Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines

Journal of Medicinal Chemistry

Volumn 40, Issue 12, 1997, Pages 1808-1819

  Prunier, Hervé ^a   Rault, Sylvain ^a   Lancelot, Jean Charles ^a   Robba, Max ^a   Renard, Pierre ^b   Delagrange, Philippe ^c   Pfeiffer, Bruno ^b   Caignard, Daniel Henri ^b   Misslin, René ^d   Guardiola Lemaitre, Béatrice ^c   Hamon, Michel ^e  

^a CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

^b ADIR   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d Laboratoire de Psychophysiologie   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLSEROTONIN; 6 (4 BENZYLPIPERAZINO)PYRIDO[3,2 E]PYRROLO[1,2 A]PYRAZINE; GRANISETRON; ONDANSETRON; PYRAZINE DERIVATIVE; QUINOXALINE DERIVATIVE; QUIPAZINE; RECEPTOR SUBUNIT; SEROTONIN AGONIST; TROPISETRON; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; DRUG DEPENDENCE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; PSYCHOSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY; VOMITING;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; CATTLE; CELL MEMBRANE; CORPUS STRIATUM; DARKNESS; FRONTAL LOBE; GUANIDINE; GUANIDINES; HIPPOCAMPUS; LIGHT; MALE; MOLECULAR STRUCTURE; PYRAZINES; PYRIDINES; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 15644378822     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960501o     Document Type: Article

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