Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-Receptor compared with the guinea pig H 1-Receptor

Molecular Pharmacology

Volumn 75, Issue 3, 2009, Pages 454-465

  Straßer, Andrea ^a   Wittmann, Hans Joachim ^a   Kunze, Marc ^a   Elz, Sigurd ^a   Seifert, Roland ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; HISTAMINE DERIVATIVE; HISTAMINE H1 RECEPTOR; MEPYRAMINE; PHENOPRODIFEN DERIVATIVE; PHENYLHISTAMINE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG; GUANIDINE DERIVATIVE; HISTAMINE; HISTAMINE AGONIST; IMIDAZOLE DERIVATIVE; N1 (3 CYCLOHEXYLBUTANOYL) N2 (3 (1H IMIDAZOL 4 YL)PROPYL)GUANIDINE; N1-(3-CYCLOHEXYLBUTANOYL)-N2-(3-(1H-IMIDAZOL-4-YL)PROPYL)GUANIDINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; GUINEA PIG; HUMAN VERSUS ANIMAL COMPARISON; INSECT CELL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE; ANIMAL; BINDING SITE; CELL LINE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; GENETICS; HUMAN; INSECT; METABOLISM; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING SITES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANIDINES; GUINEA PIGS; HISTAMINE; HISTAMINE AGONISTS; HUMANS; IMIDAZOLES; INSECTS; RECEPTORS, HISTAMINE H1; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62149143377     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.053009     Document Type: Article

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