-
1
-
-
34250877865
-
Genetic pathways to primary and secondary glioblastoma
-
Ohgaki, H.; Kleihues, P. Genetic pathways to primary and secondary glioblastoma. Am. J. Pathol., 2007, 170, 1445.
-
(2007)
Am. J. Pathol
, vol.170
, pp. 1445
-
-
Ohgaki, H.1
Kleihues, P.2
-
2
-
-
14244265590
-
Epidemiology and etiology of gliomas
-
Ohgaki, H.; Kleihues, P. Epidemiology and etiology of gliomas. Acta Neuropathol., 2005, 109, 93.
-
(2005)
Acta Neuropathol
, vol.109
, pp. 93
-
-
Ohgaki, H.1
Kleihues, P.2
-
3
-
-
0026048607
-
Second neoplasms after acute lymphoblastic leukemia in childhood
-
Neglia, J.P.; Meadows, A.T.; Robison, L.L.; Kim, T.H.; Newton, W.A.; Ruymann, F.B.; Sather, H.N.; Hammond, G.D. N. Second neoplasms after acute lymphoblastic leukemia in childhood. Engl. J. Med., 1991, 325, 1330.
-
(1991)
Engl. J. Med
, vol.325
, pp. 1330
-
-
Neglia, J.P.1
Meadows, A.T.2
Robison, L.L.3
Kim, T.H.4
Newton, W.A.5
Ruymann, F.B.6
Sather, H.N.7
Hammond, G.D.N.8
-
4
-
-
0032420791
-
Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital
-
Walter, A.W.; Hancock, M.L.; Pui, C.H.; Hudson, M.M.; Ochs, J.S.; Rivera, G.K.; Pratt, C.B.; Royett, J.M.; Kun, L.E. J. Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital. J. Clin. Oncol., 1998, 16, 3761.
-
(1998)
J. Clin. Oncol
, vol.16
, pp. 3761
-
-
Walter, A.W.1
Hancock, M.L.2
Pui, C.H.3
Hudson, M.M.4
Ochs, J.S.5
Rivera, G.K.6
Pratt, C.B.7
Royett, J.M.8
Kun, L.E.J.9
-
5
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp, R.; Mason, W.P.; van den Bent, M.J.; Weller, M.; Fisher, B.; Taphoorn, M.J.B.; Belanger, K.; Brandes, A.A.; Marosi, C.; Bogdahn, U.; Curschmann, J.; Janzer, R.C.; Ludwin, S.K.; Gorlia, T.; Allgeier, A.; Lacombe, D.; Cairncross, G.; Eisenhauer, E.; Mirimanoff, R.O. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med., 2005, 352, 987.
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 987
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
Weller, M.4
Fisher, B.5
Taphoorn, M.J.B.6
Belanger, K.7
Brandes, A.A.8
Marosi, C.9
Bogdahn, U.10
Curschmann, J.11
Janzer, R.C.12
Ludwin, S.K.13
Gorlia, T.14
Allgeier, A.15
Lacombe, D.16
Cairncross, G.17
Eisenhauer, E.18
Mirimanoff, R.O.19
-
6
-
-
33745010017
-
Radiotherapy and temozolomide for newly diagnosed glioblastoma: Recursive partitioning analysis of the EORTC 26981-NCIC CE3 phase III randomized trial
-
Mirimanoff, R.O.; Gorlia, T.; Mason, W.; Van den Bent, M.J.; Kortmann, R.D.; Fisher, B.; Reni, M.; Brandes, A.A.; Curschmann, J.; Villa, S.; Cairncross, G.; Allgeier, A.; Lacombe, D.; Stupp, R. Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981-NCIC CE3 phase III randomized trial. J. Clin. Oncol., 2006, 24, 2563.
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 2563
-
-
Mirimanoff, R.O.1
Gorlia, T.2
Mason, W.3
Van den Bent, M.J.4
Kortmann, R.D.5
Fisher, B.6
Reni, M.7
Brandes, A.A.8
Curschmann, J.9
Villa, S.10
Cairncross, G.11
Allgeier, A.12
Lacombe, D.13
Stupp, R.14
-
7
-
-
0037161024
-
Chemothertapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomized trials
-
Stewart, L.A. Chemothertapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomized trials. Lancet, 2002, 359, 1011.
-
(2002)
Lancet
, vol.359
, pp. 1011
-
-
Stewart, L.A.1
-
8
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi, M.E.; Diserens, A.C.; Gorlia, T.; Hamou, M.F.; de Tribolet, N.; Weller, M.; Kros, J.M.; Hainfellner, J.A.; Mason, W.; Mariani, L.; Bromberg, J.E.C.; Hau, P.; Mirimanoff, R.O.; Cairncross, G.; Janzer, R.C.; Stupp, R. MGMT gene silencing and benefit from temozolomide in glioblastoma. New Engl. J. Med., 2005, 352, 997.
-
(2005)
New Engl. J. Med
, vol.352
, pp. 997
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
Hamou, M.F.4
de Tribolet, N.5
Weller, M.6
Kros, J.M.7
Hainfellner, J.A.8
Mason, W.9
Mariani, L.10
Bromberg, J.E.C.11
Hau, P.12
Mirimanoff, R.O.13
Cairncross, G.14
Janzer, R.C.15
Stupp, R.16
-
9
-
-
0037692954
-
Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
-
Tolcher, A.W.; Gerson, S.L.; Denis, L.; Geyer, C.; Hammond, L.A.; Patnaik, A.; Goetz, A.D.; Schwartz, G.; Edwards, T.; Reyderman, L.; Statkevich, P.; Cutler, D.L.; Rowinsky, E.K. Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. Br. J. Cancer, 2003, 88, 1004.
