Use of antimicrobial prophylaxis for major surgery: Baseline results from the National Surgical Infection Prevention Project

Archives of Surgery

Volumn 140, Issue 2, 2005, Pages 174-182

  Bratzler, Dale W ^a   Houck, Peter M ^b   Richards, Chesley ^c   Steele, Lynn ^d   Dellinger, E Patchen ^e   Fry, Donald E ^f   Wright, Claudia ^a   Ma, Allen ^a   Carr, Karina ^a   Red, Lisa ^a  

^a OK Found for Medical Quality   (United States)

^b Centers for Medicare and Medicaid Services   (United States)

^c NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

ABDOMINAL HYSTERECTOMY; ANEURYSM SURGERY; ANTIBIOTIC PROPHYLAXIS; ANTIMICROBIAL THERAPY; COLORECTAL SURGERY; CORONARY ARTERY BYPASS GRAFT; DRUG EFFICACY; DRUG USE; ENDARTERECTOMY; HIP ARTHROPLASTY; HOSPITAL PATIENT; HUMAN; INCISION; KNEE ARTHROPLASTY; MAJOR CLINICAL STUDY; MAJOR SURGERY; MEDICARE; OPEN HEART SURGERY; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; REVIEW; VAGINAL HYSTERECTOMY; VASCULAR SURGERY; VEIN BYPASS;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; ARTHROPLASTY, REPLACEMENT; CARDIAC SURGICAL PROCEDURES; DRUG THERAPY, COMBINATION; FEMALE; HEALTH CARE SURVEYS; HUMANS; MALE; MEDICARE; SURGICAL WOUND INFECTION; TIME FACTORS; UNITED STATES; VASCULAR SURGICAL PROCEDURES;

EID: 13644249838     PISSN: 00040010     EISSN: None     Source Type: Journal    
DOI: 10.1001/archsurg.140.2.174     Document Type: Review

References (78)

