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Volumn 6, Issue 1, 2009, Pages 42-53

Brain-derived neurotrophic factor (BDNF) has proliferative effects on neural stem cells through the truncated TRK-B receptor, MAP kinase, AKT, and STAT-3 signaling pathways

Author keywords

Neural stem cells; Neurotrophic factors; Trk receptors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NESTIN; NEUROTROPHIN; NEUROTROPHIN 3 RECEPTOR; NEUROTROPHIN RECEPTOR P75; PROTEIN KINASE B; PROTEIN TYROSINE KINASE A; STAT3 PROTEIN;

EID: 61849173592     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720209787466028     Document Type: Article
Times cited : (151)

References (75)
  • 1
    • 0029165971 scopus 로고
    • BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors
    • Ahmed, S, Reynolds, BA, Weiss, S. (1995) BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors. J Neurosci 15: 5765-5778.
    • (1995) J Neurosci , vol.15 , pp. 5765-5778
    • Ahmed, S.1    Reynolds, B.A.2    Weiss, S.3
  • 2
    • 33746647820 scopus 로고    scopus 로고
    • Neurotrophin signaling: Many exciting surprises!
    • Arévalo, JC, Wu, SH. (2006) Neurotrophin signaling: many exciting surprises! Cell Mol Life Sci 63: 1523-1537.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1523-1537
    • Arévalo, J.C.1    Wu, S.H.2
  • 3
    • 41649104921 scopus 로고    scopus 로고
    • Neurotrophins - More than Neurotrophic
    • Ayyadhury, S, Heese, K. (2007) Neurotrophins - More than Neurotrophic. Curr Immunol Rev 3: 189-215.
    • (2007) Curr Immunol Rev , vol.3 , pp. 189-215
    • Ayyadhury, S.1    Heese, K.2
  • 4
    • 0038452619 scopus 로고    scopus 로고
    • Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways
    • Barnabe-Heider, F, Miller, FD. (2003) Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. J Neurosci 23: 5149-5160.
    • (2003) J Neurosci , vol.23 , pp. 5149-5160
    • Barnabe-Heider, F.1    Miller, F.D.2
  • 5
    • 38349018267 scopus 로고    scopus 로고
    • Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development
    • Bartkowska, K, Paquin, A, Gauthier, AS, Kaplan, DR, Miller, FD. (2007) Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development. Development 134: 4369-4380.
    • (2007) Development , vol.134 , pp. 4369-4380
    • Bartkowska, K.1    Paquin, A.2    Gauthier, A.S.3    Kaplan, D.R.4    Miller, F.D.5
  • 6
    • 33751079857 scopus 로고    scopus 로고
    • Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain
    • Bauer, S, Patterson, PH. (2006) Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J Neurosci 26: 12089-12099.
    • (2006) J Neurosci , vol.26 , pp. 12089-12099
    • Bauer, S.1    Patterson, P.H.2
  • 9
    • 10644221931 scopus 로고    scopus 로고
    • Neurospheres: Insights into neural stem cell biology
    • Campos, LS. (2004) Neurospheres: insights into neural stem cell biology. J Neurosci Res 78: 761-769.
    • (2004) J Neurosci Res , vol.78 , pp. 761-769
    • Campos, L.S.1
  • 10
    • 40349114504 scopus 로고    scopus 로고
    • Role of the brain-derived neurotrophic factor at glutamatergic synapses
    • Carvalho, AL, Caldeira, MV, Santos, SD, Duarte, CB. (2008) Role of the brain-derived neurotrophic factor at glutamatergic synapses. Br J Pharmacol 153: S310-S324.
    • (2008) Br J Pharmacol , vol.153
    • Carvalho, A.L.1    Caldeira, M.V.2    Santos, S.D.3    Duarte, C.B.4
  • 11
    • 0025165823 scopus 로고
    • Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor
    • Cattaneo, E, McKay, R. (1990) Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor. Nature 347: 762-765.