-
(2003)
Br. J. Cancer
, vol.88
, pp. 1004
-
-
Tolcher, A.W.1
Gerson, S.L.2
Denis, L.3
Geyer, C.4
Hammond, L.A.5
Patnaik, A.6
Goetz, A.D.7
Schwartz, G.8
Edwards, T.9
Reyderman, L.10
Statkevich, P.11
Cutler, D.L.12
Rowinsky, E.K.13
-
10
-
-
0027294649
-
Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials
-
Curran, W.J.Jr.; Scott, C.B.; Horton, J.; Nelson, J.S.; Weinstein, A.S.; Fischbach, A.J.; Chang, C.H.; Rotman, M.; Asbell, S.O.; Krisch, R.E.; Nelson, D.E. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J. Natl. Cancer Inst., 1993, 85, 704.
-
(1993)
J. Natl. Cancer Inst
, vol.85
, pp. 704
-
-
Curran Jr, W.J.1
Scott, C.B.2
Horton, J.3
Nelson, J.S.4
Weinstein, A.S.5
Fischbach, A.J.6
Chang, C.H.7
Rotman, M.8
Asbell, S.O.9
Krisch, R.E.10
Nelson, D.E.11
-
11
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med., 1971, 285, 1182.
-
(1971)
N. Engl. J. Med
, vol.285
, pp. 1182
-
-
Folkman, J.1
-
12
-
-
0015380016
-
Tumor dormancy in vivo by prevention of neovascularization
-
Gimbrone, M.A.Jr.; Leapman, S.B.; Cotran, R.S.; Folkman, J. Tumor dormancy in vivo by prevention of neovascularization. J. Exp. Med., 1972, 136, 261.
-
(1972)
J. Exp. Med
, vol.136
, pp. 261
-
-
Gimbrone Jr, M.A.1
Leapman, S.B.2
Cotran, R.S.3
Folkman, J.4
-
13
-
-
0028216334
-
Thalidomide is an inhibitor of angiogenesis
-
D'Amato, R.J.; Loughnan, M.S.; Flynn, E.; Folkman, J. Thalidomide is an inhibitor of angiogenesis. Proc. Natl. Acad. Sci. USA, 1994, 91, 4082.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4082
-
-
D'Amato, R.J.1
Loughnan, M.S.2
Flynn, E.3
Folkman, J.4
-
14
-
-
0033954292
-
Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas
-
Fine, H.A.; Figg, W.D.; Jaeckle, K.; Wen, P.Y.; Kyritsis, A.P.; Loeffler, J.S.; Levin, V.A.; Black, P.M.; Kaplan, R.; Pluda, J.M.; Yung, W.K. Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. J. Clin. Oncol., 2000, 18, 708.
-
(2000)
J. Clin. Oncol
, vol.18
, pp. 708
-
-
Fine, H.A.1
Figg, W.D.2
Jaeckle, K.3
Wen, P.Y.4
Kyritsis, A.P.5
Loeffler, J.S.6
Levin, V.A.7
Black, P.M.8
Kaplan, R.9
Pluda, J.M.10
Yung, W.K.11
-
15
-
-
0037811745
-
Phase II trial of thalidomide and carmustine for patients with recurrent highgrade gliomas
-
Fine, H.A.; Wen, P.Y.; Maher, E.A.; Viscosi, E.; Batchelor, T.; Lakhani, N.; Figg, W.D.; Purow, B.W.; Borkowf, C.B. Phase II trial of thalidomide and carmustine for patients with recurrent highgrade gliomas. J. Clin. Oncol., 2003, 21, 2299.
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 2299
-
-
Fine, H.A.1
Wen, P.Y.2
Maher, E.A.3
Viscosi, E.4
Batchelor, T.5
Lakhani, N.6
Figg, W.D.7
Purow, B.W.8
Borkowf, C.B.9
-
16
-
-
0038737156
-
Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma
-
Salmaggi, A.; Eoli, M.; Frigerio, S.; Silviani, A.; Gelati, M.; Corsini, E.; Broggi, G.; Boiardi, A. Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma. J. Neurooncol., 2003, 62, 297.
-
(2003)
J. Neurooncol
, vol.62
, pp. 297
-
-
Salmaggi, A.1
Eoli, M.2
Frigerio, S.3
Silviani, A.4
Gelati, M.5
Corsini, E.6
Broggi, G.7
Boiardi, A.8
-
17
-
-
0037389767
-
Levels of soluble vacular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A
-
Lamszus, K.; Ulbricht, U.; Matschke, J.; Brockmann, M.A.; Fillbrandt, R.; Westphal, M. Levels of soluble vacular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A. Clin. Cancer Res., 2003, 9, 1399.
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 1399
-
-
Lamszus, K.1
Ulbricht, U.2
Matschke, J.3
Brockmann, M.A.4
Fillbrandt, R.5
Westphal, M.6
-
18
-
-
85036821362
-
-
Conrad, C.; Friedman, H.; Reardon, D.; Provenzale, J.; Jackson, E.; Serajuddin, H.; Laurent, D.; Chen, B.; Yung, W.K.A. A phase I/II trial of single-agent PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM). J. Clin. Oncol., 2004, 22(14S), 1512.
-
Conrad, C.; Friedman, H.; Reardon, D.; Provenzale, J.; Jackson, E.; Serajuddin, H.; Laurent, D.; Chen, B.; Yung, W.K.A. A phase I/II trial of single-agent PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM). J. Clin. Oncol., 2004, 22(14S), 1512.
