Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1564-1568

  Sakamoto, Toshihiro ^a   Moriya, Minoru ^a   Haga, Yuji ^a   Takahashi, Toshiyuki ^a   Shibata, Takunobu ^a   Okamoto, Osamu ^a   Nonoshita, Katsumasa ^a   Kitazawa, Hidefumi ^a   Hidaka, Masayasu ^a   Gomori, Akira ^a   Iwaasa, Hisashi ^a   Ishihara, Akane ^a   Kanatani, Akio ^a   Fukami, Takehiro ^a   Gao, Ying Duo ^b   MacNeil, Douglas J ^b   Yang, Lihu ^b  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonist; Neuropeptide Y; NPY; Obesity; Y5 receptor

Indexed keywords

NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y5 RECEPTOR; SPIROINDOLINE 3,4' PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FOOD INTAKE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; AMINES; ANIMALS; BIOLOGICAL AVAILABILITY; BRAIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; INDOLES; INHIBITORY CONCENTRATION 50; ISOCYANATES; MODELS, CHEMICAL; PEPTIDE LIBRARY; RATS; RECEPTORS, NEUROPEPTIDE Y; UREA;

RATTUS;

EID: 61349115065     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.035     Document Type: Article

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