Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma

Pancreas

Volumn 26, Issue 2, 2003, Pages 166-172

  Ryschich, E ^a   Werner, J ^a   Gebhard, M M ^a   Klar, E ^a   Schmidt, Jan ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

2 Methoxyestradiol; Angiogenesis inhibition; Experimental; Paclitaxel; Pancreatic carcinoma; TNP 470

Indexed keywords

2 METHOXYESTRADIOL; ANGIOGENESIS INHIBITOR; FUMAGILLOL CHLOROACETYLCARBAMATE; PACLITAXEL; SODIUM CHLORIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; HISTOPATHOLOGY; MALE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; TUMOR VOLUME;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; CYCLOHEXANES; ESTRADIOL; MALE; NEOPLASM TRANSPLANTATION; PACLITAXEL; PANCREATIC NEOPLASMS; RATS; RATS, INBRED LEW; SESQUITERPENES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0037374464     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200303000-00013     Document Type: Article

References (35)

1. Harris J. Bruckner H. Adjuvant and neoadjuvant therapies of pancreatic cancer: a review. Int J Pancreatol 2001;29:1-7.
2. Cooperman AM, Kini S, Snady H, et al. Current surgical therapy for carcinoma of the pancreas. J Clin Gastroenterol 2000;31:107-13.
3. Kerbel RS. Tumor angiogenesis: past, present and the near future. Carcinogenesis 2000;21:505-15.
4. Arbiser JL, Panigrathy D, Klauber N, et al. The antiangiogenic agents TNP-470 and 2-methoxyestradiol inhibit the growth of angiosarcoma in mice. J Am Acad Dermatol 1999;40:925-9.
5. Yue TL, Wang X, Louden CS, et al. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. Mol Pharmacol 1997;51:951-62.
6. Klauber N, Parangi S, Flynn E, et al. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and Taxol. Cancer Res 1997;57:81-6.
7. Thompson WD, Li WW, Maragoudakis M. The clinical manipulation of angiogenesis: pathology, side effects, surprises, and opportunities with novel human therapies. J Pathol 1999;187:503-10.
8. O'Reilly MS, Brem H, Folkman J. Treatment of murine hemangioendotheliomas with the angiogenesis inhibitor AGM-1470. J Pediatr Surg 1995;30:325-9.
9. Castronovo V, Belotti D. TNP-470 (AGM-1470): mechanisms of action and early clinical development. Eur J Cancer 1996;32A:2520-7.
10. Ahmed MH, Arai T, Konno H, et al. Regression of metastatic liver tumors in rats treated with angiogenesis inhibitor TNP-470: occurrence of apoptosis and necrosis. Jpn J Cancer Res 1997;88:977-81.
11. Fujioka T, Hasegawa M, Ogiu K, et al. Antitumor effects of angiogenesis inhibitor 0-(chloroacetyl-carbamoyl) fumagillol (TNP-470) against murine renal cell carcinoma. J Urol 1996;155:1775-8.
12. Parangi S, O'Reilly M, Christofori G, et al. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci U S A 1996;93:2002-7.
13. Konno H, Tanaka T, Kanai T, et al. Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential. Cancer 1996;77:1736-40.
14. Shusterman S, Grupp S, Barr R, et al. The angiogenesis inhibitor tnp-470 effectively inhibits human neuroblastoma xenograft growth, especially in the setting of subclinical disease. Clin Cancer Res 2001;7:977-84.
15. Kawarada Y, Ishikura H, Kishimoto T, et al. Inhibitory effects of the antiangiogenic agent TNP-470 on establishment and growth of hematogenous metastasis of human pancreatic carcinoma in SCID beige mice in vivo. Pancreas 1997;15:251-7.
16. Kato H, Ishikura H, Kawarada Y, et al. Anti-angiogenic treatment of peritoneal dissemination of pancreas adenocarcinoma: a study using TNP-470. Jpn J Cancer Res 2001;92:67-73.
17. Hotz HG, Reber HA, Hotz B, et al. Angiogenesis inhibitor TNP-470 reduces human pancreatic cancer growth. J Gastrointest Surg 2001;5:131-8.
18. Bhargava P, Marshall J, Rizvi N, et al. A Phase I and pharmacokinetic study of TNP-470 administered weekly to patients with advanced cancer. Clin Cancer Res 1999;5:1989-95.
19. Logothetis CJ, Wu KK, Finn LD, et al. Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer. Clin Cancer Res 2001;7:1198-203.
20. Stadler WM, Kuzel T, Shapiro C, et al. Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma. J Clin Oncol 1999;17:2541-5.
21. Attalla H, Makela TP, Adlercreutz H, et al. 2-Methoxyestradiol arrests cells in mitosis without depolymerizing tubulin. Biochem Biophys Res Commun 1996;228:467-73.
22. Banerjeei SK, Zoubine MN, Sarkar DK, et al. 2-Methoxyestradiol blocks estrogen-induced rat pituitary tumor growth and tumor angiogenesis: possible role of vascular endothelial growth factor. Anticancer Res 2000;20:2641-5.
23. Fotsis T, Zhang Y, Pepper MS, et al. The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth. Nature 1994;368:237-9.
24. Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by Taxol. Nature 1979;277:665-7.
25. Belotti D, Vergani V, Drudis T, et al. The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res 1996;2:1843-9.
26. Lau DH, Xue L, Young LJ, et al. Paclitaxel (Taxol): an inhibitor of angiogenesis in a highly vascularized transgenic breast cancer. Cancer Biother Radiopharm 1999;14:31-6.
27. Pettengill OS, Faris RA, Bell RHJ, et al. Derivation of ductlike cell lines from a transplantable acinar cell carcinoma of the rat pancreas. Am J Pathol 1993;143:292-303.
28. Schmidt J, Ryschich E, Daniel V, et al. Vascular structure and microcirculation of experimental pancreatic carcinoma in the rat. Eur J Surg 2000;166:328-35.
29. Klyscz T, Junger M, Jung F, et al. Cap image - a new kind of computer-assisted video image analysis system for dynamic capillary microscopy. Biomed Tech (Berl) 1997;42:168-75.
30. Folkman J. Angiogenesis: initiation and control. Ann N Y Acad Sci 1982;401:212-27.
31. Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1995;1:149-53.
32. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenesis switch during tumorigenesis. Cell 1996;86:353-64.
33. Fukumura D, Yuan F, Monsky WL, et al. Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. Am J Pathol 1997;151:679-88.
34. Ochsenbein AF, Sierro S, Odermatt B, et al. Roles of tumor localization, second signals and cross priming in cytotoxic T-cell induction. Nature 2001;411:1058-64.
35. Ganss R, Hanahan D. Tumor microenvironment can restrict the effectiveness of activated anti-tumor lymphocytes. Cancer Res 1998;58:4673-81.