Screening for Genetic Modifiers of Amyloid Toxicity in Yeast

Methods in Enzymology

Volumn 412, Issue , 2006, Pages 201-222

  Giorgini, Flaviano ^a   Muchowski, Paul J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID;

AMYOTROPHIC LATERAL SCLEROSIS; CAENORHABDITIS ELEGANS; DEGENERATIVE DISEASE; DNA MODIFICATION; DNA SEQUENCE; DROSOPHILA; FRIEDREICH ATAXIA; GENE AMPLIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC MANIPULATION; GENETIC SCREENING; HIGH THROUGHPUT SCREENING; HUNTINGTON CHOREA; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; REVIEW; SACCHAROMYCES CEREVISIAE; YEAST;

AMYLOID; GENE EXPRESSION REGULATION, FUNGAL; GENETIC SCREENING; MODELS, GENETIC; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSFORMATION, GENETIC;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 33749632459     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(06)12013-3     Document Type: Review

References (54)

1. Chen D.C., Yang B.C., and Kuo T.T. One-step transformation of yeast in stationary phase. Curr. Genet. 21 (1992) 83-84
2. Fields S., and Johnston M. Cell biology. Whither model organism research?. Science 307 (2005) 1885-1886
3. Fields S., and Sternglanz R. The two-hybrid system: An assay for protein-protein interactions. Trends Genet. 10 (1994) 286-292
4. Flower T.R., Chesnokova L.S., Froelich C.A., Dixon C., and Witt S.N. Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J. Mol. Biol. 351 (2005) 1081-1100
5. Forsburg S.L. The art and design of genetic screens: Yeast. Nat. Rev. Genet. 2 (2001) 659-668
6. Giaever G., Chu A.M., Ni L., Connelly C., Riles L., Veronneau S., Dow S., Lucau-Danila A., Anderson K., Andre B., Arkin A.P., Astromoff A., El-Bakkoury M., Bangham R., Benito R., Brachat S., Campanaro S., Curtiss M., Davis K., Deutschbauer A., Entian K.D., Flaherty P., Foury F., Garfinkel D.J., Gerstein M., Gotte D., Guldener U., Hegemann J.H., Hempel S., Herman Z., Jaramillo D.F., Kelly D.E., Kelly S.L., Kotter P., LaBonte D., Lamb D.C., Lan N., Liang H., Liao H., Liu L., Luo C., Lussier M., Mao R., Menard P., Ooi S.L., Revuelta J.L., Roberts C.J., Rose M., Ross-Macdonald P., Scherens B., Schimmack G., Shafer B., Shoemaker D.D., Sookhai-Mahadeo S., Storms R.K., Strathern J.N., Valle G., Voet M., Volckaert G., Wang C.Y., Ward T.R., Wilhelmy J., Winzeler E.A., Yang Y., Yen G., Youngman E., Yu K., Bussey H., Boeke J.D., Snyder M., Philippsen P., Davis R.W., and Johnston M. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418 (2002) 387-391
7. Gietz R.D., and Schiestl R.H. Transforming yeast with DNA. Methods Mol. Cell. Biol. 5 (1996) 255-269
8. Giorgini F., Guidetti P., Nguyen Q., Bennett S.C., and Muchowski P.J. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat. Genet. 37 5 (2005) 526-531
9. Giorgini F., and Muchowski P.J. Connecting the dots in Huntington's disease with protein interaction networks. Genome Biol. 6 (2005) 210
10. Goehler H., Lalowski M., Stelzl U., Waelter S., Stroedicke M., Worm U., Droege A., Lindenberg K.S., Knoblich M., Haenig C., Herbst M., Suopanki J., Scherzinger E., Abraham C., Bauer B., Hasenbank R., Fritzsche A., Ludewig A.H., Buessow K., Coleman S.H., Gutekunst C.A., Landwehrmeyer B.G., Lehrach H., and Wanker E.E. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol. Cell. 15 (2004) 853-865
11. Goffeau A., Barrell B.G., Bussey H., Davis R.W., Dujon B., Feldmann H., Galibert F., Hoheisel J.D., Jacq C., Johnston M., Louis E.J., Mewes H.W., Murakami Y., Philippsen P., Tettelin H., and Oliver S.G. Life with 6000 genes. Science 274 (1996) 563-567 546
12. Grunenfelder B., and Winzeler E.A. Treasures and traps in genome-wide data sets: Case examples from yeast. Nat. Rev. Genet. 3 (2002) 653-661
