Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2′-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs

Molecular Cancer Therapeutics

Volumn 8, Issue 7, 2009, Pages 2015-2026

  Preston, Thomas J ^a   Henderson, Jeffrey T ^a   McCallum, Gordon P ^a   Wells, Peter G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDRO 8 OXO 2' DEOXYGUANOSINE; ALPHA OXOGUANINE GLYCOSYLASE 1; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CELL NUCLEUS DNA; CISPLATIN; FORMAMIDOPYRIMIDINE GLYCOSYLASE; MENADIONE; MITOCHONDRIAL DNA; OXALIPLATIN; PLATINUM DERIVATIVE; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALPHA OGG1 GENE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL GENE; CANCER THERAPY; CELL CLONE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; DRUG EFFICACY; DRUG RESPONSE; EMBRYO CELL; ESCHERICHIA COLI; EXCISION REPAIR; FPG GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIFIBRINOLYTIC AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL PROLIFERATION; CELLS, CULTURED; CISPLATIN; DEOXYGUANOSINE; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ESCHERICHIA COLI PROTEINS; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; IMMUNOENZYME TECHNIQUES; KIDNEY; ORGANOPLATINUM COMPOUNDS; OXIDANTS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; VITAMIN K 3;

EID: 61349196954     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0929     Document Type: Article

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