Uncoupling of a CLC Cl-/H+ Exchange Transporter by Polyatomic Anions

Journal of Molecular Biology

Volumn 362, Issue 4, 2006, Pages 682-690

  Nguitragool, Wang ^a   Miller, Christopher ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

anion binding; antiporter; chloride channel; CLC; coupling

Indexed keywords

ANION; ANTIPORTER; BACTERIAL PROTEIN; BROMIDE; CHLORIDE CHANNEL; CHLORIDE ION; HALIDE; NITRATE; PROTON; THIOCYANATE;

ARTICLE; BINDING SITE; CATALYSIS; CELL FUNCTION; CHLORIDE TRANSPORT; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; MEMBRANE TRANSPORT; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN STRUCTURE; PROTON TRANSPORT; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS);

EID: 33748310543     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.07.006     Document Type: Article

References (22)

1. White M.M., and Miller C. A voltage-gated anion channel from electric organ of Torpedo californica. J. Biol. Chem. 254 (1979) 10161-10166
2. Miller C. Open-state substructure of single chloride channels from Torpedo electroplax. Phil. Trans. Roy. Soc. ser. B 299 (1982) 401-411
3. Jentsch T.J., Steinmeyer K., and Schwarz G. Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature 348 (1990) 510-514
4. - channels. Nature 427 (2004) 803-807
5. Picollo A., and Pusch M. Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature 436 (2005) 420-423
6. Scheel O., Zdebik A.A., Lourdel S., and Jentsch T.J. Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature 436 (2005) 424-427
7. Iyer R., Iverson T.M., Accardi A., and Miller C. A biological role for prokaryotic ClC chloride channels. Nature 419 (2002) 715-718
8. De Angeli A., Monachello D., Ephritikhine G., Frachisse J.M., Thomine S., Gambale F., and Barbier-Brygoo H. AtCLCa, a proton/nitrate antiporter, mediates nitrate accumulation in plant vacuoles. Nature 442 (2006) 939-942
9. Maduke M., Pheasant D.J., and Miller C. High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel. J. Gen. Physiol. 114 (1999) 713-722
10. - channels. J. Gen. Physiol. 123 (2004) 109-119
11. Dutzler R., Campbell E.B., Cadene M., Chait B.T., and MacKinnon R. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature 415 (2002) 287-294
12. Dutzler R., Campbell E.B., and MacKinnon R. Gating the selectivity filter in ClC chloride channels. Science 300 (2003) 108-112
13. Lobet S., and Dutzler R. Ion binding properties of the CLC chloride selectivity filter. EMBO J. 25 (2005) 24-33
14. + exchanger. J. Gen. Physiol. 126 (2005) 563-570
15. Bruce L.J., Robinson H.C., Guizouarn H., Borgese F., Harrison P., King M.J., et al. Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Nature Genet. 37 (2005) 1258-1263
16. - exchange by slc26a3 and slc26a6. J. Gen. Physiol. 127 (2006) 511-524
17. Zhou Y., and MacKinnon R. The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J. Mol. Biol. 333 (2003) 965-975
18. 2+-ATPase of the sarcoplasmic reticulum. Annu. Rev. Biochem. 73 (2004) 269-292
19. Artigas P., and Gadsby D.C. Ion occlusion/deocclusion partial reactions in individual palytoxin-modified Na/K pumps. Ann. N.Y. Acad. Sci. 986 (2003) 116-126
20. --dependent neurotransmitter transporters. Nature 437 (2005) 215-223
21. - coordinating tyrosine residue. J. Mol. Biol. In the press. doi:10.1016/j.jmb.2006.07.081.
22. Hodel A., Kim S.-H., and Brunger A.T. Model bias in macromolecular crystal structures. Acta Crystallog. sect. A 48 (1992) 851-858