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Volumn 9, Issue 5, 1998, Pages 513-538

Sequence-specific DNA minor groove binders. Design and synthesis of netropsin and distamycin analogues

Author keywords

[No Author keywords available]

Indexed keywords

DISTAMYCIN; GROOVE BINDERS; MINOR GROOVES; NETROPSIN;

EID: 0032170961     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc980008m     Document Type: Review
Times cited : (291)

References (300)
  • 1
    • 0019364861 scopus 로고
    • DNA modification and cancer
    • Waring, M. J. (1981) DNA modification and cancer. Annu. Rev. Biochem. 50, 159.
    • (1981) Annu. Rev. Biochem. , vol.50 , pp. 159
    • Waring, M.J.1
  • 2
    • 0024463685 scopus 로고
    • DNA and associated targets for drug design
    • Hurley, L. H. (1989) DNA and associated targets for drug design. J. Med. Chem. 32, 2027.
    • (1989) J. Med. Chem. , vol.32 , pp. 2027
    • Hurley, L.H.1
  • 3
    • 0020394591 scopus 로고
    • Antibiotic-DNA interactions: Intermolecular nuclear overhauser effects in the netropsin-d(CGC-GAATTCGCG) complex in solution
    • Patel, D. J. (1982) Antibiotic-DNA interactions: intermolecular nuclear overhauser effects in the netropsin-d(CGC-GAATTCGCG) complex in solution. Proc. Natl. Acad Sci. U.S.A. 79, 6424.
    • (1982) Proc. Natl. Acad Sci. U.S.A. , vol.79 , pp. 6424
    • Patel, D.J.1
  • 6
    • 0023040893 scopus 로고
    • 1H NMR studies on the interaction between distamycin a and a symmetrical DNa dodecamer
    • 1H NMR studies on the interaction between distamycin A and a symmetrical DNA dodecamer. Biochemistry 25, 3296.
    • (1986) Biochemistry , vol.25 , pp. 3296
    • Klevit, R.E.1    Wemmer, D.E.2    Reid, B.R.3
  • 7
    • 0023494886 scopus 로고
    • A bifurcated hydrogen bonded conformation in the d(A.T) base pairs of the DNA dodecamer d(CGCAAATTTGCG) and its complex with distamycin
    • Coll, M., Frederick, C. A., Wang, A. H. J., and Rich, A. (1987) A bifurcated hydrogen bonded conformation in the d(A.T) base pairs of the DNA dodecamer d(CGCAAATTTGCG) and its complex with distamycin. Proc. Natl. Acad. Sci. U.S.A. 84, 8385.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 8385
    • Coll, M.1    Frederick, C.A.2    Wang, A.H.J.3    Rich, A.4
  • 8
    • 0024495831 scopus 로고
    • Molecular structure of the netropsin-d(CGCGATATCGCG) complex: DNA conformation in an alternating at segment
    • Coll, M., Aymami, J., van der Marel, G. A., van Boom, J. H., Rich, A., and Wang, A. H.-J. (1989) Molecular structure of the netropsin-d(CGCGATATCGCG) complex: DNA conformation in an alternating AT segment. Biochemistry 28, 310.
    • (1989) Biochemistry , vol.28 , pp. 310
    • Coll, M.1    Aymami, J.2    Van Der Marel, G.A.3    Van Boom, J.H.4    Rich, A.5    Wang, A.H.-J.6
  • 9
    • 0001015292 scopus 로고
    • Structural characterization of a 2:1 distamycin A·d(CGCAAATTGGC) complex by two-dimensional NMR
    • Pelton, J. G., and Wemmer, D. E. (1989) Structural characterization of a 2:1 distamycin A·d(CGCAAATTGGC) complex by two-dimensional NMR. Proc. Natl. Acad. Sci. U.S.A. 86, 5723.
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 5723
    • Pelton, J.G.1    Wemmer, D.E.2
  • 12
    • 0027219319 scopus 로고
    • Molecular structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor groove binding drug netropsin
    • Tabernero, L., Verdaguer, N., Coll, M., Fita, I., van der Marel, G. A., van Boom, J. H., Rich, A., and Aymami, J. (1993) Molecular structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor groove binding drug netropsin. Biochemistry 32, 8403.
    • (1993) Biochemistry , vol.32 , pp. 8403
    • Tabernero, L.1    Verdaguer, N.2    Coll, M.3    Fita, I.4    Van Der Marel, G.A.5    Van Boom, J.H.6    Rich, A.7    Aymami, J.8
  • 13
    • 0027280323 scopus 로고
    • NMR characterization of a heterocomplex formed by distamycin and its analog 2-ImD with d(CGCAAGTTGGC):d(GCCAACTTGCG): Preference for the 1:1:1 2-ImD:Dst:DNa complex over the 2:1 2-ImD:DNa and the 2:1 Dst:DNa complexes
    • Geierstanger B. H., Dwyer, T. J., Bathini, Y., Lown, J. W., and Wemmer, D. E. (1993) NMR characterization of a heterocomplex formed by distamycin and its analog 2-ImD with d(CGCAAGTTGGC):d(GCCAACTTGCG): Preference for the 1:1:1 2-ImD:Dst:DNA complex over the 2:1 2-ImD:DNA and the 2:1 Dst:DNA complexes. J. Am. Chem. Soc. 115, 4474.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 4474
    • Geierstanger, B.H.1    Dwyer, T.J.2    Bathini, Y.3    Lown, J.W.4    Wemmer, D.E.5
  • 14
    • 0028956354 scopus 로고
    • Refinement of netropsin bound to DNA: Bias and feedback in electron density map interpretation
    • Goodsell, D. S., Kopka, M. L., and Dickerson, R. E. (1995) Refinement of netropsin bound to DNA: Bias and feedback in electron density map interpretation. Biochemistry 34, 4983.
    • (1995) Biochemistry , vol.34 , pp. 4983
    • Goodsell, D.S.1    Kopka, M.L.2    Dickerson, R.E.3
  • 15
    • 0028402160 scopus 로고
    • Binding of two distamycin a molecules in the minor groove of an alternating B-DNa duplex
    • Chen, X., Ramakrishnan, B., Rao, S. T., and Sundaraligam, M. (1994) Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex. Struct. Biol. 1, 169.
    • (1994) Struct. Biol. , vol.1 , pp. 169
    • Chen, X.1    Ramakrishnan, B.2    Rao, S.T.3    Sundaraligam, M.4
  • 16
    • 0029375390 scopus 로고
    • Crystal structures of B-form DNA-RNA chimers complexed with distamycin
    • Chen, X., Ramakrishnan, B., and Sundaralingam, M. (1995) Crystal structures of B-form DNA-RNA chimers complexed with distamycin. Nat. Struct. Biol. 2, 733.
    • (1995) Nat. Struct. Biol. , vol.2 , pp. 733
    • Chen, X.1    Ramakrishnan, B.2    Sundaralingam, M.3
  • 17
    • 0031576986 scopus 로고    scopus 로고
    • Crystal structures of the side-by-side binding of distamycin to AT-containing DNA octamers d(ICITACIC) and d(ICATATIC)
    • Chen, X., Ramakrishnan, B., and Sundaralingam, M. (1997) Crystal structures of the side-by-side binding of distamycin to AT-containing DNA octamers d(ICITACIC) and d(ICATATIC). J. Mol. Biol. 267, 1157.
    • (1997) J. Mol. Biol. , vol.267 , pp. 1157
    • Chen, X.1    Ramakrishnan, B.2    Sundaralingam, M.3
  • 19
    • 0031424230 scopus 로고    scopus 로고
    • Crystallographic insights into DNA minor groove recognition by drugs
    • Neidle, S. N. (1997) Crystallographic insights into DNA minor groove recognition by drugs. Biopolymers 44, 105.
    • (1997) Biopolymers , vol.44 , pp. 105
    • Neidle, S.N.1
  • 20
    • 0000524403 scopus 로고
    • Map of distamycin, netropsin and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA·Fe(II)
    • Van Dyke, M. W., Hertzberg, R. P., and Dervan, P. B. (1983) Map of distamycin, netropsin and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA·Fe(II). Proc. Natl. Acad. Sci. U.S.A. 79, 5470.
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 5470
    • Van Dyke, M.W.1    Hertzberg, R.P.2    Dervan, P.B.3
  • 21
    • 0023177036 scopus 로고
    • Comparison of binding sites in DNa for berenil, netropsin and distamycin. a footprinting study
    • Portugal, J., and Waring, M. J. (1987) Comparison of binding sites in DNA for berenil, netropsin and distamycin. A footprinting study. Eur. J. Biochem. 167, 281.
    • (1987) Eur. J. Biochem. , vol.167 , pp. 281
    • Portugal, J.1    Waring, M.J.2
  • 22
    • 0023650355 scopus 로고
    • Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA
    • Portugal, J., and Waring, M. J. (1987) Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA. FEBS Lett. 225, 195.
    • (1987) FEBS Lett. , vol.225 , pp. 195
    • Portugal, J.1    Waring, M.J.2
  • 23
    • 0023226908 scopus 로고
    • Quantitative footprinting analysis of the netropsin-DNA interaction
    • Ward, B., Rehfuss, R., and Dabrowiak, J. C. (1987) Quantitative footprinting analysis of the netropsin-DNA interaction. J. Biomol. Struct. Dyn. 4, 685.
    • (1987) J. Biomol. Struct. Dyn. , vol.4 , pp. 685
    • Ward, B.1    Rehfuss, R.2    Dabrowiak, J.C.3
  • 24
    • 0023851982 scopus 로고
    • Determination of netropsin-DNA binding constants from footprinting data
    • Ward, B., Rehfuss, R., Goodisman, J., and Dabrowiak, J. C. (1988) Determination of netropsin-DNA binding constants from footprinting data. Biochemistry 27, 1198.
    • (1988) Biochemistry , vol.27 , pp. 1198
    • Ward, B.1    Rehfuss, R.2    Goodisman, J.3    Dabrowiak, J.C.4
  • 25
    • 0029059536 scopus 로고
    • DNA sequence preferences of several AT-selective minor groove binding ligands
    • Abu-Daya, A., Brown, P. M., and Fox, K. R. (1995) DNA sequence preferences of several AT-selective minor groove binding ligands. Nucleic Acids Res. 23, 3385.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 3385
    • Abu-Daya, A.1    Brown, P.M.2    Fox, K.R.3
  • 26
    • 0027941139 scopus 로고
    • Relative binding affinities of distamycin and its analog to d-(CGCAAGTTGGC)·d(GCCAACTTGCG): Comparison of simulation results with experiment
    • Singh, S. B., Wemmer, D. E., and Kollman, P. A. (1994) Relative binding affinities of distamycin and its analog to d-(CGCAAGTTGGC)·d(GCCAACTTGCG): Comparison of simulation results with experiment. Proc. Natl. Acad. Sci. U.S.A. 91, 7673.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 7673
    • Singh, S.B.1    Wemmer, D.E.2    Kollman, P.A.3
  • 27
    • 0029814566 scopus 로고    scopus 로고
    • Hydrogen bond geometry in DNA-minor groove binding drug complexes
    • Tabernero, L., Bella, J., and Aleman, C. (1996) Hydrogen bond geometry in DNA-minor groove binding drug complexes. Nucleic Acids Res. 24, 3458.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 3458
    • Tabernero, L.1    Bella, J.2    Aleman, C.3
  • 28
    • 0028944342 scopus 로고
    • Interaction of minor groove ligands to an AAATT/AATTT site: Correlation of thermodynamic characterization and solution structure
    • Rentzeperis, D., and Marky, L. A. (1995) Interaction of minor groove ligands to an AAATT/AATTT site: Correlation of thermodynamic characterization and solution structure. Biochemistry 34, 2937.
    • (1995) Biochemistry , vol.34 , pp. 2937
    • Rentzeperis, D.1    Marky, L.A.2
  • 29
    • 0023115514 scopus 로고
    • Specific activation of transcription initiation by the sequence specific DNA-binding agents distamycin a and netropsin
    • a. Bruzik, J. P., Auble, D. T., and DeHaseth, P. L. (1987) Specific activation of transcription initiation by the sequence specific DNA-binding agents distamycin A and netropsin. Biochemistry 26, 950.
    • (1987) Biochemistry , vol.26 , pp. 950
    • Bruzik, J.P.1    Auble, D.T.2    Dehaseth, P.L.3
  • 30
    • 0024314258 scopus 로고
    • Mammalian topoisomerase II activity is modulated by the DNA minor groove binder distamycin in simian virus 40 DNA
    • b. Fesen, M., and Pommier, Y. (1989) Mammalian topoisomerase II activity is modulated by the DNA minor groove binder distamycin in simian virus 40 DNA. J. Biol. Chem. 264, 11354.
    • (1989) J. Biol. Chem. , vol.264 , pp. 11354
    • Fesen, M.1    Pommier, Y.2
  • 31
    • 0024594222 scopus 로고
    • Modulation of topoisomerase II catalytic activity by DNA minor groove binding agents distamycin, Hoechst 33258, and 4′,6-diamidino-2-phenylindole
    • Woynarowski, J. M., McHugh, M., Sigmund, R. D., and Beerman, T. A. (1989) Modulation of topoisomerase II catalytic activity by DNA minor groove binding agents distamycin, Hoechst 33258, and 4′,6-diamidino-2-phenylindole. Mol. Pharmacol. 35, 177.
    • (1989) Mol. Pharmacol. , vol.35 , pp. 177
    • Woynarowski, J.M.1    McHugh, M.2    Sigmund, R.D.3    Beerman, T.A.4
  • 32
    • 0024503784 scopus 로고
    • DNA minor groove binding agents interfere with topoisomerase II mediated lesions induced by epipodophyllotoxin derivative VM-26 and acridine derivative m-AMSA in nuclei from L1210 cells
    • Woynarowski, J. M., Sigmund, R. D., and Beerman, T. A. (1989) DNA minor groove binding agents interfere with topoisomerase II mediated lesions induced by epipodophyllotoxin derivative VM-26 and acridine derivative m-AMSA in nuclei from L1210 cells. Biochemistry 28, 3850.
    • (1989) Biochemistry , vol.28 , pp. 3850
    • Woynarowski, J.M.1    Sigmund, R.D.2    Beerman, T.A.3
  • 33
    • 0024357433 scopus 로고
    • Effect of minor groove binding drugs on mammalian topoisomerase I activity
    • McHugh, M. M., Woynarowski, J. M., Sigmund, R. D., and Beerman, T. A. (1989) Effect of minor groove binding drugs on mammalian topoisomerase I activity. Biochem. Pharmacol. 38, 2323.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 2323
    • McHugh, M.M.1    Woynarowski, J.M.2    Sigmund, R.D.3    Beerman, T.A.4
  • 35
    • 0024467298 scopus 로고
    • Distamycin paradoxically stimulates the copying of oligo(dA)·Poly(dT) by DNA polymerases
    • Levy, A., Weisman-Shomer, P., and Fry, M. (1989) Distamycin paradoxically stimulates the copying of oligo(dA)·Poly(dT) by DNA polymerases. Biochemistry 28, 7262.