13. Hartwell L.H. Nobel Lecture. Yeast and cancer. Biosci. Rep. 22 (2002) 373-394
14. Hughes R.E., Lo R.S., Davis C., Strand A.D., Neal C.L., Olson J.M., and Fields S. Altered transcription in yeast expressing expanded polyglutamine. Proc. Natl. Acad. Sci. USA 98 (2001) 13201-13206
15. Hughes T.R., Roberts C.J., Dai H., Jones A.R., Meyer M.R., Slade D., Burchard J., Dow S., Ward T.R., Kidd M.J., Friend S.H., and Marton M.J. Widespread aneuploidy revealed by DNA microarray expression profiling. Nat. Genet. 25 (2000) 333-337
16. Ito T., Tashiro K., Muta S., Ozawa R., Chiba T., Nishizawa M., Yamamoto K., Kuhara S., and Sakaki Y. Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc. Natl. Acad. Sci. USA 97 (2000) 1143-1147
17. Johnston M. The yeast genome: On the road to the Golden Age. Curr. Opin. Genet. Dev. 10 (2000) 617-623
18. Johnston M., and Davis R.W. Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. Mol. Cell. Biol. 4 (1984) 1440-1448
19. Kohalmi S.E., and Kunz B.A. Role of neighbouring bases and assessment of strand specificity in ethylmethanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine mutagenesis in the SUP4-o gene of Saccharomyces cerevisiae. J. Mol. Biol. 204 (1988) 561-568
20. Krobitsch S., and Lindquist S. Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc. Natl. Acad. Sci. USA 97 (2000) 1589-1594
21. Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Epplen J.T., Schols L., and Riess O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18 (1998) 106-108
22. Kumar A., Vidan S., and Snyder M. Insertional mutagenesis: Transposon-insertion libraries as mutagens in yeast. Methods Enzymol. 350 (2002) 219-229
23. Kunz B.A., Pierce M.K., Mis J.R., and Giroux C.N. DNA sequence analysis of the mutational specificity of u.v. light in the SUP4-o gene of yeast. Mutagenesis 2 (1987) 445-453
24. Lawrence C.W. Classical mutagenesis techniques. Methods Enzymol. 350 (2002) 189-199
25. Lee G.S., Savage E.A., Ritzel R.G., and von Borstel R.C. The base-alteration spectrum of spontaneous and ultraviolet radiation-induced forward mutations in the URA3 locus of Saccharomyces cerevisiae. Mol. Gen. Genet. 214 (1988) 396-404
26. Link C.D. Transgenic invertebrate models of age-associated neurodegenerative diseases. Mech. Ageing Dev. 122 (2001) 1639-1649
27. Longtine M.S., McKenzie III A., Demarini D.J., Shah N.G., Wach A., Brachat A., Philippsen P., and Pringle J.R. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14 (1998) 953-961
28. Madeo F., Herker E., Wissing S., Jungwirth H., Eisenberg T., and Frohlich K.U. Apoptosis in yeast. Curr. Opin. Microbiol. 7 (2004) 655-660
29. Marsh J.L., and Thompson L.M. Can flies help humans treat neurodegenerative diseases?. Bioessays 26 (2004) 485-496
30. McLean P.J., Kawamata H., and Hyman B.T. Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience 104 (2001) 901-912
31. Meriin A.B., Zhang X., He X., Newnam G.P., Chernoff Y.O., and Sherman M.Y. Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J. Cell Biol. 157 (2002) 997-1004
32. Muchowski P.J., Schaffar G., Sittler A., Wanker E.E., Hayer-Hartl M.K., and Hartl F.U. Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc. Natl. Acad. Sci. USA 97 (2000) 7841-7846
33. Mumberg D., Muller R., and Funk M. Regulatable promoters of Saccharomyces cerevisiae: Comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res. 22 (1994) 5767-5768
34. Mumberg D., Muller R., and Funk M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156 (1995) 119-122
35. Nurse P.M. Nobel Lecture. Cyclin dependent kinases and cell cycle control. Biosci. Rep. 22 (2002) 487-499
36. Outeiro T.F., and Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302 (2003) 1772-1775
