Giacomo Castelvetro's salads. Anti-HER2 oncogene nutraceuticals since the 17th century?

Clinical and Translational Oncology

Volumn 10, Issue 1, 2008, Pages 30-34

  Colomer, Ramón ^a   Lupu, Ruth ^b   Papadimitropoulou, Adriana ^c   Vellón, Luciano ^d   Vázquez Martín, Alejandro ^e   Brunet, Joan ^e   Fernández Gutiérrez, Alberto ^f   Segura Carretero, Antonio ^f   Menéndez, Javier A ^e  

^a MD ANDERSON CANCER CENTER   (Spain)

^b NORTHWESTERN UNIVERSITY   (United States)

^c HELLENIC PASTEUR INSTITUTE   (Greece)

^d CIC BIOGUNE   (Spain)

^e HOSPITAL JOSEP TRUETA   (Spain)

^f UNIVERSITY OF GRANADA   (Spain)

Author keywords

Breast Cancer; HER2; Mediterranean Diet; Oleic Acid; Olive oil; Polyphenols

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MESSENGER RNA; NUTRACEUTICAL; OLEIC ACID; OLEUROPEIN; OLIVE OIL; PHENOL DERIVATIVE; POLYPHENOL; REACTIVE OXYGEN METABOLITE; TOCOPHEROL DERIVATIVE; TRANSCRIPTION FACTOR PEA3; VEGETABLE OIL;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BREAST CANCER; CANCER PREVENTION; FOOD COMPOSITION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HISTORY OF MEDICINE; HUMAN; MEDITERRANEAN DIET; NONHUMAN; NUTRIGENOMICS; ONCOGENE NEU; ORGANOLEPTIC PROPERTY; VEGETABLE; BREAST TUMOR; FEMALE; GENETICS; PROTO ONCOGENE; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; FEMALE; GENES, ERBB-2; GENES, TUMOR SUPPRESSOR; HUMANS; PLANT OILS; VEGETABLES;

EID: 43249128900     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-008-0151-7     Document Type: Article

References (34)

1. Castelvetro G (1989) The fruit, herbs & vegetables of Italy. Viking, London
2. Sant M, Allemani C, Sieri S et al (2007) Salad vegetables dietary pattern protects against HER-2-positive breast cancer: A prospective Italian study. Int J Cancer 121:911-914
3. Mariman EC (2006) Nutrigenomics and nutrigenetics: The 'omics' revolution in nutritional science. Biotechnol Appl Biochem 44:119-128
4. Ferguson LR (2006) Nutrigenomics: Integrating genomic approaches into nutrition research. Mol Diagn Ther 10:101-108
5. Tripathi YB, Tripathi P, Arjmandi BH (2005) Nutraceuticals and cancer management. Front Biosci 10:1607-1618
6. Yarden Y (2001) Biology of HER2 and its importance in breast cancer. Oncology 61[Suppl 2]:1-13
7. Nahta R, Yu D, Hung MC et al (2006) Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 3:269-280
8. Trichopoulou A, Lagiou P, Kuper H, Trichopoulos D (2000) Cancer and Mediterranean dietary traditions. Cancer Epidemiol Biomarkers Prev 9:869-873
9. Colomer R, Menendez JA (2006) Mediterranean diet, olive oil and cancer. Clin Transl Oncol 8:15-21
10. Escrich E, Solanas M, Moral R et al (2006) Are the olive oil and other dietary lipids related to cancer? Experimental evidence. Clin Transl Oncol 8:868-883
11. Owen RW, Giacosa A, Hull WE et al (2000) The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur J Cancer 36:1235-1247
12. Visioli F, Galli C (2000) Olive oil: More than just oleic acid. Am J Clin Nutr 72:853
13. Kraus MH, Popescu NC, Amsbaugh SC, King CR (1987) Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J 6:605-610
14. Hollywood DP, Hurst HC (1995) Targeting gene transcription: A new strategy to down-regulate c-erbB-2 expression in mammary carcinoma. Br J Cancer 71:753-757
15. Hurst HC (2001) Update on HER-2 as a target for cancer therapy: The ERBB2 promoter and its exploitation for cancer treatment. Breast Cancer Res 3:395-398
16. Menendez JA, Vellon L, Colomer R, Lupu R (2005) Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification. Ann Oncol 16:359-371
17. Nelson R (2005) Oleic acid suppresses overexpression of ERBB2 oncogene. Lancet Oncol 6:69
18. Menendez JA, Papadimitropoulou A, Vellon L, Lupu R (2006) A genomic explanation connecting "Mediterranean diet", olive oil and cancer: Oleic acid, the main monounsaturated Fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells. Eur J Cancer 42:2425-2432
19. Menendez JA, Lupu R (2006) Mediterranean dietary traditions for the molecular treatment of human cancer: Anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9). Curr Pharm Biotechnol 7:495-502
20. Menendez JA, Vazquez-Martin A, Colomer R et al (2007) Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer 7:80
21. Menendez JA, Ropero S, Lupu R, Colomer R (2004) Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells. Ann Oncol 15:1719-1721
22. Fogliano V, Sacchi R (2006) Oleocanthal in olive oil: Between myth and reality. Mol Nutr Food Res 50:5-6
23. Solanas M, Hurtado A, Costa I et al (2002) Effects of a high olive oil diet on the clinical behavior and histopathological features of rat DMBA-induced mammary tumors compared with a high corn oil diet. Int J Oncol 21:745-753
24. Moral R, Solanas M, Garcia G et al (2003) Modulation of EGFR and neu expression by n-6 and n-9 high-fat diets in experimental mammary adenocarcinomas. Oncol Rep 10:1417-1424
25. Sieri S, Krogh V, Pala V et al (2004) Dietary patterns and risk of breast cancer in the ORDET cohort. Cancer Epidemiol Biomarkers Prev 13:567-572
26. Haber B (1997) The Mediterranean diet: A view from history. Am J Clin Nutr 66[4 Suppl]:1053S-1057S
27. Bougnoux P, Giraudeau B, Couet C (2006) Diet, cancer, and the lipidome. Cancer Epidemiol Biomarkers Prev 15:416-421
28. Menendez JA, Vazquez-Martin A, Ropero S et al (2006) HER2 (erbB-2)-targeted effects of the ?-3 polyunsaturated fatty acid ?-linolenic acid (ALA; T8:3n-3) in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anto-HER2 cocktail". Clin Transl Oncol 8:812-820
29. Andrewes P, Busch JL, de Joode T et al (2003) Sensory properties of virgin olive oil polyphenols: Identification of deacetoxy-ligstroside aglycon as a key contributor to pungency. J Agric Food Chem 51:1415-1420
30. Beauchamp GK, Keast RS, Morel D et al (2005) Phytochemistry: ibuprofen-like activity in extravirgin olive oil. Nature 437:45-46
31. Mondello C, Guasconi V, Giulotto E, Nuzzo F (2002) Gamma-ray and hydrogen peroxide induction of gene amplification in hamster cells deficient in DNA double strand break repair. DNA Repair (Amst) 1:483-493
32. Borek C (2004) Dietary antioxidants and human cancer. Integr Cancer Ther 3:333-341
33. Kim YI (1999) Folate and carcinogenesis: Evidence, mechanisms, and implications. J Nutr Biochem 2:66-68
34. Way TD, Kao MC, Lin JK (2004) Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 279:4479-4489