    • (1990) Nature , vol.347 , pp. 762-765
    • Cattaneo, E.1    McKay, R.2
  • 12
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: A convergence point for many signalling pathways
    • Chao, MV. (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4: 299-309.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 13
    • 33847724415 scopus 로고    scopus 로고
    • Truncated tyrosine kinase B brain-derived neurotrophic factor receptor directs cortical neural stem cells to a glial cell fate by a novel signaling mechanism
    • Cheng, A, Coksaygan, T, Tang, H, Khatri, R, Balice-Gordon, RJ, Rao, MS, Mattson, MP. (2007) Truncated tyrosine kinase B brain-derived neurotrophic factor receptor directs cortical neural stem cells to a glial cell fate by a novel signaling mechanism. J Neurochem 100: 1515-1530.
    • (2007) J Neurochem , vol.100 , pp. 1515-1530
    • Cheng, A.1    Coksaygan, T.2    Tang, H.3    Khatri, R.4    Balice-Gordon, R.J.5    Rao, M.S.6    Mattson, M.P.7
  • 15
    • 0028076182 scopus 로고
    • An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3
    • Clary, DO, Reichardt, LF. (1994) An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3. Proc Natl Acad Sci USA 91: 11133-11137.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11133-11137
    • Clary, D.O.1    Reichardt, L.F.2
  • 16
    • 0037137686 scopus 로고    scopus 로고
    • EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells
    • Doetsch, F, Petreanu, L, Caille, I, Garcia-Verdugo, JM, Alvarez-Buylla, A. (2002) EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 36: 1021-1034.
    • (2002) Neuron , vol.36 , pp. 1021-1034
    • Doetsch, F.1    Petreanu, L.2    Caille, I.3    Garcia-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 18
    • 0033844835 scopus 로고    scopus 로고
    • Sequential treatment of sh-sy5y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells
    • Encinas, M, Iglesias, M, Liu, Y, Wang, H, Muhaisen, A, Ceña, V, Gallego, C, Comella, JX. (2000) Sequential treatment of sh-sy5y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem 75: 991-1003.
    • (2000) J Neurochem , vol.75 , pp. 991-1003
    • Encinas, M.1    Iglesias, M.2    Liu, Y.3    Wang, H.4    Muhaisen, A.5    Ceña, V.6    Gallego, C.7    Comella, J.X.8
  • 20
    • 32344444731 scopus 로고    scopus 로고
    • The putative neural stem cell marker, nestin, is expressed in heterogeneous cell types in the adult rat neocortex
    • Ernst, C, Christie, BR. (2006) The putative neural stem cell marker, nestin, is expressed in heterogeneous cell types in the adult rat neocortex. Neuroscience 138: 183-188.
    • (2006) Neuroscience , vol.138 , pp. 183-188
    • Ernst, C.1    Christie, B.R.2
  • 21
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • Gage, FH. (2000) Mammalian neural stem cells. Science 287: 1433-1438.
    • (2000) Science , vol.287 , pp. 1433-1438
    • Gage, F.H.1
  • 23
    • 0037106147 scopus 로고    scopus 로고
    • Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation
    • Ge, W, Martinowich, K, Wu, X, He, F, Miyamoto, A, Fan, G, Weinmaster, G. (2002) Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. J Neurosci Res 69: 848-860.
    • (2002) J Neurosci Res , vol.69 , pp. 848-860
    • Ge, W.1    Martinowich, K.2    Wu, X.3    He, F.4    Miyamoto, A.5    Fan, G.6    Weinmaster, G.7
  • 24
    • 0028217132 scopus 로고
    • Requirement for BDNF in activity-dependent survival of cortical neurons
    • Ghosh, A, Carnahan, J, Greenberg, ME. (1994) Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263: 1618-1623.
