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Volumn 79, Issue 1, 2009, Pages 63-68

Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats

Author keywords

Dual acting antidepressants; Enantiomers; Mirtazapine; Neuropathic pain

Indexed keywords

MIRTAZAPINE;

EID: 60549114392     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2008.12.015     Document Type: Article
Times cited : (6)

References (43)
  • 1
    • 38549169461 scopus 로고    scopus 로고
    • Mirtazapine decreases the pain feeling in healthy participants
    • Arnold P., Vuadens P., Kuntzer T., Gobelet C., and Deriaz O. Mirtazapine decreases the pain feeling in healthy participants. Clin. J. Pain 24 (2008) 116-119
    • (2008) Clin. J. Pain , vol.24 , pp. 116-119
    • Arnold, P.1    Vuadens, P.2    Kuntzer, T.3    Gobelet, C.4    Deriaz, O.5
  • 3
    • 0036948923 scopus 로고    scopus 로고
    • Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs
    • Baker G., and Prior T. Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs. Ann. Med. 34 7-8 (2002) 537-543
    • (2002) Ann. Med. , vol.34 , Issue.7-8 , pp. 537-543
    • Baker, G.1    Prior, T.2
  • 5
    • 2442717628 scopus 로고    scopus 로고
    • Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache
    • Bendtsen L., and Jensen R. Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. Neurology 62 (2004) 1706-1711
    • (2004) Neurology , vol.62 , pp. 1706-1711
    • Bendtsen, L.1    Jensen, R.2
  • 6
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett G., and Xie Y. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33 (1988) 87-107
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.1    Xie, Y.2
  • 7
    • 13444287930 scopus 로고    scopus 로고
    • Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain
    • Bomholt S.F., Mikkelsen J.D., and Blackburn-Munro G. Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology 48 (2005) 252-263
    • (2005) Neuropharmacology , vol.48 , pp. 252-263
    • Bomholt, S.F.1    Mikkelsen, J.D.2    Blackburn-Munro, G.3
  • 8
    • 15244361329 scopus 로고    scopus 로고
    • Spinal 5-HT1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats: effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT
    • Bonnefont J., Chapuy E., Clottes E., Alloui A., and Eschalier A. Spinal 5-HT1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats: effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT. Pain 114 (2005) 482-490
    • (2005) Pain , vol.114 , pp. 482-490
    • Bonnefont, J.1    Chapuy, E.2    Clottes, E.3    Alloui, A.4    Eschalier, A.5
  • 9
    • 0037096409 scopus 로고    scopus 로고
    • Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain
    • Burgess S.E., Gardell L.R., Ossipov M.H., Malan Jr. T.P., Vanderah T.W., Lai J., and Porreca F. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J. Neurosci. 22 (2002) 5129-5136
    • (2002) J. Neurosci. , vol.22 , pp. 5129-5136
    • Burgess, S.E.1    Gardell, L.R.2    Ossipov, M.H.3    Malan Jr., T.P.4    Vanderah, T.W.5    Lai, J.6    Porreca, F.7
  • 10
    • 0029888880 scopus 로고    scopus 로고
    • The pharmacologic profile of mirtazapine
    • de Boer T. The pharmacologic profile of mirtazapine. J. Clin. Psychiatry 57 Suppl. 4 (1996) 19-25
    • (1996) J. Clin. Psychiatry , vol.57 , Issue.SUPPL. 4 , pp. 19-25
    • de Boer, T.1
  • 11
    • 0023929271 scopus 로고
    • Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers
    • de Boer T., Maura G., Raiteri M., de Vos C.J., Wieringa J., and Pinder R.M. Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers. Neuropharmacology 27 (1988) 399-408
    • (1988) Neuropharmacology , vol.27 , pp. 399-408
    • de Boer, T.1    Maura, G.2    Raiteri, M.3    de Vos, C.J.4    Wieringa, J.5    Pinder, R.M.6
  • 14
    • 33644852975 scopus 로고    scopus 로고
    • Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats
    • Freynhagen R., Vogt J., Lipfert P., and Muth-Selbach U. Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats. Brain Res. Bull. 69 (2006) 168-173
    • (2006) Brain Res. Bull. , vol.69 , pp. 168-173
    • Freynhagen, R.1    Vogt, J.2    Lipfert, P.3    Muth-Selbach, U.4
  • 15
    • 0023837235 scopus 로고
    • Pharmacological evaluation of in vivo tests for alpha 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza-analog ORG 3770
    • Gower A., Broekkamp C., Rijk H., and Van Delft A. Pharmacological evaluation of in vivo tests for alpha 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza-analog ORG 3770. Arch. Int. Pharmacodyn. Ther. 291 (1988) 185-201
