Molecular-genetic PET imaging using HSV1-tK mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs

Journal of Nuclear Medicine

Volumn 50, Issue 3, 2009, Pages 409-416

  Najjar, Amer M ^a   Nishii, Ryuichi ^a   Maxwell, David S ^a   Volgin, Andrei ^a   Mukhopadhyay, Uday ^a   Bornmann, William G ^a   Tong, William ^a   Alauddin, Mian ^a   Gclovani, Juri G ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

18F FEAU; 18F FHBG; A168H; HSV1 tk

Indexed keywords

2' DEOXY 2' FLUORO 5 ETHYL 1 BETA DEXTRO ARABINOFURANOSYLURACIL F 18; 5 ETHYL 2' FLUOROURACIL ARABINOSIDE; 9 [4 FLUORO 3 (HYDROXYMETHYL)BUTYL]GUANINE F 18; ACICLOVIR DERIVATIVE; ALANINE; FLUORINE 18; GREEN FLUORESCENT PROTEIN; HISTIDINE; MICROPET-R4; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ACCUMULATION; ENZYME BINDING; ENZYME SPECIFICITY; HERPES SIMPLEX VIRUS 1; HSV1 TK GENE; HUMAN; HUMAN CELL; MOLECULAR GENETICS; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; TRANSGENE; TUMOR XENOGRAFT; VIRUS GENE; VIRUS MUTANT;

ANIMALS; ARABINOFURANOSYLURACIL; CELL LINE, TUMOR; FEASIBILITY STUDIES; FLUORINE RADIOISOTOPES; FLUOROURACIL; GENES, REPORTER; GUANINE; HERPESVIRUS 1, HUMAN; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; MUTATION; NEOPLASM TRANSPLANTATION; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE KINASE; TRANSPLANTATION, HETEROLOGOUS;

EID: 62449145537     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.058735     Document Type: Article

References (29)

1. Gelovani Tjuvajev J, Blasberg RG. In vivo imaging of molecular-genetic targets for cancer therapy. Cancer Cell. 2003;3:327-332.
2. Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer. 2002;2:683-693.
3. Blasberg RG, Gelovani J. Molecular-genetic imaging: a nuclear medicine-based perspective. Mol Imaging. 2002;1:280-300.
4. Tjuvajev JG, Finn R, Watanabe K, et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res. 1996;56:4087-4095.
5. Tjuvajev JG, Avril N, Oku T, et al. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res. 1998;58:4333-4341.
6. Serganova I, Doubrovin M, Vider J, et al. Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Cancer Res. 2004;64:6101-6108.
7. Hajitou A, Trepel M, Lilley CE, et al. A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell. 2006;125:385-398.
8. 18F]FEAU. Nat Protocols. 2007;2:416-423.
9. 18F]FHBG): a new potential imaging agent for viral infection and gene therapy using PET. Nucl Med Biol. 1998; 25:175-180.
10. 18F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med. 2001; 42:1225-1234.
11. 18F]FHBG. Nat Protocols. 2007;1:3069-3074.
12. Penuelas I, Haberkorn U, Yaghoubi S, Gambhir SS. Gene therapy imaging in patients for oncological applications. Eur J Nucl Med Mol Imaging. 2005; 32(suppl 2):S384-S403.
13. Jacobs A, Voges J, Reszka R, et al. Positron-emission tomography of vector- mediated gene expression in gene therapy for gliomas. Lancet. 2001;358:727-729.
14. 3H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture. Mol Imaging Biol. 2005;7:296-303.
15. Ponomarev V, Doubrovin M, Shavrin A, et al. A human-derived reporter gene for noninvasive imaging in humans: mitochondrial thymidine kinase type 2. J Nucl Med. 2007;48:819-826.
16. Kummer C, Winkeler A, Dittmar C, et al. Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector. Mol Imaging. 2007;6:181-192.
17. Shin JH, Chung JK, Kang JH, et al. Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSVl-tk. Eur J Nucl Med Mol Imaging. 2004;31:425-432.
18. Balzarini J, Liekens S, Solaroli N, El Omari K, Stammers DK, Karlsson A. Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation. J Biol Chem. 2006;281:19273-19279.
19. Berman HM, Westbrook J, Feng Z, et al. The protein data bank. Nucleic Acids Res. 2000;28:235-242.
20. Case DA, Cheatham TE III, Darden T, et al. The Amber biomolecular simulation programs. J Comput Chem. 2005;26:1668-1688.
21. Jain AN. Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine. J Med Chem. 2003;46:499-511.
22. Jain AN. Ligand-based structural hypotheses for virtual screening. J Med Chem. 2004;47:947-961.
23. Ponomarev V, Doubrovin M, Serganova I, et al. Cytoplasmically retargeted HSVl-tk/GFP reporter gene mutants for optimization of noninvasive molecular- genetic imaging. Neoplasia. 2003;5:245-254.
24. Ory DS, Neugeboren BA, Mulligan RC. A stable human-derived packaging cell line for production of high titer retro virus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci USA. 1996;93:11400-11406.
25. Likar Y, Dobrenkov K, Olszewska M, et al. A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs. J Nucl Med. 2008;49:713-720.
26. Champness JN, Bennett MS, Wien F, et al. Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands. Proteins. 1998;32:350-361.
27. Gambhir SS, Bauer E, Black ME, et al. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci USA. 2000;97:2785-2790.
28. Gilbert C, Bestman-Smith J, Boivin G. Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms. Drug Resist Updat. 2002;5:88-114.
29. Morfin F, Thouvenot D. Herpes simplex virus resistance to antiviral drugs. J Clin Virol. 2003;26:29-37.