IL-10 gene modified dendritic cells inhibit T helper type 1-mediated alloimmune responses and promote immunological tolerance in diabetes

Cellular and Molecular Immunology

Volumn 5, Issue 1, 2008, Pages 41-46

  Zhu, Huifen ^a   Qiu, Wenhong ^a,b   Lei, Ping ^a   Zhou, Wei ^a   Wen, Xue ^a   He, Fengrong ^a   Li, Li ^a   Dai, Hong ^a   Shen, Guanxin ^a   Gong, Feili ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b JIANGHAN UNIVERSITY   (China)

Author keywords

dendritic cell; IDDM; IL 10; immune tolerance; islet transplantation

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4;

ALLOTRANSPLANTATION; ANIMAL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CELL PROLIFERATION; DENDRITIC CELL; GENETIC TRANSFECTION; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GRAFT REJECTION; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MOUSE; PANCREAS ISLET TRANSPLANTATION; TH1 CELL; TRANSPLANTATION TOLERANCE;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELL PROLIFERATION; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; GLUCOSE TOLERANCE TEST; GRAFT REJECTION; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TH1 CELLS; TRANSFECTION; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 47049114061     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2008.5     Document Type: Article

References (24)

1. Alvin CP. Diabetes mellitus, Harrisons principle of internal medicine, 16th. edition 2152.
2. Ryan EA, Lakey JR, Paty BW, et al. Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes. 2002;51:2148-2157. (Pubitemid 34729020)
3. Buonocore S, Flamand V, Goldman M, Braun MY. Bone marrow-derived immature dendritic cells prime in vivo alloreactive T cells for interleukin-4-dependent rejection of major histocompatibility complex class II antigen-disparate cardiac allograft. Transplantation. 2003;75:407-413. (Pubitemid 36222970)
4. Thomson AW, Lu L. Dendritic cells as regulators of immune reactivity: implications for transplantation. Transplantation. 1999; 68:1-8. (Pubitemid 29352820)
5. Yang SS, Li WM, Liu W, et al. IL-10 gene modified dendritic cells induced antigen-specific tolerance in experimental autoimmune myocarditis. Clin Immunol. 2006;121:63-73. (Pubitemid 44380417)
6. Newland A, Russ G, Krishnan R. Natural killer cells prime the responsiveness of autologous CD4+ T cells to CTLA4-Ig and interleukin-10 mediated inhibition in an allogeneic dendritic cell-mixed lymphocyte reaction. Immunology. 2006;118:216-223. (Pubitemid 43727426)
7. Li WM, Wei L, Cheng G, et al. Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats. Chin Med J (Engl). 2006;119:1646-1652.
8. Jia L, Kovacs JR, Zheng Y, et al. Attenuated alloreactivity of dendritic cells engineered with surface-modified microspheres carrying a plasmid encoding interleukin-10. Biomaterials. 2006; 27:2076-2082. (Pubitemid 41759502)
9. van Duivenvoorde LM, van Mierlo GJ, Boonman ZF, Toes RE. Dendritic cells: Vehicles for tolerance induction and prevention of autoimmune diseases. Immunobiology. 2006;211:627-632.
10. Rutella S, Danese S, Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood. 2006;108:1435-1440. (Pubitemid 44316106)
11. Gabra BH, Sirois P. Beneficial effect of chronic treatment with the selective bradykinin B1 receptor antagonists, R-715 and R-954, in attenuating streptozotocin-diabetic thermal hyperalgesia in mice. Peptides. 2003;24:1131-1139. (Pubitemid 37386299)
12. Salgame P, Varadhachary AS, Primiano LL, Fincke JE, Muller S, Monestier M. An ELISA for detection of apoptosis. Nucleic Acids Res. 1997;2:680-681. (Pubitemid 27298256)
13. Linetsky E, Bottino R, Lehmann R, Alejandro R, Inverardi L, Ricordi C. Improved human islet isolation using a new enzyme blend liberase. Diabetes. 1997;46:1120-1123. (Pubitemid 27271071)
14. Nyqvist D, Mattsson G, Köhler M, et al. Pancreatic islet function in a transgenic mouse expressing fluorescent protein. J Endocrinol. 2005;186:333-341. (Pubitemid 41167402)
15. Nyqvist D, Köhler M, Wahlstedt H, Berggren PO. Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts. Diabetes. 2005;54:2287-2293. (Pubitemid 41134254)
16. Seung E, Mordes JP, Greiner DL, Rossini AA. Induction of tolerance for islet transplantation for type 1 diabetes. Curr Diab Rep. 2003;3:329-335. (Pubitemid 38906790)
17. Gao W, Demirci G, Li XC. Negative T cell costimulation and islet tolerance. Diabetes Metab Res Rev. 2003;19:179-185. (Pubitemid 36675957)
18. Reijonen H, Mallone R, Heninger AK, et al. GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes. 2004; 53:1987-1994. (Pubitemid 38970746)
19. Marzorati S, Pileggi A, Ricordi C. Allogeneic islet transplantation. Expert Opin Biol Ther. 2007;7:1627-1645. (Pubitemid 350157492)
20. Zhu M, Wei MF, Liu F, Shi HF, Wang G, Chen S. Allogeneic T-cell apoptosis induced by interleukin-10-modified dendritic cells: A mechanism of prolongation of intestine allograft survival? Transplant Proc. 2004;36:2436-2437. (Pubitemid 39550866)
21. Sia C. Imbalance in Th cell polarization and its relevance in type 1 diabetes mellitus. Rev Diabet Stud. 2005;2:182-184.
22. Bykovskaia SN, Shurin GV, Graner S, et al. Differentiation of immunostimulatory stem cell and monocyte-derived dendritic cells involves maturation of intracellular compartments responsible for antigen presentation and secretion. Stem Cell. 2002;20:380-393.
23. Serreze DV, Chapman HD, Post CM, Johnson EA, Suarez- Pinzon WL, Rabinovitch A. Th1 to Th2 cytokine shifts in nonobese diabetic mice: Sometimes an outcome, rather than the cause, of diabetes resistance elicited by immuno-stimulation. J Immunol. 2001;166:1352-1359. (Pubitemid 32060298)
24. Furukawa H, Oshima K, Tung T, Cui G, Laks H, Sen L. Liposomemediated combinatorial cytokine gene therapy induces localized synergistic immunosuppression and promotes long-term survival of cardiac allografts. J Immunol. 2005;174:6983-6992. (Pubitemid 40705663)