    • (1988) Arch. Int. Pharmacodyn. Ther. , vol.291 , pp. 185-201
    • Gower, A.1    Broekkamp, C.2    Rijk, H.3    Van Delft, A.4
  • 16
    • 0023924046 scopus 로고
    • A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
    • Hargreaves K., Dubner R., Brown F., Flores C., and Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32 (1988) 77-88
    • (1988) Pain , vol.32 , pp. 77-88
    • Hargreaves, K.1    Dubner, R.2    Brown, F.3    Flores, C.4    Joris, J.5
  • 17
    • 6244309292 scopus 로고    scopus 로고
    • Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats
    • Iyengar S., Webster A.A., Hemrick-Luecke S.K., Xu J.Y., and Simmons R.M.A. Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats. J. Pharmacol. Exp. Ther. 311 (2004) 576-584
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , pp. 576-584
    • Iyengar, S.1    Webster, A.A.2    Hemrick-Luecke, S.K.3    Xu, J.Y.4    Simmons, R.M.A.5
  • 18
    • 33750812245 scopus 로고    scopus 로고
    • Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition
    • Jones C.K., Eastwood B.J., Need A.B., and Shannon H.E. Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition. Neuropharmacology 51 (2006) 1172-1180
    • (2006) Neuropharmacology , vol.51 , pp. 1172-1180
    • Jones, C.K.1    Eastwood, B.J.2    Need, A.B.3    Shannon, H.E.4
  • 19
    • 34347215896 scopus 로고    scopus 로고
    • Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice
    • Kayser V., Elfassi I.E., Aubel B., Melfort M., Julius D., Gingrich J.A., Hamon M., and Bourgoin S. Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain 130 (2007) 235-248
    • (2007) Pain , vol.130 , pp. 235-248
    • Kayser, V.1    Elfassi, I.E.2    Aubel, B.3    Melfort, M.4    Julius, D.5    Gingrich, J.A.6    Hamon, M.7    Bourgoin, S.8
  • 20
    • 0028244829 scopus 로고
    • Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells
    • Kooyman A.R., Zwart R., Vanderheijden P.M.L., Van Hooft J.A., and Vijverberg H.P.M. Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 33 (1994) 501-507
    • (1994) Neuropharmacology , vol.33 , pp. 501-507
    • Kooyman, A.R.1    Zwart, R.2    Vanderheijden, P.M.L.3    Van Hooft, J.A.4    Vijverberg, H.P.M.5
  • 21
    • 33847102344 scopus 로고    scopus 로고
    • Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain
    • Leventhal L., Smith V., Hornby G., Andree T.H., Brandt M.R., and Rogers K.E. Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain. J. Pharmacol. Exp. Ther. 320 (2007) 1178-1185
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , pp. 1178-1185
    • Leventhal, L.1    Smith, V.2    Hornby, G.3    Andree, T.H.4    Brandt, M.R.5    Rogers, K.E.6
  • 22
    • 34347250846 scopus 로고    scopus 로고
    • Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat
    • Lu Y., and Perl E.R. Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat. J. Physiol. 582 (2007) 127-136
    • (2007) J. Physiol. , vol.582 , pp. 127-136
    • Lu, Y.1    Perl, E.R.2
  • 23
    • 0031785813 scopus 로고    scopus 로고
    • Neurochemical effects of the enantiomers of mirtazapine in normal rats
    • McGrath C., Burrows G., and Norman T. Neurochemical effects of the enantiomers of mirtazapine in normal rats. Eur. J. Pharmacol. 356 2-3 (1998) 121-126
    • (1998) Eur. J. Pharmacol. , vol.356 , Issue.2-3 , pp. 121-126
    • McGrath, C.1    Burrows, G.2    Norman, T.3
  • 26
    • 0036257715 scopus 로고    scopus 로고
    • Antinociceptive role of 5-HT1A receptors in rat spinal cord
    • Nadeson R., and Goodchild C.S. Antinociceptive role of 5-HT1A receptors in rat spinal cord. Br. J. Anaesth. 88 (2002) 679-684
    • (2002) Br. J. Anaesth. , vol.88 , pp. 679-684
    • Nadeson, R.1    Goodchild, C.S.2
  • 27
    • 24144463970 scopus 로고    scopus 로고
    • Contribution of the peripheral 5-HT2A receptor to mechanical hyperalgesia in a rat model of neuropathic pain
    • Nitanda A., Yasunami N., Tokumo K., Fujii H., Hirai T., and Nishio H. Contribution of the peripheral 5-HT2A receptor to mechanical hyperalgesia in a rat model of neuropathic pain. Neurochem. Int. 47 (2005) 394-400
    • (2005) Neurochem. Int. , vol.47 , pp. 394-400
    • Nitanda, A.1    Yasunami, N.2    Tokumo, K.3    Fujii, H.4    Hirai, T.5    Nishio, H.6
  • 28
    • 17744394535 scopus 로고    scopus 로고
    • The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain
