Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth

Journal of Medicinal Chemistry

Volumn 40, Issue 15, 1997, Pages 2323-2334

  Cushman, Mark ^a   He, Hu Ming ^a   Katzenellenbogen, John A ^b   Varma, Ravi K ^c   Hamel, Ernest ^d   Lin, Chii M ^d   Ram, Siya ^e   Sachdeva, Yesh P ^e  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e Pharm Eco Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2',2',2' TRIFLUOROETHOXY) 6 OXIMINOESTRADIOL; 2 ETHOXY 6 METHOXIMINOESTRADIOL; 2 ETHOXY 6 OXIMINOESTRADIOL; 2 ETHOXYESTRADIOL; 2 METHOXYESTRADIOL; COLCHICINE; ESTRADIOL DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; NEOVASCULARIZATION (PATHOLOGY); SOLID TUMOR;

ANIMALS; BIOPOLYMERS; BRAIN; CATTLE; CELL DIVISION; ESTRADIOL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; RATS; RECEPTORS, ESTROGEN; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS; TUMOR CELLS, CULTURED;

EID: 0030767873     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9700833     Document Type: Article

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