Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1471-1476

  Sharma, Lisa ^a   Tsai, Yuan Chin ^b   Liu, Angela A ^b   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

5H Dibenzo c,h 1,6 naphthyridin 6 ones; Cytotoxicity; Multidrug resistance; Topoisomerase I targeting agents

Indexed keywords

2 (DIMETHYLAMINO) N [5 [2 (DIMETHYLAMINO]ETHYL] 2,3 METHYLENEDIOXY 6 OXO 5H 5,6 DIBENZO[C,H][1,6]NAPHTHYRIDIN 9 YL)ACETAMIDE; 5 (2 DIMETHYLAMINOETHYL) 9 (2 DIMETHYLETHYLAMINO) 2,3 METHYLENEDIOXY 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYL] 8 [2 (DIMETHYLAMINO)ETHYLAMINO] 2,3 METHYLENEDIOXY 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 5 BUTYL 2,3 DIMETHOXY 9 NITRO 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 5 BUTYL 8 [2 (DIMETHYLAMINO)ETHYLAMINO] 2,3 METHYLENEDIOXY 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 5 BUTYL 9 (2 DIMETHYLAMINOETHYLAMINO) 2,3 METHYLENEDIOXY 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 5H 2 (DIMETHYLAMINO) N [5 [2 (DIMETHYLAMINO]ETHYL] 2,3 METHYLENEDIOXY 6 OXO 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 8 YL)ACETAMIDE; 9 AMINO 5 BUTYL 2,3 DIMETHOXY 9 NITRO 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; CAMPTOTHECIN; CYTOTOXIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; N (5 BUTYL 2,3 METHYLENEDIOXY 6 OXO 5H DIBENZO[C,H]1,6]NAPHTHYRIDIN 8 YL) 2 (DIMETHYLAMINO)ACETAMIDE; N (5 BUTYL 2,3 METHYLENEDIOXY 6 OXO 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 9 YL) 2 (DIMETHYLAMINO)ACETAMIDE; NAPHTHYRIDINE DERIVATIVE; TOPOTECAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LEUKEMIA P 388; LYMPHOBLASTOMA; MOUSE; NONHUMAN;

CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; HUMANS; INHIBITORY CONCENTRATION 50; NAPHTHYRIDINES;

EID: 61349125497     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.048     Document Type: Article

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