-
-
-
-
19
-
-
16844371774
-
A phase I trial of PTK787/ZK (PTK/ZK), an oral VEGF tyrosine kinase inhibitor, in combination with either temozolomide or lumustine for patients with recurrent glioblastoma multiforme (GBM)
-
Reardon, D.; Friedman, H.S.; Yung, W.K.A.; Brada, M.; Conrad, C.; Provenzale, J.; Jackson, E.F.; Serajuddin, H.; Laurent, D.; Reitsma, D. A phase I trial of PTK787/ZK (PTK/ZK), an oral VEGF tyrosine kinase inhibitor, in combination with either temozolomide or lumustine for patients with recurrent glioblastoma multiforme (GBM). Proc. Am. Soc. Clin. Oncol., 2004, 23, 110.
-
(2004)
Proc. Am. Soc. Clin. Oncol
, vol.23
, pp. 110
-
-
Reardon, D.1
Friedman, H.S.2
Yung, W.K.A.3
Brada, M.4
Conrad, C.5
Provenzale, J.6
Jackson, E.F.7
Serajuddin, H.8
Laurent, D.9
Reitsma, D.10
-
20
-
-
0026708632
-
The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
-
Kim, K.J.; Li, B.; Houck, K.; Winer, J.; Ferrara, N. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors, 1992, 7, 53.
-
(1992)
Growth Factors
, vol.7
, pp. 53
-
-
Kim, K.J.1
Li, B.2
Houck, K.3
Winer, J.4
Ferrara, N.5
-
21
-
-
33947191055
-
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
-
Vredenburgh, J.J.; Desjardins, A.; Herndon, J.E.2nd.; Dowell, J.M.; Reardon, D.A.; Quinn, J.A.; Rich, J.N.; Sathornsumetee, S.; Gururangan, S.; Wagner, M.; Bigner, D.D.; Friedman, A.H.; Friedman, H.S. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin. Cancer Res., 2007, 13, 1253.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 1253
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon 2nd, J.E.3
Dowell, J.M.4
Reardon, D.A.5
Quinn, J.A.6
Rich, J.N.7
Sathornsumetee, S.8
Gururangan, S.9
Wagner, M.10
Bigner, D.D.11
Friedman, A.H.12
Friedman, H.S.13
-
22
-
-
36049037819
-
-
Vredenburgh, J.J.; Desjardins, A.; Herndon, J.E.2nd.; Marcello, J.; Reardon, D.A.; Quinn, J.A.; Rich, J.N.; Sathornsumetee, S.; Gururangan, S.; Sampson, J.; Wagner, M.; Bailey, L.: Bigner, D.D.; Friedman, A.H.; Friedman, H.S. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J. Clin. Oncol., 2007, 25, 4722.
-
Vredenburgh, J.J.; Desjardins, A.; Herndon, J.E.2nd.; Marcello, J.; Reardon, D.A.; Quinn, J.A.; Rich, J.N.; Sathornsumetee, S.; Gururangan, S.; Sampson, J.; Wagner, M.; Bailey, L.: Bigner, D.D.; Friedman, A.H.; Friedman, H.S. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J. Clin. Oncol., 2007, 25, 4722.
-
-
-
-
23
-
-
0018574156
-
Impact of continously administered catechol estrogens on uterine growth and luteinizing hormone secretion
-
Martucci, C.P.; Fishman, J. Impact of continously administered catechol estrogens on uterine growth and luteinizing hormone secretion. Endocrinology, 1979, 105, 1288.
-
(1979)
Endocrinology
, vol.105
, pp. 1288
-
-
Martucci, C.P.1
Fishman, J.2
-
24
-
-
0028331925
-
2-Methoxyestradiol, an endogeneous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site
-
D'Amato, R.J.; Lin, C.M.; Flynn, E.; Folkman, J.; Hamel, E. 2-Methoxyestradiol, an endogeneous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc. Natl. Acad. Sci. USA, 1994, 91, 3964.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 3964
-
-
D'Amato, R.J.1
Lin, C.M.2
Flynn, E.3
Folkman, J.4
Hamel, E.5
-
25
-
-
0742269867
-
New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent
-
Mooberry, S.L. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr. Opin. Oncol., 2003, 15, 425.
-
(2003)
Curr. Opin. Oncol
, vol.15
, pp. 425
-
-
Mooberry, S.L.1
-
26
-
-
0037105379
-
2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells
-
Chauhan, D.; Catley, L.; Hideshima, T.; Li, G.; Leblanc, R.; Gupta, D.; Sattler, M.; Richardson, P.; Schlossman, R.L.; Podar, K.; Weller, E.; Munshi, N.; Anderson, K.C. 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells. Blood, 2002, 100, 2187.
-
(2002)
Blood
, vol.100
, pp. 2187
-
-
Chauhan, D.1
Catley, L.2
Hideshima, T.3
Li, G.4
Leblanc, R.5
Gupta, D.6
Sattler, M.7
Richardson, P.8
Schlossman, R.L.9
Podar, K.10
Weller, E.11
Munshi, N.12
Anderson, K.C.13
-
27
-
-
0036897507
-
Promising preclinical activity of 2-methoxyestradiol in multiple myeloma
-
Dingli, D.; Timm, M.; Russel, S.J.; Witzig, T.E.; Rajkumar, S.V. Promising preclinical activity of 2-methoxyestradiol in multiple myeloma. Clin. Cancer Res., 2002, 8, 3948.
-
(2002)
Clin. Cancer Res
, vol.8
, pp. 3948
-
-
Dingli, D.1
Timm, M.2
Russel, S.J.3
Witzig, T.E.4
Rajkumar, S.V.5
-
28
-
-
0037071883
-
2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells
-
Qanungo, S.; Basu, A.; Das, M.; Haldar, S. 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells. Oncogene, 2002, 21, 4149.
-
(2002)
Oncogene
, vol.21
, pp. 4149
-
-
Qanungo, S.1
Basu, A.2
Das, M.3
Haldar, S.4
-
29
-
-
0034699513
-
Superoxide dismutase as a target for the selective killing of cancer cells
-
Huang, P.; Feng, L.; Oldham, E.A.; Keating, M.J.; Plunkett, W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature, 2000, 407, 390.
