Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: Does mupirocin remain effective?

Infection Control and Hospital Epidemiology

Volumn 24, Issue 5, 2003, Pages 342-346

  Walker, Elaine S ^b   Vasquez, Jose E ^b   Dula, Roy ^b   Bullock, Hollie ^b   Sarubbi, Felix A ^a  

^a East Tennessee State University   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; METICILLIN; PSEUDOMONIC ACID;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CLEARANCE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA FINGERPRINTING; DRUG EFFICACY; FEMALE; HUMAN; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NOSE INFECTION; PLASMID; STAPHYLOCOCCUS INFECTION; TREATMENT FAILURE; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE; HOSPITALS, VETERANS; HUMANS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MUPIROCIN; NASAL CAVITY; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TENNESSEE;

EID: 0037846461     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/502218     Document Type: Article

References (36)

1. Boyce JM. Methicillin-resistant Staphylococcus aureus in hospitals and long-term care facilities: microbiology, epidemiology, and preventive measures. Infect Control Hosp Epidemiol 1992;13:725-737.
2. Muder RR, Brennen C, Wagener MM, et al. Methicillin-resistant staphylococcal colonization and infection in a long-term care facility. Ann Intern Med 1991;114:107-112.
3. Spindel SJ, Strausbaugh LJ, Jacobson C. Infections caused by Staphylococcus aureus in a Veterans' Affairs nursing home care unit: a 5-year experience. Infect Control Hosp Epidemiol 1995;16:217-223.
4. Nicolle LE, Dyck B, Thompson G, et al. Regional dissemination and control of epidemic methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 1999;20:202-205.
5. Meier PA, Carter CD, Wallace SE, Hollis RJ, Pfaller MA, Herwaldt LA. A prolonged outbreak of methicillin-resistant Staphylococcus aureus in the burn unit of a tertiary medical center. Infect Control Hosp Epidemiol 1996;17:798-802.
6. Murray-Leisure KA, Geib S, Graceley D, et al. Control of epidemic methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 1990;11:343-350.
7. Girou E, Pujade G, Legrand P, Cizeau F, Brun-Buisson C. Selective screening of carriers for control of methicillin-resistant Staphylococcus aureus (MRSA) in high-risk hospital areas with a high level of endemic MRSA. Clin Infect Dis 1998;27:543-550.
8. Kotilainen P, Routamaa M, Peltonen R, et al. Eradication of methicillin-resistant Staphylococcus aureus from a health center ward and associated nursing home. Arch Intern Med 2001;161:859-863.
9. Arnold MS, Dempsey JM, Fishman M, McAuley PJ, Tibert C, Vallande NC. The best hospital practices for controlling methicillin-resistant Staphylococcus aureus: the cutting edge. Infect Control Hosp Epidemiol 2002;23:69-76.
10. Farr BM, Jarvis WR. Would active surveillance cultures help control healthcare-related methicillin-resistant Staphylococcus aureus infections? Infect Control Hosp Epidemiol 2002;23:65-68.
11. Barrett SP. The value of nasal mupirocin in containing an outbreak of methicillin-resistant Staphylococcus aureus in an orthopaedic unit. J Hosp Infect 1990;15:137-142.
12. Cimochowski GE, Harostock MD, Brown R, Bernardi M, Alonzo N, Coyle K. Intranasal mupirocin reduces sternal wound infection after open heart surgery in diabetics and nondiabetics. Ann Thorac Surg 2001;71:1572-1579.
13. Kluytmans JA, Mouton JW, VandenBergh MFQ, et al. Reduction of surgical-site infections in cardiothoracic surgery by elimination of nasal carriage of Staphylococcus aureus. Infect Control Hosp Epidemiol 1996;17:780-785.
