737438
-
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase: Effect on Mdm2 binding
-
Sakaguchi K, et al. (2000) Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase: Effect on Mdm2 binding. J Biol Chem 275:9278-9283.
-
(2000)
J Biol Chem
, vol.275
, pp. 9278-9283
-
-
Sakaguchi, K.1
-
38
-
-
40749116458
-
TAp73 α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation
-
Malaguarnera R, et al. (2008) TAp73 α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation. Mol Cancer Res 6:64-77.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 64-77
-
-
Malaguarnera, R.1
-
40
-
-
9844252882
-
NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein
-
Hajduk PJ, et al. (1997) NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein. J Med Chem 40:3144-3150.
-
(1997)
J Med Chem
, vol.40
, pp. 3144-3150
-
-
Hajduk, P.J.1
-
41
-
-
0042121237
-
Multiple sequence alignment with the Clustal series of programs
-
Chenna R, et al. (2003) Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res 31:3497-3500.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 3497-3500
-
-
Chenna, R.1
|