Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists

Journal of Medicinal Chemistry

Volumn 49, Issue 3, 2006, Pages 1125-1139

  Becker, Daniel P ^a   Flynn, Daniel L ^b   Moormann, Alan E ^d   Nosal, Roger ^d   Villamil, Clara I ^c   Loeffler, Richard ^d   Gullikson, Gary W ^d   Moummi, Chafiq ^d   Yang, Dai C ^d  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b Deciphera Pharmaceuticals LLC   (United States)

^c ABBOTT LABORATORIES   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 CHLORO 2,3 DIHYDRO 2 METHYL N [2 (8 PYRROLIZIDINYL)ETHYL]BENZO[B]FURAN 7 CARBOXAMIDE; 4 AMINO 5 CHLORO N [(HEXAHYDRO 1H PYRROLIZIN 1 YL)METHYL] 2 METHOXYBENZAMIDE; 4 AMINO 5 CHLORO N [(HEXAHYDRO 1H PYRROLIZIN 1 YL)METHYL] 2 METHOXYBENZENECARBOXAMIDE; 6 CHLORO N [(HEXAHYDRO 1H PYRROLIZIN 1 YL)METHYL]IMIDAZO[1,2 A]PYRIDINE 8 CARBOXAMIDE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; AMIDE; BENZAMIDE DERIVATIVE; BETA ADRENERGIC RECEPTOR; CISAPRIDE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; ESTER DERIVATIVE; HEXAHYDRO 1H PYRROLIZIN 1 YLMETHYL 1 METHYL 1H INDOLE 3 CARBOXYLATE; IMIDAZOPYRIDINE DERIVATIVE; MONOAMINE; PRUCALOPRIDE; PYRROLIZIDINE DERIVATIVE; RENZAPRIDE; SC 53117; SD HTF 919; SEROTONIN 1 RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 AGONIST; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR; TEGASEROD; TETRAHYDRO 1H PYRROLIZIN 4(5H) YL 6 CHLOROIMIDAZO[1,2 A]PYRIDINE 8 CARBOXAMIDE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; BEZOLD JARISCH REFLEX ASSAY; CONTROLLED STUDY; DOG; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ESOPHAGUS MUSCLE; MUSCLE CONTRACTILITY; NONHUMAN; RAT; RECEPTOR AFFINITY; STOMACH ANTRUM; STOMACH EMPTYING; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BENZAMIDES; BRADYCARDIA; BRAIN; DOGS; ESOPHAGUS; ESTERS; FEMALE; GASTRIC EMPTYING; GUINEA PIGS; IMIDAZOLES; INDOLES; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PYLORIC ANTRUM; PYRROLES; PYRROLIZIDINE ALKALOIDS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN, 5-HT4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32344450371     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0509501     Document Type: Article

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