Substituted dipiperidine alcohols as potent CCR2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3562-3564

  Xia, Mingde ^a   Hou, Cuifen ^a   DeMong, Duane ^a   Pollack, Scott ^a   Pan, Meng ^a   Brackley, James ^a   Singer, Monica ^a   Matheis, Michele ^a   Cavender, Druie ^a   Wachter, Michael ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

CCR2 antagonist; Chemokines; MCP 1

Indexed keywords

4 (INDOL 3 YL)PIPERIDINE; ACETONITRILE; ALCOHOL; ALPHA BROMOESTER; CARBOXYLIC ACID DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR2; CHLORIDE; ESTER DERIVATIVE; HALOGEN; INDOLE; PHENYL PIPERIDINYL DERIVATIVE; PIPERIDINE; UREA DERIVATIVE;

ACYLATION; ARTICLE; BINDING AFFINITY; BROMINATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG INHIBITION; ENANTIOMER; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ALCOHOLS; BINDING SITES; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PIPERIDINES; RECEPTORS, CCR2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44649172158     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.010     Document Type: Article

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