Preventing Bacterial Resistance in Surgical Patients

Surgical Clinics of North America

Volumn 89, Issue 2, 2009, Pages 501-519

  Evans, Heather L ^a   Sawyer, Robert G ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Antibiotic cycling; Bacterial resistance; Health care associated infections; Infection control; Multidrug resistant organisms

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CEFEPIME; CEFOTETAN; CEPHALOSPORIN; CEPHALOSPORIN DERIVATIVE; CILASTATIN PLUS IMIPENEM; DAPTOMYCIN; ERTAPENEM; GENTAMICIN; LINEZOLID; PENICILLIN DERIVATIVE; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TIGECYCLINE; VANCOMYCIN;

ABDOMINAL INFECTION; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; DRUG CHOICE; HEALTH PROGRAM; HEALTH SERVICE; HOSPITAL; HUMAN; HYGIENE; INFECTION CONTROL; INFECTION PREVENTION; INFECTION RISK; MEDICAL PRACTICE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MIXED INFECTION; MORTALITY; MULTIDRUG RESISTANCE; OUTPATIENT; PERITONITIS; PREOPERATIVE TREATMENT; PREVALENCE; PRIORITY JOURNAL; REVIEW; SKIN INFECTION; SURGICAL INFECTION; SURGICAL PATIENT;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; HUMANS; INFECTION CONTROL; RISK FACTORS; SURGICAL WOUND INFECTION;

EID: 61549104502     PISSN: 00396109     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.suc.2008.09.011     Document Type: Review

References (132)

1. Moet G.J., Jones R.N., Biedenbach D.J., et al. Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004). Diagn Microbiol Infect Dis 57 (2007) 7-13
2. National Nosocomial Infections Surveillance System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 32 (2004) 470-485
3. Awad S.S., Elhabash S.I., Lee L., et al. Increasing incidence of methicillin-resistant Staphylococcus aureus skin and soft-tissue infections: reconsideration of empiric antimicrobial therapy. Am J Surg 194 (2007) 606-610
4. Lee T.C., Carrick M.M., Scott B.G., et al. Incidence and clinical characteristics of methicillin-resistant Staphylococcus aureus necrotizing fasciitis in a large urban hospital. Am J Surg 194 (2007) 809-812
5. Miller L.G., Perdreau-Remington F., Rieg G., et al. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med 352 (2005) 1445-1453
6. Young D.M., Harris H.W., Charlebois E.D., et al. An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients. Arch Surg 139 (2004) 947-951
7. Daum R.S. Clinical practice: skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med 357 (2007) 380-390
8. Moran G.J., Krishnadasan A., Gorwitz R.J., et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 355 (2006) 666-674
9. Stevens D.L., Bisno A.L., Chambers H.F., et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 41 (2005) 1373-1406
10. Wang J.T., Chang S.C., Ko W.J., et al. A hospital-acquired outbreak of methicillin-resistant Staphylococcus aureus infection initiated by a surgeon carrier. J Hosp Infect 47 (2001) 104-109
11. Solomkin J.S., Bjornson H.S., Cainzos M., et al. A consensus statement on empiric therapy for suspected gram-positive infections in surgical patients. Am J Surg 187 (2004) 134-135
12. Jones M.E., Karlowsky J.A., Draghi D.C., et al. Epidemiology and antibiotic susceptibility of bacteria causing skin and soft tissue infections in the USA and Europe: a guide to appropriate antimicrobial therapy. Int J Antimicrob Agents 22 (2003) 406-419
13. Farthmann E.H., and Schoffel U. Epidemiology and pathophysiology of intraabdominal infections (IAI). Infection 26 (1998) 329-334
14. Evans H.L., Raymond D.P., Pelletier S.J., et al. Diagnosis of intra-abdominal infection in the critically ill patient. Curr Opin Crit Care 7 (2001) 117-121
15. Solomkin J.S., Mazuski J.E., Baron E.J., et al. Guidelines for the selection of anti-infective agents for complicated intra-abdominal infections. Clin Infect Dis 37 (2003) 997-1005
16. Malangoni M.A. Evaluation and management of tertiary peritonitis. Am Surg 66 (2000) 157-161
17. Evans H.L., Raymond D.P., Pelletier S.J., et al. Tertiary peritonitis (recurrent diffuse or localized disease) is not an independent predictor of mortality in surgical patients with intraabdominal infection. Surg Infect (Larchmt) 2 (2001) 255-263
18. Pelletier S.J., Raymond D.P., Crabtree T.D., et al. Outcome analysis of intraabdominal infection with resistant Gram-positive organisms. Surg Infect (Larchmt) 3 (2002) 11-19
19. Roehrborn A., Thomas L., Potreck O., et al. The microbiology of postoperative peritonitis. Clin Infect Dis 33 (2001) 1513-1519
