Design, synthesis and biological evaluation of a novel class of anticancer agents: Anthracenylisoxazole lexitropsin conjugates

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 4, 2009, Pages 1671-1680

  Han, Xiaochun ^b   Li, Chun ^b   Mosher, Michael D ^a,b   Rider, Kevin C ^b   Zhou, Peiwen ^b,c   Crawford, Ronald L ^b   Fusco, William ^b   Paszczynski, Andrzej ^b   Natale, Nicholas R ^b  

^a UNIVERSITY OF NEBRASKA AT KEARNEY   (United States)

^b UNIVERSITY OF IDAHO   (United States)

^c AK Scientific Inc   (United States)

Author keywords

Anthracene; Anti tumor; G quadruplex; Isoxazole; Pyrrole

Indexed keywords

ANTHRACENE DERIVATIVE; ISOXAZOLE DERIVATIVE; LEXITROPSIN;

AMIDATION; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG DNA BINDING; DRUG DOSE COMPARISON; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SINGLE DRUG DOSE;

ANTHRACENES; ANTINEOPLASTIC AGENTS; AZOLES; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NETROPSIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60049090567     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.056     Document Type: Article

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