    • (1989) Biochemistry , vol.28 , pp. 7262
    • Levy, A.1    Weisman-Shomer, P.2    Fry, M.3
  • 36
    • 0025117437 scopus 로고
    • Effects of minor groove binding drugs on camptothecin-induced DNA lesions in L1210 nuclei
    • McHugh, M., Sigmund, R. D., and Beerman, T. A. (1990) Effects of minor groove binding drugs on camptothecin-induced DNA lesions in L1210 nuclei. Biochem. Pharmacol. 39, 707.
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 707
    • McHugh, M.1    Sigmund, R.D.2    Beerman, T.A.3
  • 38
    • 0026597269 scopus 로고
    • Distamycin-induced inhibition of homeodomain-DNA complexes
    • Dorn, A., Affolter, M., Muller, M., Gehring, W. J., and Leupin, W. (1992) Distamycin-induced inhibition of homeodomain-DNA complexes. EMBO J. 11, 279.
    • (1992) EMBO J. , vol.11 , pp. 279
    • Dorn, A.1    Affolter, M.2    Muller, M.3    Gehring, W.J.4    Leupin, W.5
  • 39
    • 0026572134 scopus 로고
    • Netropsin specifically enhances RNA polymerase II termination at terminator sites in vitro
    • Ueno, A., Baek, K, Jeon, C., and Agarwal, K. (1992) Netropsin specifically enhances RNA polymerase II termination at terminator sites in vitro. Proc. Natl. Acad. Sci. U.S.A. 89, 3676.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 3676
    • Ueno, A.1    Baek, K.2    Jeon, C.3    Agarwal, K.4
  • 40
    • 0026495668 scopus 로고
    • Evidence that a minor groove-binding peptide and a major groove-binding protein can simultaneously occupy a common binding site on DNA
    • Oakley, M. G., Mrksich, M., and Dervan, P. B. (1992) Evidence that a minor groove-binding peptide and a major groove-binding protein can simultaneously occupy a common binding site on DNA. Biochemistry 31, 10969.
    • (1992) Biochemistry , vol.31 , pp. 10969
    • Oakley, M.G.1    Mrksich, M.2    Dervan, P.B.3
  • 41
    • 0029915870 scopus 로고    scopus 로고
    • Distamysin-induced inhibition of formation of a nucleoprotein complex between the terminase small subunit G1P and the nonencapsidated end (pacL site) of Bacillus subtilis bacteriophage SPP1
    • Chai, S., and Alonso, J. C. (1996) Distamysin-induced inhibition of formation of a nucleoprotein complex between the terminase small subunit G1P and the nonencapsidated end (pacL site) of Bacillus subtilis bacteriophage SPP1. Nucleic Acids Res. 24, 282.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 282
    • Chai, S.1    Alonso, J.C.2
  • 42
    • 0016174223 scopus 로고
    • Netropsin. a specific probe for A-T regions of duplex deoxyribonucleic acid
    • Wartell, R. M., Larson, J. E., and Wells, R. D. (1974) Netropsin. A specific probe for A-T regions of duplex deoxyribonucleic acid. J. Biol. Chem. 249, 6719.
    • (1974) J. Biol. Chem. , vol.249 , pp. 6719
    • Wartell, R.M.1    Larson, J.E.2    Wells, R.D.3
  • 43
    • 0022587259 scopus 로고
    • Non-intercalating DNA-binding ligands: Specificity of the interaction and there use as tools in biophysical, biochemical and biological investigations of the genetic material
    • Zimmer, C., and Wähnert, U. (1986) Non-intercalating DNA-binding ligands: specificity of the interaction and there use as tools in biophysical, biochemical and biological investigations of the genetic material. Prog. Biophys. Mol. Biol. 47, 31.
    • (1986) Prog. Biophys. Mol. Biol. , vol.47 , pp. 31
    • Zimmer, C.1    Wähnert, U.2
  • 44
    • 0002628632 scopus 로고
    • Netropsin and the lexitropsins. the search for sequence-specific minor-groove-binding ligands
    • (C. L. Propst and T. J. Perun, T. J., Eds.) Dekker, New York
    • Kopka, M. L., and Larsen, T. A. (1992) Netropsin and the lexitropsins. The search for sequence-specific minor-groove-binding ligands. In Nucleic Acid Targeted Drug Design (C. L. Propst and T. J. Perun, T. J., Eds.) pp 303-374, Dekker, New York.
    • (1992) Nucleic Acid Targeted Drug Design , pp. 303-374
    • Kopka, M.L.1    Larsen, T.A.2
  • 45
    • 0343877635 scopus 로고
    • Sequence specific recognition of B-DNA by oligo(N-methylpyrrole carboxamides)
    • Youngquist, R. S., and Dervan, P. B. (1985) Sequence specific recognition of B-DNA by oligo(N-methylpyrrole carboxamides). Proc. Natl. Acad. Sci. U.S.A. 82, 2565.
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 2565
    • Youngquist, R.S.1    Dervan, P.B.2
  • 46
    • 0022693818 scopus 로고
    • Design of sequence-specific DNA-binding molecules
    • Dervan, P. B. (1986) Design of sequence-specific DNA-binding molecules. Science 232, 464.
    • (1986) Science , vol.232 , pp. 464
    • Dervan, P.B.1
  • 47
    • 0022900621 scopus 로고
    • Isohelical analysis of groove-binding drugs
    • Goodsell, D., and Dickerson, R. E. (1986) Isohelical analysis of groove-binding drugs. J. Med. Chem. 29, 727.
    • (1986) J. Med. Chem. , vol.29 , pp. 727
    • Goodsell, D.1    Dickerson, R.E.2
  • 49
    • 0024421137 scopus 로고
    • Novel linked antiviral and antitumor agents related to netropsin and distamycin: Synthesis and biological evaluation
    • Lown, J. W., Krowicki, K., Balzarini, J., Newman, R. A., and De Clercq, E. (1989) Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation. J. Med. Chem. 32, 2368.
    • (1989) J. Med. Chem. , vol.32 , pp. 2368
    • Lown, J.W.1    Krowicki, K.2    Balzarini, J.3    Newman, R.A.4    De Clercq, E.5
  • 50
    • 0026637636 scopus 로고
    • Anti-HIV-I activity of linked lexitropsins
    • Wang, W., and Lown, J. W. (1992) Anti-HIV-I activity of linked lexitropsins. J. Med. Chem. 35, 2890.
    • (1992) J. Med. Chem. , vol.35 , pp. 2890
    • Wang, W.1    Lown, J.W.2
  • 51
    • 0030772582 scopus 로고    scopus 로고
    • DNA binding studies and influence on the activity of DNA topoisomerases of bis-netropsin: Different effects of analogues containing cis and trans ethylene linkers
    • Burckhardt, G., Simon, H., Störl, K., Triebel, H., Walter, A., Lown, J. W., and Zimmer, Ch. (1997) DNA binding studies and influence on the activity of DNA topoisomerases of bis-netropsin: different effects of analogues containing cis and trans ethylene linkers. J. Biomol. Struct. Dyn. 15, 81.
    • (1997) J. Biomol. Struct. Dyn. , vol.15 , pp. 81
    • Burckhardt, G.1    Simon, H.2    Störl, K.3    Triebel, H.4    Walter, A.5    Lown, J.W.6    Zimmer, Ch.7
  • 52
    • 0031058026 scopus 로고    scopus 로고
    • Effects of bifunctional netropsin-related minor groove-binding ligands on mammalian type I topoisomerase
    • Wang, Z., Zimmer, C., Lown, J. W., and Knippers, R. (1997) Effects of bifunctional netropsin-related minor groove-binding ligands on mammalian type I topoisomerase. Biochem. Pharmacol. 53, 309.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 309
    • Wang, Z.1    Zimmer, C.2    Lown, J.W.3    Knippers, R.4
  • 53
    • 0025375379 scopus 로고
    • Molecular recognition between oligopeptides and nucleic acids: DNa binding specificity of a series of bis-netropsin analogues deduced from footprinting analysis
    • Kissinger, K. L., Dabrowiak, J. C., and Lown, J. W. (1990) Molecular recognition between oligopeptides and nucleic acids: DNA binding specificity of a series of bis-netropsin analogues deduced from footprinting analysis. Chem. Res. Toxicol. 3, 162.
    • (1990) Chem. Res. Toxicol. , vol.3 , pp. 162
    • Kissinger, K.L.1    Dabrowiak, J.C.2    Lown, J.W.3
  • 54
    • 0026027735 scopus 로고
    • Sequence-selective DNA binding by linked bis-N-methylpyrrole dipeptides: An analysis by MPE footprinting and force field calculations
    • Rao, K. E., Zimmermann, J., and Lown, J. W. (1991) Sequence-selective DNA binding by linked bis-N-methylpyrrole dipeptides: an analysis by MPE footprinting and force field calculations. J. Org. Chem. 56, 786.
    • (1991) J. Org. Chem. , vol.56 , pp. 786
    • Rao, K.E.1    Zimmermann, J.2    Lown, J.W.3
  • 55
    • 0027981564 scopus 로고
    • Isohelicity and strand selectivity in the minor groove binding of chiral (1R,2R)- and (1S,2S)-bis(netropsin)-1,2-cyclopropanedicarboxamide ligands to duplex DNA
    • Singh, M. P., Plouvier, B., Hill, G. C., Gueck, J., Pon, R. T., and Lown, J. W. (1994) Isohelicity and strand selectivity in the minor groove binding of chiral (1R,2R)- and (1S,2S)-bis(netropsin)-1,2-cyclopropanedicarboxamide ligands to duplex DNA. J. Am. Chem. Soc. 116, 7006.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 7006
    • Singh, M.P.1    Plouvier, B.2    Hill, G.C.3    Gueck, J.4    Pon, R.T.5    Lown, J.W.6
  • 56
    • 0029905747 scopus 로고    scopus 로고
    • Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNa polymerization: A novel induced-fit of 3,5-m-pyridyl bisdistamycin to enzyme-associated template-primer
    • Filipowsky, M. E., Kopka, M. L., Brazil-Zison, M., Lown, J. W., and Dickerson, R. E. (1996) Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: A novel induced-fit of 3,5-m-pyridyl bisdistamycin to enzyme-associated template-primer. Biochemistry 35, 15397.
    • (1996) Biochemistry , vol.35 , pp. 15397
    • Filipowsky, M.E.1    Kopka, M.L.2    Brazil-Zison, M.3    Lown, J.W.4    Dickerson, R.E.5
  • 59
    • 0023985829 scopus 로고
    • Theoretical study of the sequence selectivity of isolexins, isohelical DNA groove binding ligands. Proposal for GC minor groove specific compounds
    • Zakrzewska, K., and Pullman, B. (1988) Theoretical study of the sequence selectivity of isolexins, isohelical DNA groove binding ligands. Proposal for GC minor groove specific compounds. J. Biomol. Struct. Dyn. 5, 1043.
    • (1988) J. Biomol. Struct. Dyn. , vol.5 , pp. 1043
    • Zakrzewska, K.1    Pullman, B.2
  • 60
    • 0345049778 scopus 로고
    • Molecular mechanisms of specificity in DNA-antitumor drug interactions
    • (J. Jortner and B. Pullman, Eds.) Kluwer Academic Publishers, Dordrecht
    • Pullman, B. (1989) Molecular mechanisms of specificity in DNA-antitumor drug interactions. In Perspectives in Quantum Chemistry (J. Jortner and B. Pullman, Eds.) Kluwer Academic Publishers, Dordrecht.
    • (1989) Perspectives in Quantum Chemistry
    • Pullman, B.1
  • 61
    • 0023755698 scopus 로고
    • Drug recognition of DNA. Proposal for GC minor groove specific ligands: Vinylexins
    • Zakrzewska, K., Randrianarivelino, M., and Pullman, B. (1988) Drug recognition of DNA. Proposal for GC minor groove specific ligands: vinylexins. J. Biomol. Struct. Dyn. 6, 331.
    • (1988) J. Biomol. Struct. Dyn. , vol.6 , pp. 331
    • Zakrzewska, K.1    Randrianarivelino, M.2    Pullman, B.3
  • 62
    • 0026462851 scopus 로고
    • The 2-amino group of guanine is absolutely required for specific binding of the anti-cancer antibiotic echinomycin to DNA
    • Marchand, C., Bailly, C., McLean, M. J., Moroney, S. E., and Waring, M. J. (1992) The 2-amino group of guanine is absolutely required for specific binding of the anti-cancer antibiotic echinomycin to DNA. Nucleic Acids Res. 20, 5601.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 5601
    • Marchand, C.1    Bailly, C.2    McLean, M.J.3    Moroney, S.E.4    Waring, M.J.5
  • 63
    • 0007211352 scopus 로고
    • New binding sites for antitumor antibiotics created by relocating the purine 2-amino group in DNA
    • Bailly, C., Marchand, C., and Waring, M. J. (1993) New binding sites for antitumor antibiotics created by relocating the purine 2-amino group in DNA. J. Am. Chem. Soc. 115, 3784.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 3784
    • Bailly, C.1    Marchand, C.2    Waring, M.J.3
  • 64
    • 0028032864 scopus 로고
    • The purine 2-amino group as a critical recognition element for binding of small molecules to DNA
    • Waring, M. J., and Bailly, C. (1994) The purine 2-amino group as a critical recognition element for binding of small molecules to DNA. Gene 149, 69.
    • (1994) Gene , vol.149 , pp. 69
    • Waring, M.J.1    Bailly, C.2
  • 65
    • 0028943105 scopus 로고
    • Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotic
    • Bailly, C., and Waring, M. J. (1995) Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotic. Nucleic Acids Res. 23, 885.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 885
    • Bailly, C.1    Waring, M.J.2
  • 66
    • 0030450388 scopus 로고    scopus 로고
    • PCR-based development of DNA substrates containing modified bases: An efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins
    • Bailly, C., Payet, D., Travers, A. A., and Waring, M. J. (1996) PCR-based development of DNA substrates containing modified bases: an efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins. Proc. Natl. Acad. Sci. U.S.A. 93, 13623-13628.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 13623-13628
    • Bailly, C.1    Payet, D.2    Travers, A.A.3    Waring, M.J.4
  • 67
    • 0023937678 scopus 로고
    • Lexitropsins: Rational design of DNA sequence reading agents as novel anti-cancer agents and potential cellular probes
    • Lown, J. W. (1988) Lexitropsins: rational design of DNA sequence reading agents as novel anti-cancer agents and potential cellular probes. Anti-Cancer Drug Des. 3, 25.
    • (1988) Anti-Cancer Drug Des. , vol.3 , pp. 25
    • Lown, J.W.1
  • 68
    • 0028449202 scopus 로고
    • DNA recognition by lexitropsins, minor groove binding agents
    • Lown, J. W. (1994) DNA recognition by lexitropsins, minor groove binding agents. J. Mol. Recogni. 7, 79.
    • (1994) J. Mol. Recogni. , vol.7 , pp. 79
    • Lown, J.W.1
  • 69
    • 0022455164 scopus 로고
    • Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin
    • Lown, J. W., Krowicki, K., Balzarini, J., and De Clercq, E. (1986) Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin. J. Med. Chem. 29, 1210.
    • (1986) J. Med. Chem. , vol.29 , pp. 1210
    • Lown, J.W.1    Krowicki, K.2    Balzarini, J.3    De Clercq, E.4
  • 70
    • 0022858456 scopus 로고
    • Molecular recognition between oligopeptides and nucleic acids: Novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity
    • Lown, J. W., Krowicki, K., Bhat, U. G., Skorobogaty, A., Ward, B., and Dabrowiak, J. C. (1986) Molecular recognition between oligopeptides and nucleic acids: novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity. Biochemistry 25, 7408.
