Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation

Journal of Biological Chemistry

Volumn 281, Issue 28, 2006, Pages 19273-19279

  Balzarini, Jan ^a   Liekens, Sandra ^a   Solaroli, Nicola ^b   El Omari, Kamel ^c   Stammers, David K ^c   Karlsson, Anna ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ENZYMES; LIGAMENTS; MUTAGENESIS; SUBSTRATES; VIRUSES;

AMINO ACID MUTATION; KINASE ACTIVITY; PYRIMIDINE NUCLEOSIDE ANALOGUE BINDING; THYMIDINE (DTHD) KINASE (TK);

AMINO ACIDS;

ALANINE; GANCICLOVIR; MUTANT PROTEIN; NITROGEN; NUCLEOSIDE ANALOG; PHENYLALANINE; PURINE; PYRIMIDINE; THYMIDINE KINASE; THYMIDINE TRIPHOSPHATE; TYROSINE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; HERPES SIMPLEX VIRUS 1; KINETICS; MUTATION; NEGATIVE FEEDBACK; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY;

ANTIVIRAL AGENTS; BINDING SITES; HERPESVIRUS 1, HUMAN; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PURINE NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; THYMIDINE KINASE;

HUMAN HERPESVIRUS 1;

EID: 33745834321     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M600414200     Document Type: Article

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