Impact of 4% chlorhexidine whole-body washing on multidrug-resistant Acinetobacter baumannii skin colonisation among patients in a medical intensive care unit

Journal of Hospital Infection

Volumn 67, Issue 2, 2007, Pages 149-155

  Borer, A ^a   Gilad, J ^a   Porat, N ^a   Megrelesvilli, R ^a   Saidel Odes, L ^a   Peled, N ^a   Eskira, S ^a   Schlaeffer, F ^a   Almog, Y ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Chlorhexidine body washing; Multidrug resistant Acinetobacter baumannii

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AZTREONAM; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CHLORHEXIDINE GLUCONATE; COLISTIN; PENICILLIN DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULTAMICILLIN; TETRACYCLINE DERIVATIVE;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CULTURE; COHORT ANALYSIS; CONTROLLED STUDY; DISINFECTION; ENDEMIC DISEASE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITAL INFECTION; HUMAN; INCIDENCE; INFECTION CONTROL; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MORAXELLACEAE INFECTION; MULTIDRUG RESISTANCE; PREVALENCE; PROSPECTIVE STUDY; RASH; RETROSPECTIVE STUDY; SKIN CULTURE; SKIN DECONTAMINATION; SKIN INFECTION; STATISTICAL SIGNIFICANCE;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; CHLORHEXIDINE; COHORT STUDIES; CROSS INFECTION; DISINFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; PREVALENCE; PROSPECTIVE STUDIES; SKIN;

EID: 35148863678     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2007.07.023     Document Type: Article

References (30)

1. Cohen M.L. Epidemiology of drug resistance: implications for a post-antimicrobial era. Science 257 (1992) 1050-1055
2. Acar J.F., and Goldstein F.W. Consequences of increasing resistance to antimicrobial agents. Clin Infect Dis 27 (1998) 125-130
3. Archibald L., Phillips L., Monnet D., et al. Antimicrobial resistance in isolates from inpatients and outpatients in the United States: increasing importance of the intensive care unit. Clin Infect Dis 24 (1997) 211-215
4. Marais E., de Jong G., Ferraz V., Maloba B., and Duse A.G. Interhospital transfer of pan-resistant Acinetobacter strains in Johannesburg, South Africa. Am J Infect Control 32 (2004) 278-281
5. Livermore D.M. The threat from the pink corner. Ann Med 35 (2003) 226-234
6. Wisplinghoff H., Schmitt R., Wohrmann A., Stefanik D., and Seifert H. Resistance to disinfectants in epidemiologically defined clinical isolates of Acinetobacter baumannii. J Hosp Infect 66 (2007) 174-181
7. Wendt C., Dietze B., Dietz E., and Ruden H. Survival of Acinetobacter baumannii on dry surfaces. J Clin Microbiol 35 (1997) 1394-1397
8. Landman D., Quale J.M., Mayorga D., et al. Citywide clonal outbreak of multiresistant Acinetobacter baumannii and Pseudomonas aeruginosa in Brooklyn, NY: the preantibiotic era has returned. Arch Intern Med 162 (2002) 1515-1520
9. Corbella X., Montero A., Pujol M., et al. Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J Clin Microbiol 38 (2000) 4086-4095
10. Smolyakov R., Borer A., Riesenberg K., et al. Nosocomial multi-drug resistant Acinetobacter baumannii bloodstream infection: risk factors and outcome with ampicillin-sulbactam treatment. J Hosp Infect 54 (2003) 32-38
11. O'Grady N.P., Alexander M., Patchen Dellinger E., et al. Guidelines for the prevention of intravascular catheter-related infections. Morb Mortal Wkly Rep 51 (2002) 1-26
12. Silverman J., Vasquez J.A., Sobel J.D., and Zervos M.J. Comparative in vitro activity of antiseptics and disinfectants versus clinical isolates of Candida species. Infect Control Hosp Epidemiol 20 (1999) 676-684
13. Borer A, Ostrowsky B, Espinel-Ingroff A, et al. In vitro activity of handwashing agents against Candida albicans. Presented at the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, USA, December 2001.
14. National Committee for Clinical Laboratory Standards (NCCLS). Performance standards for antimicrobial susceptibility testing. 11th informational supplement, NCCLS document M100-S11, Wayne, PA; 2001.
15. Beck-Sague C.M., Jarvis W.R., Brook J.H., et al. Epidemic bacteremia due to Acinetobacter baumannii in five intensive care units. Am J Epidemiol 132 (1990) 723-733
16. Tenover F.C., Arbeit R.D., Goering R.V., et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 33 (1995) 2233-2239
17. Larson E.L. Persistent carriage of gram-negative bacteria on hands. Am J Infect Control 9 (1981) 112-119
18. Larson E.L., Cronquist A.B., Whittier S., et al. Differences in skin flora between inpatients and chronically ill outpatients. Heart Lung 29 (2000) 298-305
19. Seifert H., Dijkshoorn L., Gerner-Smidt P., et al. Distribution of Acinetobacter species on human skin: comparison of phenotypic and genotypic identification methods. J Clin Microbiol 35 (1997) 2819-2825
20. Smolyakov R, Schlaeffer F, Riesenberg K, et al. Persistence of a multiresistant Acinetobacter baumannii clone causing bacteremia in a tertiary hospital in southern Israel. Presented at the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, USA, December 2001.
21. Navon-Venezia S., Ben-Ami R., and Carmeli Y. Update on Pseudomonas aeruginosa and Acinetobacter baumannii infections in the healthcare setting. Curr Opin Infect Dis 18 (2005) 306-313
22. Keswick B.H., Berge C.A., Bartolo R.G., et al. Antimicrobial soaps: their role in personal hygiene. In: Aly R., Beutner K.R., and Maibach H. (Eds). Cutaneous Infection and Therapy. 1st edn (1997), Marcel Dekker, New York 49-82
23. Meberg A., and Schoyen R. Bacterial colonization and neonatal infections. Effects of skin and umbilical disinfection in the nursery. Acta Paediatr Scand 74 (1985) 366-371
24. Borer A., Gilad J., Yagupsky P., et al. Community-acquired methicillin-resistant staphylococcus aureus in institutionalized adults with developmental disabilities. Emerg Infect Dis 8 (2002) 966-970
25. Mackenzie I. Preoperative skin preparation and surgical outcome. J Hosp Infect 11 (1988) 27-32
26. Webster J., and Osborne S. Preoperative bathing or showering with skin antiseptics to prevent surgical site infection. Cochrane Database Syst Rev 19 (2006) CD004985
27. Vernon M.O., Hayden M.K., Trick W.E., et al. Chlorhexidine gluconate to cleanse patients in a medical intensive care unit: the effectiveness of source control to reduce the bioburden of vancomycin-resistant enterococci. Arch Intern Med 166 (2006) 306-312
28. Garibaldi R.A. Prevention of intraoperative wound contamination with chlorhexidine shower and scrub. J Hosp Infect 11 (1988) 5-9
29. Webster J., and Faoagali J.L. An in-use comparison of chlorhexidine gluconate 4% w/v, glycol-poly-siloxane plus methylcellulose and a liquid soap in a special care baby unit. J Hosp Infect 14 (1989) 141-151
30. Larson E. Skin hygiene and infection prevention: more of the same or different approaches?. Clin Infect Dis 29 (1999) 1287-1294