    • (1986) Biochemistry , vol.25 , pp. 7408
    • Lown, J.W.1    Krowicki, K.2    Bhat, U.G.3    Skorobogaty, A.4    Ward, B.5    Dabrowiak, J.C.6
  • 71
    • 0023177093 scopus 로고
    • Synthesis of novel imidazole-containing DNA minor groove binding oligopeptides related to the antiviral antibiotic netropsin
    • Krowicki, K, and Lown, J. W. (1987) Synthesis of novel imidazole-containing DNA minor groove binding oligopeptides related to the antiviral antibiotic netropsin. J. Org. Chem. 52, 3493.
    • (1987) J. Org. Chem. , vol.52 , pp. 3493
    • Krowicki, K.1    Lown, J.W.2
  • 72
    • 0023648332 scopus 로고
    • Molecular recognition between oligopeptides and nucleic acids: Monocationic imidazole lexitropsins that display enhanced GC sequence dependent DNA binding
    • Kissinger, K. L., Krowicki, K., Dabrowiak, J. C., and Lown, J. W. (1987) Molecular recognition between oligopeptides and nucleic acids: monocationic imidazole lexitropsins that display enhanced GC sequence dependent DNA binding. Biochemistry 26, 5590.
    • (1987) Biochemistry , vol.26 , pp. 5590
    • Kissinger, K.L.1    Krowicki, K.2    Dabrowiak, J.C.3    Lown, J.W.4
  • 77
    • 0023933991 scopus 로고
    • Molecular recognition between oligopeptides and nucleic acids: Influence of Van der Waals contacts in determining the 3′-terminus of DNA sequences read by monocationic lexitropsins
    • Lee, M., Krowicki, K., Hartley, J. A., Pon, R. T., and Lown, J. W. (1988) Molecular recognition between oligopeptides and nucleic acids: influence of Van der Waals contacts in determining the 3′-terminus of DNA sequences read by monocationic lexitropsins. J. Am. Chem. Soc. 110, 3641.
    • (1988) J. Am. Chem. Soc. , vol.110 , pp. 3641
    • Lee, M.1    Krowicki, K.2    Hartley, J.A.3    Pon, R.T.4    Lown, J.W.5
  • 78
    • 0024462560 scopus 로고
    • Variation of DNA sequence specificity of DNA-oligopeptide binding ligands related to netropsin: Imidazole-containing lexitropsins
    • Burckhardt, G., Luck, G., Zimmer, C., Störl, J., Krowicki, K., and Lown, J. W. (1989) Variation of DNA sequence specificity of DNA-oligopeptide binding ligands related to netropsin: imidazole-containing lexitropsins. Biochim. Biophys. Acta 1009, 11.
    • (1989) Biochim. Biophys. Acta , vol.1009 , pp. 11
    • Burckhardt, G.1    Luck, G.2    Zimmer, C.3    Störl, J.4    Krowicki, K.5    Lown, J.W.6
  • 79
    • 0027310186 scopus 로고
    • GC base sequence recognition by oligo-(imidazolecarboxamide) and C-terminus-modified analogues of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediamine-tetraacetate-iron(II) footprinting studies
    • Lee, M., Rhodes, A. L., Wyatt, M. D., Forrow, S., and Hartley, J. A. (1993) GC base sequence recognition by oligo-(imidazolecarboxamide) and C-terminus-modified analogues of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediamine-tetraacetate-iron(II) footprinting studies. Biochemistry 32, 4237.
    • (1993) Biochemistry , vol.32 , pp. 4237
    • Lee, M.1    Rhodes, A.L.2    Wyatt, M.D.3    Forrow, S.4    Hartley, J.A.5
  • 80
    • 0028293726 scopus 로고
    • Synthesis and DNa binding properties of a series of N to C linked and imidazole containing analogues of distamycin
    • Wyatt, M. D., Garbiras, B. J., Lee, M., Forrow, S. M., and Hartley, J. A. (1994) Synthesis and DNA binding properties of a series of N to C linked and imidazole containing analogues of distamycin. Bioorg. Med. Chem. Lett. 4, 801.
    • (1994) Bioorg. Med. Chem. Lett. , vol.4 , pp. 801
    • Wyatt, M.D.1    Garbiras, B.J.2    Lee, M.3    Forrow, S.M.4    Hartley, J.A.5
  • 81
    • 0025058164 scopus 로고
    • Synthesis of novel thiazole containing DNA minor groove binding oligopeptides related to the antibiotic distamycin
    • Rao, K. E., Bathini, Y., and Lown, J. W. (1990) Synthesis of novel thiazole containing DNA minor groove binding oligopeptides related to the antibiotic distamycin. J. Org. Chem. 55, 728.
    • (1990) J. Org. Chem. , vol.55 , pp. 728
    • Rao, K.E.1    Bathini, Y.2    Lown, J.W.3
  • 82
    • 0025311054 scopus 로고
    • Molecular recognition between oligopeptides and nucleic acids: DNA sequence specificity and binding properties of thiazole-lexitropsins incorporating the concepts of base site acceptance and avoidance
    • Rao, K. E., Shea, R. G., Yadagiri, B., and Lown, J. W. (1990) Molecular recognition between oligopeptides and nucleic acids: DNA sequence specificity and binding properties of thiazole-lexitropsins incorporating the concepts of base site acceptance and avoidance. Anti-Cancer Drug Des. 5, 3.
    • (1990) Anti-Cancer Drug Des. , vol.5 , pp. 3
    • Rao, K.E.1    Shea, R.G.2    Yadagiri, B.3    Lown, J.W.4
  • 87
    • 0019598899 scopus 로고
    • Molecular electrostatic potential of the nucleic acids
    • Pullman, A., and Pullman, B. (1981) Molecular electrostatic potential of the nucleic acids. Q. Rev. Biophys. 14, 289.
    • (1981) Q. Rev. Biophys. , vol.14 , pp. 289
    • Pullman, A.1    Pullman, B.2
  • 88
    • 0023374851 scopus 로고
    • Origins of netropsin binding affinity and specificity: Correlation of thermodynamic and structural data
    • Marky, L. A., and Breslauer, K. J. (1987) Origins of netropsin binding affinity and specificity: correlation of thermodynamic and structural data. Proc. Natl. Acad Sci. U.S.A. 84, 4359.
    • (1987) Proc. Natl. Acad Sci. U.S.A. , vol.84 , pp. 4359
    • Marky, L.A.1    Breslauer, K.J.2
  • 89
    • 0027941139 scopus 로고
    • Relative binding affinities of distamycin and its analog to d(CGCAAGTTGGC)·d(GCCAACTTGCG): Comparison of simulation results with experiment
    • Singh, S. B., Wemmer, D. E., and Kollman, P. A. (1994) Relative binding affinities of distamycin and its analog to d(CGCAAGTTGGC)·d(GCCAACTTGCG): Comparison of simulation results with experiment. Proc. Natl. Acad. Sci. U.S.A. 91, 7673.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 7673
    • Singh, S.B.1    Wemmer, D.E.2    Kollman, P.A.3
  • 91
    • 0027237479 scopus 로고
    • Groove- and sequence-selective alkylation of DNA by sulfonate esters tethered to lexitropsins
    • Zhang, Y., Chen, F.-X., Mehta, P., and Gold, B. (1993) Groove- and sequence-selective alkylation of DNA by sulfonate esters tethered to lexitropsins. Biochemistry 32, 7954.
    • (1993) Biochemistry , vol.32 , pp. 7954
    • Zhang, Y.1    Chen, F.-X.2    Mehta, P.3    Gold, B.4
  • 92
    • 0031571628 scopus 로고    scopus 로고
    • Specific binding of Hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: Calorimetric and spectroscopic studies
    • Haq, I., Ladbury, J. E., Chowdhry, B. Z., Jenkins, T. C., and Chaires, J. B. (1997) Specific binding of Hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies. J. Mol. Biol. 271, 244.
    • (1997) J. Mol. Biol. , vol.271 , pp. 244
    • Haq, I.1    Ladbury, J.E.2    Chowdhry, B.Z.3    Jenkins, T.C.4    Chaires, J.B.5
  • 93
    • 0023143089 scopus 로고
    • Alteration of the sequence specificity of distamycin on DNA by replacement of an N-methylpyrrole carboxamide with pyridine-2-carboxamide
    • Wade, W. S., and Dervan, P. B. (1987) Alteration of the sequence specificity of distamycin on DNA by replacement of an N-methylpyrrole carboxamide with pyridine-2-carboxamide. J. Am. Chem. Soc. 109, 1574
    • (1987) J. Am. Chem. Soc. , vol.109 , pp. 1574
    • Wade, W.S.1    Dervan, P.B.2
  • 94
    • 0030341328 scopus 로고    scopus 로고
    • Synthetic analogues of netropsin and distamycin. III. Synthesis of a pyridine analogue of the antitumor antibiotics
    • Bielawski, K., Bartulewicz, D., Krajewska, D., and Rozanski, A. (1996) Synthetic analogues of netropsin and distamycin. III. Synthesis of a pyridine analogue of the antitumor antibiotics. Rocz. Akad. Bialymst. 41, 293-304.
    • (1996) Rocz. Akad. Bialymst. , vol.41 , pp. 293-304
    • Bielawski, K.1    Bartulewicz, D.2    Krajewska, D.3    Rozanski, A.4
  • 96
    • 0026571173 scopus 로고
    • Cooperative binding of distamycin-A to DNA in the 2:1 mode
    • Fagan, P., and Wemmer, D. E. (1992) Cooperative binding of distamycin-A to DNA in the 2:1 mode. J. Am. Chem. Soc. 114, 1080.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 1080
    • Fagan, P.1    Wemmer, D.E.2
  • 98
    • 0027445693 scopus 로고
    • Binding affinities of synthetic peptides, pyridine-2-carboxamidone-tropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA
    • Wade, W. S., Mrksich, M., and Dervan, P. B. (1993) Binding affinities of synthetic peptides, pyridine-2-carboxamidone-tropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA. Biochemistry 32, 11385.
    • (1993) Biochemistry , vol.32 , pp. 11385
    • Wade, W.S.1    Mrksich, M.2    Dervan, P.B.3
  • 99
    • 0028212564 scopus 로고
    • Structural and dynamic characterization of the hetrerodimeric and homodimeric complexes between distamycin and 1-methylimidazole-2-carboxamine-netropsin bound to the minor groove of DNA
    • Geierstanger, B. H., Jacobsen, J. P., Mrksich, M., Dervan, P. B., and Wemmer, D. E. (1994) Structural and dynamic characterization of the hetrerodimeric and homodimeric complexes between distamycin and 1-methylimidazole-2-carboxamine-netropsin bound to the minor groove of DNA. Biochemistry 33, 3055.
    • (1994) Biochemistry , vol.33 , pp. 3055
    • Geierstanger, B.H.1    Jacobsen, J.P.2    Mrksich, M.3    Dervan, P.B.4    Wemmer, D.E.5
  • 100
    • 0026661689 scopus 로고
    • Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin
    • Mrksich, M., Wade, W. S., Dwyer, T. J., Geierstanger, B. H., Wemmer, D. E., and Dervan, P. B. (1992) Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin. Proc. Natl. Acad. Sci. U.S.A. 89, 7586.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 7586
    • Mrksich, M.1    Wade, W.S.2    Dwyer, T.J.3    Geierstanger, B.H.4    Wemmer, D.E.5    Dervan, P.B.6
  • 101
    • 0028171224 scopus 로고
    • Design of a G·C-specific DNa minor groove-binding peptide
    • Geierstanger, B. H., Mrksich, M., Dervan, P. B., and Wemmer, D. E. (1994) Design of a G·C-specific DNA minor groove-binding peptide. Science 266, 646.
    • (1994) Science , vol.266 , pp. 646
    • Geierstanger, B.H.1    Mrksich, M.2    Dervan, P.B.3    Wemmer, D.E.4
  • 102
    • 0031571640 scopus 로고    scopus 로고
    • Definign GC-specificity in the minor groove: Side-by-side binding of diimidazole lexitropsin to CATGGCCATG
    • Kopka, M. L., Goodsell, D. S., Han, G. W., Chiu, T. K., Lown, J. W., and Dickerson, R. E. (1997) Definign GC-specificity in the minor groove: side-by-side binding of diimidazole lexitropsin to CATGGCCATG. Structure 5, 1033.
    • (1997) Structure , vol.5 , pp. 1033
    • Kopka, M.L.1    Goodsell, D.S.2    Han, G.W.3    Chiu, T.K.4    Lown, J.W.5    Dickerson, R.E.6
  • 104
    • 0028119199 scopus 로고
    • Design of a covalent peptide heterodimer for sequence-specific recognition in the minor groove of double-helical DNA
    • Mrksich, M., and Dervan, P. B. (1994) Design of a covalent peptide heterodimer for sequence-specific recognition in the minor groove of double-helical DNA. J. Am. Chem. Soc. 116, 3663.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 3663
    • Mrksich, M.1    Dervan, P.B.2
  • 106
    • 0027970146 scopus 로고
    • Hairpin peptide motif. a new class of oligopeptides for sequence-speicific recognition in the minor groove of double-helical DNA
    • Mrksich, M., and Dervan, P. B. (1994) Hairpin peptide motif. A new class of oligopeptides for sequence-speicific recognition in the minor groove of double-helical DNA. J. Am. Chem. Soc. 116, 7983.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 7983
    • Mrksich, M.1    Dervan, P.B.2
  • 107
    • 0028853924 scopus 로고
    • Cyclic polyamides for recognition in the minor groove of DNA
    • Cho, J., Parks, M. E., and Dervan, P. B. (1995) Cyclic polyamides for recognition in the minor groove of DNA. Proc. Natl. Acad. Sci. U.S.A. 92, 10389.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 10389
    • Cho, J.1    Parks, M.E.2    Dervan, P.B.3
  • 108
    • 0030567759 scopus 로고    scopus 로고
    • Extension of sequence-specific recognition in the minor groove of DNA by pyrrole-imidazole polyamide to 9-13 base pairs
    • Trauger, J. W., Baird, E. E., Mrksich, M., and Dervan, P. B. (1996) Extension of sequence-specific recognition in the minor groove of DNA by pyrrole-imidazole polyamide to 9-13 base pairs. J. Am. Chem. Soc. 118, 6160.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 6160
    • Trauger, J.W.1    Baird, E.E.2    Mrksich, M.3    Dervan, P.B.4
  • 109
    • 0027996184 scopus 로고
    • Synthesis of novel cross-linked bis-lexitropsins
    • Al-Said, N. H., and Lown, J. W. (1994) Synthesis of novel cross-linked bis-lexitropsins. Tetrahedron Lett. 35, 7577.
