Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N, N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Influence on topoisomerase I-targeting activity and cytotoxicity

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 13, 2004, Pages 3731-3742

  Ruchelman, Alexander L ^a   Kerrigan, John E ^b,c   Li, Tsai Kun ^b   Zhou, Nai ^b   Liu, Angela ^b   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,c,d  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 8,9 DIMETHOXY 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 2 AMINO 8,9 DIMETHOXY 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 3 AMINO 8,9 DIMETHOXY 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 4 AMINO 8,9 DIMETHOXY 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 5H 8,9 DIMETHOXY 5 (2 N,N DIMETHYLAMINOETHYL) 2,3 METHYLENEDIOXYDIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 1 NITRO 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2 NITRO 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 3 NITRO 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 4 NITRO 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; AMINE; CAMPTOTHECIN; CYTOTOXIC AGENT; DNA TOPOISOMERASE; IRINOTECAN; NITRO DERIVATIVE; TOPOTECAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN;

AMINATION; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA; DNA TOPOISOMERASES, TYPE I; ELECTROSTATICS; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NAPHTHYRIDINES; NITROGEN;

EID: 2942513563     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.076     Document Type: Article

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