Islet autoantibody development during follow-up of high-risk children from the general Norwegian population from three months of age: Design and early results from the MIDIA study

Journal of Autoimmunity

Volumn 29, Issue 1, 2007, Pages 44-51

  Stene, Lars C ^a,b   Witsø, Elisabet ^a   Torjesen, Peter A ^b,c   Rasmussen, Trond ^a   Magnus, Per ^a   Cinek, Ondrej ^d   Wetlesen, Turid ^a   Rønningen, Kjersti S ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c AKER UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

Author keywords

Autoimmunity; Prospective studies; Type 1 diabetes

Indexed keywords

ANTIGEN; AUTOANTIBODY; GLUTAMATE DECARBOXYLASE; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; INSULIN; RADIOISOTOPE;

ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; BLOOD SAMPLING; CONFIDENCE INTERVAL; FEMALE; FOLLOW UP; GENOTYPE; HETEROZYGOTE; HIGH RISK POPULATION; HLA SYSTEM; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INSULINOMA; MAJOR CLINICAL STUDY; MALE; NORWAY; PANCREAS ISLET; POPULATION RESEARCH; PRESCHOOL CHILD; PRIORITY JOURNAL; PROBABILITY; SEROCONVERSION;

AUTOANTIBODIES; DIABETES MELLITUS, TYPE 1; FEMALE; FOLLOW-UP STUDIES; HLA-D ANTIGENS; HUMANS; INFANT; INFANT, NEWBORN; ISLETS OF LANGERHANS; MALE; NORWAY; RISK;

EID: 34347353296     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2007.04.003     Document Type: Article

References (65)