    • (1994) Tetrahedron Lett. , vol.35 , pp. 7577
    • Al-Said, N.H.1    Lown, J.W.2
  • 110
    • 0028142728 scopus 로고
    • A new DNA minor groove binding motif: Cross-linked lexitropsins
    • Chen, Y.-H., and Lown, J. W. (1994) A new DNA minor groove binding motif: cross-linked lexitropsins. J. Am. Chem. Soc. 116, 6995.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 6995
    • Chen, Y.-H.1    Lown, J.W.2
  • 112
    • 0029870833 scopus 로고    scopus 로고
    • Design of distamycin analogues to probe the physical origin of the antiparallel side by side oligopeptide binding motif in DNA minor groove recognition
    • Chen, Y.-H., Yang, Y., and Lown, J. W. (1996) Design of distamycin analogues to probe the physical origin of the antiparallel side by side oligopeptide binding motif in DNA minor groove recognition. Biochem. Biophys. Res. Commun. 220, 213.
    • (1996) Biochem. Biophys. Res. Commun. , vol.220 , pp. 213
    • Chen, Y.-H.1    Yang, Y.2    Lown, J.W.3
  • 113
    • 0030567754 scopus 로고    scopus 로고
    • Optimization of the hairpin polyamide design for recognition of the minor groove of DNA
    • Parks, M. E., Baird, E. E., and Dervan, P. B. (1996) Optimization of the hairpin polyamide design for recognition of the minor groove of DNA. J. Am. Chem. Soc. 118, 6147.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 6147
    • Parks, M.E.1    Baird, E.E.2    Dervan, P.B.3
  • 114
  • 115
    • 0029957034 scopus 로고    scopus 로고
    • Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif
    • Kelly, J. J., Baird, E. E., and Dervan, P. B. (1996) Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif. Proc. Natl. Acad. Sci. U.S.A. 93, 6981.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 6981
    • Kelly, J.J.1    Baird, E.E.2    Dervan, P.B.3
  • 117
    • 0029662190 scopus 로고    scopus 로고
    • Effects of the A·T/T·A degeneracy of pyrrole-imidazole polyamide recognition in the minor groove of DNA
    • White, S., Baird, E. E., and Dervan, P. B. (1996) Effects of the A·T/T·A degeneracy of pyrrole-imidazole polyamide recognition in the minor groove of DNA. Biochemistry 35, 12532.
    • (1996) Biochemistry , vol.35 , pp. 12532
    • White, S.1    Baird, E.E.2    Dervan, P.B.3
  • 118
    • 0030133318 scopus 로고    scopus 로고
    • Extended hairpin polyamide motif for sequence-specific recognition in the minor groove of DNA
    • Trauger, J. W., Baird, E. E., and Dervan, P. B. (1996) Extended hairpin polyamide motif for sequence-specific recognition in the minor groove of DNA. Chem. Biol. 3, 369.
    • (1996) Chem. Biol. , vol.3 , pp. 369
    • Trauger, J.W.1    Baird, E.E.2    Dervan, P.B.3
  • 119
  • 121
    • 0030813474 scopus 로고    scopus 로고
    • Orientation preferences of pyrrole-imidazole polyamides in the minor groove of DNA
    • White, S., Baird, E. E., and Dervan, P. B. (1997) Orientation preferences of pyrrole-imidazole polyamides in the minor groove of DNA. J. Am. Chem. Soc. 119, 6953.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 6953
    • White, S.1    Baird, E.E.2    Dervan, P.B.3
  • 122
    • 0031215078 scopus 로고    scopus 로고
    • On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides
    • White, S., Baird, E. E., and Dervan, P. B. (1997) On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. Chem. Biol. 4, 569.
    • (1997) Chem. Biol. , vol.4 , pp. 569
    • White, S.1    Baird, E.E.2    Dervan, P.B.3
  • 123
    • 0029999063 scopus 로고    scopus 로고
    • Extending the recognition site of designed minor groove binding molecules
    • Geierstanger, B. H., Mrksich, M., Dervan, P. B., and Wemmer, D. E. (1996) Extending the recognition site of designed minor groove binding molecules. Nat. Struct. Biol. 3, 321.
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 321
    • Geierstanger, B.H.1    Mrksich, M.2    Dervan, P.B.3    Wemmer, D.E.4
  • 124
    • 0030059085 scopus 로고    scopus 로고
    • Solid-phase synthesis of polyamides containing imidazole and pyrrole amino acids
    • Baird, E. E., and Dervan, P. B. (1997) Solid-phase synthesis of polyamides containing imidazole and pyrrole amino acids. J. Am. Chem. Soc. 118, 6141.
    • (1997) J. Am. Chem. Soc. , vol.118 , pp. 6141
    • Baird, E.E.1    Dervan, P.B.2
  • 125
    • 0030745572 scopus 로고    scopus 로고
    • Discrimination of 5′-GGGG-3′, 5′-GCGC-3′, and 5′-GGCC-3′ sequences in the minor groove of DNA by eight-ring hairpin polyamides
    • Swalley, S. E., Baird, E. E., and Dervan, P. B. (1997) Discrimination of 5′-GGGG-3′, 5′-GCGC-3′, and 5′-GGCC-3′ sequences in the minor groove of DNA by eight-ring hairpin polyamides. J. Am. Chem. Soc. 119, 8756.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 8756
    • Swalley, S.E.1    Baird, E.E.2    Dervan, P.B.3
  • 126
    • 0029841915 scopus 로고    scopus 로고
    • 2-3′ sequence in the minor groove of DNa by a eight-ring hairpin polyamide
    • 2-3′ sequence in the minor groove of DNA by a eight-ring hairpin polyamide. J. Am. Chem. Soc. 119, 8198-8206.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 8198-8206
    • Swalley, S.E.1    Baird, E.E.2    Dervan, P.B.3
  • 127
    • 0030953342 scopus 로고    scopus 로고
    • Recognition of seven base pair sequences in the minor groove of DNA by ten-ring pyrrole-imidazole polyamide hairpin
    • Turner, J. M., Baird, E. E., and Dervan, P. B. (1997) Recognition of seven base pair sequences in the minor groove of DNA by ten-ring pyrrole-imidazole polyamide hairpin. J. Am. Chem. Soc. 119, 7636.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 7636
    • Turner, J.M.1    Baird, E.E.2    Dervan, P.B.3
  • 128
  • 129
    • 0032576722 scopus 로고    scopus 로고
    • Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands
    • White, S., Szewczyk, J. W., Turner, J. M., Baird, E. E., and Dervan, P. B. (1998) Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature 391, 468.
    • (1998) Nature , vol.391 , pp. 468
    • White, S.1    Szewczyk, J.W.2    Turner, J.M.3    Baird, E.E.4    Dervan, P.B.5
  • 130
    • 0032564881 scopus 로고    scopus 로고
    • Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove
    • Herman, D. M., Baird, E. E., and Dervan, P. B. (1998) Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove. J. Am. Chem. Soc. 120, 1382.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 1382
    • Herman, D.M.1    Baird, E.E.2    Dervan, P.B.3
  • 131
    • 0031573870 scopus 로고    scopus 로고
    • Polyamides as artificial regulators of gene expression
    • Weisz, K. (1997) Polyamides as artificial regulators of gene expression. Angew. Chem., Int. Ed. Engl. 36, 2592.
    • (1997) Angew. Chem., Int. Ed. Engl. , vol.36 , pp. 2592
    • Weisz, K.1
  • 132
  • 134
    • 0037964352 scopus 로고    scopus 로고
    • Reading the minor groove
    • Hélène, C. (1998) Reading the minor groove. Nature 391, 43.
    • (1998) Nature , vol.391 , pp. 43
    • Hélène, C.1
  • 136
    • 0029786013 scopus 로고    scopus 로고
    • Recognition of DNA by designed ligands at subnanomolar concentrations
    • Trauger, J. W., Baird, E. E., and Dervan, P. B. (1996) Recognition of DNA by designed ligands at subnanomolar concentrations. Nature 382, 559.
    • (1996) Nature , vol.382 , pp. 559
    • Trauger, J.W.1    Baird, E.E.2    Dervan, P.B.3
  • 139
    • 0029005427 scopus 로고
    • Exceptional and selective stabilization of A-T rich DNA-DNA duplexes by N-methylpyrrole carboxamide peptides conjugated to oligodeoxynucleotides
    • Sinyakov, A. N., Lokhov, S. G., Kutyavin, I. V., Gamper, H. B., and Meyer, R. B., Jr. (1995) Exceptional and selective stabilization of A-T rich DNA-DNA duplexes by N-methylpyrrole carboxamide peptides conjugated to oligodeoxynucleotides. J. Am. Chem. Soc. 117, 4995.
    • (1995) J. Am. Chem. Soc. , vol.117 , pp. 4995
    • Sinyakov, A.N.1    Lokhov, S.G.2    Kutyavin, I.V.3    Gamper, H.B.4    Meyer R.B., Jr.5
  • 140
    • 0030013003 scopus 로고    scopus 로고
    • Cooperative triple-helix formation via a minor groove dimerization domain
    • Szewczyk, J. W., Baird, E. E., and Dervan, P. B. (1996) Cooperative triple-helix formation via a minor groove dimerization domain. J. Am. Chem. Soc. 118, 6778.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 6778
    • Szewczyk, J.W.1    Baird, E.E.2    Dervan, P.B.3
  • 141
    • 0029762862 scopus 로고    scopus 로고
    • Sequence-specific recognition of DNa by a major and minor groove binding ligand
    • Szewczyk, J. W., Baird, E. E., and Dervan, P. B. (1996) Sequence-specific recognition of DNA by a major and minor groove binding ligand. Angew. Chem., Int. Ed. Engl. 35, 1487.
    • (1996) Angew. Chem., Int. Ed. Engl. , vol.35 , pp. 1487
    • Szewczyk, J.W.1    Baird, E.E.2    Dervan, P.B.3
  • 143
    • 0027170140 scopus 로고
    • Microgonotropens and their interactions with DNA. 2. Quantitative evaluation of equilibrium constants for 1:1 and 2:1 binding of dien-microgonotropen-a, -b, and -c as well as distamycin and Hoechst 33258
    • Browne, K. A., He, G.-X., and Bruice, T. C. (1993) Microgonotropens and their interactions with DNA. 2. Quantitative evaluation of equilibrium constants for 1:1 and 2:1 binding of dien-microgonotropen-a, -b, and -c as well as distamycin and Hoechst 33258. J. Am. Chem. Soc. 115, 7072.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 7072
    • Browne, K.A.1    He, G.-X.2    Bruice, T.C.3
  • 145
    • 0028241780 scopus 로고
    • 2 and tren-microgonotropen-b by 2D NMR spectroscopy and restrained molecular modeling
    • 2 and tren-microgonotropen-b by 2D NMR spectroscopy and restrained molecular modeling. J. Am. Chem. Soc. 116, 3726.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 3726
    • Blaskó, A.1    Browne, K.A.2    Bruice, T.C.3
  • 146
    • 0028180557 scopus 로고
    • Microgonotropens and their interactions with DNA. 4. Synthesis of the tripyrrole peptides tren-microgonotropen-a, -b, and -c and characterization of their interactions with dsDNA
    • He, G.-X., Browne, K. A., Blaskò, A., and Bruice, T. C. (1994) Microgonotropens and their interactions with DNA. 4. Synthesis of the tripyrrole peptides tren-microgonotropen-a, -b, and -c and characterization of their interactions with dsDNA. J. Am. Chem. Soc. 116, 3716.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 3716
    • He, G.-X.1    Browne, K.A.2    Blaskò, A.3    Bruice, T.C.4
  • 147
    • 0027236649 scopus 로고
    • Microgonotropens and their interactions with DNA. 1. Synthesis of the tripyrrole peptides dien-microgonotropen-a, -b, and -c and characterization of their interactions with dsDNA
    • He, G.-X., Browne, K. A., Groppe, J. C., Blaskò, A., Mei, H.-Y., and Bruice, T. C. (1993) Microgonotropens and their interactions with DNA. 1. Synthesis of the tripyrrole peptides dien-microgonotropen-a, -b, and -c and characterization of their interactions with dsDNA. J. Am. Chem. Soc. 115, 7061.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 7061
    • He, G.-X.1    Browne, K.A.2    Groppe, J.C.3    Blaskò, A.4    Mei, H.-Y.5    Bruice, T.C.6
  • 148
    • 0029042541 scopus 로고
    • 2: Tren-microgonotropen-b:Zn-(II) complex and solution studies of metal ion complexes of Tren-microgonotropen-b interacting with DNA
    • 2: Tren-microgonotropen-b:Zn-(II) complex and solution studies of metal ion complexes of Tren-microgonotropen-b interacting with DNA. BioOrg. Med. Chem. 3, 631.
    • (1995) BioOrg. Med. Chem. , vol.3 , pp. 631
    • Blaskò, A.1    Browne, K.A.2    Bruice, T.C.3
  • 149
    • 0029206199 scopus 로고
    • A novel minor groove binding reagent designed to serve as a "truck" to carry DNa modifying moieties into the major groove
    • Xue, T., Browne, K. A., and Bruice, T. C. (1995) A novel minor groove binding reagent designed to serve as a "truck" to carry DNA modifying moieties into the major groove. Bioconjugate Chem. 6, 82.
    • (1995) Bioconjugate Chem. , vol.6 , pp. 82
    • Xue, T.1    Browne, K.A.2    Bruice, T.C.3
  • 150
    • 0027964620 scopus 로고
    • Bending and straightening of DNA induced by the same ligand: Characterization with atomic force microscope
    • Hansma, H. G., Browne, K. A., Groppe, J. C., Bezanilla, M., and Bruice, T. C. (1994) Bending and straightening of DNA induced by the same ligand: characterization with atomic force microscope. Biochemistry 33, 8436.
    • (1994) Biochemistry , vol.33 , pp. 8436
    • Hansma, H.G.1    Browne, K.A.2    Groppe, J.C.3    Bezanilla, M.4    Bruice, T.C.5
  • 151
    • 0030995578 scopus 로고    scopus 로고
    • A microgonotropen branched cecaaza decabutylamine and its DNA and DNA/transcription factor interactions
    • Bruice, T. C., Sengupta, D., Blaskò, A., Chiang, S.-Y., and Beerman, T. A. (1997) A microgonotropen branched cecaaza decabutylamine and its DNA and DNA/transcription factor interactions. BioOrg. Med. Chem. 5, 685.
    • (1997) BioOrg. Med. Chem. , vol.5 , pp. 685
    • Bruice, T.C.1    Sengupta, D.2    Blaskò, A.3    Chiang, S.-Y.4    Beerman, T.A.5
  • 152
    • 11944256352 scopus 로고
    • Chemistry of phosphodiesters, DNA and models. 2. the hydrolysis of bis-(8-hydroxyquinoline) phosphate in the absence and presence of metal ions
    • Browne, K. A., and Bruice, T. C. (1992) Chemistry of phosphodiesters, DNA and models. 2. The hydrolysis of bis-(8-hydroxyquinoline) phosphate in the absence and presence of metal ions. J. Am. Chem. Soc. 114, 4951.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 4951
    • Browne, K.A.1    Bruice, T.C.2
  • 153
    • 0026556818 scopus 로고
    • Rational design of substituted trispyrrole peptides that complex with DNA by both selective minor-groove binding and electrostatic interaction with the phosphate backbone
    • Bruice, T. C., Mei, H.-H., He, G.-X., and Lopez, V. (1992) Rational design of substituted trispyrrole peptides that complex with DNA by both selective minor-groove binding and electrostatic interaction with the phosphate backbone. Proc. Natl. Acad. Sci. U.S.A. 89, 1700.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 1700
    • Bruice, T.C.1    Mei, H.-H.2    He, G.-X.3    Lopez, V.4
  • 154
    • 0002328448 scopus 로고
    • Selectivity in alkylating agent-DNA interactions
    • (S. Neidle and M. J. Waring, Eds.) Macmillan, London
    • Hartley, J. A. (1993) Selectivity in alkylating agent-DNA interactions. In Molecular Aspects of Anticancer Drug-DNA Interactions (S. Neidle and M. J. Waring, Eds.) Vol. 1, pp 1-31, Macmillan, London.