20. Bare M., Castells X., Garcia A., et al. Importance of appropriateness of empiric antibiotic therapy on clinical outcomes in intra-abdominal infections. Int J Technol Assess Health Care 22 (2006) 242-248
21. Krobot K., Yin D., Zhang Q., et al. Effect of inappropriate initial empiric antibiotic therapy on outcome of patients with community-acquired intra-abdominal infections requiring surgery. Eur J Clin Microbiol Infect Dis 23 (2004) 682-687
22. Mazuski J.E., Sawyer R.G., Nathens A.B., et al. The Surgical Infection Society guidelines on antimicrobial therapy for intra-abdominal infections: an executive summary. Surg Infect (Larchmt) 3 (2002) 161-173
23. Sturkenboom M.C., Goettsch W.G., Picelli G., et al. Inappropriate initial treatment of secondary intra-abdominal infections leads to increased risk of clinical failure and costs. Br J Clin Pharmacol 60 (2005) 438-443
24. Tellado J.M., Sen S.S., Caloto M.T., et al. Consequences of inappropriate initial empiric parenteral antibiotic therapy among patients with community-acquired intra-abdominal infections in Spain. Scand J Infect Dis 39 (2007) 947-955
25. Kumar A., Roberts D., Wood K.E., et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34 (2006) 1589-1596
26. Vazquez-Aragon P., Lizan-Garcia M., Cascales-Sanchez P., et al. Nosocomial infection and related risk factors in a general surgery service: a prospective study. J Infect 46 (2003) 17-22
27. Klevens R.M., Edwards J.R., Richards Jr. C.L., et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 122 (2007) 160-166
28. Giacometti A., Cirioni O., Schimizzi A.M., et al. Epidemiology and microbiology of surgical wound infections. J Clin Microbiol 38 (2000) 918-922
29. Harbarth S., Samore M.H., Lichtenberg D., et al. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation 101 (2000) 2916-2921
30. Kachroo S., Dao T., Zabaneh F., et al. Tolerance of vancomycin for surgical prophylaxis in patients undergoing cardiac surgery and incidence of vancomycin-resistant enterococcus colonization. Ann Pharmacother 40 (2006) 381-385
31. Nelson C.L., Green T.G., Porter R.A., et al. One day versus seven days of preventive antibiotic therapy in orthopedic surgery. Clin Orthop Relat Res 176 (1983) 258-263
32. Terpstra S., Noordhoek G.T., Voesten H.G., et al. Rapid emergence of resistant coagulase-negative staphylococci on the skin after antibiotic prophylaxis. J Hosp Infect 43 (1999) 195-202
33. Bratzler D.W., and Houck P.M. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis 38 (2004) 1706-1715
34. Bratzler D.W., Houck P.M., Richards C., et al. Use of antimicrobial prophylaxis for major surgery: baseline results from the National Surgical Infection Prevention Project. Arch Surg 140 (2005) 174-182
35. Nasim A., Thompson M.M., Naylor A.R., et al. The impact of MRSA on vascular surgery. Eur J Vasc Endovasc Surg 22 (2001) 211-214
36. Taylor M.D., and Napolitano L.M. Methicillin-resistant Staphylococcus aureus infections in vascular surgery: increasing prevalence. Surg Infect (Larchmt) 5 (2004) 180-187
37. Muto C.A., Jernigan J.A., Ostrowsky B.E., et al. SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus. Infect Control Hosp Epidemiol 24 (2003) 362-386
38. Kluytmans J.A., Mouton J.W., VandenBergh M.F., et al. Reduction of surgical-site infections in cardiothoracic surgery by elimination of nasal carriage of Staphylococcus aureus. Infect Control Hosp Epidemiol 17 (1996) 780-785
39. Mekontso-Dessap A., Kirsch M., Brun-Buisson C., et al. Poststernotomy mediastinitis due to Staphylococcus aureus: comparison of methicillin-resistant and methicillin-susceptible cases. Clin Infect Dis 32 (2001) 877-883
40. Perl T.M., Cullen J.J., Wenzel R.P., et al. Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med 346 (2002) 1871-1877
41. Itani K.M., Wilson S.E., Awad S.S., et al. Ertapenem versus cefotetan prophylaxis in elective colorectal surgery. N Engl J Med 355 (2006) 2640-2651
42. Siegel J.D., Rhinehart E., Jackson M., et al. Management of multidrug-resistant organisms in health care settings, 2006. Am J Infect Control 35 (2007) S165-S193
43. Evans H.L., Lefrak S.N., Lyman J., et al. Cost of gram-negative resistance. Crit Care Med 35 (2007) 89-95
44. Raymond D.P., Pelletier S.J., Crabtree T.D., et al. Impact of antibiotic-resistant gram-negative bacilli infections on outcome in hospitalized patients. Crit Care Med 31 (2003) 1035-1041
