Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1374-1377

  Pasternak, Alexander ^a   Goble, Stephen D ^a   Doss, George A ^a   Tsou, Nancy N ^a   Butora, Gabor ^a   Vicario, Pasquale P ^a   Ayala, Julia Marie ^a   Struthers, Mary ^a   DeMartino, Julie A ^a   Mills, Sander G ^a   Yang, Lihu ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonist; CCR2; Chemokine

Indexed keywords

AMIDE; ANTIINFLAMMATORY AGENT; BENZYLAMIDE; CYCLOPENTANE; CYCLOPENTANE DERIVATIVE; PIPERIDINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATION; CYCLIZATION; IC 50; SYNTHESIS;

ACETALS; CRYSTALLOGRAPHY, X-RAY; CYCLOPENTANES; HUMANS; KINETICS; MOLECULAR CONFORMATION; MONOCYTES; RECEPTORS, CCR2; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38949145354     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.016     Document Type: Article

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