    • (1993) Molecular Aspects of Anticancer Drug-DNA Interactions , vol.1 , pp. 1-31
    • Hartley, J.A.1
  • 155
    • 0000167527 scopus 로고    scopus 로고
    • Pluramycins. Old drugs having modern friends in structural biology
    • Hansen, M., and Hurley, L. (1996) Pluramycins. Old drugs having modern friends in structural biology. Acc Chem. Res. 29, 249.
    • (1996) Acc Chem. Res. , vol.29 , pp. 249
    • Hansen, M.1    Hurley, L.2
  • 156
    • 0000813992 scopus 로고
    • The mitomycins: Natural cross-linkers of DNA
    • (S. Neidle and M. J. Waring, Eds.) Macmillan, London
    • Tomasz, M. (1994) The mitomycins: natural cross-linkers of DNA. In Molecular Aspects of Anticancer Drug-DNA Interactions (S. Neidle and M. J. Waring, Eds.) Vol. 2, pp 312-349, Macmillan, London.
    • (1994) Molecular Aspects of Anticancer Drug-DNA Interactions , vol.2 , pp. 312-349
    • Tomasz, M.1
  • 157
    • 0025125075 scopus 로고
    • 2 adduct by NMR and molecular modeling studies. Determination of the stereochemistry of the covalent linkage site, orientation in the minor groove of DNA and effect on local DNA structure
    • 2 adduct by NMR and molecular modeling studies. Determination of the stereochemistry of the covalent linkage site, orientation in the minor groove of DNA and effect on local DNA structure. J. Am. Chem. Soc. 112, 3279.
    • (1990) J. Am. Chem. Soc. , vol.112 , pp. 3279
    • Boyd, F.L.1    Cheatham, S.F.2    Remers, W.3    Hill, G.C.4    Hurley, L.H.5
  • 158
    • 0028131645 scopus 로고
    • Crystal structure of a covalent DNA-drug adduct: Anthramycin bound to CCAACGTTGG and a molecular explanation of specificity
    • Kopka, M. L., Goodsell, D., Baikalov, I., Grzeskowiak, K., Cascio, D., and Dickerson, R. E. (1994) Crystal structure of a covalent DNA-drug adduct: anthramycin bound to CCAACGTTGG and a molecular explanation of specificity. Biochemistry 33, 13593.
    • (1994) Biochemistry , vol.33 , pp. 13593
    • Kopka, M.L.1    Goodsell, D.2    Baikalov, I.3    Grzeskowiak, K.4    Cascio, D.5    Dickerson, R.E.6
  • 159
    • 0001911789 scopus 로고
    • Molecular aspects of the interaction of (+)-CC-1065 with DNA
    • (S. Neidle and M. J. Waring, Eds.) Macmillan, London
    • Hurley, L. H., and Draves, P. H. (1993) Molecular aspects of the interaction of (+)-CC-1065 with DNA. In Molecular Aspects of Anticancer Drug-DNA Interactions (S. Neidle and M. J. Waring, Eds.) Vol. 1, pp 89-133, Macmillan, London.
    • (1993) Molecular Aspects of Anticancer Drug-DNA Interactions , vol.1 , pp. 89-133
    • Hurley, L.H.1    Draves, P.H.2
  • 160
    • 0027951509 scopus 로고
    • (+)-CC-1065 as a probe for intrinsic and protein-induced bending of DNA
    • Hurley, L. H., and Sun, D. (1994) (+)-CC-1065 as a probe for intrinsic and protein-induced bending of DNA. J. Mol. Recognit. 7, 123.
    • (1994) J. Mol. Recognit. , vol.7 , pp. 123
    • Hurley, L.H.1    Sun, D.2
  • 161
    • 0029782488 scopus 로고    scopus 로고
    • CC-1065 and the duocarmycins: Understanding their biological function through mechanistic studies
    • Boger, D. L., and Johnson, D. S. (1996) CC-1065 and the duocarmycins: Understanding their biological function through mechanistic studies. Angew. Chem., Int. Ed. Engl. 35, 1438.
    • (1996) Angew. Chem., Int. Ed. Engl. , vol.35 , pp. 1438
    • Boger, D.L.1    Johnson, D.S.2
  • 162
    • 0006828126 scopus 로고
    • Novel DNA groove binding alkylators: Design, synthesis, and biological evaluation
    • Krowicki, K., Balzarini, J., De Clercq, E., Newman, R. A., and Lown, J. W. (1988) Novel DNA groove binding alkylators: design, synthesis, and biological evaluation. J. Med. Chem. 31, 341.
    • (1988) J. Med. Chem. , vol.31 , pp. 341
    • Krowicki, K.1    Balzarini, J.2    De Clercq, E.3    Newman, R.A.4    Lown, J.W.5
  • 164
    • 0022408319 scopus 로고
    • Sequence-specific cleavage of double-helical DNA. N-bromoacetyldistamycin
    • Baker, B. F., and Dervan, P. B. (1985) Sequence-specific cleavage of double-helical DNA. N-bromoacetyldistamycin. J. Am. Chem. Soc. 107, 8266.
    • (1985) J. Am. Chem. Soc. , vol.107 , pp. 8266
    • Baker, B.F.1    Dervan, P.B.2
  • 165
    • 0024517471 scopus 로고
    • Sequence-specific cleavage of DNA by N-bromoacetyldistamycin. Product and kinetic analyses
    • Baker, B. F., and Dervan, P. B. (1989) Sequence-specific cleavage of DNA by N-bromoacetyldistamycin. Product and kinetic analyses. J. Am. Chem. Soc. 111, 2700.
    • (1989) J. Am. Chem. Soc. , vol.111 , pp. 2700
    • Baker, B.F.1    Dervan, P.B.2
  • 166
    • 0027173263 scopus 로고
    • Design, synthesis, and biological evaluation of DNA sequence and minor groove selective alkylating agents
    • Lee, M., Rhodes, A. L., Wyatt, M. D., Forrow, S., and Hartley, J. A. (1993) Design, synthesis, and biological evaluation of DNA sequence and minor groove selective alkylating agents. Anti-Cancer Drug Des. 8, 173.
    • (1993) Anti-Cancer Drug Des. , vol.8 , pp. 173
    • Lee, M.1    Rhodes, A.L.2    Wyatt, M.D.3    Forrow, S.4    Hartley, J.A.5
  • 167
    • 0029087804 scopus 로고
    • Design, synthesis, DNA sequence preferential alkylation and biological evaluation of N-mustard derivatives of distamycin and netropsin analogues
    • Xie, G., Gupta, R., and Lown, J. W. (1995) Design, synthesis, DNA sequence preferential alkylation and biological evaluation of N-mustard derivatives of distamycin and netropsin analogues. Anti-Cancer Drug Des. 10, 389.
    • (1995) Anti-Cancer Drug Des. , vol.10 , pp. 389
    • Xie, G.1    Gupta, R.2    Lown, J.W.3
  • 168
    • 0028865427 scopus 로고
    • Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size: Evidence for increased cytotoxicity with enhanced sequence specificity
    • Wyatt, M. D., Lee, M., Garbirasd, B. J., Souhami, R. L., and Hartley, J. A. (1995) Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size: Evidence for increased cytotoxicity with enhanced sequence specificity. Biochemistry 34, 13034.
    • (1995) Biochemistry , vol.34 , pp. 13034
    • Wyatt, M.D.1    Lee, M.2    Garbirasd, B.J.3    Souhami, R.L.4    Hartley, J.A.5
  • 169
    • 0028662405 scopus 로고
    • Structure-activity relationship of a series of nitrogen-mustard- and pyrrole-containing minor groove-binding agents related to distamycin
    • Wyatt, M. D., Garbiras, B. J., Haskell, M. K., Lee, M., Souhami, R. L., and Hartley, J. A. (1994) Structure-activity relationship of a series of nitrogen-mustard- and pyrrole-containing minor groove-binding agents related to distamycin. Anti-Cancer Drug Des. 9, 511.
    • (1994) Anti-Cancer Drug Des. , vol.9 , pp. 511
    • Wyatt, M.D.1    Garbiras, B.J.2    Haskell, M.K.3    Lee, M.4    Souhami, R.L.5    Hartley, J.A.6
  • 170
    • 0031029254 scopus 로고    scopus 로고
    • Alkylation specificity for a series of distamycin analogues that tether chlorambucil
    • Wyatt, M. D., Lee, M., and Hartley, J. A. (1997) Alkylation specificity for a series of distamycin analogues that tether chlorambucil. Anti-Cancer Drug Des. 12, 49.
    • (1997) Anti-Cancer Drug Des. , vol.12 , pp. 49
    • Wyatt, M.D.1    Lee, M.2    Hartley, J.A.3
  • 171
    • 0029922036 scopus 로고    scopus 로고
    • Backbone and benzoyl mustard carrying moiety modifies DNA interactions of distamycin analogues
    • Ciucci, A., Manzini, S., Lombardi, P., and Arcamone, F. (1996) Backbone and benzoyl mustard carrying moiety modifies DNA interactions of distamycin analogues. Nucleic Acids Res. 24, 311.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 311
    • Ciucci, A.1    Manzini, S.2    Lombardi, P.3    Arcamone, F.4
  • 172
    • 0028883930 scopus 로고
    • Design, synthesis and evaluation of novel bismustard cross-linked lexitropsins
    • Chen, H. Y., Liu, J. X., and Lown, J. W. (1995) Design, synthesis and evaluation of novel bismustard cross-linked lexitropsins. BioOrg. Med. Chem. Lett. 5, 2223.
    • (1995) BioOrg. Med. Chem. Lett. , vol.5 , pp. 2223
    • Chen, H.Y.1    Liu, J.X.2    Lown, J.W.3
  • 174
    • 0026062591 scopus 로고
    • Specific inhibition of human DNa ligase adenylation by a distamycin derivative possessing antitumor activity
    • Montecucco, A., Fontana, M., Focher, F., Lestingi, M., Spadari, S., and Ciarrochi, G. (1991) Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity. Nucleic Acids Res. 19, 1067.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 1067
    • Montecucco, A.1    Fontana, M.2    Focher, F.3    Lestingi, M.4    Spadari, S.5    Ciarrochi, G.6
  • 176
    • 0028889093 scopus 로고
    • DNa sequence-specific adenine alkylation by the novel drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin
    • Broggini, M., Coley, H. M., Mongelli, N., Pesenti, E., Wyatt, M. D., Hartley, J. A., and D'Incalci, M. (1995) DNA sequence-specific adenine alkylation by the novel drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin. Nucleic Acids Res. 23, 81.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 81
    • Broggini, M.1    Coley, H.M.2    Mongelli, N.3    Pesenti, E.4    Wyatt, M.D.5    Hartley, J.A.6    D'Incalci, M.7
  • 179
    • 0027466085 scopus 로고
    • The effects of a benzoic acid mustard derivative of distamycin a (FCE 24517) and related minor groove-binding distamycin analogues on the activity of major groove-binding alkylating agents
    • Coley, H. M., Mongelli, N., and D'Incalci, M. (1993) The effects of a benzoic acid mustard derivative of distamycin A (FCE 24517) and related minor groove-binding distamycin analogues on the activity of major groove-binding alkylating agents. Biochem. Pharmacol. 45, 619.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 619
    • Coley, H.M.1    Mongelli, N.2    D'Incalci, M.3
  • 181
    • 0030819908 scopus 로고    scopus 로고
    • Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: Synthesis, DNa binding and cytotoxicity studies
    • Brooks, N., Hartley, J. A., Simpson, J. E., Wright, S. R., Woo, S., Centioni, S., Fontaine, M. D., McIntyre, T. E., and Lee, M. (1997) Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: synthesis, DNA binding and cytotoxicity studies. BioOrg. Med. Chem. 5, 1497.
    • (1997) BioOrg. Med. Chem. , vol.5 , pp. 1497
    • Brooks, N.1    Hartley, J.A.2    Simpson, J.E.3    Wright, S.R.4    Woo, S.5    Centioni, S.6    Fontaine, M.D.7    McIntyre, T.E.8    Lee, M.9
  • 182
    • 84872635316 scopus 로고
    • Nitrogen mustards in treatment of neoplatic disease
    • Rhoads, C. J. (1946) Nitrogen mustards in treatment of neoplatic disease. J. Am. Med. Assoc. 131, 656.
    • (1946) J. Am. Med. Assoc. , vol.131 , pp. 656
    • Rhoads, C.J.1
  • 183
    • 0029915634 scopus 로고    scopus 로고
    • Design, synthesis, cytotoxic properties and preliminary DNa sequencing evaluation of CPI-N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency
    • Wang, Y., Gupta, R., Huang, L., Luo, W., and Lown, J. W. (1996) Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI-N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency. Anti-Cancer Drug Des. 11, 15.
    • (1996) Anti-Cancer Drug Des. , vol.11 , pp. 15
    • Wang, Y.1    Gupta, R.2    Huang, L.3    Luo, W.4    Lown, J.W.5
  • 187
    • 0027882506 scopus 로고
    • Affinity cross-linking of duplex DNa by a pyrrole-oligopeptide conjugate
    • Sigurdsson, S. T., Rink, S. M., and Hopkins, P. B. (1993) Affinity cross-linking of duplex DNA by a pyrrole-oligopeptide conjugate. J. Am. Chem. Soc. 115, 12633.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 12633
    • Sigurdsson, S.T.1    Rink, S.M.2    Hopkins, P.B.3
  • 190
    • 0030474335 scopus 로고    scopus 로고
    • Novel DNA-directed alkylating agents consisting of naphthalimide, nitrogen mustard and lexitropsin moieties: Synthesis, DNA sequence specificity and biological evaluation
    • Gupta, R., Liu, J., Xie, G., and Lown, J. W. (1996) Novel DNA-directed alkylating agents consisting of naphthalimide, nitrogen mustard and lexitropsin moieties: synthesis, DNA sequence specificity and biological evaluation. Anti-Cancer Drug Des. 11, 581.
    • (1996) Anti-Cancer Drug Des. , vol.11 , pp. 581
    • Gupta, R.1    Liu, J.2    Xie, G.3    Lown, J.W.4
  • 191
    • 0025382508 scopus 로고
    • Chemical and photochemical probing of DNA complexes
    • Nielsen, P. E. (1990) Chemical and photochemical probing of DNA complexes. J. Mol. Recognit. 3, 1.
    • (1990) J. Mol. Recognit. , vol.3 , pp. 1
    • Nielsen, P.E.1
  • 192
    • 0028336665 scopus 로고
    • Molecular and cellular pharmacology of novel photoactive psoralen and coumarin conjugates of pyrrole- and imidazole-containing analogues of netropsin
    • Hartley, J. A., McAdam, S. R., Das, S., Roldan, M. C., Haskell, M. K., and Lee, M. (1994) Molecular and cellular pharmacology of novel photoactive psoralen and coumarin conjugates of pyrrole- and imidazole-containing analogues of netropsin. Anti-Cancer Drug Des. 9, 181.
