Contribution of the peripheral 5-HT2A receptor to mechanical hyperalgesia in a rat model of neuropathic pain

Neurochemistry International

Volumn 47, Issue 6, 2005, Pages 394-400

  Nitanda, Aya ^a   Yasunami, Naho ^a   Tokumo, Kohji ^a   Fujii, Hiromitsu ^a   Hirai, Takao ^a   Nishio, Hiroaki ^a  

^a FUKUYAMA UNIVERSITY   (Japan)

Author keywords

5 HT2A receptor; Hyperalgesia; Neuropathic pain; Serotonin

Indexed keywords

KETANSERIN; METHYSERGIDE; PINDOLOL; SARPOGRELATE; SEROTONIN 2A RECEPTOR; SEROTONIN ANTAGONIST; TROPISETRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HINDLIMB; HYPERALGESIA; MALE; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; DENERVATION; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; HYPERALGESIA; KETANSERIN; LIGATION; MALE; NEURALGIA; PAIN THRESHOLD; PERIPHERAL NERVES; PERIPHERAL NERVOUS SYSTEM DISEASES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SENSORY; SCIATIC NEUROPATHY; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SUCCINATES;

EID: 24144463970     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2005.06.002     Document Type: Article

References (22)

1. N. Attal, F. Jazat, V. Kayser, and G. Guilbaud Further evidence for 'pain-related' behaviors in a model of unilateral peripheral mononeuropathy Pain 41 1990 235 251
2. G.J. Bennett, and Y.K. Xie A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man Pain 33 1988 87 107
3. F.G. Boess, and I.L. Martin Molecular biology of 5-HT receptors Neuropharmacology 33 1994 275 317
4. G. Catheline, V. Kayser, and G. Guilbaud Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: involvement of κ-, but not δ-opioid receptors Eur. J. Pharmacol. 315 1996 135 143
5. 2A receptor by site-directed mutagenesis: Inverse agonist activity of antipsychotic drugs J. Pharmacol. Exp. Ther. 286 1998 85 90
6. M.H. Hanna, and S.J. Peat Ketanserin in reflex sympathetic dystrophy. A double-blind placebo controlled cross-over trial Pain 38 1989 145 150
7. H. Hara, M. Osakabe, A. Kitajima, Y. Tamao, and R. Kikumoto MCI-9042, a new antiplatelet agent is a selective S2-serotonergic receptor antagonist Thromb. Haemost. 65 1991 415 420
8. 2-receptor antagonist ketanserin restores the 5-HT-induced contraction depressed by methysergide in large coronary arteries of calf Naunyn Schmiedebergs Arch. Pharmacol. 328 1985 295 300
9. R. Kikumoto, H. Hara, K. Ninomiya, M. Osakabe, M. Sugano, H. Fukami, and Y. Tamao Syntheses and platelet aggregation inhibitory and antithrombotic properties of [2-[ω-amino-alkoxy]phenylethyl]benzenes J. Med. Chem. 33 1990 1818 1823
10. + currents in dorsal root ganglion neurons from rats with a painful neuropathy Pain 81 1999 15 24
11. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
12. O. Magnusson, L.B. Nilsson, and D. Westerlund Simultaneous determination of dopamine. DOPAC and homovanillic acid J. Chromatogr. 221 1980 237 247
13. R. Nicholson, J. Small, A.K. Dixon, D. Spanswick, and K. Lee Serotonin receptor mRNA expression in rat dorsal root ganglion neurons Neurosci. Lett. 337 2003 119 122
14. H. Nishio, A. Inoue, and Y. Nakata Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes Arch. Int. Pharmacodyn. Ther. 331 1996 189 202
15. 2 receptor antagonist sarpogrelate reduces urinary and plasma levels of thromboxane A2 and urinary albumin excretion in non-insulin-dependent diabetes mellitus patients Clin. Exp. Pharmacol. Physiol. 26 1999 461 464
16. M.H. Ossipov, J. Lai, T.P. Malan, and F. Porreca Spinal and supraspinal mechanisms of neuropathic pain Ann. N.Y. Acad. Sci. 909 2000 12 24
17. T. Otake, H. Ieshima, H. Ishida, Y. Ushigome, and S. Saito Bone atrophy in complex regional pain syndrome patients measured by microdensitometry Can. J. Anaesth. 45 1998 831 838
18. 2A receptor specificity, steroselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery J. Pharm. Pharmacol. 47 1995 310 316
19. J. Sawynok, M.J. Esser, and A.R. Reid Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and naturopathic pain test in the rat Pain 82 1999 149 158
20. A. Slominski, A. Pisarchik, I. Semak, T. Sweatman, and J. Wortsman Charaterization of the serotoninergic system in the C57BL/6 mouse skin Eur. J. Biochem. 270 2003 3335 3344
21. T. Tanaka, M. Fujita, I. Nakae, S. Tamaki, K. Hasegawa, Y. Kihara, R. Nohara, and S. Sasayama Improvement of exercise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina J. Am. Coll. Cardiol. 32 1998 1982 1986
22. R.S. Westphal, and E. Sanders-Bush Reciprocal binding properties of 5-hydroxytryptamine type 2C receptor agonists and inverse agonists Mol. Pharmacol. 46 1994 937 942