-
(2000)
Nature
, vol.407
, pp. 390
-
-
Huang, P.1
Feng, L.2
Oldham, E.A.3
Keating, M.J.4
Plunkett, W.5
-
30
-
-
0037439693
-
2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway
-
LaVallee, T.M.; Zhan, X.H.; Johnson, M.S.; Herbstritt, C.J.; Swartz, G.; Williams, M.S.; Hembrough, W.A.; Green, S.J., Pribluda, V.S. 2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res., 2003, 63, 468.
-
(2003)
Cancer Res
, vol.63
, pp. 468
-
-
LaVallee, T.M.1
Zhan, X.H.2
Johnson, M.S.3
Herbstritt, C.J.4
Swartz, G.5
Williams, M.S.6
Hembrough, W.A.7
Green, S.J.8
Pribluda, V.S.9
-
31
-
-
0037058639
-
2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells
-
Carothers, A.M.; Hughes, S.A.; Ortega, D.; Bertagnolli, M.M. 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells. Cancer Lett., 2002, 187, 77.
-
(2002)
Cancer Lett
, vol.187
, pp. 77
-
-
Carothers, A.M.1
Hughes, S.A.2
Ortega, D.3
Bertagnolli, M.M.4
-
32
-
-
0037374464
-
Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma
-
Ryschich, E.; Werner, J.; Gebhard, M.M.; Klar, E.; Schmidt, J. Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma. Pancreas, 2003, 26, 166.
-
(2003)
Pancreas
, vol.26
, pp. 166
-
-
Ryschich, E.1
Werner, J.2
Gebhard, M.M.3
Klar, E.4
Schmidt, J.5
-
33
-
-
0036173883
-
2-methoxyestradiol induces interferone gene expression and apoptosis in osteosarcoma cells
-
Maran, A.; Zhang, M.; Kennedy, A.M.; Sibonga, J.D.; Rickard, D.J.; Spelsberg, T.C.; Turner, R.T. 2-methoxyestradiol induces interferone gene expression and apoptosis in osteosarcoma cells. Bone, 2002, 30, 393.
-
(2002)
Bone
, vol.30
, pp. 393
-
-
Maran, A.1
Zhang, M.2
Kennedy, A.M.3
Sibonga, J.D.4
Rickard, D.J.5
Spelsberg, T.C.6
Turner, R.T.7
-
34
-
-
0036044045
-
Dual effect of 2-methoxyestradiol on cell cycle events in human osteosarcoma 143B cells
-
Golebiewska, J.; Rozwadowski, P.; Spodnik, J.H.; Knap, N.; Wakabayashi, T.; Wozniak, M. Dual effect of 2-methoxyestradiol on cell cycle events in human osteosarcoma 143B cells. Acta Biochim. Pol., 2002, 49, 59.
-
(2002)
Acta Biochim. Pol
, vol.49
, pp. 59
-
-
Golebiewska, J.1
Rozwadowski, P.2
Spodnik, J.H.3
Knap, N.4
Wakabayashi, T.5
Wozniak, M.6
-
35
-
-
0013449549
-
Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyestradiol: Therapeutic implications ?
-
Ghosh, R.; Ott, A.M.; Seetharam, D.; Slaga, T.J.; Kumar, A.P. Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyestradiol: therapeutic implications ? Melanoma Res., 2003, 13, 119.
-
(2003)
Melanoma Res
, vol.13
, pp. 119
-
-
Ghosh, R.1
Ott, A.M.2
Seetharam, D.3
Slaga, T.J.4
Kumar, A.P.5
-
36
-
-
0038531029
-
2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production
-
Djavaheri-Mergny, M.; Wietzerbin, J.; Besancon, F. 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. Oncogene, 2003, 22, 2558.
-
(2003)
Oncogene
, vol.22
, pp. 2558
-
-
Djavaheri-Mergny, M.1
Wietzerbin, J.2
Besancon, F.3
-
37
-
-
0037330674
-
2-Methoxyestradiol interferes with NF kappa B transcriptional activity in primitive neuroectodermal brain tumors: Implications for mamagement
-
Kumar, A.P.; Garcia, G.E.; Orsborn, J.; Levin, V.A.; Slaga, T.J. 2-Methoxyestradiol interferes with NF kappa B transcriptional activity in primitive neuroectodermal brain tumors: implications for mamagement. Carcinogenesis, 2003, 24, 209.
-
(2003)
Carcinogenesis
, vol.24
, pp. 209
-
-
Kumar, A.P.1
Garcia, G.E.2
Orsborn, J.3
Levin, V.A.4
Slaga, T.J.5
-
38
-
-
4344659253
-
2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death, in vitro
-
Lis, A.; Ciesielski, M.J.; Barone, T.A.; Scott, B.E.; Fenstermaker, R.A.; Plunkett, R.J. 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death, in vitro. Cancer Lett., 2004, 213, 57.
-
(2004)
Cancer Lett
, vol.213
, pp. 57
-
-
Lis, A.1
Ciesielski, M.J.2
Barone, T.A.3
Scott, B.E.4
Fenstermaker, R.A.5
Plunkett, R.J.6
-
39
-
-
21244482124
-
Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton
-
Chamaon, K.; Stojek, J.; Kanakis, D.; Braeuninger, S.; Kirches, E.; Krause, G.; Mawrin, C.; Dietzmann, K. Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton. J. Neurooncol., 2005, 72, 11.