14. Eltringham I. Mupirocin resistance and methicillin-resistant Staphylococcus aureus (MRSA). J Hosp Infect 1997;35:1-8.
15. Cookson BD. The emergence of mupirocin resistance: a challenge to infection control and antibiotic prescribing practice. J Antimicrob Chemother 1998;41:11-18.
16. Watanabe H, Masaki H, Asoh N, et al. Emergence and spread of low-level mupirocin resistance in methicillin-resistant Staphylococcus aureus isolated from a community hospital in Japan. J Hosp Infect 2001;47:294-300.
17. Vasquez JE, Walker ES, Franzus BW, Overbay BK, Reagan DR, Sarubbi FA. The epidemiology of mupirocin resistance among methicillin-resistant Staphylococcus aureus at a Veterans' Affairs hospital. Infect Control Hosp Epidemiol 2000;21:459-464.
18. Bradley SF, Ramsey MA, Morton TM, Kauffman CA. Mupirocin resistance: clinical and molecular epidemiology. Infect Control Hosp Epidemiol 1995;16:354-358.
19. Miller MA, Dascal A, Portnoy J, Mendelson J. Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment. Infect Control Hosp Epidemiol 1996;17:811-813.
20. dos Santos KRN, Fonseca LS, Filho PPG. Emergence of high-level mupirocin resistance in methicillin-resistant Staphylococcus aureus isolated from Brazilian university hospitals. Infect Control Hosp Epidemiol 1996;17:813-816.
21. Harbarth S, Dharan S, Liassine N, Herrault P, Auckenthaler R, Pittet D. Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 1999;43:1412-1416.
22. Gilbart J, Perry CR, Slocombe B. High-level mupirocin resistance in Staphylococcus aureus: evidence for two distinct isoleucyl-tRNA synthetases. Antimicrob Agents Chemother 1993;37:32-38.
23. Kauffman CA, Terpenning MS, He X, et al. Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long-term care facility with the use of mupirocin ointment. Am J Med 1993;94:371-378.
24. Semret M, Miller MA. Topical mupirocin for eradication of MRSA colonization with mupirocin-resistant strains. Infect Control Hosp Epidemiol 2001;22:578-580.
25. Fuchs PC, Jones RN, Barry AL. Interpretive criteria for disk-diffusion susceptibility testing of mupirocin, a topical antibiotic. J Clin Microbiol 1990;28:608-609.
26. Maslow JN, Slutsky AM, Arbeit RD. Application of pulsed-field electrophoresis to molecular epidemiology. In: Persing DH, Smith TF, White TJ, eds. Diagnostic Molecular Microbiology Principles and Practice. Washington, DC: American Society for Microbiology; 1993:563-572.
27. Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:2233-2239.
28. Rahman M, Noble WC, Cookson B. Mupirocin-resistant Staphylococcus aureus. Lancet 1987;2:387.
29. Rahman M, Noble WC, Cookson B. Transmissible mupirocin resistance in Staphylococcus aureus. Epidemiol Infect 1989;102:261-270.
30. Kavi J, Andrews JM, Wise R. Mupirocin-resistant Staphylococcus aureus. Lancet 1987;2:1472.
31. Fujimura S, Watanabe A, Beighton D. Characterization of the mup A gene in strains of methicillin-resistant Staphylococcus aureus with a low level of resistance to mupirocin. Antimicrob Agents Chemother 2001;45:641-642.
32. Layton MC, Patterson JE. Mupirocin resistance among consecutive isolates of oxacillin-resistant and borderline oxacillin-resistant Staphylococcus aureus at a university hospital. Antimicrob Agents Chemother 1994;38:1664-1667.
33. Smith GE, Kennedy CC. Staphylococcus aureus resistant to mupirocin. J Antimicrob Chemother 1988;21:141-142.
34. Mulligan ME, Murray-Leisure KA, Ribner BS, et al. Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management. Am J Med 1993;94:313-328.
35. Bradley SF. Effectiveness of mupirocin in the control of methicillin-resistant Staphylococcus aureus. Infections in Medicine 1993;10:23-31.
36. Muder RR. Mupirocin and MRSA: current status. Infections in Medicine 1993;10:21-22.