45. Gleason T.G., Crabtree T.D., Pelletier S.J., et al. Prediction of poorer prognosis by infection with antibiotic-resistant gram-positive cocci than by infection with antibiotic-sensitive strains. Arch Surg 134 (1999) 1033-1040
46. Song X., Srinivasan A., Plaut D., et al. Effect of nosocomial vancomycin-resistant enterococcal bacteremia on mortality, length of stay, and costs. Infect Control Hosp Epidemiol 24 (2003) 251-256
47. Cosgrove S.E., Sakoulas G., Perencevich E.N., et al. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 36 (2003) 53-59
48. Whitby M., McLaws M.L., and Berry G. Risk of death from methicillin-resistant Staphylococcus aureus bacteraemia: a meta-analysis. Med J Aust 175 (2001) 264-267
49. Engemann J.J., Carmeli Y., Cosgrove S.E., et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis 36 (2003) 592-598
50. Stephenson J. CDC campaign targets antimicrobial resistance in hospitals. JAMA 287 (2002) 2351-2352
51. Centers for Disease Control and Prevention. 12 steps to prevent antimicrobial resistance among hospitalized patients: campaign to prevent antimicrobial resistance. Available at: (2002). http://www.cdc.gov/drugresistance/healthcare/default.htm Accessed August 28, 2008
52. Brinsley K., Srinivasan A., Sinkowitz-Cochran R., et al. Implementation of the Campaign to prevent antimicrobial resistance in healthcare settings: 12 steps to prevent antimicrobial resistance among hospitalized adults-experiences from 3 institutions. Am J Infect Control 33 (2005) 53-54
53. Cosgrove S.E., Patel A., Song X., et al. Impact of different methods of feedback to clinicians after postprescription antimicrobial review based on the Centers For Disease Control and Prevention's 12 steps to prevent antimicrobial resistance among hospitalized adults. Infect Control Hosp Epidemiol 28 (2007) 641-646
54. Raymond D.P., Kuehnert M.J., and Sawyer R.G. Preventing antimicrobial-resistant bacterial infections in surgical patients. Surg Infect (Larchmt) 3 (2002) 375-385
55. Boyce J.M., and Pittet D. Guideline for hand hygiene in health-care settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Infect Control Hosp Epidemiol 23 (2002) S3-40
56. O'Grady N.P., Alexander M., Dellinger E.P., et al. Guidelines for the prevention of intravascular catheter-related infections. Infect Control Hosp Epidemiol 23 (2002) 759-769
57. Pittet D., Hugonnet S., Harbarth S., et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet 356 (2000) 1307-1312
58. Webster J., Faoagali J.L., and Cartwright D. Elimination of methicillin-resistant Staphylococcus aureus from a neonatal intensive care unit after hand washing with triclosan. J Paediatr Child Health 30 (1994) 59-64
59. Zafar A.B., Butler R.C., Reese D.J., et al. Use of 0.3% triclosan (Bacti-Stat) to eradicate an outbreak of methicillin-resistant Staphylococcus aureus in a neonatal nursery. Am J Infect Control 23 (1995) 200-208
60. Larson E.L., Early E., Cloonan P., et al. An organizational climate intervention associated with increased handwashing and decreased nosocomial infections. Behav Med 26 (2000) 14-22
61. Sax H., Allegranzi B., Uckay I., et al. My five moments for hand hygiene: a user-centred design approach to understand, train, monitor and report hand hygiene. J Hosp Infect 67 (2007) 9-21
62. Weber S.G., Huang S.S., Oriola S., et al. Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci: position statement from the Joint SHEA and APIC Task Force. Am J Infect Control 35 (2007) 73-85
63. Harbarth S., Fankhauser C., Schrenzel J., et al. Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 299 (2008) 1149-1157
64. McGinigle K.L., Gourlay M.L., and Buchanan I.B. The use of active surveillance cultures in adult intensive care units to reduce methicillin-resistant Staphylococcus aureus-related morbidity, mortality, and costs: a systematic review. Clin Infect Dis 46 (2008) 1717-1725
65. Miller M.A., Dascal A., Portnoy J., et al. Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment. Infect Control Hosp Epidemiol 17 (1996) 811-813
66. Walker E.S., Vasquez J.E., Dula R., et al. Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective?. Infect Control Hosp Epidemiol 24 (2003) 342-346
67. Bleasdale S.C., Trick W.E., Gonzalez I.M., et al. Effectiveness of chlorhexidine bathing to reduce catheter-associated bloodstream infections in medical intensive care unit patients. Arch Intern Med 167 (2007) 2073-2079