    • Obata H., Saito S., Koizuka S., Nishikawa K., and Goto F. The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain. Anesth. Analg. 100 (2005) 1406-1410
    • (2005) Anesth. Analg. , vol.100 , pp. 1406-1410
    • Obata, H.1    Saito, S.2    Koizuka, S.3    Nishikawa, K.4    Goto, F.5
  • 29
    • 26844512967 scopus 로고    scopus 로고
    • Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain
    • Pedersen L., Nielsen A., and Blackburn-Munro G. Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. Psychopharmacology 182 (2005) 551-561
    • (2005) Psychopharmacology , vol.182 , pp. 551-561
    • Pedersen, L.1    Nielsen, A.2    Blackburn-Munro, G.3
  • 30
    • 44849095212 scopus 로고    scopus 로고
    • Dual influence of the striatum on neuropathic hypersensitivity
    • Pertovaara A., and Wei H. Dual influence of the striatum on neuropathic hypersensitivity. Pain 137 (2008) 50-59
    • (2008) Pain , vol.137 , pp. 50-59
    • Pertovaara, A.1    Wei, H.2
  • 31
    • 0037318162 scopus 로고    scopus 로고
    • Antidepressants for chronic neuropathic pain
    • Reisner L. Antidepressants for chronic neuropathic pain. Curr. Pain Headache Rep. 7 (2003) 24-33
    • (2003) Curr. Pain Headache Rep. , vol.7 , pp. 24-33
    • Reisner, L.1
  • 32
    • 0036844495 scopus 로고    scopus 로고
    • Descending modulation in persistent pain: an update
    • Ren K., and Dubner R. Descending modulation in persistent pain: an update. Pain 100 (2002) 1-6
    • (2002) Pain , vol.100 , pp. 1-6
    • Ren, K.1    Dubner, R.2
  • 34
    • 0036193943 scopus 로고    scopus 로고
    • Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects-a possible opioid involvement in severe depression?
    • Schreiber S., Bleich A., and Pick C. Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects-a possible opioid involvement in severe depression?. J. Mol. Neurosci. 18 1-2 (2002) 143-149
    • (2002) J. Mol. Neurosci. , vol.18 , Issue.1-2 , pp. 143-149
    • Schreiber, S.1    Bleich, A.2    Pick, C.3
  • 35
    • 0037201092 scopus 로고    scopus 로고
    • The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms
    • Schreiber S., Rigai T., Katz Y., and Pick C.G. The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms. Brain Res. Bull. 58 (2002) 601-605
    • (2002) Brain Res. Bull. , vol.58 , pp. 601-605
    • Schreiber, S.1    Rigai, T.2    Katz, Y.3    Pick, C.G.4
  • 38
    • 18144372418 scopus 로고    scopus 로고
    • Mirtazapine: a review of its clinical efficacy and tolerability
    • Szegedi A., and Schwertfeger N. Mirtazapine: a review of its clinical efficacy and tolerability. Exp. Opin. Pharmacother. 6 (2005) 631-641
    • (2005) Exp. Opin. Pharmacother. , vol.6 , pp. 631-641
    • Szegedi, A.1    Schwertfeger, N.2
  • 39
    • 0036234494 scopus 로고    scopus 로고
    • An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms
    • Theobald D.E., Kirsh K.L., Holtsclaw E., Donaghy K., and Passik S.D. An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms. J. Pain Symptom Manage. 23 (2002) 442-447
    • (2002) J. Pain Symptom Manage. , vol.23 , pp. 442-447
    • Theobald, D.E.1    Kirsh, K.L.2    Holtsclaw, E.3    Donaghy, K.4    Passik, S.D.5
  • 41
    • 37049002643 scopus 로고    scopus 로고
    • Descending control of spinal nociception from the periaqueductal grey distinguishes between neurons with and without C-fibre inputs
    • Waters A.J., and Lumb B.M. Descending control of spinal nociception from the periaqueductal grey distinguishes between neurons with and without C-fibre inputs. Pain 134 (2008) 32-40
    • (2008) Pain , vol.134 , pp. 32-40
    • Waters, A.J.1    Lumb, B.M.2
  • 42
    • 33745305708 scopus 로고    scopus 로고
    • Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord
    • Yoshimura M., and Furue H. Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord. J. Pharmacol. Sci. 101 (2006) 107-117
    • (2006) J. Pharmacol. Sci. , vol.101 , pp. 107-117
    • Yoshimura, M.1    Furue, H.2
  • 43
    • 39149085669 scopus 로고    scopus 로고
    • Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-[kappa]B in a rat model of neuropathic pain
    • Zhu J., Wei X., Feng X., Song J., Hu Y., and Xu J. Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-[kappa]B in a rat model of neuropathic pain. Neurosci. Lett. 433 (2008) 33-37
    • (2008) Neurosci. Lett. , vol.433 , pp. 33-37
    • Zhu, J.1    Wei, X.2    Feng, X.3    Song, J.4    Hu, Y.5    Xu, J.6


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