-
(2005)
J. Neurooncol
, vol.72
, pp. 11
-
-
Chamaon, K.1
Stojek, J.2
Kanakis, D.3
Braeuninger, S.4
Kirches, E.5
Krause, G.6
Mawrin, C.7
Dietzmann, K.8
-
40
-
-
36448951976
-
Enhanced radiation-induced cytotoxic effect by 2-ME in glioma cells is mediated by induction of cell cycle arrest and DNA damage via activation of ATM pathways
-
Zou, H.; Zhao, S.; Zhang, J.; Lv, G.: Zhang, X.; Yu, H.; Wang, H.; Wang, L. Enhanced radiation-induced cytotoxic effect by 2-ME in glioma cells is mediated by induction of cell cycle arrest and DNA damage via activation of ATM pathways. Brain Res., 2007, 1185, 231.
-
(2007)
Brain Res
, vol.1185
, pp. 231
-
-
Zou, H.1
Zhao, S.2
Zhang, J.3
Lv, G.4
Zhang, X.5
Yu, H.6
Wang, H.7
Wang, L.8
-
41
-
-
21844458944
-
Short incubation with 2-methoxyestradiol kills malignant glioma cells independent of death receptor 5 upregulation
-
Braeuninger, S.; Chamaon, K.; Kropf, S.; Mawrin, C.; Wiedemann, F.R.; Hartig, R.; Schoeler, S.; Dietzmann, K.; Kirches, E. Short incubation with 2-methoxyestradiol kills malignant glioma cells independent of death receptor 5 upregulation. Clin. Neuropathol., 2005, 24, 175.
-
(2005)
Clin. Neuropathol
, vol.24
, pp. 175
-
-
Braeuninger, S.1
Chamaon, K.2
Kropf, S.3
Mawrin, C.4
Wiedemann, F.R.5
Hartig, R.6
Schoeler, S.7
Dietzmann, K.8
Kirches, E.9
-
42
-
-
35948958167
-
2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo
-
Cicek, M.; Iwaniec, U.T.; Goblirsch, M.J.; Vrabel, A.; Ruan, M.; Clohisy, D.R.; Turner, R.R.; Oursler, M.J. 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. Cancer Res, 2007, 67, 10106.
-
(2007)
Cancer Res
, vol.67
, pp. 10106
-
-
Cicek, M.1
Iwaniec, U.T.2
Goblirsch, M.J.3
Vrabel, A.4
Ruan, M.5
Clohisy, D.R.6
Turner, R.R.7
Oursler, M.J.8
-
43
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh, N.J.; Escuin, D.; LaVallee, T.M.; Pribluda, V.S.; Swartz, G.M.; Johnson, M.S.; Willard, M.T.; Zhong, H.; Simons, J.W.; Giannakakou, P. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell, 2003, 3, 363.
-
(2003)
Cancer Cell
, vol.3
, pp. 363
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
Willard, M.T.7
Zhong, H.8
Simons, J.W.9
Giannakakou, P.10
-
44
-
-
0030581696
-
2-Methoxyestradiol arrests cells in mitosis without depolymerizing tubulin
-
Attalla H.; Mäkelä, T.P.; Adlercreutz, H.; Andersson, L.C. 2-Methoxyestradiol arrests cells in mitosis without depolymerizing tubulin. Biochem. Biophys. Res. Commun., 1996, 228, 467.
-
(1996)
Biochem. Biophys. Res. Commun
, vol.228
, pp. 467
-
-
Attalla, H.1
Mäkelä, T.P.2
Adlercreutz, H.3
Andersson, L.C.4
-
45
-
-
33749578369
-
2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
-
Kamath, K.; Okouneva, T.; Larson, G.; Panda, D.; Wilson, L.; Jordan, M.A. 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol. Cancer Ther., 2006, 5, 2225.
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 2225
-
-
Kamath, K.1
Okouneva, T.2
Larson, G.3
Panda, D.4
Wilson, L.5
Jordan, M.A.6
-
46
-
-
33846702022
-
2-methoxyestradiol inhibits the anaphasepromoting complex and protein translation in human breast cancer cells
-
Bhati, R.; Gokmen-Polar, Y.; Sledge, G.W.Jr.; Fan, C.; Nakshatri, H.; Ketelsen, D.; Borchers, C.H.; Dial, M.J.; Patterson, C.; Klauber-DeMore, N. 2-methoxyestradiol inhibits the anaphasepromoting complex and protein translation in human breast cancer cells. Cancer Res., 2007, 67, 702.
-
(2007)
Cancer Res
, vol.67
, pp. 702
-
-
Bhati, R.1
Gokmen-Polar, Y.2
Sledge Jr, G.W.3
Fan, C.4
Nakshatri, H.5
Ketelsen, D.6
Borchers, C.H.7
Dial, M.J.8
Patterson, C.9
Klauber-DeMore, N.10
-
47
-
-
0036284778
-
The anaphase-promoting complex: Proteolysis in mitosis and beyond
-
Peters, J.M. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell, 2002, 9, 931.
-
(2002)
Mol. Cell
, vol.9
, pp. 931
-
-
Peters, J.M.1
-
48
-
-
0034333025
-
Oral administration of an estrogen metabolite induced potentiation of radiation antitumor effects in presence of wild-type p53 in non-small-cell lung cancer
-
Huober, J.B.; Nakamura, S.; Meyn, R.; Roth, J.A., Mukhopadhyay, T. Oral administration of an estrogen metabolite induced potentiation of radiation antitumor effects in presence of wild-type p53 in non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys., 2000, 48, 1127.