1. Delgado-Rodriguez M, Sillero-Arenas M, Medina-Cuadros M, Martinez-Gallego G. Nosocomial infections in surgical patients: comparison of two measures of intrinsic patient risk. Infect Control Hosp Epidemiol. 1997;18:19-23.
2. Horan TC, Culver DH, Gaynes RP, Jarvis WR, Edwards JR, Reid CR. Nosocomial infections in surgical patients in the United States, January 1986-June 1992: National Nosocomial Infections Surveillance (NNIS) System. Infect Control Hosp Epidemiol. 1993;14:73-80.
3. Wallace WC, Cinat M, Gornick WB, Lekawa ME, Wilson SE. Nosocomial infections in the surgical intensive care unit: a difference between trauma and surgical patients. Am Surg. 1999;65:987-990.
4. National Nosocomial Infections Surveillance (NNIS). Data summary from October 1986-April 1996, issued May 1996: a report from the National Nosocomial Infections Surveillance (NNIS) System. Am J Infect Control. 1996;24:380-388.
5. Auerbach AD. Prevention of surgical site infections. In: Shojania KG, Duncan BW, McDonald KM, et al, eds. Making Health Care Safer: A Critical Analysis of Patient Safety Practices. Rockville, Md: Agency for Healthcare Research and Quality; July 2001:221-244. Evidence Report/Technology Assessment 43. AHRQ publication 01-E058. Available at: http://www.ahrq.gov/clinic/ptsafety/ pdf/ptsafety.pdf. Accessed April 20, 2004.
6. Kirkland KB, Briggs JP, Trivette SL, Wilkinson WE, Sexton DJ. The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol. 1999;20:725-730.
7. Astagneau P, Rioux C, Golliot F, Brucker G. Morbidity and mortality associated with surgical site infections: results from the 1997-1999 INCISO surveillance. J Hosp Infect. 2001;48:267-274.
8. Engemann JJ, Carmeli Y, Cosgrove SE, et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infections. Clin Infect Dis. 2003;36:592-598.
9. Martone WJ, Jarvis WR, Culver DH, Haley RW. Incidence and nature of endemic and epidemic nosocomial infections. In: Bennett JV, Brachman PS, eds. Hospital Infections. 3rd ed. Boston, Mass: Little Brown & Co Inc; 1992:577-596.
10. Perencevich EN, Sands KE, Cosgrove SE, Guadagnoli E, Meara E, Platt R. Health and economic impact of surgical site infections diagnosed after hospital discharge. Emerg Infect Dis. 2003;9:196-203.
11. Jenney AW, Harrington GA, Russo PL, Spelman DW. Cost of surgical site infections following coronary artery bypass surgery. Aust N Z J Surg. 2001;71:662-664.
12. Whitehouse JD, Friedman ND, Kirkland KB, Richardson WJ, Sexton DJ. The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost. Infect Control Hosp Epidemiol. 2002;23:183-189.
13. Fry DE. The economic costs of surgical site infection. Surg Infect (Larchmt). 2002;3(suppl 1):S37-S43.
14. Hollenbeak CS, Murphy D, Dunagan WC, Fraser VJ. Nonrandom selection and the attributable cost of surgical-site infections. Infect Control Hosp Epidemiol. 2002;23:177-182.
15. Miles AA, Miles EM, Burke J. The value and duration of defense reactions of the skin to the primary lodgement of bacteria. Br J Exp Pathol. 1957;38:79-96.
16. Burke JF. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery. 1961;50:161-168.
17. Polk HC Jr, Lopez-Mayor JF. Postoperative wound infection: a prospective study of determinant factors and prevention. Surgery. 1969;66:97-103.
18. Stone HH, Hooper CA, Kolb LD, Geheber CE, Dawkins EJ. Antibiotic prophylaxis in gastric, biliary and colonic surgery. Ann Surg. 1976;184:443-452.
19. Polk HC Jr, Trachtenberg L, Finn MP. Antibiotic activity in surgical incisions: the basis for prophylaxis in selected operations. JAMA. 1980;244:1353-1354.
20. DiPiro JT, Vallner JJ, Bowden TA, Clark BA, Sisley JF. Intraoperative serum and tissue activity of cefazolin and cefoxitin. Arch Surg. 1985;120:829-832.
21. Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med. 1992;326:281-286.
22. Page CP, Bohnen JM, Fletcher JR, McManus AT, Solumkin JS, Wittman DH. Antimicrobial prophylaxis for surgical wounds: guidelines for clinical care. Arch Surg. 1993;128:79-88.
23. Dellinger EP, Gross PA, Barrett TL, et al. Quality standard for antimicrobial prophylaxis in surgical procedures: Infectious Diseases Society of America. Clin Infect Dis. 1994;18:422-427.
24. American Society of Health-System Pharmacists. ASHP therapeutic guidelines on antimicrobial prophylaxis in surgery. Am J Health Syst Pharm. 1999;56:1839-1888.
25. Mangram AJ, Horan TC, Pearson ML, et al. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol. 1999;20:250-278.
26. Antimicrobial prophylaxis in surgery [published correction appears in Med Lett Drugs Ther. 2001;43:108]. Med Lett Drugs Ther. 2001;43:92-97.