    • (1994) Science , vol.263 , pp. 1618-1623
    • Ghosh, A.1    Carnahan, J.2    Greenberg, M.E.3
  • 26
    • 12344274788 scopus 로고    scopus 로고
    • Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor
    • Hartmann, M, Brigadski, T, Erdmann, KS, Holtmann, B, Sendtner, M, Narz, F, Lessmann, V. (2004) Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor. J Cell Sci 117: 5803-5814.
    • (2004) J Cell Sci , vol.117 , pp. 5803-5814
    • Hartmann, M.1    Brigadski, T.2    Erdmann, K.S.3    Holtmann, B.4    Sendtner, M.5    Narz, F.6    Lessmann, V.7
  • 28
    • 33645858538 scopus 로고    scopus 로고
    • Alzheimers Disease-an interactive perspective
    • Heese, K, Akatsu, H. (2006) Alzheimers Disease-an interactive perspective. Curr Alzheimer Res 3: 109-121.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 109-121
    • Heese, K.1    Akatsu, H.2
  • 29
    • 33746543038 scopus 로고    scopus 로고
    • Nerve growth factor, neural stem cells and Alzheimer's disease
    • Heese, K, Low, JW, Inoue, N. (2006) Nerve growth factor, neural stem cells and Alzheimer's disease. NeuroSignals 15: 1-12.
    • (2006) NeuroSignals , vol.15 , pp. 1-12
    • Heese, K.1    Low, J.W.2    Inoue, N.3
  • 30
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • Heinrich, PC, Behrmann, I, Muller-Newen, G, Schaper, F, Graeve, L. (1998) Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 334: 297-314.
    • (1998) Biochem J , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 32
    • 0037820641 scopus 로고    scopus 로고
    • Neural progenitor cells lack immunogenicity and resist destruction as allografts
    • Hori, J, Ng, TF, Shatos, M, Klassen, H, Streilein, JW, Young, MJ. (2003) Neural progenitor cells lack immunogenicity and resist destruction as allografts. Stem Cells 21: 405-416.
    • (2003) Stem Cells , vol.21 , pp. 405-416
    • Hori, J.1    Ng, T.F.2    Shatos, M.3    Klassen, H.4    Streilein, J.W.5    Young, M.J.6
  • 33
    • 0037459048 scopus 로고    scopus 로고
    • The p75 receptor is required for BDNF-induced differentiation of neural precursor cells
    • Hosomi, S, Yamashita, T, Aoki, M, Tohyama, M. (2003) The p75 receptor is required for BDNF-induced differentiation of neural precursor cells. Biochem Biophys Res Commun 301: 1011-1015.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 1011-1015
    • Hosomi, S.1    Yamashita, T.2    Aoki, M.3    Tohyama, M.4
  • 34
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: Roles in neuronal development and function
    • Huang, EJ, Reichardt, LF. (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24: 677-736.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 35
    • 0041488911 scopus 로고    scopus 로고
    • Trk receptors: Roles in neuronal signal transduction
    • Huang, EJ, Reichardt, LF. (2003) Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72: 609-642.
    • (2003) Annu Rev Biochem , vol.72 , pp. 609-642
    • Huang, E.J.1    Reichardt, L.F.2
  • 36
    • 0027528768 scopus 로고
    • Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells
    • Ip, NY, Stitt, TN, Tapley, P, Klein, R, Glass, DJ, Fandl, J, Greene, LA, Barbacid, M, Yancopoulos, GD. (1993) Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10: 137-149.
    • (1993) Neuron , vol.10 , pp. 137-149
    • Ip, N.Y.1    Stitt, T.N.2    Tapley, P.3    Klein, R.4    Glass, D.J.5    Fandl, J.6    Greene, L.A.7    Barbacid, M.8    Yancopoulos, G.D.9
  • 37
    • 61849112508 scopus 로고    scopus 로고
    • Interleukin-6 and neural stem cells - more than gliogenesis
    • Islam, O, Gong, X, Rose-John, S, Heese, K. (2009) Interleukin-6 and neural stem cells - more than gliogenesis. Mol Biol Cell 20: 188-199.
