Mirtazapine decreases the pain feeling in healthy participants

Clinical Journal of Pain

Volumn 24, Issue 2, 2008, Pages 116-119

  Arnold, Pierre ^a,b   Vuadens, Philippe ^a,b   Kuntzer, Thierry ^b   Gobelet, Charles ^a   Deriaz, Olivier ^a  

^a SUVA   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Antidepressant; Mirtazapine; Neuropathic; Nociceptive flexion reflex; Pain; Tricyclic

Indexed keywords

MIRTAZAPINE; PLACEBO;

ADULT; ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DYSPHAGIA; ELECTROSTIMULATION; FEMALE; FLEXOR REFLEX; HUMAN; MALE; NEUROPATHIC PAIN; NOCICEPTION; NOCICEPTIVE STIMULATION; NORMAL HUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; SINGLE DRUG DOSE; SYNCOPE; UNPLEASANT METALLIC TASTE; WEAKNESS; XEROSTOMIA;

ADULT; ANALGESICS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ELECTRIC STIMULATION; FEMALE; HUMANS; LEG; MALE; MIANSERIN; MIDDLE AGED; NEURALGIA; NOCICEPTORS; PAIN MEASUREMENT; PAIN THRESHOLD; PERIPHERAL NERVES; PERIPHERAL NERVOUS SYSTEM DISEASES; PLACEBO EFFECT; REACTION TIME; REFLEX; TREATMENT OUTCOME;

EID: 38549169461     PISSN: 07498047     EISSN: None     Source Type: Journal    
DOI: 10.1097/AJP.0b013e318159f94a     Document Type: Article

References (25)

1. McCleane G. Pharmacological strategies in relieving neuropathic pain. Expert Opin Pharmacother. 2004;5:1299-1312.
2. Jensen TS. Anticonvulsants in neuropathic pain: rationale and clinical evidence. Eur J Pain. 2002;6(suppl A):61-68.
3. McQuay HJ, Tramer M, Nye BA, et al. A systematic review of antidepressants in neuropathic pain. Pain. 1996;68:217-227.
4. Eisenberg E, McNicol ED, Carr DB. Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials. JAMA. 2005;293:3043-3052.
5. Mattia C, Paoletti F, Coluzzi F, et al. New antidepressants in the treatment of neuropathic pain. A review. Minerva Anestesiol. 2002;68:105-114.
6. Reisner L. Antidepressants for chronic neuropathic pain. Curr Pain Headache Rep. 2003;7:24-33.
7. Schreiber S, Bleich A, Pick CG. Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioidmediated antinociceptive effects - a possible opioid involvement in severe depression? J Mol Neurosci. 2002;18:143-149.
8. Montgomery SA. Safety of mirtazapine: a review. Int Clin Psychopharmacol. 1995;10(suppl 4):37-45.
9. Nelson JC. Safety and tolerability of the new antidepressants. J Clin Psychiatry. 1997;58(suppl 6):26-31.
10. Brannon GE, Stone KD. The use of mirtazapine in a patient with chronic pain. J Pain Symptom Manage. 1999;18:382-385.
11. Theobald DE, Kirsh KL, Holtsclaw E, et al. An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms. J Pain Symptom Manage. 2002;23:442-447.
12. Samborski W, Lezanska-Szpera M, Rybakowski JK. Effects of antidepressant mirtazapine on fibromyalgia symptoms. Rocz Akad Med Bialymst. 2004;49:265-269.
13. Bomholt SF, Mikkelsen JD, Blackburn-Munro G. Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology. 2005;48:252-263.
14. Galer BS, Jensen MP. Development and preliminary validation of a pain measure specific to neuropathic pain: the Neuropathic Pain Scale. Neurology. 1997;48:332-338.
15. Jensen MP, Turner JA, Romano JM, et al. Comparative reliability and validity of chronic pain intensity measures. Pain. 1999;83:157-162.
16. Melzack R. The short-form McGill Pain Questionnaire. Pain. 1987;30:191-197.
17. Scherrington CS. Flexion reflex of the limb, crossed extension reflex and reflex stepping and standing. J Physiol (London). 1910;40:28-121.
18. Kugelberg E, Eklund K, Grimby L. An electromyographic study of the nociceptive reflexes of the lower limb. Mechanism of the plantar responses. Brain. 1960;83:394-410.
19. Dowman R. A noninvasive strategy for identifying and quantifying innocuous and nociceptive peripheral afferent activity evoked by nerve stimulation. Physiol Behav. 1993;53:1163-1169.
20. Syrovegin AV, Kukushkin ML, Gnezdilov AV, et al. EMG responses in humans during painful heterosegmentary stimulation. Bull Exp Biol Med. 2000;130:1069-1073.
21. Skljarevski V, Ramadan NM. The nociceptive flexion reflex in humans: review article. Pain. 2002;96:3-8.
22. Willer JC. Clinical exploration of nociception with the use of reflexologic techniques. Neurophysiol Clin. 1990;20:335-356.
23. Coquoz D, Porchet HC, Dayer P. Central analgesic effects of desipramine, fluvoxamine, and moclobemide after single oral dosing: a study in healthy volunteers. Clin Pharmacol Ther. 1993;54:339-344.
24. Willer JC. Comparative study of perceived pain and nociceptive flexion reflex in man. Pain. 1977;3:69-80.
25. French DJ, France CR, France JL, et al. The influence of acute anxiety on assessment of nociceptive flexion reflex thresholds in healthy young adults. Pain. 2005;114:358-363.