Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson's disease

Neuroscience

Volumn 140, Issue 1, 2006, Pages 67-76

  Novikova, L ^a   Garris, B L ^a   Garris, D R ^a   Lau, Y S ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

chronic parkinsonian mouse; dopaminergic neurodegeneration; microglial activation; neuroapoptosis; TUNEL; tyrosine hydroxylase

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; DOPAMINE; PROBENECID; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL VACUOLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; CORPUS STRIATUM; DEGRANULATION; DISEASE MODEL; IMMUNOREACTIVITY; MACROGLIA; MALE; MICROGLIA; MORPHOMETRICS; MOUSE; NERVE CELL; NERVE DEGENERATION; NICK END LABELING; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DOPAMINE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; NERVE DEGENERATION; PARKINSON DISEASE; PHOSPHOPYRUVATE HYDRATASE; STATISTICS, NONPARAMETRIC; SUBSTANTIA NIGRA; TIME FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 33646338882     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.02.007     Document Type: Article

References (48)

1. Aloisi F. The role of microglia and astrocytes in CNS immune surveillance and immunopathology. Adv Exp Med Biol 468 (1999) 123-133
2. Anglade P., Vyas S., Javoy-Agid F., Herrero M.T., Michel P.P., Marquez J., Mouatt-Prigent A., Ruberg M., Hirsch E.C., and Agid Y. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 12 (1997) 25-31
3. Banati R.B., Daniel S.E., and Blunt S.B. Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease. Mov Disord 13 (1998) 221-227
4. Batchelor P.E., Liberatore G.T., Wong J.Y., Porritt M.J., Frerichs F., Donnan G.A., and Howells D.W. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. J Neurosci 19 (1999) 1708-1716
5. Blum D., Torch S., Lambeng N., Nissou M., Benabid A.L., Sadoul R., and Verna J.M. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP. contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65 (2001) 135-172
6. Czlonkowska A., Kohutnicka M., Kurkowska-Jastrzebska I., and Czlonkowski A. Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice model. Neurodegeneration 5 (1996) 137-143
7. Du Y., Ma Z., Lin S., Dodel R.C., Gao F., Bales K.R., Triarhou L.C., Chernet E., Perry K.W., Nelson D.L., Luecke S., Phebus L.A., Bymaster F.P., and Paul S.M. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A 98 (2001) 14669-14674
8. Duvoisin R.C. Genetic and environmental factors in Parkinson's disease. Adv Neurol 80 (1999) 161-163
9. Franklin K.B.J., and Paxinos G. The mouse brain in stereotaxic coordinates (1996), Academic Press, London
10. Garris B.L., and Garris D.R. Digital chemospectrophotographic identification of intracellular hyperlipidemia in diabetic epithelial cells. structural and metabolic basis of organoatrophy. Pathobiology 71 (2004) 77-83
11. Garris D.R., and Garris B.L. Cytolipotoxicity-induced involution of the female reproductive tract following expression of obese (ob/ob) and diabetes (db/db) genotype mutations. progressive, hyperlipidemic transformation into adipocytic tissues. Reprod Tox 18 (2004) 81-91
12. Garris B.L., Novikova L., Lau Y.S., and Garris D.R. Hypophyseal lipoapoptosis. diabetes (db/db) mutation-associated cytolipidemia promotes pituitary cellular disruption and dysfunction. Pituitary 7 (2004) 5-14
13. Garris D.R. Aggression-associated changes in murine olfactory tubercle bioamines. Brain Res 963 (2003) 150-155
14. Gavrieli Y., Sherman Y., and Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119 (1992) 493-501
15. Gebicke-Haerter P.J. Microglia in neurodegeneration. molecular aspects. Microsc Res Tech 54 (2001) 47-58
16. Gehrmann J., Matsumoto Y., and Kreutzberg G.W. Microglia. intrinsic immuneffector cell of the brain. Brain Res Rev 20 (1995) 269-287
17. Giasson B.I., Ischiropoulos H., Lee V.M., and Trojanowski J.Q. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radic Biol Med 32 (2002) 1264-1275
18. Hanisch U.K. Microglia as a source and target of cytokines. Glia 40 (2002) 140-155
19. Heikkila R.E., Sieber B.A., Manzino L., and Sonsalla P.K. Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse. Mol Chem Neuropathol 10 (1989) 171-183
20. Jackson-Lewis V., Jakowec M., Burke R.E., and Przedborski S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 4 (1995) 257-269