68. Borer A., Gilad J., Porat N., et al. Impact of 4% chlorhexidine whole-body washing on multidrug-resistant Acinetobacter baumannii skin colonisation among patients in a medical intensive care unit. J Hosp Infect 67 (2007) 149-155
69. Evans H.L., Chan J., Dellit T.H., et al. Impact of 2% chlorhexidine whole body washing on nosocomial infections among trauma patients. Surg Infect (Larchmt) 9 (2008) 239-240 [abstract]
70. Vernon M.O., Hayden M.K., Trick W.E., et al. Chlorhexidine gluconate to cleanse patients in a medical intensive care unit: the effectiveness of source control to reduce the bioburden of vancomycin-resistant enterococci. Arch Intern Med 166 (2006) 306-312
71. MacDougall C., and Polk R.E. Antimicrobial stewardship programs in health care systems. Clin Microbiol Rev 18 (2005) 638-656
72. Craig W.A., Uman S.J., Shaw W.R., et al. Hospital use of antimicrobial drugs: survey at 19 hospitals and results of antimicrobial control program. Ann Intern Med 89 (1978) 793-795
73. McGowan Jr. J.E., and Finland M. Usage of antibiotics in a general hospital: effect of requiring justification. J Infect Dis 130 (1974) 165-168
74. Cannon J.P., and Silverman R.M. A pharmacist-driven antimicrobial approval program at a Veterans Affairs hospital. Am J Health Syst Pharm 60 (2003) 1358-1362
75. White Jr. A.C., Atmar R.L., Wilson J., et al. Effects of requiring prior authorization for selected antimicrobials: expenditures, susceptibilities, and clinical outcomes. Clin Infect Dis 25 (1997) 230-239
76. LaRosa L.A., Fishman N.O., Lautenbach E., et al. Evaluation of antimicrobial therapy orders circumventing an antimicrobial stewardship program: investigating the strategy of stealth dosing. Infect Control Hosp Epidemiol 28 (2007) 551-556
77. Linkin D.R., Fishman N.O., Landis J.R., et al. Effect of communication errors during calls to an antimicrobial stewardship program. Infect Control Hosp Epidemiol 28 (2007) 1374-1381
78. Carling P., Fung T., Killion A., et al. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol 24 (2003) 699-706
79. Goldmann D.A., Weinstein R.A., Wenzel R.P., et al. Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals: a challenge to hospital leadership. JAMA 275 (1996) 234-240
80. Larson E.L., Quiros D., Giblin T., et al. Relationship of antimicrobial control policies and hospital and infection control characteristics to antimicrobial resistance rates. Am J Crit Care 16 (2007) 110-120
81. Quale J., Landman D., Saurina G., et al. Manipulation of a hospital antimicrobial formulary to control an outbreak of vancomycin-resistant enterococci. Clin Infect Dis 23 (1996) 1020-1025
82. Lan C.K., Hsueh P.R., Wong W.W., et al. Association of antibiotic utilization measures and reduced incidence of infections with extended-spectrum beta-lactamase-producing organisms. J Microbiol Immunol Infect 36 (2003) 182-186
83. Piroth L., Aube H., Doise J.M., et al. Spread of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae: are beta-lactamase inhibitors of therapeutic value?. Clin Infect Dis 27 (1998) 76-80
84. Rahal J.J., Urban C., Horn D., et al. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA 280 (1998) 1233-1237
85. Rice L.B., Lakticova V., Helfand M.S., et al. In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enterococci. J Infect Dis 190 (2004) 2162-2166
86. May A.K., Melton S.M., McGwin G., et al. Reduction of vancomycin-resistant enterococcal infections by limitation of broad-spectrum cephalosporin use in a trauma and burn intensive care unit. Shock 14 (2000) 259-264
87. O'Connor K.A., Kingston M., O'Donovan M., et al. Antibiotic prescribing policy and Clostridium difficile diarrhoea. QJM 97 (2004) 423-429
88. Wilcox M.H., Freeman J., Fawley W., et al. Long-term surveillance of cefotaxime and piperacillin-tazobactam prescribing and incidence of Clostridium difficile diarrhoea. J Antimicrob Chemother 54 (2004) 168-172
89. Allegranzi B., Luzzati R., Luzzani A., et al. Impact of antibiotic changes in empirical therapy on antimicrobial resistance in intensive care unit-acquired infections. J Hosp Infect 52 (2002) 136-140
90. Burke J.P. Antibiotic resistance-squeezing the balloon?. JAMA 280 (1998) 1270
91. Zillich A.J., Sutherland J.M., Wilson S.J., et al. Antimicrobial use control measures to prevent and control antimicrobial resistance in US hospitals. Infect Control Hosp Epidemiol 27 (2006) 1088-1095
92. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: sixteenth informational supplement M100-S16; 2006.
