Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile

ChemMedChem

Volumn 3, Issue 10, 2008, Pages 1539-1548

  Gitto, Rosaria ^a   De Luca, Laura ^a   Ferro, Stefania ^a   Occhiuto, Francesco ^a   Samperi, Stefania ^a   De Sarro, Giovanbattista ^b   Russo, Emilio ^b   Ciranna, Lucia ^c   Costa, Lara ^c   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

Anticonvulsant activity hcn 1a neurons molecular modeling neurotransmitters nr2b nmda antagonists

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTICONVULSIVE AGENT; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR2B NMDA RECEPTOR; PROTEIN SUBUNIT;

ANIMAL; ARTICLE; BINDING SITE; BIOLOGY; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DBA MOUSE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; MOUSE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTICONVULSANTS; BINDING SITES; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; HUMANS; LIGANDS; MICE; MICE, INBRED DBA; MODELS, MOLECULAR; NEUROTRANSMITTER AGENTS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54849429143     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800124     Document Type: Article

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