Case study: An evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action

Toxicological Sciences

Volumn 108, Issue 1, 2009, Pages 59-68

  Yamada, Tomoya ^a   Uwagawa, Satoshi ^a   Okuno, Yasuyoshi ^a   Cohen, Samuel M ^b   Kaneko, Hideo ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

^b NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Chemical carcinogenesis; Conceptual framework; Dose response relationships; Phenobarbital; Risk assessment

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B; DNA; METOFLUTHRIN; PHENOBARBITAL; PYRETHROID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; ENZYME INDUCTION; FEMALE; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER HYPERTROPHY; LIVER TUMOR; LIVER WEIGHT; MALE; NONHUMAN; RAT; SMOOTH ENDOPLASMIC RETICULUM;

ANIMALS; CELL PROLIFERATION; CYCLOPROPANES; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUOROBENZENES; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; ORGAN SIZE; PHENOBARBITAL; PYRETHRINS; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RISK ASSESSMENT; SPECIES SPECIFICITY; TIME FACTORS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 61349170756     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp007     Document Type: Article

References (45)

1. Boobis, A. R., Cohen, S. M., Dellarco, V., McGregor, D., Meek, M. E., Vickers, C., Willcocks, D., and Farland, W. (2006). IPCS framework for analyzing the relevance of a cancer mode of action for humans. Crit. Rev. Toxicol. 36, 781-792.
2. Capen, C. C. (2001). Toxic responses of the endocrine system. In Toxicology: The Basic Science of Poisons, 6th edn (C. D. Klaassen, Ed.), pp. 711-759. McGraw Hill, New York.
3. Caplen, N. J., Parrish, S., Imani, F., Fire, A., and Morgan, R. A. (2001). Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl. Acad. Sci. U. S. A. 98, 9742-9747.
4. Cohen, S. M., and Ellwein, L. B. (1990). Cell proliferation in carcinogenesis. Science 249, 1007-1011.
5. Cohen, S. M., and Ellwein, L. B. (1991). Genetic errors, cell proliferation, and carcinogenesis. Cancer Res. 51, 6493-6505.
6. Cohen, S. M., Klaunig, J., Meek, M. E., Hill, R. N., Pastoor, T., Lehman-McKeeman, L., Bucher, J., Longfellow, D.-G., Seed, J., Dellarco, V., et al. (2004). Evaluating the human relevance of chemically induced animal tumours. Toxicol. Sci. 78, 181-186.
7. Deguchi, Y., Yamada, T., Hirose, Y., Nagahori, H., Kushida, M., Sumida, K., Sukata, T., Tomigahara, Y., Nishioka, K., Uwagawa, S., et al. (2009). Mode of action analysis for the synthetic pyrethroid Metofluthrin-induced rat liver tumors: Evidence for hepatic CYP2B induction and heparocyte proliferation. Toxicol. Sci. doi:10.1093/ toxsci/kfp006.
8. Dellarco, V. L., McGregor, D., Berry, S. C., Cohen, S. M., and Boobis, A. R. (2006). Thiazopyr and thyroid disruption: Case study within the context of the 2006 IPCS human relevance framework for analysis of a cancer mode of action. Crit. Rev. Toxicol. 36, 793-401.
9. Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., and Weber, K. (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498.
10. Ghadially, F. N. (1997). Endoplasmic reticulum. In Ultrastructural Pathology of the Cell and Matrix, 4th edn., pp. 433402. Butterworth-Heimemann, Boston, MA.
11. Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., and Driver, S. E. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.
