Mutations of Cys-17 and Ala-271 in the human histamine H2 receptor determine the species selectivity of guanidine-type agonists and increase constitutive activity

Journal of Pharmacology and Experimental Therapeutics

Volumn 321, Issue 3, 2007, Pages 975-982

  Preuss, Hendrik ^a   Ghorai, Prasanta ^a,b   Kraus, Anja ^a   Dove, Stefan ^a   Buschauer, Armin ^a   Seifert, Roland ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALANINE; GUANIDINE; GUANOSINE TRIPHOSPHATASE; HISTAMINE H2 RECEPTOR; HYBRID PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; CELL MEMBRANE; ENZYME ACTIVITY; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ADENYLATE CYCLASE; ALANINE; ANIMALS; BACULOVIRIDAE; CELL LINE; CELL MEMBRANE; CYSTEINE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUANIDINE; GUANOSINE TRIPHOSPHATE; GUINEA PIGS; HISTAMINE; HISTAMINE AGONISTS; HISTAMINE H2 ANTAGONISTS; HUMANS; MUTATION, MISSENSE; RECEPTORS, HISTAMINE H2; RECOMBINANT FUSION PROTEINS; SPECIES SPECIFICITY; SPODOPTERA; TRANSFECTION;

EID: 34248598463     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.120519     Document Type: Article

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