27. ACOG Committee on Practice Bulletins. Antibiotic Prophylaxis for Gynecologic Procedures. Washington, DC: American College of Obstetricians and Gynecologists; January 2001. ACOG Practice Bulletin 23.
28. Gilbert DN, Moellering RC, Sande MA. The Sanford Guide to Antimicrobial Therapy, 2003. 33rd ed. Hyde Park, Vt: Antimicrobial Therapy Inc; 2003:123-124.
29. Polk HC Jr, Wilson MA. Systemic antibiotic prophylaxis in surgery. In: Fry DE, ed. Surgical Infections. Boston, Mass: Little Brown & Co Inc; 1995:127-133.
30. Silver A, Eichorn A, Kral J, et al. Timeliness and use of antibiotic prophylaxis in selected inpatient surgical procedures. Am J Surg. 1996;171:548-552.
31. Matuschka PR, Cheadle WG, Burke JD, Garrison RN. A new standard of care: administration of preoperative antibiotics in the operating room. Am Surg. 1997;63:500-503.
32. Gorecki P, Schein M, Rucinski JC, Wise L. Antibiotic administration in patients undergoing common surgical procedures in acommunity teaching hospital: the chaos continues. World J Surg. 1999;23:429-433.
33. Trick WE, Scheckler WE, Tokars JI, et al. Modifiable risk factors associated with deep sternal site infection after coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2000;119:108-114.
34. Burke JP. Maximizing appropriate antibiotic prophylaxis for surgical patients: an update from LDS Hospital, Salt Lake City. Clin Infect Dis. 2001;33(suppl 2):S78-S83.
35. Richards C, Emori TG, Peavy G, Gaynes RP. Promoting quality through measurement of performance and response: prevention success stories. Emerg Infect Dis. 2001;7:299-301.
36. Gaynes R, Richards C, Edwards J, et al. Feeding back surveillance data to prevent hospital-acquired infections. Emerg Infect Dis. 2001;7:295-298.
37. Gaynes RP, Culver DH, Horan TC, et al. Surgical site infection (SSI) rates in the United States, 1992-1998: the National Nosocomial Infections Surveillance System basic SSI risk index. Clin Infect Dis. 2001;33(suppl 2):S69-S77.
38. National Nosocomial Infections Surveillance System. National Nosocomial Infections Surveillance (NNIS) System Report: data summary from January 1992 to June 2002, issued August 2002. Am J Infect Control. 2002;30:458-475.
39. Jencks SF, Wilensky GR. The Health Care Quality Improvement Initiative: a new approach to quality assurance in Medicare. JAMA. 1992;268:900-904.
40. Jencks SF, Cuerdon T, Burwen DR, et al. Quality of medical care delivered to Medicare beneficiaries: a profile at state and national levels. JAMA. 2000;284:1670-1676.
41. Jencks SF, Huff ED, Cuerdon T. Change in the quality of care delivered to Medicare beneficiaries 1998-1999 to 2000-2001. JAMA. 2003;289:305-312.
42. Surgical Infection Prevention Project description. Available at: http://www.medqic.org/sip. Accessed April 20, 2004.
43. US Public Health Service. International Classification of Diseases, Ninth Revision: Clinical Modification. 4th ed. Washington, DC: US Dept of Health and Human Services; 1991. Report PHS91-1260.
44. Bernard HR, Cole WR. The prophylaxis of surgical infection: the effect of prophylactic antimicrobial drugs on the incidence of infection following potentially contaminated operations. Surgery. 1964;56:151-157.
45. Meijer WS, Schmitz PI, Jeekel J. Meta-analysis of randomized, controlled clinical trials of antibiotic prophylaxis in biliary tract surgery. Br J Surg. 1990;77:283-290.
46. Kreter B, Woods M. Antibiotic prophylaxis for cardiothoracic operations: metaanalysis of thirty years of clinical trials. J Thorac Cardiovasc Surg. 1992;104:590-599.
47. McDonald M, Grabsch E, Marshall C, Forbes A. Single- versus multiple-dose antimicrobial prophylaxis for major surgery: a systematic review. Aust N Z J Surg. 1998;68:388-396.
48. Pollard JP, Hughes SO, Scott JE, Evans MJ, Benson MK. Antibiotic prophylaxis in total hip replacement. BMJ. 1979;1:707-709.
49. Williams DN, Gustilo RB, Beverly R, Kind AC. Bone and serum concentrations of five cephalosporin drugs: relevance to prophylaxis and treatment in orthopedic surgery. Clin Drthop. 1983;179:253-265.
50. Nelson CL, Green TG, Porter RA, Warren RD. One day versus seven days of preventive antibiotic therapy in orthopedic surgery. Clin Orthop. 1983;176:258-263.
51. Heydemann JS, Nelson CL. Short-term preventive antibiotics. Clin Orthop. 1986;205:184-187.
52. Oishi CS, Carrion WV, Hoaglund FT. Use of parenteral prophylactic antibiotics in clean orthopaedic surgery: a review of the literature. Clin Orthop. 1993;296:249-255.
53. Mauerhan DR, Nelson CL, Smith DL, et al. Prophylaxis against infection in total joint arthroplasty: one day of cefuroxime compared with three days of cefazolin. J Bone Joint Surg Am. 1994;76:39-45.