12. Furukawa, S., Usuda, K., Fujieda, Y., Tamura, T., Miyamoto, Y., Hayashi, K., Ikeyama, S., Goryo, M., and Okada, K. (2000). Apoptosis and cell proliferation in rat hepatocytes induced by barbiturates. J. Vet. Med. Sci. 62, 23-28.
13. Gold, L. S., Manley, N. B., Slone, T. H., and Ward, J. M. (2001). Compendium of chemical carcinogens by target organ: Results of chronic bioassays in rats, mice, hamsters, dogs, and monkeys. Toxicol. Pathol. 29, 639-652.
14. Hasmall, S. C., and Roberts, R. A. (1999). The perturbation of apoptosis and mitosis by drugs and xenobiotics. Pharmacol. Ther. 82, 63-70.
15. Hirose, Y., Nagahori, H., Yamada, T., Deguchi, Y., Tomigahara, Y., Nishioka, K., Uwagawa, S., Kawamura, S., Isobe, N., Lake, B. G., et al. (2009). Comparison of the effects of the synthetic pyrethroid Metoifluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes. Toxicology. doi:10.1016/j.tox.2009.01.007.
16. Holsapple, M. P., Pitot, H. C., Cohen, S. H., Boobis, A. R., Klaunig, J. E., Pastoor, T., Dellarco, V. L., and Dragan, Y. P. (2006). Mode of action in relevance of rodent liver tumours to human cancer risk. Toxicol. Sci. 89, 51-56.
17. International Agency for Research on Cancer. (2001). Some thyrotropic agents. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 79. IARC Press, Lyon.
18. Jones. H. B., and Clarke, N. A. B. (1993). Assessment of the influence of subacute phenobarbitone administration on multi-tissue cell proliferation in the rat using bromodeoxyuridine immunocytochemistry. Arch. Toxicol. 67, 622-628.
19. Klaunig, J. E., and Kamendulis, L. M. (2004). The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 44, 239-267.
20. Kolaja, K. L., Stevenson, D. E., Johnson, J. T., Walburg, E. F., Jr., and Klaunig, J. E. (1996). Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats. Fundam. Appl. Toxicol. 29, 219-228.
21. Lubet, R. A., Nims, R. W., Ward, J. M., Rice, J. M., and Diwan, B. A. (1989). Induction of cytochrome P450b and it's relationship to liver tumor promotion. J. Am. Coll. Toxicol. 8, 259-268.
22. Lucas, J. R., Shono, Y., Iwasaki, T., Ishiwatari, T., Spero, N., and Berizon, G. (2007). U. S. Laboratory and field trials of Metolluthrin (sumione) emanators for reducing mosquito biting outdoors. J. Am. Mosq. Control Assoc. 23, 47-54.
23. McClain, R. M. (1994). Mechanistic consideration in the regulation and classification 4 chemical carcinogens. In Nutritional Toxicology (F. N. Kotsonis, M. Mackey, and J. Hjelle, Eds.), pp. 273-302. Raven Press, Ltd, New York.
24. McClain, R. M., Keller, D. K., Casciano, D., Fu, P., MacDonald, J., Popp, J., and Sagartz, J. (2001). Neonatal mouse model: Review of methods and results. Toxicol. Pathol. 29(Suppl.), 128-137.
25. Meek, M. E., Bucher, J. R., Cohen, S. M., Dellarco, V., Hill, R. N., Lehman-McKeeman, L. D., Longfellow, D. G., Pastoor, T., Seed, L, and Patton, D. E. (2003). A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 33, 591-653.
26. Moore, J. T., Moore, L. B., Maglich, J. M., and Kliewer, S. A. (2003). Functional and structural comparison of PXR and CAR. Biochim. Biophys. Acta 1619, 235-238.
27. Neveau, M. L., Hully, J. R., Paul, D. L., and Pitot, H. C. (1990). Reversible alteration in the expression of the gap junctional protein connexion 32 during tumor promotion in the rat liver and its role during cell proliferation. Cancer Commun. 2, 21-31.
28. Olsen, J. H., Boice, J. D., Jr., Jensen, J. P., and Fraumeni, J. F., Jr. (1989). Cancer among epileptic patients exposed to anticonvulsant drugs. J. Natl. Cancer Inst. 81, 803-808.