37. Outeiro T.F., and Muchowski P.J. Molecular genetics approaches in yeast to study amyloid diseases. J. Mol. Neurosci. 23 (2004) 49-60
38. Pan X., Yuan D.S., Xiang D., Wang X., Sookhai-Mahadeo S., Bader J.S., Hieter P., Spencer F., and Boeke J.D. A robust toolkit for functional profiling of the yeast genome. Mol. Cell. 16 (2004) 487-496
39. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., and Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
40. Puccio H., and Koenig M. Recent advances in the molecular pathogenesis of Friedreich ataxia. Hum. Mol. Genet. 9 (2000) 887-892
41. Reid R.J., Lisby M., and Rothstein R. Cloning-free genome alterations in Saccharomyces cerevisiae using adaptamer-mediated PCR. Methods Enzymol. 350 (2002) 258-277
42. Rine J. Gene overexpression in studies of Saccharomyces cerevisiae. Methods Enzymol. 194 (1991) 239-251
43. Rothstein R. Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast. Methods Enzymol. 194 (1991) 281-301
44. Schneider J.C., and Guarente L. Vectors for expression of cloned genes in yeast: Regulation, overproduction, and underproduction. Methods Enzymol. 194 (1991) 373-388
45. Schwikowski B., Uetz P., and Fields S. A network of protein-protein interactions in yeast. Nat. Biotechnol. 18 (2000) 1257-1261
46. Sherman M.Y., and Muchowski P.J. Making yeast tremble: Yeast models as tools to study neurodegenerative disorders. Neuromolecular Med. 4 (2003) 133-146
47. Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., and Gwinn-Hardy K. alpha-Synuclein locus triplication causes Parkinson's disease. Science 302 (2003) 841
48. Tong A.H., Evangelista M., Parsons A.B., Xu H., Bader G.D., Page N., Robinson M., Raghibizadeh S., Hogue C.W., Bussey H., Andrews B., Tyers M., and Boone C. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294 (2001) 2364-2368
49. Uetz P., Giot L., Cagney G., Mansfield T.A., Judson R.S., Knight J.R., Lockshon D., Narayan V., Srinivasan M., Pochart P., Qureshi-Emili A., Li Y., Godwin B., Conover D., Kalbfleisch T., Vijayadamodar G., Yang M., Johnston M., Fields S., and Rothberg J.M. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403 (2000) 623-627
50. Uptain S.M., and Lindquist S. Prions as protein-based genetic elements. Annu. Rev. Microbiol. 56 (2002) 703-741
51. West Jr. R.W., Yocum R.R., and Ptashne M. Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: Location and function of the upstream activating sequence UASG. Mol. Cell. Biol. 4 (1984) 2467-2478
52. Willingham S., Outeiro T.F., DeVit M.J., Lindquist S.L., and Muchowski P.J. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 302 (2003) 1769-1772
53. Winzeler E.A., Shoemaker D.D., Astromoff A., Liang H., Anderson K., Andre B., Bangham R., Benito R., Boeke J.D., Bussey H., Chu A.M., Connelly C., Davis K., Dietrich F., Dow S.W., El Bakkoury M., Foury F., Friend S.H., Gentalen E., Giaever G., Hegemann J.H., Jones T., Laub M., Liao H., Licbundguth N., Lockhart D.J., Lucau-Danila A., Lussier M., M'Rabet N., Menard P., Mittmann M., Pai C., Rebischung C., Revuelta J.L., Riles L., Roberts C.J., Ross-MacDonald P., Scherens B., Snyder M., Sookhai-Mahadeo S., Storms R.K., Veronneau S., Voet M., Volckaert G., Ward T.R., Wysocki R., Yen G.S., Yu K., Zimmermann K., Philippsen P., Johnston M., and Davis R.W. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285 (1999) 901-906
54. Zhang X., Smith D.L., Meriin A.B., Engemann S., Russel D.E., Roark M., Washington S.L., Maxwell M.M., Marsh J.L., Thompson L.M., Wanker E.E., Young A.B., Housman D.E., Bates G.P., Sherman M.Y., and Kazantsev A.G. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc. Natl. Acad. Sci. USA 102 (2005) 892-897