    • (1994) Anti-Cancer Drug Des. , vol.9 , pp. 181
    • Hartley, J.A.1    McAdam, S.R.2    Das, S.3    Roldan, M.C.4    Haskell, M.K.5    Lee, M.6
  • 193
    • 0028333872 scopus 로고
    • Psoralen-lexitropsin hybrids: DNA sequence selectivity of photoinduced cross-linking from MPE footprinting and exonuclease II stop assay, and mode of binding from electric linear dichroism
    • Rao, K. E., Gosselin, G., Mrani, D., Périgaud, C., Imbach, J. L., Bailly, C., Hénichart, J. P., Colson, P., Houssier, C., and Lown, J. W. (1994) Psoralen-lexitropsin hybrids: DNA sequence selectivity of photoinduced cross-linking from MPE footprinting and exonuclease II stop assay, and mode of binding from electric linear dichroism. Anti-Cancer Drug Des. 9, 221.
    • (1994) Anti-Cancer Drug Des. , vol.9 , pp. 221
    • Rao, K.E.1    Gosselin, G.2    Mrani, D.3    Périgaud, C.4    Imbach, J.L.5    Bailly, C.6    Hénichart, J.P.7    Colson, P.8    Houssier, C.9    Lown, J.W.10
  • 194
    • 0029041359 scopus 로고
    • Novel cytotoxic DNA sequence and minor groove targeted photosensitizers: Conjugates of pyrene and netropsin analogues
    • Hartley, J. A., Webber, J., Wyatt, M. D., Bordenick, N., and Lee, M. (1995) Novel cytotoxic DNA sequence and minor groove targeted photosensitizers: Conjugates of pyrene and netropsin analogues. BioOrg. Med. Chem. Lett. 3, 623.
    • (1995) BioOrg. Med. Chem. Lett. , vol.3 , pp. 623
    • Hartley, J.A.1    Webber, J.2    Wyatt, M.D.3    Bordenick, N.4    Lee, M.5
  • 195
    • 0027950223 scopus 로고
    • Poly(pyrrolecarboxamides) linked to photoactivable chromophore isoalloxazine. Synthesis, selective binding, and DNA cleaving properties
    • Herfeld, P., Helissey, P., and Giorgi-Renault, S. (1994) Poly(pyrrolecarboxamides) linked to photoactivable chromophore isoalloxazine. Synthesis, selective binding, and DNA cleaving properties. Bioconjugate Chem. 5, 67.
    • (1994) Bioconjugate Chem. , vol.5 , pp. 67
    • Herfeld, P.1    Helissey, P.2    Giorgi-Renault, S.3
  • 198
    • 0029857269 scopus 로고    scopus 로고
    • DNA minor groove cleaving agents: Synthesis, DNA binding and DNA cleaving properties of anthraquinone-oligopyrrolecarboxamide hybrids
    • Helissey, P., Bailly, C., Vishwakarma, J. N., Auclair, C., Waring, M. J., and Giorgi-Renault, S. (1996) DNA minor groove cleaving agents: synthesis, DNA binding and DNA cleaving properties of anthraquinone-oligopyrrolecarboxamide hybrids. Anti-Cancer Drug Des. 11, 527-551.
    • (1996) Anti-Cancer Drug Des. , vol.11 , pp. 527-551
    • Helissey, P.1    Bailly, C.2    Vishwakarma, J.N.3    Auclair, C.4    Waring, M.J.5    Giorgi-Renault, S.6
  • 199
    • 0011697055 scopus 로고
    • Metalloporphyrins as versatile catalysts for oxidation reactions and oxidative DNA cleavage
    • Meunier, B. (1992) Metalloporphyrins as versatile catalysts for oxidation reactions and oxidative DNA cleavage. Chem. Rev. 92, 141.
    • (1992) Chem. Rev. , vol.92 , pp. 141
    • Meunier, B.1
  • 201
    • 0028047910 scopus 로고
    • Structure and energetics in the complexes of a double-stranded B-DNa dodecamer with netropsin derivatives of a tricationic water-soluble porphyrin: A theoretical investigation
    • Perrée-Fauvet, M., and Gresh, N. (1994) Structure and energetics in the complexes of a double-stranded B-DNA dodecamer with netropsin derivatives of a tricationic water-soluble porphyrin: a theoretical investigation. J. Biomol. Struct. Dyn. 11, 1203.
    • (1994) J. Biomol. Struct. Dyn. , vol.11 , pp. 1203
    • Perrée-Fauvet, M.1    Gresh, N.2
  • 202
    • 0000851731 scopus 로고
    • Synthesis of halogenated oligo-N-methylpyrrole-carboxamide derivatives and their photochemical DNA cleavage activities
    • Matsumoto, T., Utsumi, Y., Sakai, Y., Toyooka, K., and Shibuya, M. (1992) Synthesis of halogenated oligo-N-methylpyrrole-carboxamide derivatives and their photochemical DNA cleavage activities. Heterocycles 34, 1697.
    • (1992) Heterocycles , vol.34 , pp. 1697
    • Matsumoto, T.1    Utsumi, Y.2    Sakai, Y.3    Toyooka, K.4    Shibuya, M.5
  • 203
    • 0010313514 scopus 로고
    • Tumour hypoxia: Challenges for cancer chemotherapy
    • (M. J. Waring and B. A. J. Ponder, Eds.) Kluwer Academic Publishers, London
    • Wilson, W. R. (1992) Tumour hypoxia: challenges for cancer chemotherapy. In The Search for New Anticancer Drugs (M. J. Waring and B. A. J. Ponder, Eds.) pp 87-131, Kluwer Academic Publishers, London.
    • (1992) The Search for New Anticancer Drugs , pp. 87-131
    • Wilson, W.R.1
  • 204
    • 0028146654 scopus 로고
    • Evidence for the direct interaction of reduced metronidazole derivatives with DNA bases
    • Tocher, J. H., and Edwards, D. I. (1994) Evidence for the direct interaction of reduced metronidazole derivatives with DNA bases. Biochem. Pharmacol. 48, 1089.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1089
    • Tocher, J.H.1    Edwards, D.I.2
  • 205
    • 0024400480 scopus 로고
    • Oxygen trasfer from the nitro group of a nitroaromatic radiosensitizer to a DNa sugar damage product
    • Kappen, L. S., Lee, T. R., Yang, C.-C., and Goldberg, I. H. (1989) Oxygen trasfer from the nitro group of a nitroaromatic radiosensitizer to a DNA sugar damage product. Biochemistry 28, 4540.
    • (1989) Biochemistry , vol.28 , pp. 4540
    • Kappen, L.S.1    Lee, T.R.2    Yang, C.-C.3    Goldberg, I.H.4
  • 206
    • 0025157670 scopus 로고
    • Synthesis of nitrated oligo-N-methylpyrrole carboxamide derivatives and their photochemical DNA cleaving properties
    • Nishiwaki, E., Lee, H., Matsumoto, T., Toyooka, K., Sakurai, H., and Shibuya, M. (1990) Synthesis of nitrated oligo-N-methylpyrrole carboxamide derivatives and their photochemical DNA cleaving properties. Tetrahedron Lett. 31, 1299.
    • (1990) Tetrahedron Lett. , vol.31 , pp. 1299
    • Nishiwaki, E.1    Lee, H.2    Matsumoto, T.3    Toyooka, K.4    Sakurai, H.5    Shibuya, M.6
  • 208
    • 0028630756 scopus 로고
    • DNA-binding properties of nitroarene oligopeptides designed as hypoxia-selective agents
    • Jenkins, T. C., Parrick, J., and Porssa, M. (1994) DNA-binding properties of nitroarene oligopeptides designed as hypoxia-selective agents. Anti-Cancer Drug Des. 9, 477.
    • (1994) Anti-Cancer Drug Des. , vol.9 , pp. 477
    • Jenkins, T.C.1    Parrick, J.2    Porssa, M.3
  • 209
    • 0041611724 scopus 로고
    • Synthesis of sulfonamido oligo-N-methylpyrrole-carboxamide derivatives and their photochemical DNA cleavage activities
    • Matsumoto, T., Sakai, Y., Toyooka, K., and Shibuya, M. (1992) Synthesis of sulfonamido oligo-N-methylpyrrole-carboxamide derivatives and their photochemical DNA cleavage activities. Heterocycles 33, 135.
    • (1992) Heterocycles , vol.33 , pp. 135
    • Matsumoto, T.1    Sakai, Y.2    Toyooka, K.3    Shibuya, M.4
  • 210
    • 0000299739 scopus 로고
    • Synthesis of oligo-N-methylpyrrolecarboxamide derivatives and their photochemical DNA cleaving activities
    • Nishiwaki, E., Nakagawa, H., Takasaki, M., Matsumoto, T., Sakurai, H., and Shibuya, M. (1990) Synthesis of oligo-N-methylpyrrolecarboxamide derivatives and their photochemical DNA cleaving activities. Heterocycles 31, 1763.
    • (1990) Heterocycles , vol.31 , pp. 1763
    • Nishiwaki, E.1    Nakagawa, H.2    Takasaki, M.3    Matsumoto, T.4    Sakurai, H.5    Shibuya, M.6
  • 211
    • 0025157670 scopus 로고
    • Synthesis of nitrated oligo-N-methylpyrrole carboxamide derivatives and their photochemical DNA cleaving activities
    • Nishiwaki, E., Lee, H., Matsumoto, T., Toyooka, K., Sakurai, H., and Shibuya, M. (1990) Synthesis of nitrated oligo-N-methylpyrrole carboxamide derivatives and their photochemical DNA cleaving activities. Tetrahedron Lett 31, 1299.
    • (1990) Tetrahedron Lett , vol.31 , pp. 1299
    • Nishiwaki, E.1    Lee, H.2    Matsumoto, T.3    Toyooka, K.4    Sakurai, H.5    Shibuya, M.6
  • 212
    • 0025973664 scopus 로고
    • Sequence-specific cleavage of double-stranded DNA caused by X-ray ionization of the platinum atom in the Pt-bis-netropsin-DNA complex
    • Grokhovsky, S. L., and Zubarev, V. E. (1991) Sequence-specific cleavage of double-stranded DNA caused by X-ray ionization of the platinum atom in the Pt-bis-netropsin-DNA complex. Nucleic Acids Res. 19, 257.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 257
    • Grokhovsky, S.L.1    Zubarev, V.E.2
  • 214
    • 0002636670 scopus 로고
    • Sequence-specificity of drug-DNA interactions
    • (C. L. Propst and T. J. Perun, Eds.) Dekker, New York
    • Dabrowiak, J. C., Stankus, A. A., and Goodisman, J. (1992) Sequence-specificity of drug-DNA interactions. In Nucleic Acid Targeted Drug Design (C. L. Propst and T. J. Perun, Eds.) pp 93-149, Dekker, New York.
    • (1992) Nucleic Acid Targeted Drug Design , pp. 93-149
    • Dabrowiak, J.C.1    Stankus, A.A.2    Goodisman, J.3
  • 215
    • 0028899328 scopus 로고
    • Comparison of different footprinting methodologies for detecting binding sites for a small ligand on DNA
    • Bailly, C., and Waring, M. J. (1995) Comparison of different footprinting methodologies for detecting binding sites for a small ligand on DNA. J. Biomol. Struct. Dyn. 12, 869.
    • (1995) J. Biomol. Struct. Dyn. , vol.12 , pp. 869
    • Bailly, C.1    Waring, M.J.2
  • 216
    • 0000483886 scopus 로고
    • DNA affinity cleaving. Sequence specific cleavage of DNA by distamycin-EDTA·Fe(II) and EDTA-distamycin·Fe(II)
    • Taylor, J. S., Schultz, P. G., and Dervan, P. B. (1984) DNA affinity cleaving. Sequence specific cleavage of DNA by distamycin-EDTA·Fe(II) and EDTA-distamycin·Fe(II). Tetrahedron 40, 457.
    • (1984) Tetrahedron , vol.40 , pp. 457
    • Taylor, J.S.1    Schultz, P.G.2    Dervan, P.B.3
  • 217
    • 0010010119 scopus 로고
    • Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrole-carboxamide-EDTA·Fe(II)
    • Schultz, P. G., and Dervan, P. B. (1983) Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrole-carboxamide-EDTA·Fe(II). Proc. Natl. Acad. Sci. U.S.A. 80, 6834.
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.80 , pp. 6834
    • Schultz, P.G.1    Dervan, P.B.2
  • 218
    • 0020448650 scopus 로고
    • Design and synthesis of a sequence-specific DNa cleaving molecule. (distamycin-EDTA)iron(II)
    • Schultz, P. G., Taylor, J. S., and Dervan P. B. (1982) Design and synthesis of a sequence-specific DNA cleaving molecule. (distamycin-EDTA)iron(II). J. Am. Chem. Soc. 104, 6861.
    • (1982) J. Am. Chem. Soc. , vol.104 , pp. 6861
    • Schultz, P.G.1    Taylor, J.S.2    Dervan, P.B.3
  • 220
    • 0000399159 scopus 로고
    • Sequence-specific recognition of B-DNA by bis(EDTA-distamycin)-fumaramide
    • Youngquist, R. S., and Dervan, P. B. (1985) Sequence-specific recognition of B-DNA by bis(EDTA-distamycin)-fumaramide. J. Am. Chem. Soc. 107, 5528.
    • (1985) J. Am. Chem. Soc. , vol.107 , pp. 5528
    • Youngquist, R.S.1    Dervan, P.B.2
  • 221
    • 0001623048 scopus 로고
    • A synthetic peptide binds 16 base pairs of A,T double helical DNA
    • Youngquist, R. S., and Dervan, P. B. (1987) A synthetic peptide binds 16 base pairs of A,T double helical DNA. J. Am. Chem. Soc. 109, 7564.
    • (1987) J. Am. Chem. Soc. , vol.109 , pp. 7564
    • Youngquist, R.S.1    Dervan, P.B.2
  • 222
    • 0342987251 scopus 로고
    • Design of peptides that bind in the minor groove of DNa at 5′-(A,T)G(A,T)C(A,T)-3′ sequences by a dimeric side-by-side motif
    • Wade, W. S., Mrksich, M., and Dervan, P. B. (1992) Design of peptides that bind in the minor groove of DNA at 5′-(A,T)G(A,T)C(A,T)-3′ sequences by a dimeric side-by-side motif. J. Am. Chem. Soc. 114, 8783.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 8783
    • Wade, W.S.1    Mrksich, M.2    Dervan, P.B.3
  • 223
    • 0027276389 scopus 로고
    • Antiparallel side-by-side heterodimer for sequence-specific recognition in the minor groove of DNA by distamycin/1-methylimidazole-2-carboxamide-netropsin pair
    • Mrksich, M., and Dervan, P. B. (1993) Antiparallel side-by-side heterodimer for sequence-specific recognition in the minor groove of DNA by distamycin/1-methylimidazole-2-carboxamide-netropsin pair. J. Am. Chem. Soc. 115, 2572.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 2572
    • Mrksich, M.1    Dervan, P.B.2
  • 225
    • 0020482324 scopus 로고
    • Structure of the glycyl-L-histidyl-L-lysine-copper(II) complex in solution
    • Freedman, J. H., Pickart, L., Weinstein, B., Minis, W. B., and Peisach, J. (1982) Structure of the glycyl-L-histidyl-L-lysine-copper(II) complex in solution. Biochemistry 21, 4540.