-
(2000)
Int. J. Radiat. Oncol. Biol. Phys
, vol.48
, pp. 1127
-
-
Huober, J.B.1
Nakamura, S.2
Meyn, R.3
Roth, J.A.4
Mukhopadhyay, T.5
-
49
-
-
33751298106
-
2-methoxyestradiol, an endogeneous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation
-
Zou, H.; Adachi, M.; Imai, K.; Hareyama, M.; Yoshioka, K.; Zhao, S.; Shinomura, Y. 2-methoxyestradiol, an endogeneous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation. Clin. Cancer Res., 2006, 12, 6532.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 6532
-
-
Zou, H.1
Adachi, M.2
Imai, K.3
Hareyama, M.4
Yoshioka, K.5
Zhao, S.6
Shinomura, Y.7
-
50
-
-
34548548398
-
Radiosensitization and modulation of p44/42 mitogenactivated protein kinase by 2-Methoxyestradiol in prostate cancer models
-
Casarez, E.V.; Dunlap-Brown, M.E.; Conaway, M.R.; Amorino, G.P. Radiosensitization and modulation of p44/42 mitogenactivated protein kinase by 2-Methoxyestradiol in prostate cancer models. Cancer Res., 2007, 67, 8316.
-
(2007)
Cancer Res
, vol.67
, pp. 8316
-
-
Casarez, E.V.1
Dunlap-Brown, M.E.2
Conaway, M.R.3
Amorino, G.P.4
-
51
-
-
25444465116
-
Both microtubulestabilizing and microtubule-destabilizing drugs inhibit hypoxiainducible factor-1.. accumulation and activity by disrupting microtubule finction
-
Escuin, D.; Kline, E.R.; Giannakakou, P. Both microtubulestabilizing and microtubule-destabilizing drugs inhibit hypoxiainducible factor-1.. accumulation and activity by disrupting microtubule finction. Cancer Res., 2005, 65, 9021.
-
(2005)
Cancer Res
, vol.65
, pp. 9021
-
-
Escuin, D.1
Kline, E.R.2
Giannakakou, P.3
-
52
-
-
3042823868
-
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
-
Chakravarti, A.; Zhai, G.; Suzuki, Y.; Sarkesh, S.; Black, P.M.; Muzikansky, A.; Loeffler, J.S. J. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. Clin. Oncol., 2004, 22, 1926.
-
(2004)
Clin. Oncol
, vol.22
, pp. 1926
-
-
Chakravarti, A.1
Zhai, G.2
Suzuki, Y.3
Sarkesh, S.4
Black, P.M.5
Muzikansky, A.6
Loeffler, J.S.J.7
-
53
-
-
0036235624
-
Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma
-
Nagai, S.; Washiyama, K.; Kurimoto, M.; Takaku, A.; Endo, S.; Kumanishi, T. Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma. J. Neurosurg., 2002, 96, 909.
-
(2002)
J. Neurosurg
, vol.96
, pp. 909
-
-
Nagai, S.1
Washiyama, K.2
Kurimoto, M.3
Takaku, A.4
Endo, S.5
Kumanishi, T.6
-
54
-
-
0038179723
-
Cost of migration: Invasion of malignant gliomas and implication for treatment
-
Giese, A.; Bjerkvig, R.; Berens, M.E.; Westphal, M. Cost of migration: invasion of malignant gliomas and implication for treatment. J. Clin. Oncol., 2003, 21, 1624.
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 1624
-
-
Giese, A.1
Bjerkvig, R.2
Berens, M.E.3
Westphal, M.4
-
55
-
-
13444294190
-
Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets
-
Hoelzinger, D.B.; Mariani, L.; Weis, J.; Woyke, T.; Berens, T.J.; McDonough, W.S.; Sloan, A.; Coons, S.W.; Berens, M.E. Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia, 2005, 7, 7.
-
(2005)
Neoplasia
, vol.7
, pp. 7
-
-
Hoelzinger, D.B.1
Mariani, L.2
Weis, J.3
Woyke, T.4
Berens, T.J.5
McDonough, W.S.6
Sloan, A.7
Coons, S.W.8
Berens, M.E.9
-
56
-
-
17144398831
-
Possible future issues in the treatment of glioblastomas: Special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis
-
Lefranc, F.; Brotchi, J.; Kiss, R. Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. J. Clin. Oncol., 2005, 23, 2411.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 2411
-
-
Lefranc, F.1
Brotchi, J.2
Kiss, R.3
-
57
-
-
1342268265
-
Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide
-
Kanzawa, T.; Bedwell, J.; Kondo, Y.; Kondo, S.; Germano, I.M. Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide. J. Neurosurg., 2003, 99, 1047.
-
(2003)
J. Neurosurg
, vol.99
, pp. 1047
-
-
Kanzawa, T.1
Bedwell, J.2
Kondo, Y.3
Kondo, S.4
Germano, I.M.5
-
58
-
-
1842865745
-
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
-
Kanzawa, T.; Germano, I.M.; Komata, T.; Ito, H.; Kondo, Y.; Kondo, S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ., 2004, 11, 448.
-
(2004)
Cell Death Differ
, vol.11
, pp. 448
-
-
Kanzawa, T.1
Germano, I.M.2
Komata, T.3
Ito, H.4
Kondo, Y.5
Kondo, S.6
-
59
-
-
1942424799
-
Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells
-
Takeuchi, H.; Kanzawa, T.; Kondo, Y.; Kondo, S. Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells. Br. J. Cancer, 2004, 90, 1069.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 1069
-
-
Takeuchi, H.1
Kanzawa, T.2
Kondo, Y.3
Kondo, S.4
-
60
-
-
33846252663
-
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine
-
Roos, W.P.; Batista, I.F.; Naumann, S.C.; Wick, W.; Weller, M.; Menck, C.F.; Kaina, B. Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene, 2007, 26, 186.
-
(2007)
Oncogene
, vol.26
, pp. 186
-
-
Roos, W.P.1
Batista, I.F.2
Naumann, S.C.3
Wick, W.4
Weller, M.5
Menck, C.F.6
Kaina, B.7
-
61
-
-
37349067228
-
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
-
Chen, Y.; McMillan-Ward, E.; Kong, J.; Israels, S.J.; Gibson, S.B. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ., 2008, 15, 171.