93. Dellit T.H., Owens R.C., McGowan Jr. J.E., et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 44 (2007) 159-177
94. Sharp S.E. Effective reporting of susceptibility test results. Diagn Microbiol Infect Dis 16 (1993) 251-254
95. Steffee C.H., Morrell R.M., and Wasilauskas B.L. Clinical use of rifampicin during routine reporting of rifampicin susceptibilities: a lesson in selective reporting of antimicrobial susceptibility data. J Antimicrob Chemother 40 (1997) 595-598
96. Langdale P., and Millar M.R. Influence of laboratory sensitivity reporting on antibiotic prescribing preferences of general practitioners in the Leeds area. J Clin Pathol 39 (1986) 233-234
97. Tan T.Y., McNulty C., Charlett A., et al. Laboratory antibiotic susceptibility reporting and antibiotic prescribing in general practice. J Antimicrob Chemother 51 (2003) 379-384
98. Barnes M.P. Influence of laboratory reports on prescribing of antimicrobials for urinary tract infection. J Clin Pathol 33 (1980) 481-483
99. Campo L., and Mylotte J.M. Use of microbiology reports by physicians in prescribing antimicrobial agents. Am J Med Sci 296 (1988) 392-398
100. Cunney R.J., and Smyth E.G. The impact of laboratory reporting practice on antibiotic utilisation. Int J Antimicrob Agents 14 (2000) 13-19
101. Morgan M.S. Perceptions of a medical microbiology service: a survey of laboratory users. J Clin Pathol 48 (1995) 915-918
102. Schentag J.J., Ballow C.H., Fritz A.L., et al. Changes in antimicrobial agent usage resulting from interactions among clinical pharmacy, the infectious disease division, and the microbiology laboratory. Diagn Microbiol Infect Dis 16 (1993) 255-264
103. Calfee D.P., Brooks J., Zirk N.M., et al. A pseudo-outbreak of nosocomial infections associated with the introduction of an antibiotic management programme. J Hosp Infect 55 (2003) 26-32
104. Richards M.J., Robertson M.B., Dartnell J.G., et al. Impact of a web-based antimicrobial approval system on broad-spectrum cephalosporin use at a teaching hospital. Med J Aust 178 (2003) 386-390
105. Shojania K.G., Yokoe D., Platt R., et al. Reducing vancomycin use utilizing a computer guideline: results of a randomized controlled trial. J Am Med Inform Assoc 5 (1998) 554-562
106. Varonen H., Kortteisto T., and Kaila M. What may help or hinder the implementation of computerized decision support systems (CDSSs): a focus group study with physicians. Fam Pract 25 (2008) 162-167
107. Evans R.S., Pestotnik S.L., Classen D.C., et al. A computer-assisted management program for antibiotics and other antiinfective agents. N Engl J Med 338 (1998) 232-238
108. Pestotnik S.L., Classen D.C., Evans R.S., et al. Implementing antibiotic practice guidelines through computer-assisted decision support: clinical and financial outcomes. Ann Intern Med 124 (1996) 884-890
109. Paul M., Andreassen S., Tacconelli E., et al. Improving empirical antibiotic treatment using TREAT, a computerized decision support system: cluster randomized trial. J Antimicrob Chemother 58 (2006) 1238-1245
110. Betts R.F., Valenti W.M., Chapman S.W., et al. Five-year surveillance of aminoglycoside usage in a university hospital. Ann Intern Med 100 (1984) 219-222
111. Gerding D.N., and Larson T.A. Aminoglycoside resistance in gram-negative bacilli during increased amikacin use. Comparison of experience in 14 United States hospitals with experience in the Minneapolis Veterans Administration Medical Center. Am J Med 79 (1985) 1-7
112. Ruiz-Palacios G.M., Ponce de Leon S., Sifuentes J., et al. Control of emergence of multi-resistant gram-negative bacilli by exclusive use of amikacin. Am J Med 80 (1986) 71-75
113. Young E.J., Sewell C.M., Koza M.A., et al. Antibiotic resistance patterns during aminoglycoside restriction. Am J Med Sci 290 (1985) 223-227