    • (1982) Biochemistry , vol.21 , pp. 4540
    • Freedman, J.H.1    Pickart, L.2    Weinstein, B.3    Minis, W.B.4    Peisach, J.5
  • 226
  • 228
    • 0026826544 scopus 로고
    • Design of a sequence-specific DNA-cleaving molecule which conjugates a copper-chelating peptide, a netropsin residue, and an acridine chromophore
    • Bailly, C., Sun, J. S., Colson, P., Houssier, C., Hélène, C., Waring, M. J., and Hénichart, J. P. (1992) Design of a sequence-specific DNA-cleaving molecule which conjugates a copper-chelating peptide, a netropsin residue, and an acridine chromophore. Bioconjugate Chem. 3, 100.
    • (1992) Bioconjugate Chem. , vol.3 , pp. 100
    • Bailly, C.1    Sun, J.S.2    Colson, P.3    Houssier, C.4    Hélène, C.5    Waring, M.J.6    Hénichart, J.P.7
  • 230
    • 0030842839 scopus 로고    scopus 로고
    • Recognition and cleavage of DNa by a distamycin-salen·copper conjugate
    • Routier, S., Bernier, J. L., Catteau, J. P., and Bailly, C. (1997) Recognition and cleavage of DNA by a distamycin-salen·copper conjugate, BioOrg. Med. Chem. Lett. 7, 1729.
    • (1997) BioOrg. Med. Chem. Lett. , vol.7 , pp. 1729
    • Routier, S.1    Bernier, J.L.2    Catteau, J.P.3    Bailly, C.4
  • 231
    • 0002746148 scopus 로고    scopus 로고
    • Bleomycins: A strucural model for specificity, binding, and double strand cleavage
    • Stubbe, J., Kozarich, J. W., Wu, W., and Vanderwall, D. E. (1996) Bleomycins: a strucural model for specificity, binding, and double strand cleavage. Acc. Chem. Res. 29, 322.
    • (1996) Acc. Chem. Res. , vol.29 , pp. 322
    • Stubbe, J.1    Kozarich, J.W.2    Wu, W.3    Vanderwall, D.E.4
  • 232
    • 0027280640 scopus 로고
    • A designed synthetic analogue of Co(III)-bleomycin with enhanced DNA-binding and photocleaving activity
    • Farinas, E., Tan, J. D., Baidya, N., and Mascharak, P. K. (1993) A designed synthetic analogue of Co(III)-bleomycin with enhanced DNA-binding and photocleaving activity. J. Am. Chem. Soc. 115, 2996.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 2996
    • Farinas, E.1    Tan, J.D.2    Baidya, N.3    Mascharak, P.K.4
  • 234
    • 0021908242 scopus 로고
    • Copper(II)- and iron-(II)-complexes of methyl-2-(2-aminoethyl)-aminomethylpyridine-6-carboxyl-histidinate (AMPHIS), a peptide mimicking the metal-chelating moiety of bleomycin. An ESR study
    • Hénichart, J. P., Bernier, J. L., Houssin, R., Lohez, M., Kénani, A., and Catteau, J. P. (1985) Copper(II)- and iron-(II)-complexes of methyl-2-(2-aminoethyl)-aminomethylpyridine-6-carboxyl-histidinate (AMPHIS), a peptide mimicking the metal-chelating moiety of bleomycin. An ESR study. Biochem. Biophys. Res. Commun. 126, 1036.
    • (1985) Biochem. Biophys. Res. Commun. , vol.126 , pp. 1036
    • Hénichart, J.P.1    Bernier, J.L.2    Houssin, R.3    Lohez, M.4    Kénani, A.5    Catteau, J.P.6
  • 235
    • 85047671832 scopus 로고
    • A novel bleomycin model compound bearing hydrophilic steric factor exhibited high oxygen activating capacity
    • Kohda, J., Shinozuka, K., and Sawai, H. (1995) A novel bleomycin model compound bearing hydrophilic steric factor exhibited high oxygen activating capacity. Tetrahedron Lett. 36, 5575.
    • (1995) Tetrahedron Lett. , vol.36 , pp. 5575
    • Kohda, J.1    Shinozuka, K.2    Sawai, H.3
  • 238
    • 0027214106 scopus 로고
    • Design of DNA-cleaving molecules which incorporate a simplified metal-complexing moiety of bleomycin and lexitropsin carriers
    • Huang, L., Morgan, R., and Lown, J. W. (1993) Design of DNA-cleaving molecules which incorporate a simplified metal-complexing moiety of bleomycin and lexitropsin carriers. Bioorg. Med. Chem. Lett. 3, 1751.
    • (1993) Bioorg. Med. Chem. Lett. , vol.3 , pp. 1751
    • Huang, L.1    Morgan, R.2    Lown, J.W.3
  • 239
    • 0028016122 scopus 로고
    • Design and synthesis of DNA cleaving bleomycin models: 1,2-trans disubstituted cyclopropane units as novel linkers
    • Huang, L., Quada, J. C., and Lown, J. W. (1994) Design and synthesis of DNA cleaving bleomycin models: 1,2-trans disubstituted cyclopropane units as novel linkers. Tetrahedron Lett. 35, 5323.
    • (1994) Tetrahedron Lett. , vol.35 , pp. 5323
    • Huang, L.1    Quada, J.C.2    Lown, J.W.3
  • 240
    • 0029104653 scopus 로고
    • Design, synthesis, and sequence selective DNa cleavage of functional models of bleomycins. 1. Hybrids incorporating a simple metal-complexing moiety of bleomycin and lexitropsin carriers
    • Huang, L., Quada, J. C., Jr., and Lown, J. W. (1995) Design, synthesis, and sequence selective DNA cleavage of functional models of bleomycins. 1. Hybrids incorporating a simple metal-complexing moiety of bleomycin and lexitropsin carriers. Bioconjugate Chem. 6, 21.
    • (1995) Bioconjugate Chem. , vol.6 , pp. 21
    • Huang, L.1    Quada J.C., Jr.2    Lown, J.W.3
  • 241
    • 0029057666 scopus 로고
    • Design, synthesis, and sequence selective DNA cleavage of functional models of bleomycins. II. 1,2-trans-disubstituted cyclopropane units as novel linkers
    • Huang, L., Quada, J. C., Jr., and Lown, J. W. (1995) Design, synthesis, and sequence selective DNA cleavage of functional models of bleomycins. II. 1,2-trans-disubstituted cyclopropane units as novel linkers. BioOrg. Med. Chem. 3, 647.
    • (1995) BioOrg. Med. Chem. , vol.3 , pp. 647
    • Huang, L.1    Quada J.C., Jr.2    Lown, J.W.3
  • 243
    • 0028243633 scopus 로고
    • On the role of the bithiazole moiety in sequence-selective DNA cleavage by Fe·bleomycin
    • Kane, S. A., Natrajan, A., and Hecht, S. M. (1994) On the role of the bithiazole moiety in sequence-selective DNA cleavage by Fe·bleomycin. J. Biol. Chem. 269, 10899.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10899
    • Kane, S.A.1    Natrajan, A.2    Hecht, S.M.3
  • 244
    • 0029099533 scopus 로고
    • 2. a binding model based on NMR experiments and restrained molecular dynamics calculations
    • 2. A binding model based on NMR experiments and restrained molecular dynamics calculations. J. Am. Chem. Soc. 117, 7891.
    • (1995) J. Am. Chem. Soc. , vol.117 , pp. 7891
    • Manderville, R.A.1    Ellena, J.F.2    Hecht, S.M.3
  • 246
    • 0026718016 scopus 로고
    • Designed enediynes: A new class of DNA-cleaving molecules with potent and selective anticancer activity
    • Nicolaou, K. C., Dai, W.-M., Tsay, S.-C., Estevez, V. A., and Wrasidlo, W. (1992) Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity. Science 256, 1172.
    • (1992) Science , vol.256 , pp. 1172
    • Nicolaou, K.C.1    Dai, W.-M.2    Tsay, S.-C.3    Estevez, V.A.4    Wrasidlo, W.5
  • 248
    • 0026045597 scopus 로고
    • Chemistry and biology of the enedyine anticancer antibiotics
    • Nicolaou, K. C., and Dai, W.-M. (1991) Chemistry and biology of the enedyine anticancer antibiotics. Angew. Chem., Int. Ed. Engl. 30, 1387
    • (1991) Angew. Chem., Int. Ed. Engl. , vol.30 , pp. 1387
    • Nicolaou, K.C.1    Dai, W.-M.2
  • 249
    • 0027519257 scopus 로고
    • Synthesis of a hybrid molecule containing neocarzinostatin chromophore analogue and minor groove binder
    • Tokuda, M., Fujiwara, K., Gomibuchi, T., Hirama, M., Uesugi, M., and Sugiura, Y. (1993) Synthesis of a hybrid molecule containing neocarzinostatin chromophore analogue and minor groove binder. Tetrahedron Lett. 34, 669.
    • (1993) Tetrahedron Lett. , vol.34 , pp. 669
    • Tokuda, M.1    Fujiwara, K.2    Gomibuchi, T.3    Hirama, M.4    Uesugi, M.5    Sugiura, Y.6
  • 251
    • 0030946785 scopus 로고    scopus 로고
    • Enediynelexitropsin DNA-targeted anticancer agents. Physicochemical and cytotoxic properties in human neoplastic cells in vitro, and intracellular distribution
    • Xie, Y., Miller, G. G., Cubitt, S. A., Soderlind, K.-J., Allalunis-Turner, M. J., and Lown, J. W. (1997) Enediynelexitropsin DNA-targeted anticancer agents. Physicochemical and cytotoxic properties in human neoplastic cells in vitro, and intracellular distribution. Anti-Cancer Drug Des. 12, 169.
    • (1997) Anti-Cancer Drug Des. , vol.12 , pp. 169
    • Xie, Y.1    Miller, G.G.2    Cubitt, S.A.3    Soderlind, K.-J.4    Allalunis-Turner, M.J.5    Lown, J.W.6
  • 252
    • 0027936341 scopus 로고
    • The effect on DNa cleavage potency of tethering a simple cyclic enediyne to a netropsin analog
    • Semmelhack, M. F., and Gallagher, J. J. (1994) The effect on DNA cleavage potency of tethering a simple cyclic enediyne to a netropsin analog. J. Org. Chem. 59, 4357.
    • (1994) J. Org. Chem. , vol.59 , pp. 4357
    • Semmelhack, M.F.1    Gallagher, J.J.2
  • 253
    • 0028004788 scopus 로고
    • New class of DNA-cleaving agents based on trimethylenemethane
    • Bregant, T. M., Groppe, J., and Little, R. D. (1994) New class of DNA-cleaving agents based on trimethylenemethane. J. Am. Chem. Soc. 116, 3635.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 3635
    • Bregant, T.M.1    Groppe, J.2    Little, R.D.3
  • 254
    • 0029047101 scopus 로고
    • The binding modes of a rationally designed photoactivated DNa nuclease determined by NMR
    • Spielmann, H. P., Fagan, P. A., Bregant, T. M., Little, R. D., and Wemmer, D. E. (1995) The binding modes of a rationally designed photoactivated DNA nuclease determined by NMR. Nucleic Acids Res. 23, 1576.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1576
    • Spielmann, H.P.1    Fagan, P.A.2    Bregant, T.M.3    Little, R.D.4    Wemmer, D.E.5
  • 255
    • 0027261230 scopus 로고
    • Synthesis and DNA cleaving properties of hybrid molecules containing propargylic sulfones and minor groove binding lexitropsins
    • Xie, G., Morgan, A. R., and Lown, J. W. (1993) Synthesis and DNA cleaving properties of hybrid molecules containing propargylic sulfones and minor groove binding lexitropsins. Bioorg. Med. Chem. Lett. 3, 1565.
    • (1993) Bioorg. Med. Chem. Lett. , vol.3 , pp. 1565
    • Xie, G.1    Morgan, A.R.2    Lown, J.W.3
  • 256
    • 0029257271 scopus 로고
    • Netropsin and spermine conjugates of a water-soluble quinocarcin analog: Analysis of sequence-specific DNa interactions
    • Flanagan, M. E., Rollins, S. B., and Williams, R. M. (1995) Netropsin and spermine conjugates of a water-soluble quinocarcin analog: analysis of sequence-specific DNA interactions. Chem. Biol. 2, 145.
    • (1995) Chem. Biol. , vol.2 , pp. 145
    • Flanagan, M.E.1    Rollins, S.B.2    Williams, R.M.3
  • 257
    • 0026637211 scopus 로고
    • Crystal strucutre of the 2:1 complex between d(GAAGCTTC) and the anticancer drug actinomycin D
    • Kamitori, S., and Takusagawa, F. (1992) Crystal strucutre of the 2:1 complex between d(GAAGCTTC) and the anticancer drug actinomycin D. J. Mol. Biol. 225, 445.
    • (1992) J. Mol. Biol. , vol.225 , pp. 445
    • Kamitori, S.1    Takusagawa, F.2
  • 259
    • 0029962943 scopus 로고    scopus 로고
    • DNA bending and unwinding associated with actinomycin D antibiotics bound to partially overlapping sites on DNA
    • Chen, H., Liu, X., and Patel, D. J. (1996) DNA bending and unwinding associated with actinomycin D antibiotics bound to partially overlapping sites on DNA. J. Mol. Biol. 258, 457.
    • (1996) J. Mol. Biol. , vol.258 , pp. 457
    • Chen, H.1    Liu, X.2    Patel, D.J.3
  • 260
    • 0000052344 scopus 로고
    • Intercalate drug binding to DNA
    • Wang, A. H. J. (1992) Intercalate drug binding to DNA. Curr. Opin. Struct. Biol. 2, 361.
    • (1992) Curr. Opin. Struct. Biol. , vol.2 , pp. 361
    • Wang, A.H.J.1
  • 261
    • 0011882110 scopus 로고
    • Daunomycin binding to DNA: From the macroscopic to the microscopic
    • (B. Pullman and J. Jortner, Eds.) Kluwer Academic Publishers, Dordrecht, The Netherlands
    • Chaires, J. B. (1990) Daunomycin binding to DNA: from the macroscopic to the microscopic. In Molecular Basis of Specificity in Nucleic Acid-Drug Interactions (B. Pullman and J. Jortner, Eds.) pp 225-245, Kluwer Academic Publishers, Dordrecht, The Netherlands.
    • (1990) Molecular Basis of Specificity in Nucleic Acid-Drug Interactions , pp. 225-245
    • Chaires, J.B.1
  • 262
    • 0012939919 scopus 로고
    • Echinomycin and related quinoxaline antibiotics
    • (S. Neidle and M. J. Waring, Eds.) Macmillan, London
    • Waring, M. J. (1993) Echinomycin and related quinoxaline antibiotics. In Molecular Aspects of Anticancer Drug-DNA Interactions (S. Neidle and M. J. Waring, Eds.) Vol. 1, pp 213-242, Macmillan, London.