21. Jeon B.S., Jackson-Lewis V., and Burke R.E. 6-Hydroxydopamine lesion of the rat substantia nigra. time course and morphology of cell death. Neurodegeneration 4 (1995) 131-137
22. Kreutzberg G.W. Microglia. a sensor for pathological events in the CNS. Trends Neurosci 19 (1996) 312-318
23. Lau Y.S., and Meredith G.E. From drugs of abuse to parkinsonism. The MPTP mouse model of Parkinson's disease. Methods Mol Med 79 (2003) 103-116
24. Lau Y.S., Novikova L., and Roels C. MPTP treatment in mice does not transmit and cause Parkinsonian neurotoxicity in non-treated cagemates through close contact. Neurosci Res 52 (2005) 371-378
25. Lau Y.S., Trobough K.L., Crampton J.M., and Wilson J.A. Effects of probenecid on striatal dopamine depletion in acute and long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Gen Pharmacol 21 (1990) 181-187
26. Le Couteur D.G., Muller M., Yang M.C., Mellick G.D., and McLean A.J. Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease. Rev Environ Health 17 (2002) 51-64
27. Leist M., and Nicotera P. Apoptosis, excitotoxicity, and neuropathology. Exp Cell Res 239 (1998) 183-201
28. Liu B., Du L., and Hong J.S. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. J Pharmacol Exp Ther 293 (2000) 607-617
29. Mackenzie I.R., Hao C., and Munoz D.G. Role of microglia in senile plaque formation. Neurobiol Aging 16 (1995) 797-804
30. McGeer P.L., Itagaki S., Boyes B.E., and McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38 (1988) 1285-1291
31. Meredith G.E., Totterdell S., Petroske E., Santa Cruz K., Callison Jr. R.C., and Lau Y.S. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res 956 (2002) 156-165
32. Mizuno Y., Shimoda-Matsubayashi S., Matsumine H., Morikawa N., Hattori N., and Kondo T. Genetic and environmental factors in the pathogenesis of Parkinson's disease. Adv Neurol 80 (1999) 171-179
33. Mochizuki H., Goto K., Mori H., and Mizuno Y. Histochemical detection of apoptosis in Parkinson's disease. J Neurol Sci 137 (1996) 120-123
34. Nagatsu T., Mogi M., Ichinose H., and Togari A. Changes in cytokines and neurotrophins in Parkinson's disease. J Neural Transm Suppl 60 (2000) 277-290
35. Nicotra A., and Parvez S. Apoptotic molecules and MPTP-induced cell death. Neurotoxicol Teratol 24 (2002) 599-605
36. Petroske E., Meredith G.E., Callen S., Totterdell S., and Lau Y.S. Mouse model of Parkinsonism. a comparison between subacute MPTP and chronic MPTP/probenecid treatment. Neuroscience 106 (2001) 589-601
37. Pocock J.M., and Liddle A.C. Microglial signalling cascades in neurodegenerative disease. Prog Brain Res 132 (2001) 555-565
38. Portera-Cailliau C., Price D.L., and Martin L.J. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J Comp Neurol 378 (1997) 70-87
39. Przedborski S., and Jackson-Lewis V. Mechanisms of MPTP toxicity. Mov Disord 13 Suppl 1 (1998) 35-38
40. Rogers J., Luber-Narod J., Styren S.D., and Civin W.H. Expression of immune system-associated antigens by cells of the human central nervous system. relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9 (1988) 339-349
41. Roth K.A., and D'Sa C. Apoptosis and brain development. Ment Retard Dev Disabil Res Rev 7 (2001) 261-266
42. Serra P.A., Sciola L., Delogu M.R., Spano A., Monaco G., Miele E., Rocchitta G., Miele M., Migheli R., and Desole M.S. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes. J Biol Chem 277 (2002) 34451-34461
43. Tatton N.A., and Kish S.J. In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77 (1997) 1037-1048
44. Turmel H., Hartmann A., Parain K., Douhou A., Srinivasan A., Agid Y., and Hirsch E.C. Caspase-3 activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Mov Disord 16 (2001) 185-189
45. Vila M., Jackson-Lewis V., Guegan C., Wu D.C., Teismann P., Choi D.K., Tieu K., and Przedborski S. The role of glial cells in Parkinson's disease. Curr Opin Neurol 14 (2001) 483-489
46. Wu D.C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., Choi D.K., Ischiropoulos H., and Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22 (2002) 1763-1771
47. Wullner U., Kornhuber J., Weller M., Schulz J.B., Loschmann P.A., Riederer P., and Klockgether T. Cell death and apoptosis regulating proteins in Parkinson's disease. a cautionary note. Acta Neuropathol (Berl) 97 (1999) 408-412
48. Yuan J., and Yankner B.A. Apoptosis in the nervous system. Nature 407 (2000) 802-809