114. Gerding D.N., Larson T.A., Hughes R.A., et al. Aminoglycoside resistance and aminoglycoside usage: ten years of experience in one hospital. Antimicrob Agents Chemother 35 (1991) 1284-1290
115. Kollef M.H., Vlasnik J., Sharpless L., et al. Scheduled change of antibiotic classes: a strategy to decrease the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med 156 (1997) 1040-1048
116. Kollef M.H., Ward S., Sherman G., et al. Inadequate treatment of nosocomial infections is associated with certain empiric antibiotic choices. Crit Care Med 28 (2000) 3456-3464
117. Gruson D., Hilbert G., Vargas F., et al. Rotation and restricted use of antibiotics in a medical intensive care unit: impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gram-negative bacteria. Am J Respir Crit Care Med 162 (2000) 837-843
118. Bergstrom C.T., Lo M., and Lipsitch M. Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals. Proc Natl Acad Sci U S A 101 (2004) 13285-13290
119. Bonhoeffer S., Lipsitch M., and Levin B.R. Evaluating treatment protocols to prevent antibiotic resistance. Proc Natl Acad Sci U S A 94 (1997) 12106-12111
120. Lipsitch M., Bergstrom C.T., and Levin B.R. The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions. Proc Natl Acad Sci U S A 97 (2000) 1938-1943
121. Raymond D.P., Pelletier S.J., Crabtree T.D., et al. Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit. Crit Care Med 29 (2001) 1101-1108
122. Hughes M.G., Evans H.L., Chong T.W., et al. Effect of an intensive care unit rotating empiric antibiotic schedule on the development of hospital-acquired infections on the non-intensive care unit ward. Crit Care Med 32 (2004) 53-60
123. Allegranzi B., Gottin L., Bonora S., et al. Antibiotic rotation in intensive care units: its usefulness should be demonstrated without pitfalls. Crit Care Med 30 (2002) 2170-2171
124. Paterson D.L., and Rice L.B. Empirical antibiotic choice for the seriously ill patient: are minimization of selection of resistant organisms and maximization of individual outcome mutually exclusive?. Clin Infect Dis 36 (2003) 1006-1012
125. Evans H.L., Hughes M.G., Chong T.W., et al. Comparison of dual- versus single-antibiotic rotation strategies in an intensive care unit. Surg Infect 3 (2002) 45 [abstract]
126. Evans H.L., Milburn M.L., Hughes M.G., et al. Nature of gram-negative rod antibiotic resistance during antibiotic rotation. Surg Infect 6 (2005) 223-231
127. Martinez J.A., Nicolas J.M., Marco F., et al. Comparison of antimicrobial cycling and mixing strategies in two medical intensive care units. Crit Care Med 34 (2006) 329-336
128. Hedrick T.L., Schulman A.S., McElearney S.T., et al. Outbreak of resistant Pseudomonas aeruginosa infections during a quarterly cycling antibiotic regimen. Surg Infect (Larchmt) 9 (2008) 139-152
129. Warren D.K., Hill H.A., Merz L.R., et al. Cycling empirical antimicrobial agents to prevent emergence of antimicrobial-resistant gram-negative bacteria among intensive care unit patients. Crit Care Med 32 (2004) 2450-2456
130. Barie P.S., Hydo L.J., Shou J., et al. Influence of antibiotic therapy on mortality of critical surgical illness caused or complicated by infection. Surg Infect (Larchmt) 6 (2005) 41-54
131. Bennett K.M., Scarborough J.E., Sharpe M., et al. Implementation of antibiotic 0rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit. J Trauma 63 (2007) 307-311
132. Smith R.L., Evans H.L., Chong T.W., et al. Reduction in rates of methicillin-resistant Staphylococcus aureus infection after introduction of quarterly linezolid-vancomycin cycling in a surgical intensive care unit. Surg Infect (Larchmt) 9 (2008) 423-431