    • (2009) Mol Biol Cell , vol.20 , pp. 188-199
    • Islam, O.1    Gong, X.2    Rose-John, S.3    Heese, K.4
  • 38
    • 0037369556 scopus 로고    scopus 로고
    • Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1
    • Ito, H, Nakajima, A, Nomoto, H, Furukawa, S. (2003) Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1. J Neurosci Res 71: 648-658.
    • (2003) J Neurosci Res , vol.71 , pp. 648-658
    • Ito, H.1    Nakajima, A.2    Nomoto, H.3    Furukawa, S.4
  • 39
    • 33847163934 scopus 로고    scopus 로고
    • Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
    • Kee, N, Teixeira, CM, Wang, AH, Frankland, PW. (2007) Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci 10: 355-362.
    • (2007) Nat Neurosci , vol.10 , pp. 355-362
    • Kee, N.1    Teixeira, C.M.2    Wang, A.H.3    Frankland, P.W.4
  • 40
    • 0028963215 scopus 로고
    • Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone
    • Kirschenbaum, B, Goldman, SA. (1995) Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone. Proc Natl Acad Sci USA 92: 210-214.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 210-214
    • Kirschenbaum, B.1    Goldman, S.A.2
  • 41
    • 33847392514 scopus 로고    scopus 로고
    • Untangling the signalling wires
    • Kholodenko, BN. (2007) Untangling the signalling wires. Nat Cell Biol 9: 247-249.
    • (2007) Nat Cell Biol , vol.9 , pp. 247-249
    • Kholodenko, B.N.1
  • 42
    • 33751184564 scopus 로고    scopus 로고
    • The dark side of the NGF family: Neurotrophins in neoplasias
    • Krüttgen, A, Schneider, I, Weis, J. (2006) The dark side of the NGF family: neurotrophins in neoplasias. Brain Pathol 16: 304-310.
    • (2006) Brain Pathol , vol.16 , pp. 304-310
    • Krüttgen, A.1    Schneider, I.2    Weis, J.3
  • 43
    • 0032534610 scopus 로고    scopus 로고
    • NT-3-mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo
    • Kumar, S, Kahn, MA, Dinh, L, de Vellis, J. (1998) NT-3-mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo. J Neurosci Res 54: 754-765.
    • (1998) J Neurosci Res , vol.54 , pp. 754-765
    • Kumar, S.1    Kahn, M.A.2    Dinh, L.3    de Vellis, J.4
  • 44
    • 0031127402 scopus 로고    scopus 로고
    • Embryonic precursor cells that express trk receptors: Induction of different cell fates by NGF, BDNF, NT-3, and CNTF
    • Lachyankar, MB, Condon, PJ, Quesenberry, PJ, Litofsky, NS, Rechte, LD, Ross, AH. (1997) Embryonic precursor cells that express trk receptors: induction of different cell fates by NGF, BDNF, NT-3, and CNTF. Exp Neurol 144: 350-360.
    • (1997) Exp Neurol , vol.144 , pp. 350-360
    • Lachyankar, M.B.1    Condon, P.J.2    Quesenberry, P.J.3    Litofsky, N.S.4    Rechte, L.D.5    Ross, A.H.6
  • 45
    • 0035976524 scopus 로고    scopus 로고
    • Regulation of cell survival by secreted proneurotrophins
    • Lee, R, Kermani, P, Teng, KK, Hempstead, BL. (2001) Regulation of cell survival by secreted proneurotrophins. Science 294: 1945-1948.
    • (2001) Science , vol.294 , pp. 1945-1948
    • Lee, R.1    Kermani, P.2    Teng, K.K.3    Hempstead, B.L.4
  • 46
    • 0012315645 scopus 로고    scopus 로고
    • Neurotrophin secretion: Current facts and future prospects
    • Lessmann, V, Gottmann, K, Malcangio, M. (2003) Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 69: 341-374.
