Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells

Cancer Biology and Therapy

Volumn 6, Issue 10, 2007, Pages 1644-1648

  Jiang, Rongcai ^a,b   Choi, Woonyoung ^a   Hu, Limei ^a   Gerner, Eugene W ^c   Hamilton, Stanley R ^a   Zhang, Wei ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

DENSPM; Glioblastoma; mTOR; Polyamine

Indexed keywords

HYDROGEN PEROXIDE; INITIATION FACTOR 4B; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; N1,N11 DIETHYLNORSPERMINE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYAMINE; PROTEIN KINASE B; PROTEIN P70; TEMOZOLOMIDE; ANTINEOPLASTIC AGENT; CELL ADHESION MOLECULE; DRUG DERIVATIVE; N(1),N(11) DIETHYLNORSPERMINE; N(1),N(11)-DIETHYLNORSPERMINE; PROTEIN KINASE; SPERMINE; UNCLASSIFIED DRUG;

ANOIKIS; ARTICLE; CATABOLISM; CELL ADHESION; CELL DEATH; CELL GROWTH; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE ACTIVATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MICROTUBULE; OXIDATIVE STRESS; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ENZYMOLOGY; METABOLISM; NEOPLASM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; DOWN-REGULATION; GLIOBLASTOMA; HUMANS; HYDROGEN PEROXIDE; NEOPLASMS; POLYAMINES; PROTEIN KINASES; SPERMINE;

EID: 41649120239     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.10.4800     Document Type: Article

References (37)