Expansion of wild type allele rather than back mutation in pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi

Molecular and Biochemical Parasitology

Volumn 135, Issue 1, 2004, Pages 159-163

  Mita, Toshihiro ^a   Kaneko, Akira ^a,b   Lum, Jeffery K ^c   Zungu, Innocent L ^d   Tsukahara, Takahiro ^a   Eto, Hideaki ^a   Kobayakawa, Takatoshi ^a   Björkman, Anders ^b   Tanabe, Kazuyuki ^e  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c BINGHAMTON UNIVERSITY   (United States)

^d MINISTRY OF HEALTH   (Malawi)

^e OSAKA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Back mutation; Chloroquine; P. falciparum chloroquine resistance transporter gene; P. falciparum multiple drug resistance gene 1; PCR; pfcrt; pfmdr1; Plasmodium falciparum; Polymerase chain reaction

Indexed keywords

CHLOROQUINE;

ALLELE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; GENE; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; HAPLOTYPE; MALAWI; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER GENE; PREVALENCE; PRIORITY JOURNAL; REVERTANT;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIMALARIALS; ATP-BINDING CASSETTE TRANSPORTERS; CHLOROQUINE; DNA RESTRICTION ENZYMES; DNA, PROTOZOAN; GENES, PROTOZOAN; GENOTYPE; HAPLOTYPES; MALAWI; MEMBRANE PROTEINS; PLASMODIUM FALCIPARUM; POPULATION DYNAMICS; PROTOZOAN PROTEINS; SEQUENCE ANALYSIS, DNA;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 1842662623     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2004.01.011     Document Type: Article

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