Antagonism of peripheral 5-HT4 receptors reduces visceral and cutaneous pain in mice, and induces visceral analgesia after simultaneous inactivation of 5-HT3 receptors

Brain Research

Volumn 788, Issue 1-2, 1998, Pages 20-24

  Espejo, Emilio Fdez ^a   Gil, Eladio ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

5 HT3; 5 HT4; Hotplate; Mouse; Pain; Serotonin; Writhing

Indexed keywords

4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (DIETHYLAMINO)ETHYL ESTER; BEMESETRON; SEROTONIN 3 ANTAGONIST; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HOT PLATE TEST; HYPOALGESIA; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PAIN; PAIN THRESHOLD; PRIORITY JOURNAL; VISCERAL PAIN; WRITHING TEST;

4-AMINOBENZOIC ACID; ANALGESIA; ANALYSIS OF VARIANCE; ANIMALS; MALE; MICE; PAIN; PAIN MEASUREMENT; RATS; SEROTONIN ANTAGONISTS; SKIN; TIME FACTORS; VISCERA;

EID: 0032579868     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01510-2     Document Type: Article

References (28)

1. Alvarez E.O., Banzán A.M. Histamine in dorsal and ventral hippocampus: II. Effects of H1 and H2 histamine antagonists on exploratory behavior in male rats. Physiol. Behav. 37:1986;39-45.
2. 3 receptor subtypes modulate responses to noxious colorectal distension in the rat. Brain Res. 538:1991;64-75.
3. Doak G.J., Sawynok J. Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtype. Neuroscience. 80:1997;939-949.
4. 4 receptors. Tr. Pharmacol. Sci. 16:1995;391-398.
5. Eide P.K., Hole K. The role of 5-hydroxytryptamine (5-HT) receptor subtypes and plasticity in the 5-HT systems in the regulation of nociceptive sensitivity. Cephalalgia. 13:1993;75-85.
6. Espejo E.F., Mir D. Structure of the rat's behaviour in the hot plate test. Behav. Brain Res. 56:1993;171-176.
7. Espejo E.F., Stinus L., Cador M., Mir D. Effects of morphine and naloxone on behavior in the hot plate test: an ethopharmacological study in the rat. Psychopharmacology. 113:1994;500-510.
8. Fozard J.R. MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 326:1984;36-44.
9. K.B.J. Franklin, F.V. Abbott, Techniques for assessing the effects of drugs on nociceptive responses, in: A.A. Boulton, G.B. Baker, A.J. Greenshaw (Eds.), Neuromethods: Psychopharmacology, Humana, New Jersey, 1989, pp. 145-215.
10. Gershanik O., Heikkila R.E., Duvoisin R.C. Behavioral correlations of dopamine receptor activation. Neurology. 33:1983;1489-1492.
11. Gesek F.A., Cragoe E.J. Jr., Strandhoy J.W. Synergistic alpha-1 and alpha-2 adrenergic stimulation of rat proximal nephron Na+/K+ exchange. J. Pharmacol. Exp. Ther. 249:1989;694-700.
12. 4 agonists: BIMU 1 and BIMU 8. Life Sci. 58:1996;2297-2309.
13. 3 receptor antagonists reduce inflammatory pain in rats. Eur. J. Pharmacol. 170:1989;83-86.
14. 3 receptor antagonist. Neurosci. Lett. 95:1988;313-317.
15. 3 receptor antagonists: a critical update on therapeutic potential. Tr. Neurosci. 14:1993;265-270.
16. Guilbaud G., Benoist J.M., Eschalier A., Gautron M., Kayser V. Evidence for peripheral serotonergic mechanisms in the early sensitization after carrageenin-induced inflammation: electrophysiological studies in the ventrobasal complex of the rat thalamus using a potent specific antagonist of peripheral 5-HT receptors. Brain Res. 502:1989;187-197.
17. D.L. Hammond, Inference of pain and its modulation from simple behaviors, in: C.R. Chapman, J.D. Loeser (Eds.) Issues in Pain Measurement, Raven Press, New York, 1989, pp. 69-91.
18. Hunt T.E., Wu W., Zbuzek V.K. Ondansetron blocks nifedipine-induced analgesia in rats. Anesth. Analg. 82:1996;498-500.
19. Ireland S.J., Tyers M.B. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br. J. Pharmacol. 90:1987;229-238.
20. 3 receptor channel. Annu. Rev. Physiol. 57:1995;447-468.
21. 3 receptor subtypes. Brain Res. 561:1991;61-68.
22. 3 antagonists on the writhing response in mice. Gen. Pharmacol. 26:1995;1301-1306.
23. Pelissier T., Alloui A., Caussade F., Dubray C., Cloarec A., Lavarenne J., Eschalier A. Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine-3 receptors: in vivo and in vitro evidence. J. Pharmacol. Exp. Ther. 278:1996;8-14.
24. 4 receptor. Naunyn-Schmiedebergs Arch. Pharmac. 346:1992;496-503.
25. Richardson B.P., Engel G., Donatsch P., Stadler P.A. Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature. 316:1985;126-131.
26. Schwab E.F., Zemlan F.P., Murphy R.M. Dominant spinal cord 5-HT receptor, the 5-HT-1F: relation to pain. Soc. Neurosci. Abstr. 15:1989;546.
27. Talley N.J. Review article: 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility and sensation: clinical implications. Aliment. Pharmacol. Ther. 6:1992;273-289.
28. 4 receptors in the human and guinea-pig brain. NeuroReport. 4:1993;1239-1242.