    • (2003) Prog Neurobiol , vol.69 , pp. 341-374
    • Lessmann, V.1    Gottmann, K.2    Malcangio, M.3
  • 47
    • 0029892470 scopus 로고    scopus 로고
    • Physiology of the neurotrophins
    • Lewin, GR, Barde, YA. (1996) Physiology of the neurotrophins. Annu Rev Neurosci 19: 289-317.
    • (1996) Annu Rev Neurosci , vol.19 , pp. 289-317
    • Lewin, G.R.1    Barde, Y.A.2
  • 48
  • 49
    • 4344687434 scopus 로고    scopus 로고
    • Anoikis: Cancer and the homeless cell
    • Liotta, LA, Kohn, E. (2004) Anoikis: cancer and the homeless cell. Nature 430: 973-974.
    • (2004) Nature , vol.430 , pp. 973-974
    • Liotta, L.A.1    Kohn, E.2
  • 50
    • 0033517123 scopus 로고    scopus 로고
    • STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
    • Matsuda, T, Nakamura, T, Nakao, K, Arai, T, Katsuki, M, Heike, T, Yokota, T. (1999) STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. Eur Mol Biol Org J 18: 4261-4269.
    • (1999) Eur Mol Biol Org J , vol.18 , pp. 4261-4269
    • Matsuda, T.1    Nakamura, T.2    Nakao, K.3    Arai, T.4    Katsuki, M.5    Heike, T.6    Yokota, T.7
  • 52
    • 34250029182 scopus 로고    scopus 로고
    • Signaling in adult neurogenesis: From stem cell niche to neuronal networks
    • Ninkovic, J, Götz, M. (2007) Signaling in adult neurogenesis: from stem cell niche to neuronal networks. Curr Opin Neurobiol 17: 338-344.
    • (2007) Curr Opin Neurobiol , vol.17 , pp. 338-344
    • Ninkovic, J.1    Götz, M.2
  • 56
    • 0032841623 scopus 로고    scopus 로고
    • Multipotent and restricted precursors in the central nervous system
    • Rao, MS. (1999) Multipotent and restricted precursors in the central nervous system. Anat Rec 257: 137-148.
    • (1999) Anat Rec , vol.257 , pp. 137-148
    • Rao, M.S.1
  • 57
    • 33749010358 scopus 로고    scopus 로고
    • Neurotrophin-regulated signalling pathways
    • Reichardt, LF. (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361: 1545-1564.
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1545-1564
    • Reichardt, L.F.1
  • 58
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • Reynolds, B, Weiss, S. (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255: 1707-1710.
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.1    Weiss, S.2
  • 59
    • 0025321521 scopus 로고
    • Binding of brain derived neurotrophic factor to the nerve growth factor receptor
    • Rodriguez, TA, Dechant, G, Barde, YA. (1990) Binding of brain derived neurotrophic factor to the nerve growth factor receptor. Neuron 4: 487-492.
    • (1990) Neuron , vol.4 , pp. 487-492
    • Rodriguez, T.A.1    Dechant, G.2    Barde, Y.A.3
  • 60
    • 0036344505 scopus 로고    scopus 로고
    • Neurotrophin signaling through the p75 neurotrophin receptor
    • Roux, PP, Barker, PA. (2002) Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol 67: 203-233.
    • (2002) Prog Neurobiol , vol.67 , pp. 203-233
    • Roux, P.P.1    Barker, P.A.2
  • 61
    • 58149376976 scopus 로고    scopus 로고
    • The epidermal growth factor receptor ligands at a glance
    • Schneider, MR, Wolf, E. (2008) The epidermal growth factor receptor ligands at a glance. J Cell Physiol 218: 460-466.
    • (2008) J Cell Physiol , vol.218 , pp. 460-466
    • Schneider, M.R.1    Wolf, E.2
  • 62
    • 0032526168 scopus 로고    scopus 로고
    • In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: Inducing effects of brain-derived neurotrophic factor
    • Shetty, AK, Turner, DA. (1998) In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: Inducing effects of brain-derived neurotrophic factor. J Neurobiol 35: 395-425.
