Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5517-5526

  Gillman, Kevin W ^a   Higgins, Mendi A ^a   Poindexter, Graham S ^a   Browning, Marc ^a   Clarke, Wendy J ^a   Flowers, Sharon ^a   Grace Jr , James E ^a   Hogan, John B ^a   McGovern, Rachel T ^a   Iben, Lawrence G ^a   Mattson, Gail K ^a   Ortiz, Astrid ^a   Rassnick, Stefanie ^a   Russell, John W ^a   Antal Zimanyi, Ildiko ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Brain penetrant; Imidazolone; NPY5; Obesity; Orally bioavailable

Indexed keywords

2 (3 AMINOPHENYL) 5,5 DIPHENYL 3,5 DIHYDROIMIDAZOL 4 ONE; 2 (3 PYRIDINYL) 3,5 DIHYDRO 5,5 DIPHENYL 4H IMIDAZOL 4 ONE; 2,5,5 TRIPHENYL 3,5 DIHYDROIMIDAZOL 4 ONE; IMIDAZOLE DERIVATIVE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y5 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; FOOD INTAKE; IC 50; MALE; NONHUMAN; OBESITY; RAT;

ANIMALS; ANTI-OBESITY AGENTS; EATING; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROPEPTIDE Y; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 33745599323     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.042     Document Type: Article

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