Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells

Environmental and Molecular Mutagenesis

Volumn 50, Issue 2, 2009, Pages 134-144

  Keshava, Channa ^a,b   Divi, Rao L ^c   Einem, Tracey L ^c   Richardson, Diana L ^a   Leonard, Sarah L ^c   Keshava, Nagalakshmi ^b   Poirier, Miriam C ^c   Weston, Ainsley ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Chemiluminescence immunoassay; Chemoprevention; Chlorophyllin; Interferon; Microarray; NQO1; Polycyclic aromatic hydrocarbons

Indexed keywords

BENZO[A]PYRENE; CHLOROPHYLL; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ETHOXYRESORUFIN DEETHYLASE; INTERFERON; ANTIMUTAGENIC AGENT; BENZO(A)PYRENE DNA ADDUCT; BENZO(A)PYRENE-DNA ADDUCT; CHLOROPHYLLIDE; CYP1B1 PROTEIN, HUMAN; CYTOCHROME P450;

ARTICLE; BREAST EPITHELIUM; CELL ASSAY; CELL METABOLISM; CHEMOLUMINESCENCE; CHEMOPROPHYLAXIS; DNA ADDUCT; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENETICS; MAMMARY GLAND; METABOLISM;

ANTIMUTAGENIC AGENTS; BENZO(A)PYRENE; CELL SURVIVAL; CELLS, CULTURED; CHEMILUMINESCENT MEASUREMENTS; CHLOROPHYLLIDES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; MAMMARY GLANDS, HUMAN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 60849122597     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20449     Document Type: Article

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