29. Olsen, J. H., Schulgen, G., Boice, J. D., Jr., Whysner, J., Travis, L. B., Williams, G. M., Johnson, F. B., and McGee, J. O. (1995). Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma. Cancer Res. 55, 294-297.
30. Parzefall, W., Erber, E., Sedivy, R., and Schulte-Hermann, R. (1991). Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters. Cancer Res. 51, 1143-1147.
31. Pirttiaho, H. I., Sotaniemi, E. A., Pelkonen, R. O., and Pitkanen, U. (1982). Hepatic blood flow and drug, metabolism in patients on enzyme-inducing anticonvulsants. Eur. J. Clin. Pharmacol. 22 441-445.
32. Price, R. J., Giddings, A. M., Scott, M. P., Walters, D. G., and Capen, C. C. (2008). Effect of pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes. Toxicology 243, 84-95.
33. Pustylnyak, V. O., Lebedev, A. N., Gulyaeva, L. F., Lyakhovich, V. V., and Slynko, N. M. (2007). Comparative study of CYP2B induction in the liver of rats and mice by different compounds. Life Sci. 80, 324-328.
34. Qatanani, M., Zhang, J., and Moore, D. D. (ZO05). Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology 146, 995-1002.
35. Rice, J. M., Diwan,'B. A., Hu, H., Ward, J. M., Nims, R. W., and Lubet, R. A. (1994). Enhancement of hepatocarcinogenesis and induction of specific cytochrome P450-dependent monooxygenase activities by the barbiturates allobarbital, aprobarbital, pentobarbital, secobarbital and 5-phenyl- and 5-ethylbarbituric acids. Carcinogenesis 15, 395-402.
36. Ruch, R. J., and Klaunig, J. E. (1988). Kinetics of phenobarbital inhibition of intercellular communication in the mouse hepatocytes. Cancer Res. 48, 2519-2523.
37. Sipes, I. G., and Gandolfi, A. J. (1986). Biotransforniation of toxicants. In Toxicology: The Basic Science of Poisons (C. D. Klaassen, M. O. Amdur, and J. Doull, Eds.), pp. 64-98. Macmillan Publishing Company,New York.
38. Sonich-Mullin, C., Fielder, R., Wiltse, J., Baetcke, K., Dempsey, J., Fenner-Crisp, P., Grant, D., Hartley, M., Knaap, A., Kroese, D., et al. (2001). IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul. Toxicol. Pharmacol. 34, 146-152.
39. Sugatani, J., Kojima, H., Ueda, A., Kakizaki, S., Yoshinari, K., Gong, Q. H., Owens, I. S., Negishi, M., and Sueyoshi, T. (2001). The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33, 1232-1238.
40. Ueda, A., Hamadeh, H. K., Webb, H. K., Yamamoto, Y., Sueyoshi, T., Afshari, C. A., Lehmann, J. M., and Negishi, M. (2002). Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol. Pharmacol. 61, 1-6.
41. Ujihara, K., Mori, T., Iwasaki, T., Sugano, M., Shono, Y., and Matsuo, N. (2004). Metofluthrin: A potent new synthetic pyrethroid with high vapor activity against mosquitoes. Biosci. Biotechnol. Biochem. 68, 170-174.
42. Wei, P., Zliang, J., Elgan-Hafley, M., Liang-S., and Moore. D. D. (2000). The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407, 920-923.
43. Whysner, J., Ross, P. M., and Williams, G. M. (1996). Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol. Ther. 71, 153-191.
44. Yamamoto, Y., Moore, R., Goldsworthy, T. L., Negishi, M., and Maronpot, R. R. (2004). The orphan nuclear receptor constitutive active/ androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res. 64, 7197-7200.
45. Yoshinari, K., Sueyoshi, T., Moore, R., and Negishi, M. (2001). Nuclear receptor CAR as a regulatory factor for the sexually dimoriphic induction of CYB2B1 gene by phenobarbital in rat livers. Mol. Pharmacol. 59, 278-284.