1. Karvonen M., Viik-Kajander M., Moltchanova E., Libman I., LaPorte R., and Tuomilehto J. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 23 (2000) 1516-1526
2. Atkinson M.A., and Eisenbarth G.S. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358 (2001) 221-229
3. Atkinson M.A. ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?. Diabetes 54 (2005) 1253-1263
4. Diabetes Prevention Trial-Type 1 Diabetes Study Group. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 346 (2002) 1685-1691
5. European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 363 (2004) 925-931
6. The Diabetes Prevention Trial-Type 1 Study Group. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1. Diabetes Care 28 (2005) 1068-1076
7. Lernmark A. Series Introduction: Autoimmune diseases: are markers ready for prediction?. J Clin Invest 108 (2001) 1091-1096
8. Hoffenberg E.J., Bao F., Eisenbarth G.S., Uhlhorn C., Haas J.E., Sokol R.J., et al. Transglutaminase antibodies in children with a genetic risk for celiac disease. J Pediatr 137 (2000) 356-360
9. Arbuckle M.R., McClain M.T., Rubertone M.V., Scofield R.H., Dennis G.J., James J.A., et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349 (2003) 1526-1533
10. Wandstrat A.E., Carr-Johnson F., Branch V., Gray H., Fairhurst A.M., Reimold A., et al. Autoantibody profiling to identify individuals at risk for systemic lupus erythematosus. J Autoimmun 27 (2006) 153-160
11. Avouac J., Gossec L., and Dougados M. Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis 65 (2006) 845-851
12. Bingley P.J., Bonifacio E., Ziegler A.G., Schatz D.A., Atkinson M.A., and Eisenbarth G.S. Proposed guidelines on screening for risk of type 1 diabetes. Diabetes Care 24 (2001) 398
13. Achenbach P., Bonifacio E., Koczwara K., and Ziegler A.G. Natural history of type 1 diabetes. Diabetes 54 Suppl. 2 (2005) S25-S31
14. Rønningen K.S. Genetics in the prediction of insulin-dependent diabetes mellitus: from theory to practice. Ann Med 29 (1997) 387-392
15. Barker J.M., Barriga K.J., Yu L., Miao D., Erlich H.A., Norris J.M., et al. Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab 89 (2004) 3896-3902
16. Kimpimäki T., Kupila A., Hämäläinen A.M., Kukko M., Kulmala P., Savola K., et al. The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 86 (2001) 4782-4788
17. Cinek O., Wilkinson E., Paltiel L., Saugstad O.D., Magnus P., and Rønningen K.S. Screening for the IDDM high-risk genotype. A rapid microtitre plate method using serum as source of DNA. Tissue Antigens 56 (2000) 344-349
18. Lambert A.P., Gillespie K.M., Thomson G., Cordell H.J., Todd J.A., Gale E.A., et al. Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. J Clin Endocrinol Metab 89 (2004) 4037-4043
19. Ziegler A.G., Hummel M., Schenker M., and Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 48 (1999) 460-468
20. Colman P.G., Steele C., Couper J.J., Beresford S.J., Powell T., Kewming K., et al. Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody. Diabetologia 43 (2000) 203-209
21. Witsø E., Stene L.C., Paltiel L., Joner G., and Rønningen K.S. DNA extraction and HLA genotyping using mailed mouth brushes from children. Pediatr Diabetes 3 (2002) 89-94
22. Olerup O., Aldener A., and Fogdell A. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 h. Tissue Antigens 41 (1993) 119-134
23. Cinek O., Koloušková S., Šnajderová M., Šumník Z., Sedláková P., Drevínek P., et al. HLA class II genetic association of type 1 diabetes mellitus in Czech children. Pediatr Diabetes 2 (2001) 98-102
24. Cinek O., Raková K., Fuglesang O.A., and Rønningen K.S. Rapid HLA-DQ genotyping and HLA-DRB1*04 subtyping using real-time PCR with sequence specific primers. Pediatr Diabetes 7 Suppl. 5 (2006) 30-31 [Abstract]
25. Petersen J.S., Hejnæs K.R., Moody A., Karlsen A.E., Marshall M.O., Høier-Madsen M., et al. Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 43 (1994) 459-467
26. Yu L., Robles D.T., Abiru N., Kaur P., Rewers M., Kelemen K., et al. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci U S A 97 (2000) 1701-1706
27. Bingley P.J., Bonifacio E., and Mueller P.W. Diabetes Antibody Standardization Program: first assay proficiency evaluation. Diabetes 52 (2003) 1128-1136
28. Cinek O., Witsø E., Jeansson S., Rasmussen T., Drevinek P., Wetlesen T., et al. Longitudinal observation of enterovirus and adenovirus in stool samples from Norwegian infants with the highest genetic risk of type 1 diabetes. J Clin Virol 35 (2006) 33-40
29. Witsø E., Palacios G., Cinek O., Stene L.C., Grinde B., Janowicz D., et al. Natural circulation of human enteroviruses: high prevalence of human enterovirus A infections. J Clin Microbiol 44 (2006) 4095-4100
30. Witsø E., Palacios G., Rønningen K.S., Cinek O., Janowitz D., Rewers M., et al. Asymptomatic circulation of HEV71 in Norway. Virus Res 123 (2007) 19-29
31. Magnus P., Irgens L.M., Haug K., Nystad W., Skjaerven R., and Stoltenberg C. Cohort profile: The Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol 35 (2006) 1146-1150
32. Rønningen K.S., Paltiel L., Meltzer H.M., Nordhagen R., Lie K.K., Hovengen R., et al. The biobank of the Norwegian mother and child cohort study: a resource for the next 100 years. Eur J Epidemiol 21 (2006) 619-625
33. Franke B., Galloway T.S., and Wilkin T.J. Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies. Diabetes Metab Res Rev 21 (2005) 395-415