    • (1998) J Neurobiol , vol.35 , pp. 395-425
    • Shetty, A.K.1    Turner, D.A.2
  • 65
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song, G, Ouyang, G, Bao, S. (2005) The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9: 59-71.
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 66
    • 34447625239 scopus 로고    scopus 로고
    • Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: Correlation of nestin with prognosis of patient survival
    • Strojnik, T, Røsland, GV, Sakariassen, PO, Kavalar, R, Lah, T. (2007) Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival. Surg Neurol 68: 133-143.
    • (2007) Surg Neurol , vol.68 , pp. 133-143
    • Strojnik, T.1    Røsland, G.V.2    Sakariassen, P.O.3    Kavalar, R.4    Lah, T.5
  • 68
    • 34247152396 scopus 로고    scopus 로고
    • Adult neural stem cells, neurogenic niches, and cellular therapy
    • Taupin, P. (2006) Adult neural stem cells, neurogenic niches, and cellular therapy. Stem Cell Rev 2: 213-219.
    • (2006) Stem Cell Rev , vol.2 , pp. 213-219
    • Taupin, P.1
  • 69
    • 0035499887 scopus 로고    scopus 로고
    • The development of neural stem cells
    • Temple, S. (2001) The development of neural stem cells. Nature 414: 112-117.
    • (2001) Nature , vol.414 , pp. 112-117
    • Temple, S.1
  • 70
    • 1642540257 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: Signaling trios in complex biological systems
    • Teng, KK, Hempstead, BL. (2004) Neurotrophins and their receptors: signaling trios in complex biological systems. Cell Mol Life Sci 61: 35-48.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 35-48
    • Teng, K.K.1    Hempstead, B.L.2
  • 71
    • 0035152814 scopus 로고    scopus 로고
    • Neurotrophins are required for nerve growth during development
    • Tucker, KL, Meyer, M, Barde, YA. (2001) Neurotrophins are required for nerve growth during development. Nat Neurosci 4: 29-37.
    • (2001) Nat Neurosci , vol.4 , pp. 29-37
    • Tucker, K.L.1    Meyer, M.2    Barde, Y.A.3
  • 72
    • 45849098696 scopus 로고    scopus 로고
    • BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix
    • Xuan, AG, Long, DH, Gu, HG, Yang, DD, Honga, LP, Leng, SL. (2008) BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix. Neurosci Lett 440: 331-335.
    • (2008) Neurosci Lett , vol.440 , pp. 331-335
    • Xuan, A.G.1    Long, D.H.2    Gu, H.G.3    Yang, D.D.4    Honga, L.P.5    Leng, S.L.6
  • 73
    • 45549094504 scopus 로고    scopus 로고
    • BDNF Signaling during Olfactory Bulb Neurogenesis
    • Yuan, TF. (2008) BDNF Signaling during Olfactory Bulb Neurogenesis. J Neurosci 28: 5139-5140.
    • (2008) J Neurosci , vol.28 , pp. 5139-5140
    • Yuan, T.F.1
  • 74
    • 1542617770 scopus 로고    scopus 로고
    • Adult human olfactory neural progenitors cultured in defined medium
    • Zhang, X, Klueber, KM, Guo, Z, Lu, C, Roisen, FJ. (2004) Adult human olfactory neural progenitors cultured in defined medium. Exp Neurol 186: 112-123.
    • (2004) Exp Neurol , vol.186 , pp. 112-123
    • Zhang, X.1    Klueber, K.M.2    Guo, Z.3    Lu, C.4    Roisen, F.J.5
  • 75
    • 39149107803 scopus 로고    scopus 로고
    • Mechanisms and functional implications of adult neurogenesis
    • Zhao, C, Deng, W, Gage, FH. (2008) Mechanisms and functional implications of adult neurogenesis. Cell 132: 645-660.
    • (2008) Cell , vol.132 , pp. 645-660
    • Zhao, C.1    Deng, W.2    Gage, F.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.