CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents

Neuropharmacology

Volumn 39, Issue 7, 2000, Pages 1147-1155

  Menniti, Frank S ^a   Pagnozzi, Martin J ^a   Butler, Paul ^b   Chenard, Bertrand L ^a   Jaw Tsai, Sarah S ^a   Frost White, W ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

c fos induction; Cortical spreading depression; CP 101,606; NMDA receptor antagonist

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT; TRAXOPRODIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DENTATE GYRUS; DRUG BLOOD LEVEL; GENE EXPRESSION; GENE INDUCTION; IMMUNOREACTIVITY; MOUSE; NEUROPROTECTION; NONHUMAN; NORTHERN BLOTTING; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SPREADING CORTICAL DEPRESSION;

ANIMALS; BLOTTING, NORTHERN; BRAIN INJURIES; DIZOCILPINE MALEATE; ELECTRIC STIMULATION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION; GENES, FOS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICE; N-METHYLASPARTATE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SPREADING CORTICAL DEPRESSION;

EID: 0034064252     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00211-7     Document Type: Article

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