A2b receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts

Hypertension

Volumn 37, Issue 2 II, 2001, Pages 716-721

  Dubey, Raghvendra K ^a,b   Gillespie, Delbert G ^a   Zacharia, Lefteris C ^a   Mi, Zaichuan ^a   Jackson, Edwin K ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

A2B receptor; Adenosine; Cardiac fibroblast; Cardiac remodeling; Left ventricular hypertrophy; Myocardial infarction; Proliferation

Indexed keywords

1,3 DIPROPYL 8 (4 SULFOPHENYL)XANTHINE; 2 CHLOROADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINOBENZYL 5' N METHYLCARBOXAMIDOADENOSINE; 6 N CYCLOPENTYLADENOSINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 (2 HYDROXY 3 NONYL)ADENINE; ADENOSINE; ADENOSINE 5' (N METHYLCARBOXAMIDE); ADENOSINE A2B RECEPTOR; ADENOSINE DEAMINASE INHIBITOR; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; IODOTUBERICIDIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR BB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FIBROBLAST; GROWTH INHIBITION; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HYPERTENSION; MALE; MITOSIS INHIBITION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0035093023     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.37.2.716     Document Type: Conference Paper

References (12)

1. Molecular signalling mechanisms controlling growth and function of cardiac fibroblasts
2. Cardiac fibroblasts: Function of gene expression and phenotype modulation
3. Possible role of adenosine deaminase in vaso-occlusive diseases
4. 2B receptors
5. Cyclic AMP-adenosine pathway induces nitric oxide synthesis in aortic smooth muscle cells
6. 2B receptors
7. Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: Role of A2B receptors
8. 2B receptors mediate antimitogenesis in vascular smooth muscle cells
9. Clinically used estrogens differentially inhibit human aortic smooth muscle cell growth and mitogen-activated protein kinase activity
10. Formation and metabolism of adenosine and adenine nucleotides in cardiac tissue
11. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion
12. Cardiac fibroblasts express the cAMP-adenosine pathway