-
(2008)
Cell Death Differ
, vol.15
, pp. 171
-
-
Chen, Y.1
McMillan-Ward, E.2
Kong, J.3
Israels, S.J.4
Gibson, S.B.5
-
62
-
-
33846240027
-
Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model
-
Kang, S.H.; Cho, H.T.; Devi, S.; Zhang, Z.; Escuin, D.; Liang, Z.; Mao, H.; Brat, D.J.; Olson, J.J.; Simons, J.W.; LaVallee, T.M.; Giannakakou, P.; Van Meir, E.G.; Shim, H. Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Cancer Res., 2006, 66, 11991.
-
(2006)
Cancer Res
, vol.66
, pp. 11991
-
-
Kang, S.H.1
Cho, H.T.2
Devi, S.3
Zhang, Z.4
Escuin, D.5
Liang, Z.6
Mao, H.7
Brat, D.J.8
Olson, J.J.9
Simons, J.W.10
LaVallee, T.M.11
Giannakakou, P.12
Van Meir, E.G.13
Shim, H.14
-
63
-
-
0015618592
-
Development of an animal brain tumor model and its response to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea
-
Barker, M.; Hoshino, T.; Gurcay, O.; Wilson, C.B.; Nielsen, S.L.; Downie, R.; Eliason, J. Development of an animal brain tumor model and its response to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res., 1973, 33, 976.
-
(1973)
Cancer Res
, vol.33
, pp. 976
-
-
Barker, M.1
Hoshino, T.2
Gurcay, O.3
Wilson, C.B.4
Nielsen, S.L.5
Downie, R.6
Eliason, J.7
-
64
-
-
0023154428
-
Acetylated alphatubulin in Physarum: Immunological characterization of the isotype and its usage in particular microtubular organelles
-
Sasse, R.; Glyn, M.C.; Birkett, C.R.; Gull, K. Acetylated alphatubulin in Physarum: immunological characterization of the isotype and its usage in particular microtubular organelles. J. Cell Biol., 1987, 104, 41.
-
(1987)
J. Cell Biol
, vol.104
, pp. 41
-
-
Sasse, R.1
Glyn, M.C.2
Birkett, C.R.3
Gull, K.4
-
65
-
-
33750483598
-
Phase I safety, pharmakokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer
-
James, J.; Murry, D.J.; Treston, A.M.; Storniolo, A.M.; Sledge, G.W.; Sidor, C.; Miller, K.D. Phase I safety, pharmakokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. Invest. New Drugs, 2007, 25, 41.
-
(2007)
Invest. New Drugs
, vol.25
, pp. 41
-
-
James, J.1
Murry, D.J.2
Treston, A.M.3
Storniolo, A.M.4
Sledge, G.W.5
Sidor, C.6
Miller, K.D.7
-
66
-
-
32544433479
-
Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors
-
Dahut, W.L.; Lakhani, N.J.; Gulley, J.L.; Arlen, P.M.; Kohn, E.C.; Kotz, H.; McNally, D.; Parr, A.; Nguyen, D.; Yang, S.X.; Steinberg, S.M.; Venitz, J.; Sparreboom, A.; Figg, W.D. Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors. Cancer Biol. Ther., 2006, 5, 22.
-
(2006)
Cancer Biol. Ther
, vol.5
, pp. 22
-
-
Dahut, W.L.1
Lakhani, N.J.2
Gulley, J.L.3
Arlen, P.M.4
Kohn, E.C.5
Kotz, H.6
McNally, D.7
Parr, A.8
Nguyen, D.9
Yang, S.X.10
Steinberg, S.M.11
Venitz, J.12
Sparreboom, A.13
Figg, W.D.14
-
67
-
-
25144452785
-
A phase II multicenter, randomized, double-blind, safety trial assessing the pharmakokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer
-
Sweeney, C.; Liu, G.; Yiannoutsos, C.; Kolesar, J.; Horvath, D.; Staab, M.J.; Fife, K.; Armstrong, V.; Treston. A.; Sidor, C.; Wilding, G. A phase II multicenter, randomized, double-blind, safety trial assessing the pharmakokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. Clin. Cancer Res., 2005, 11, 6625.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 6625
-
-
Sweeney, C.1
Liu, G.2
Yiannoutsos, C.3
Kolesar, J.4
Horvath, D.5
Staab, M.J.6
Fife, K.7
Armstrong, V.8
Treston, A.9
Sidor, C.10
Wilding, G.11
-
68
-
-
35948946128
-
Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma
-
Rajkumar, S.V.; Richardson, P.G.; Lacy, M.Q.; Dispenzieri, A.; Greipp, P.R.; Witzig, T.E.; Schlossman, R.; Sidor, C.F.; Anderson, K.C.; Gertz, M.A. Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma. Clin. Cancer Res., 2007, 13, 6162.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 6162
-
-
Rajkumar, S.V.1
Richardson, P.G.2
Lacy, M.Q.3
Dispenzieri, A.4
Greipp, P.R.5
Witzig, T.E.6
Schlossman, R.7
Sidor, C.F.8
Anderson, K.C.9
Gertz, M.A.10
-
69
-
-
85036838505
-
-
Kirkpatrick, J.; Desjardins, A.; Quinn, J.; Rich, J.; Vredenburgh, J.; Sathornsumetee, S.; Guruangan, S.; Sidor, C.; Friedman, H.; Reardon, D. Phase II open-label, safety, pharmacokinetic and efficacy ministered orally to patients with recurrent glioblastoma multiforme. J. Clin. Oncol., 2007, 25(18S), 2065.
