Real-time analysis of amyloid fibril formation of α-synuclein using a fibrillation-state-specific fluorescent probe of JC-1

Biochemical Journal

Volumn 418, Issue 2, 2009, Pages 311-323

  Lee, Jung Ho ^a   Lee, In Hwan ^a   Choe, Young Jun ^a   Kang, Sungsoo ^a   Kim, Hui Young ^a   Gai, Wei Ping ^b   Hahn, Ji Sook ^a   Paik, Seung R ^a  

^a Seoul National University   (South Korea)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

synuclein; Amyloidogenesis; JC 1; Neurodegenerative disorder; Parkinson's disease; Protein fibrillation

Indexed keywords

AMYLOID FIBRIL; AMYLOID FIBRIL FORMATION; AMYLOIDOGENESIS; BAICALEIN; C-TERMINAL REGIONS; DRUG SCREENING; FIBRILLATION STATE; FLUORESCENCE SPECTRA; FLUORESCENT PROBES; FRET (FLUORESCENCE RESONANCE ENERGY TRANSFER); GLUTATHIONE; HIGH-THROUGHPUT; IN-VITRO; JC-1; LEWY BODIES; MOLECULAR AETIOLOGY; MOLECULAR MECHANISM; NEURODEGENERATIVE DISORDER; PARKINSON'S DISEASE; REAL TIME ANALYSIS; SPECIFIC INTERACTION; SYNUCLEIN; THIOFLAVIN;

BINDING ENERGY; DISEASES; ENERGY TRANSFER; GLYCOPROTEINS; METAL IONS; PROBES; STRATEGIC PLANNING; SULFUR COMPOUNDS;

FLUORESCENCE;

5,5',6,6' TETRACHLORO 1,1,3,3' TETRAETHYLBENZIMIDAZOLYL CARBOCYANINE IODIDE; ALPHA SYNUCLEIN; AMYLOID; BAICALEIN; DEQUALINIUM; EOSIN; FLUORESCENT DYE; GLUTATHIONE; IRON; LIPID; METAL ION; RIFAMPICIN; THIOFLAVINE; UNCLASSIFIED DRUG; 5,5',6,6' TETRACHLORO 1,1',3,3' TETRAETHYLBENZIMIDAZOLOCARBOCYANINE; 5,5',6,6'-TETRACHLORO-1,1',3,3'-TETRAETHYLBENZIMIDAZOLOCARBOCYANINE; BENZIMIDAZOLE DERIVATIVE; CARBOCYANINE; THIAZOLE DERIVATIVE;

ANALYTIC METHOD; ARTICLE; BINDING KINETICS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; MOLECULAR DYNAMICS; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN STRUCTURE; REAL TIME ANALYSIS; BIOLOGICAL MODEL; COMPARATIVE STUDY; COMPUTER SYSTEM; ENZYME SPECIFICITY; EVALUATION; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN BINDING; PROTEIN MULTIMERIZATION;

ALPHA-SYNUCLEIN; AMYLOID; BENZIMIDAZOLES; CARBOCYANINES; COMPUTER SYSTEMS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SUBSTRATE SPECIFICITY; THIAZOLES;

EID: 61449135187     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081572     Document Type: Article

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