34. Bonifacio E., Hummel M., Walter M., Schmid S., and Ziegler A.G. IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes. Diabetes Care 27 (2004) 2695-2700
35. Aly T.A., Ide A., Jahromi M.M., Barker J.M., Fernando M.S., Babu S.R., et al. Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A 103 (2006) 14074-14079
36. Tait K.F., Marshall T., Berman J., Carr-Smith J., Rowe B., Todd J.A., et al. Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository. Diabet Med 21 (2004) 358-362
37. Anaya J.M., Castiblanco J., Tobón G.J., García J., Abad V., Cuervo H., et al. Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus. J Autoimmun 26 (2006) 208-214
38. Bingley P.J., Bonifacio E., Williams A.J., Genovese S., Bottazzo G.F., and Gale E.A. Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes 46 (1997) 1701-1710
39. Bingley P.J., Williams A.J.K., and Gale E.A.M. Optimized autoantibody-based risk assessment in family members. Implications for future interventions trials. Diabetes Care 22 (1999) 1796-1801
40. Achenbach P., Warncke K., Reiter J., Naserke H.E., Williams A.J., Bingley P.J., et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 53 (2004) 384-392
41. Pugliese A., and Miceli D. The insulin gene in diabetes. Diabetes Metab Res Rev 18 (2002) 13-25
42. Barratt B.J., Payne F., Lowe C.E., Hermann R., Healy B.C., Harold D., et al. Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes 53 (2004) 1884-1889
43. Ueda H., Howson J.M., Esposito L., Heward J., Snook H., Chamberlain G., et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423 (2003) 506-511
44. Bottini N., Musumeci L., Alonso A., Rahmouni S., Nika K., Rostamkhani M., et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 36 (2004) 337-338
45. Smyth D., Cooper J.D., Collins J.E., Heward J.M., Franklyn J.A., Howson J.M., et al. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53 (2004) 3020-3023
46. Janssens A.C., Pardo M.C., Steyerberg E.W., and van Duijn C.M. Revisiting the clinical validity of multiplex genetic testing in complex diseases (Letter). Am J Hum Genet 74 (2004) 585-588
47. Rewers M., Bugawan T.L., Norris J.M., Blair A., Beaty B., Hoffman M., et al. Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia 39 (1996) 807-812
48. Kupila A., Muona P., Simell T., Arvilommi P., Savolainen H., Hämäläinen A.M., et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 44 (2001) 290-297
49. Undlien D.E., Friede T., Rammensee H.-G., Joner G., Dahl-Jørgensen K., Søvik O., et al. HLA-encoded genetic predisposition in IDDM. DR4 subtypes may be associated with different degrees of protection. Diabetes 46 (1997) 143-149
50. Joner G., Stene L.C., Njølstad P.R., and Søvik O. The Norwegian Childhood Diabetes Study Group. Marked jump in incidence of childhood onset diabetes in Norway after ten years of stable incidence: prospective nationwide study 1999-2003 (Abstract). Diabetologia 48 Suppl. 1 (2005) A103
51. Aamodt G., Stene L.C., Njølstad P.R., Søvik O., and Joner G. The Norwegian Childhood Diabetes Study Group. Spatiotemporal trends and age-period-cohort modeling of the incidence of type 1 diabetes among children aged <15 years in Norway 1973-1982 and 1989-2003. Diabetes Care 30 (2007) 884-889
52. Awdeh Z.L., Yunis E.J., Audeh M.J., Fici D., Pugliese A., Larsen C.E., et al. A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease. J Autoimmun 27 (2006) 174-181
53. Leslie D.G., and Elliott R.B. Early environmental events as a cause of IDDM. Diabetes 43 (1994) 843-850
54. Knip M., Veijola R., Virtanen S.M., Hyöty H., Vaarala O., and Åkerblom H.K. Environmental triggers and determinants of type 1 diabetes. Diabetes 54 Suppl. 2 (2005) S125-S136
55. Undlien D.E., Lie B.A., and Thorsby E. HLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved?. Trends Genet 17 (2001) 93-100
56. Sollid L.M., and Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 105 (1993) 910-922
57. Alper C.A., Husain Z., Larsen C.E., Dubey D.P., Stein R., Day C., et al. Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes. J Autoimmun 27 (2006) 89-95
58. Stene L.C., Barriga K., Norris J.M., Hoffman M., Klingensmith G., Erlich H.A., et al. Symptoms of common maternal infections in pregnancy and risk of islet autoimmunity in early childhood. Diabetes Care 26 (2003) 3136-3141
59. Virtanen S.M., Kenward M.G., Erkkola M., Kautiainen S., Kronberg-Kippila C., Hakulinen T., et al. Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes. Diabetologia 49 (2006) 1512-1521
60. Stene L.C., Barriga K., Hoffman M., Kean J., Klingensmith G., Norris J.M., et al. Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes 7 (2006) 247-253
61. Serreze D.V., Ottendorfer E.W., Ellis T.M., Gauntt C.J., and Atkinson M.A. Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets. Diabetes 49 (2000) 708-711
62. Dahlquist G. Can we slow the rising incidence of childhood-onset autoimmune diabetes? The overload hypothesis. Diabetologia 49 (2006) 20-24
63. Gale E.A. Spring harvest? Reflections on the rise of type 1 diabetes. Diabetologia (2005) 1-6
64. Stene L.C., Hyöty H., Oikarinen S., Barriga K., Norris J.M., Eisenbarth G.S., et al. Enteroviral RNA detected in children positive for islet autoantibodies predicts progression to type 1 diabetes: DAISY Study. Diabetes 55 Suppl. 1 (2006) A20 [Abstract]
65. von Herrath M.G., Fujinami R.S., and Whitton J.L. Microorganisms and autoimmunity: making the barren field fertile?. Nat Rev Microbiol 1 (2003) 151-157