Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 4, 2009, Pages 1640-1647

  Gitto, Rosaria ^a   Luca, Laura De ^a   Ferro, Stefania ^a   Citraro, Rita ^b   Sarro, Giovambattista De ^b   Costa, Lara ^c   Ciranna, Lucia ^c   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

Anticonvulsant activity; Binding affinity; Molecular modeling; NR2B NMDA antagonist; Patch clamp

Indexed keywords

1H INDOLE DERIVATIVE; 2 (4 BENZYLPIPERIDIN 1 YL) 1 (5 HYDROXY 1H INDOL 3 YL)ETHANONE; 4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; IFENPRODIL; INDOLE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ANIMALS; ANTICONVULSANTS; BINDING SITES; DRUG DESIGN; INDOLES; MEMBRANE POTENTIALS; MICE; MICE, INBRED DBA; MODELS, MOLECULAR; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60049087072     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.058     Document Type: Article

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