54. Conte JE Jr, Cohen SN, Roe BB, Elashoff RM. Antibiotic prophylaxis and cardiac surgery: a prospective double-blind comparison of single-dose versus multiple-dose regimens. Ann Intern Med. 1972;76:943-949.
55. Goldmann DA, Hopkins CC, Karchmer AW, et al. Cephalothin prophylaxis in cardiac valve surgery: a prospective, double-blind comparison of two-day and six-day regimens. J Thorac Cardiovasc Surg. 1977;73:470-479.
56. Hillis DJ, Rosenfelt FL, Spicer WJ, Stirling GR. Antibiotic prophylaxis for coronary bypass grafting: comparison of a five-day and a two-day course. J Thorac Cardiovasc Surg. 1983;86:217-221.
57. Geroulanos S, Donfried B, Schumacher F, Turina M. Cefuroxime versus ceftriaxone prophylaxis in cardiovascular surgery. Drugs Exp Clin Res. 1985;11:201-205.
58. Nooyen SM, Overbeek BP, Brutel de la Riviere A, Storm AJ, Langemeyer JJ. Prospective randomized comparison of single-dose versus multiple-dose cefuroxime for prophylaxis in coronary artery bypass grafting. Eur J Clin Microbiol Infect Dis. 1994;13:1033-1037.
59. Vuorisalo S, Pokela R, Syrjala J. Is single-dose prophylaxis sufficient for coronary artery bypass surgery? an analysis of peri- and postoperative serum cefuroxime and vancomycin levels. J Hosp Infect. 1997;37:237-247.
60. Kriaras I, Michalopoutos A, Michalis A, et al. Antibiotic prophylaxis in cardiac surgery. J Cardiovasc Surg (Torino). 1997;38:605-610.
61. Salminen US, Viljanen TU, Valtonen W, Ikonen TE, Sahlman AE, Harjula AL. Ceftriaxone versus vancomycin prophylaxis in cardiovascular surgery. J Antimicrob Chemother. 1999;44:287-290.
62. Bucknell SJ, Mohajeri M, Low J, McDonald M, Hill DG. Single- versus multiple-dose antibiotics prophylaxis for cardiac surgery. Aust N Z J Surg. 2000;70:409-411.
63. Archer GL, Armstrong BC. Alteration of staphylococcal flora in cardiac surgery patients receiving antibiotic prophylaxis. J Infect Dis. 1983;147:642-649.
64. Kernodle DS, Barg NL, Kaiser AB. Low-level colonization of hospitalized patients with methicillin-resistant coagulase-negative staphylococci and emergence of the organisms during surgical antimicrobial prophylaxis. Antimicrob Agents Chemother. 1988;32:202-208.
65. Archer GL. Alteration of cutaneous staphylococcal flora as a consequence of antimicrobial prophylaxis. Rev Infect Dis. 1991;13(suppl 10):S805-S809.
66. Terpstra S, Noodhoek GT, Voesten HG, Hendriks B, Degene JE. Rapid emergence of resistant coagulase-negative staphylococci on the skin after antimicrobial prophylaxis. J Hosp Infect. 1999;43:195-202.
67. Harbarth S, Samore MH, Lichtenberg D, Carmeli Y. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation. 2000;101:2916-2921.
68. Eggimann P, Pittet D. Infection control in the ICU. Chest. 2001;120:2059-2093.
69. Takesue Y, Yokoyama T, Akagi S, et al. Changes in the intestinal flora after the administration of prophylactic antibiotics to patients undergoing a gastrectomy. Surg Today. 2002;32:581-586.
70. Hecker MT, Aron DC, Patel NP, Lehmann MK, Donskey CJ. Unnecessary use of antimicrobials in hospitalized patients: current patterns of misuse with an emphasis on the antianaerobic spectrum of activity. Arch Intern Med. 2003;163:972-978.
71. Hoth JJ, Franklin GA, Stassen NA, Girard SM, Rodriguez RJ, Rodriguez JL. Prophylactic antibiotics adversely affect nosocomial pneumonia in trauma patients. J Trauma. 2003;55:249-254.
72. Institute of Medicine. Crossing the Quality Chasm: A New Health System for the 21st Century. Washington, DC: National Academy Press: 2001.
73. Berwick DM. Disseminating innovations in health care. JAMA. 2003;289:1969-1975.
74. Institute of Medicine. Priority Areas for National Action: Transforming Hearth Care Quality. Adams K, Corrigan JM, eds. Washington, DC: National Academy Press; 2003.
75. Pestotnik SL, Classen DC, Evans RS, Burke JP. Implementing antibiotic practice guidelines through computer-assisted decision support: clinical and financial outcomes. Ann Intern Med. 1996;124:884-890.
76. Evans RS, Pestotnik SL, Classen DC, et al. A computer-assisted management program for antibiotics and other antiinfective agents. N Engl J Med. 1998;338:232-238.
77. Joint Commission on Accreditation of Healthcare Organizations. Surgical infection prevention core performance measures for national implementation. Available at: http://www.jcaho.org/pms/core+measures/10asipmeaslistpop.pdf. Accessed April 20, 2004.
78. American Hospital Association. The Quality Initiative: Full Medicare Inpatient Update Requirements and New Measures. Available at: http://www.hospitalconnect.com/aha/key_issues/patient_safety/advocacy/ 040408qualityadvisory.html. Accessed April 20, 2004.