-
Kirkpatrick, J.; Desjardins, A.; Quinn, J.; Rich, J.; Vredenburgh, J.; Sathornsumetee, S.; Guruangan, S.; Sidor, C.; Friedman, H.; Reardon, D. Phase II open-label, safety, pharmacokinetic and efficacy ministered orally to patients with recurrent glioblastoma multiforme. J. Clin. Oncol., 2007, 25(18S), 2065.
-
-
-
-
70
-
-
0029008622
-
Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogeneous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site
-
Cushman, M.; He, H.M.; Katzenellenbogen, J.A.; Lin, C.M.; Hamel, E. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogeneous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. J. Med. Chem., 1995, 38, 2041.
-
(1995)
J. Med. Chem
, vol.38
, pp. 2041
-
-
Cushman, M.1
He, H.M.2
Katzenellenbogen, J.A.3
Lin, C.M.4
Hamel, E.5
-
71
-
-
0030767873
-
Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth
-
Cushman, M.; He, H.M.; Katzenellenbogen, J.A.; Varma, R.K.; Hamel, E.; Lin, C.M.; Ram, S.; Sachdeva, Y.P. Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth. J. Med. Chem., 1997, 40, 2323.
-
(1997)
J. Med. Chem
, vol.40
, pp. 2323
-
-
Cushman, M.1
He, H.M.2
Katzenellenbogen, J.A.3
Varma, R.K.4
Hamel, E.5
Lin, C.M.6
Ram, S.7
Sachdeva, Y.P.8
-
72
-
-
0037057582
-
The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization
-
Cushman, M.; Mohanakrishnan, A.K.; Hollingshead, M.; Hamel, E. The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization. J. Med. Chem., 2002, 45, 4748.
-
(2002)
J. Med. Chem
, vol.45
, pp. 4748
-
-
Cushman, M.1
Mohanakrishnan, A.K.2
Hollingshead, M.3
Hamel, E.4
-
73
-
-
37649019000
-
Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs - Part II
-
Rao, P.N.; Cessac, J.W.; Boyd, J.W.; Hanson, A.D.; Shah, J. Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs - Part II. Siteroids, 2008, 73, 158.
-
(2008)
Siteroids
, vol.73
, pp. 158
-
-
Rao, P.N.1
Cessac, J.W.2
Boyd, J.W.3
Hanson, A.D.4
Shah, J.5
-
74
-
-
37649021764
-
Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs - Part III
-
Rao, P.N.; Cessac, J.W.; Boyd, J.W.; Hanson, A.D.; Shah, J. Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs - Part III. Steroids, 2008, 73, 171.
-
(2008)
Steroids
, vol.73
, pp. 171
-
-
Rao, P.N.1
Cessac, J.W.2
Boyd, J.W.3
Hanson, A.D.4
Shah, J.5
-
75
-
-
4744371076
-
Effects of altering the electronics of 2-methoxyestradiol, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization
-
Edsall, A.B.; Mohanakrishnan, A.K.; Yang, D.; Fanwick, P.E.; Hamel, E.; Hanson, A.D.; Agoston, G.E.; Cushman, M. Effects of altering the electronics of 2-methoxyestradiol, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization. J. Med. Chem., 2004, 47, 5126.
-
(2004)
J. Med. Chem
, vol.47
, pp. 5126
-
-
Edsall, A.B.1
Mohanakrishnan, A.K.2
Yang, D.3
Fanwick, P.E.4
Hamel, E.5
Hanson, A.D.6
Agoston, G.E.7
Cushman, M.8
-
76
-
-
35348890352
-
Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol
-
Agoston, G.E.; Shah, J.H.; LaVallee, T.M.; Zhan, X.; Pribluda, V.S.; Treston, A.M. Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol. Bioorg. Med. Chem., 2007, 15, 7524.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 7524
-
-
Agoston, G.E.1
Shah, J.H.2
LaVallee, T.M.3
Zhan, X.4
Pribluda, V.S.5
Treston, A.M.6
-
77
-
-
37349119362
-
Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate
-
Edsall, A.B.; Agoston, G.E.; Treston, A.M.; Plum, S.M.; McClanahan, R.H.; Lu, T.S.; Song, W.; Cushman, M. Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate. J. Med. Chem., 2007, 50, 6700.
-
(2007)
J. Med. Chem
, vol.50
, pp. 6700
-
-
Edsall, A.B.1
Agoston, G.E.2
Treston, A.M.3
Plum, S.M.4
McClanahan, R.H.5
Lu, T.S.6
Song, W.7
Cushman, M.8
-
78
-
-
1642319678
-
Pharmacokinetics and efficacy of 2-methoxyestradiol and 2-methoxyestradiol-bis-sulphamate in vivo in rodents
-
Ireson, C.R.; Chander, S.K.; Purohit, A.; Perera, S.; Newman, S.P.; Parish, D.; Leese, M.P.; Smith, A.C.; Potter, B.V.L.; Reed, M.J. Pharmacokinetics and efficacy of 2-methoxyestradiol and 2-methoxyestradiol-bis-sulphamate in vivo in rodents. Br. J. Cancer, 2004, 90, 932.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 932
-
-
Ireson, C.R.1
Chander, S.K.2
Purohit, A.3
Perera, S.4
Newman, S.P.5
Parish, D.6
Leese, M.P.7
Smith, A.C.8
Potter, B.V.L.9
Reed, M.J.10
-
79
-
-
34247604099
-
In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyestradiol
-
Chander, S.K.; Foster, P.A.; Leese, M.P.; Newman, S.P.; Potter, B.V.L.; Purohit, A.; Reed, M.J. In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyestradiol. Br. J. Cancer, 2007, 96, 1368.
-
(2007)
Br. J. Cancer
, vol.96
, pp. 1368
-
-
Chander, S.K.1
Foster, P.A.2
Leese, M.P.3
Newman, S.P.4
Potter, B.V.L.5
Purohit, A.6
Reed, M.J.7
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