    • (1993) Molecular Aspects of Anticancer Drug-DNA Interactions , vol.1 , pp. 213-242
    • Waring, M.J.1
  • 263
    • 0025368037 scopus 로고
    • DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores
    • Sugiura, Y., Shiraki, T., Konishi, M., and Oki, T. (1990) DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores. Proc. Natl. Acad. Sci. U.S.A. 87, 3831.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 3831
    • Sugiura, Y.1    Shiraki, T.2    Konishi, M.3    Oki, T.4
  • 264
    • 0024561618 scopus 로고
    • Sequence-specific, strand-selective, and directional binding of neocarzinostatin chromophore to oligodeoxyribonucleotides
    • Lee, S. H., and Goldberg, I. H. (1989) Sequence-specific, strand-selective, and directional binding of neocarzinostatin chromophore to oligodeoxyribonucleotides. Biochemistry 28, 1019.
    • (1989) Biochemistry , vol.28 , pp. 1019
    • Lee, S.H.1    Goldberg, I.H.2
  • 265
    • 0026252150 scopus 로고
    • DNA recognition by intercalator-minor groove binder hybrid molecules
    • Bailly, C., and Hénichart, J. P. (1991) DNA recognition by intercalator-minor groove binder hybrid molecules. Bioconjugate Chem. 2, 379.
    • (1991) Bioconjugate Chem. , vol.2 , pp. 379
    • Bailly, C.1    Hénichart, J.P.2
  • 266
    • 0001071346 scopus 로고
    • Molecular pharmacology of intercalator-minor groove binder hybrid groove binder hybrid molecules
    • (S. Neidle and M. J. Waring, Eds.) Macmillan, London
    • Bailly, C., and Hénichart, J. P. (1994) Molecular pharmacology of intercalator-minor groove binder hybrid groove binder hybrid molecules. In Molecular Aspects of Anticancer Drug-DNA Interactions (S. Neidle and M. J. Waring, Eds.) Vol. 2, pp 162-196, Macmillan, London.
    • (1994) Molecular Aspects of Anticancer Drug-DNA Interactions , vol.2 , pp. 162-196
    • Bailly, C.1    Hénichart, J.P.2
  • 267
    • 0021164318 scopus 로고
    • DNA interaction with low molecular weight ligands with different structures. III. Complexes of DNA with distactins
    • Krivtsora, M. A., Moroshkina, E. B., and Glibin, E. (1984) DNA interaction with low molecular weight ligands with different structures. III. Complexes of DNA with distactins. Mol. Biol. 18, 950.
    • (1984) Mol. Biol. , vol.18 , pp. 950
    • Krivtsora, M.A.1    Moroshkina, E.B.2    Glibin, E.3
  • 269
    • 0023762722 scopus 로고
    • The synthesis and DNA footprinting of acridine-linked netropsin and distamycin bifunctional mixed ligands
    • Eliadis, A., Phillips, D. R., Reiss, J. A., and Skorobogaty, A. (1988) The synthesis and DNA footprinting of acridine-linked netropsin and distamycin bifunctional mixed ligands. J. Chem. Soc., Chem. Commun. 1049.
    • (1988) J. Chem. Soc., Chem. Commun. , vol.1049
    • Eliadis, A.1    Phillips, D.R.2    Reiss, J.A.3    Skorobogaty, A.4
  • 270
    • 0026510909 scopus 로고
    • Synthesis of novel DNA photocleaving agents with potent DNA cleaving activity
    • Shinomiya, M., and Kuroda, R. (1992) Synthesis of novel DNA photocleaving agents with potent DNA cleaving activity. Tetrahedron Lett. 33, 2697.
    • (1992) Tetrahedron Lett. , vol.33 , pp. 2697
    • Shinomiya, M.1    Kuroda, R.2
  • 271
    • 0029073181 scopus 로고
    • Novel DNA photocleaving agents with high DNA sequence sopecificity related to the antibiotic bleomycin A2
    • Kuroda, R., Satoh, H., Shinomiya, M., Watanabe, T., and Otsuka, O. (1995) Novel DNA photocleaving agents with high DNA sequence sopecificity related to the antibiotic bleomycin A2. Nucleic Acids Res. 23, 1524.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1524
    • Kuroda, R.1    Satoh, H.2    Shinomiya, M.3    Watanabe, T.4    Otsuka, O.5
  • 272
    • 0024894027 scopus 로고
    • Design, synthesis, DNA-binding and biological activity of a series of DNa minor groove binding intercalating drugs
    • Bailly, C., Pommery, N., Houssin, R., and Hénichart, J. P. (1989) Design, synthesis, DNA-binding and biological activity of a series of DNA minor groove binding intercalating drugs. J. Pharm. Sci. 78, 910.
    • (1989) J. Pharm. Sci. , vol.78 , pp. 910
    • Bailly, C.1    Pommery, N.2    Houssin, R.3    Hénichart, J.P.4
  • 273
    • 0025381502 scopus 로고
    • Molecular recognition between oligopeptides and nucleic acids. DNA sequence specificity and binding properties of an acridine-linked netropsin hybrid ligand
    • Bailly, C., Helbecque, N., Hénichart, J. P., Colson, P., Houssier, C., Rao, K. E., Shea, R. G., and Lown, J. W. (1990) Molecular recognition between oligopeptides and nucleic acids. DNA sequence specificity and binding properties of an acridine-linked netropsin hybrid ligand. J. Mol. Recognit. 3, 26.
    • (1990) J. Mol. Recognit. , vol.3 , pp. 26
    • Bailly, C.1    Helbecque, N.2    Hénichart, J.P.3    Colson, P.4    Houssier, C.5    Rao, K.E.6    Shea, R.G.7    Lown, J.W.8
  • 274
    • 0028000647 scopus 로고
    • Stimulation of site-specific topoisomerase II-mediated DNA cleavage by an N-methylpyrrolecarboxamide-anilinoacridine conjugate: Relation to DNA binding
    • Fossé, P., René, B., Saucier, J. M., Hénichart, J. P., Waring, M. J., Colson, P., Houssier, C., and Bailly, C. (1994) Stimulation of site-specific topoisomerase II-mediated DNA cleavage by an N-methylpyrrolecarboxamide-anilinoacridine conjugate: relation to DNA binding. Biochemistry 33, 9865.
    • (1994) Biochemistry , vol.33 , pp. 9865
    • Fossé, P.1    René, B.2    Saucier, J.M.3    Hénichart, J.P.4    Waring, M.J.5    Colson, P.6    Houssier, C.7    Bailly, C.8
  • 276
    • 0030022599 scopus 로고    scopus 로고
    • The 1′-substituent on the anilino ring of the antitumor drug amsacrine is a critical element for topoisomerase II inhibition and cytotoxicity
    • René, B., Fossé, P., Khélifa, T., Jacquemin-Sablon, A., and Bailly, C. (1996) The 1′-substituent on the anilino ring of the antitumor drug amsacrine is a critical element for topoisomerase II inhibition and cytotoxicity. Mol. Pharmacol. 49, 343.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 343
    • René, B.1    Fossé, P.2    Khélifa, T.3    Jacquemin-Sablon, A.4    Bailly, C.5
  • 282
    • 0029148053 scopus 로고
    • Effects of two distamycin-ellipticine hybrid molecules on topoisomerase I and II-mediated DNA cleavage: Relation to cytotoxicity
    • Riou, J. F., Grondard, L., Naudin, A., and Bailly, C. (1995) Effects of two distamycin-ellipticine hybrid molecules on topoisomerase I and II-mediated DNA cleavage: relation to cytotoxicity. Biochem. Pharmacol. 50, 424.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 424
    • Riou, J.F.1    Grondard, L.2    Naudin, A.3    Bailly, C.4
  • 284
    • 0025845308 scopus 로고
    • Bis(pyrrolecarboxamide) linked to intercalating chromophore oxazolopyridocarbazole (OPC): Selective binding to DNA and polynucleotides
    • Subra, F., Carteau, S., Pager, J., Paoletti, J., Paoletti, C., Auclair, C., Mrani, D., Gosselin, G., and Imbach, J. L. (1991) Bis(pyrrolecarboxamide) linked to intercalating chromophore oxazolopyridocarbazole (OPC): selective binding to DNA and polynucleotides. Biochemistry 30, 1642.
    • (1991) Biochemistry , vol.30 , pp. 1642
    • Subra, F.1    Carteau, S.2    Pager, J.3    Paoletti, J.4    Paoletti, C.5    Auclair, C.6    Mrani, D.7    Gosselin, G.8    Imbach, J.L.9
  • 285
    • 0027492740 scopus 로고
    • Inhibition of the moloney murine leukemia virus cycle at a post reverse transcriptional step by the netropsin-intercalating hybrid molecule netropsin-oxazolopyridocarbazole
    • Subra, F., Mouscadet, J. F., Lavignon, M., Roy, C., and Auclair, C. (1993) Inhibition of the moloney murine leukemia virus cycle at a post reverse transcriptional step by the netropsin-intercalating hybrid molecule netropsin-oxazolopyridocarbazole. Biochem. Pharmacol. 45, 93.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 93
    • Subra, F.1    Mouscadet, J.F.2    Lavignon, M.3    Roy, C.4    Auclair, C.5
  • 286
    • 0028197039 scopus 로고
    • Selective binding to polynucleotides of the hybrid intercalating groove binder bis-(pyrrolecarboxamide)-oxazolopyridocarbazole: A molecular modeling study
    • Goulaouic, H., Carteau, S., Subra, F., Mouscadet, J. F., Auclair, C., and Sun, J.-S. (1994) Selective binding to polynucleotides of the hybrid intercalating groove binder bis-(pyrrolecarboxamide)-oxazolopyridocarbazole: a molecular modeling study. Biochemistry 33, 1412.
    • (1994) Biochemistry , vol.33 , pp. 1412
    • Goulaouic, H.1    Carteau, S.2    Subra, F.3    Mouscadet, J.F.4    Auclair, C.5    Sun, J.-S.6
  • 288
    • 0022600942 scopus 로고
    • Kinetic and equilibrium studies of the interaction of amsacrine and anilino ring-substituted analogues with DNA
    • Denny, W. A., and Wakelin, L. P. G. (1986) Kinetic and equilibrium studies of the interaction of amsacrine and anilino ring-substituted analogues with DNA. Cancer Res. 46, 1717.
    • (1986) Cancer Res. , vol.46 , pp. 1717
    • Denny, W.A.1    Wakelin, L.P.G.2
  • 289
    • 0026513412 scopus 로고
    • Sequence-specificity of the binding of 9-aminoacridine- and amsacrine-4-carboxamides to DNA studied by DNase I footprinting
    • Bailly, C., Denny, W. A., Mellor, L., Wakelin, L. P. G., and Waring, M. J. (1992) Sequence-specificity of the binding of 9-aminoacridine- and amsacrine-4-carboxamides to DNA studied by DNase I footprinting. Biochemistry 31, 3514.
    • (1992) Biochemistry , vol.31 , pp. 3514
    • Bailly, C.1    Denny, W.A.2    Mellor, L.3    Wakelin, L.P.G.4    Waring, M.J.5
  • 290
    • 5244233576 scopus 로고    scopus 로고
    • Interaction of DNA-threading netropsin-amsacrine combilexin with DNA and chromatin
    • Bourdouxhe-Housiaux, C., Colson, P., Houssier, C., Waring, M. J., and Bailly, C. (1996) Interaction of DNA-threading netropsin-amsacrine combilexin with DNA and chromatin. Biochemistry 35, 4251.
    • (1996) Biochemistry , vol.35 , pp. 4251
    • Bourdouxhe-Housiaux, C.1    Colson, P.2    Houssier, C.3    Waring, M.J.4    Bailly, C.5
  • 291
    • 0030996693 scopus 로고    scopus 로고
    • Copper-dependent Oxidative and Topoisomerase II-mediated DNa Cleavage by a Netropsin-Amsacrine Combilexin
    • Hénichart, J. P., Waring, M. J., Riou, J. F., Denny, W. A., and Bailly, C. (1997) Copper-dependent Oxidative and Topoisomerase II-mediated DNA Cleavage by a Netropsin-Amsacrine Combilexin. Mol. Pharmacol. 51, 448-461.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 448-461
    • Hénichart, J.P.1    Waring, M.J.2    Riou, J.F.3    Denny, W.A.4    Bailly, C.5
  • 292
    • 0029133581 scopus 로고
    • Novel acridine-triazenes as prototype combilexins: Synthesis, DNA binding, and biological activity
    • McCaunaughie, A. W., and Jenkins, T. C. (1995) Novel acridine-triazenes as prototype combilexins: synthesis, DNA binding, and biological activity. J. Med. Chem. 38, 3488.
    • (1995) J. Med. Chem. , vol.38 , pp. 3488
    • McCaunaughie, A.W.1    Jenkins, T.C.2
  • 293
    • 0029944095 scopus 로고    scopus 로고
    • Design, synthesis and to poisomerase II inhibition activity of 4′-demethylepipodophyllotoxin-lexitropsin conjugates
    • Gupta, R., Al-Said, N. H., Oreski, B., and Lown, J. W. (1996) Design, synthesis and to poisomerase II inhibition activity of 4′-demethylepipodophyllotoxin-lexitropsin conjugates. Anti-Cancer Drug Des. 11, 325.
    • (1996) Anti-Cancer Drug Des. , vol.11 , pp. 325
    • Gupta, R.1    Al-Said, N.H.2    Oreski, B.3    Lown, J.W.4
  • 294
    • 0030591698 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of hybrid molecules containing the pyrroloquinoline nucleus and DNA-minor groove binders
    • Zhao, R., Oreski, B., and Lown, J. W. (1996) Synthesis and biological evaluation of hybrid molecules containing the pyrroloquinoline nucleus and DNA-minor groove binders. BioOrg. Med. Chem. Lett. 6, 2169.
    • (1996) BioOrg. Med. Chem. Lett. , vol.6 , pp. 2169
    • Zhao, R.1    Oreski, B.2    Lown, J.W.3
  • 295
    • 0028942445 scopus 로고
    • Design and development of sequence selective lexitropsin DNA minor groove binders
    • Lown, J. W. (1995) Design and development of sequence selective lexitropsin DNA minor groove binders. Drug Dev. Res. 34, 145.
    • (1995) Drug Dev. Res. , vol.34 , pp. 145
    • Lown, J.W.1
  • 298
    • 0029141654 scopus 로고
    • Strategies for the design of minor groove binders: A re-evaluation based on the emergence of site-selective carbohydrate binders
    • Kahne, D. (1995) Strategies for the design of minor groove binders: a re-evaluation based on the emergence of site-selective carbohydrate binders. Chem. Biol. 2, 7.
    • (1995) Chem. Biol. , vol.2 , pp. 7
    • Kahne, D.1
  • 299
    • 0028535425 scopus 로고
    • Gene transfer with a series of lipophilic DNA-binding molecules
    • Remy, J.-S., Sirlin, C., Vierling, P., and Behr, J.-P. (1994) Gene transfer with a series of lipophilic DNA-binding molecules. Bioconjugate Chem. 5, 647.
    • (1994) Bioconjugate Chem. , vol.5 , pp. 647
    • Remy, J.-S.1    Sirlin, C.2    Vierling, P.3    Behr, J.-P.4


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