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Volumn 19, Issue 1, 2009, Pages 3-14

Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy

Author keywords

Anti viral; Conjugate; Fosamprenavir; HIV; Nanocarrier; Prodrug; Targeted drug delivery; Tenofovir disoproxil fumarate

Indexed keywords

ABACAVIR; ADEFOVIR; AMPRENAVIR; AMPRENAVIR PHOSPHATE; ATAZANAVIR; DARUNAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; ENFUVIRTIDE; ETRAVIRINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INDINAVIR; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; MACROGOL; MARAVIROC; NANOCARRIER; NELFINAVIR; NEVIRAPINE; NOVIR; RALTEGRAVIR; RITONAVIR; SALZENTRY; SAQUINAVIR; STAVUDINE; TENOFOVIR DISOPROXIL; TIPRANAVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS PROTEIN; VIRUS RNA; ZALCITABINE; ZIDOVUDINE;

EID: 59849092368     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(09)50001-9     Document Type: Review
Times cited : (27)

References (103)
  • 1
    • 85031361032 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS and The World Health Organization-2007 AIDS epidemic update.-(2007)-http://www.unaids.org/en/ KnowledgeCentre/Resources/Publications/-2007_epiupdate_en.pdf -Accessed [June 11, 2008]
    • Joint United Nations Programme on HIV/AIDS and The World Health Organization-2007 AIDS epidemic update.-(2007)-http://www.unaids.org/en/ KnowledgeCentre/Resources/Publications/-2007_epiupdate_en.pdf -Accessed [June 11, 2008]
  • 2
    • 85031359528 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS and The World Health Organization-2006 report on the global AIDS epidemic, June 11, 2008
    • Joint United Nations Programme on HIV/AIDS and The World Health Organization-2006 report on the global AIDS epidemic. -(2006) http://www.unaids.org/en/KnowledgeCentre/Resources/Publications/ -[June 11, 2008]
    • (2006)
  • 3
    • 33744959926 scopus 로고    scopus 로고
    • The HIV-AIDS pandemic at 25-the global response
    • Merson M. -The HIV-AIDS pandemic at 25-the global response. -N. Engl. J. Med., 354, 2414-2417, 2006.
    • (2006) N. Engl. J. Med , vol.354 , pp. 2414-2417
    • Merson, M.1
  • 5
    • 36749088862 scopus 로고    scopus 로고
    • HIV drug development: The next 25 years
    • Flexner C. - HIV drug development: the next 25 years. - Nat. Rev. Drug Discov., 6, 959-965, 2007.
    • (2007) Nat. Rev. Drug Discov , vol.6 , pp. 959-965
    • Flexner, C.1
  • 6
    • 20144372481 scopus 로고    scopus 로고
    • Janssen P., Lewi P., Arnold E., Daeyaert F., De Jong M., Heeres J., Koymans L., Vinkers M., Guillemont J., Pasquier E., Kukla M., Ludovici D., Andries K., De Bethune M., Pauwels R., Das K., Clark A., Frenkel Y., Hughes S., Medaer B., De Knaep F., Bohets H., De Clerck F., Lampo A., Williams P., Stoffels P. - In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-4-4-[(1E)-2-cyanoethenyl]-2,6-dimethyphenyl] amino]-2-pyrimidinyl]amino]benzonitrile (R278474), Rilpivirine). - J. Med. Chem., 48, 1901-1909, 2005.
    • Janssen P., Lewi P., Arnold E., Daeyaert F., De Jong M., Heeres J., Koymans L., Vinkers M., Guillemont J., Pasquier E., Kukla M., Ludovici D., Andries K., De Bethune M., Pauwels R., Das K., Clark A., Frenkel Y., Hughes S., Medaer B., De Knaep F., Bohets H., De Clerck F., Lampo A., Williams P., Stoffels P. - In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-4-4-[(1E)-2-cyanoethenyl]-2,6-dimethyphenyl] amino]-2-pyrimidinyl]amino]benzonitrile (R278474), Rilpivirine). - J. Med. Chem., 48, 1901-1909, 2005.
  • 7
    • 20644469472 scopus 로고    scopus 로고
    • Antiretroviral therapies for treatment-experienced patients: Current status and research challenges
    • Struble K., Murray J., Cheng B., Gegeny T., Miller V., Gulick R. - Antiretroviral therapies for treatment-experienced patients: current status and research challenges. - AIDS, 19, 747-756, 2005.
    • (2005) AIDS , vol.19 , pp. 747-756
    • Struble, K.1    Murray, J.2    Cheng, B.3    Gegeny, T.4    Miller, V.5    Gulick, R.6
  • 10
    • 0036050539 scopus 로고    scopus 로고
    • DE - Strategies in the design of antiviral drugs
    • Clercq E. DE - Strategies in the design of antiviral drugs. - Nat. Rev. Drug Discov., 1, 13-25, 2002.
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 13-25
    • Clercq, E.1
  • 12
    • 1642387849 scopus 로고    scopus 로고
    • An overall picture of chemokine receptors: Basic research and drug development
    • Chen L., Pei G., Zhang W. - An overall picture of chemokine receptors: basic research and drug development. - Curr. Pharm. Des., 10, 1045-1055, 2004.
    • (2004) Curr. Pharm. Des , vol.10 , pp. 1045-1055
    • Chen, L.1    Pei, G.2    Zhang, W.3
  • 13
    • 2942555662 scopus 로고    scopus 로고
    • HIV co-receptors as targets for antiviral therapy
    • Schols D. - HIV co-receptors as targets for antiviral therapy. - Curr. Top. Med. Chem., 4, 883-893, 2004.
    • (2004) Curr. Top. Med. Chem , vol.4 , pp. 883-893
    • Schols, D.1
  • 14
    • 32544446940 scopus 로고    scopus 로고
    • HIV and the chemokine system: 10 years later
    • Lusso P. - HIV and the chemokine system: 10 years later. - EMBO J., 25, 447-456, 2006.
    • (2006) EMBO J , vol.25 , pp. 447-456
    • Lusso, P.1
  • 15
    • 33745092046 scopus 로고    scopus 로고
    • Kazmierski W., Kenakin T., Gudmundsson K. - Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5, and CXCR4. - Chem. Bio. Drug Des., 67, 13-26, 2006.
    • Kazmierski W., Kenakin T., Gudmundsson K. - Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5, and CXCR4. - Chem. Bio. Drug Des., 67, 13-26, 2006.
  • 16
    • 36749073433 scopus 로고    scopus 로고
    • The design of drugs for HIV and HCV
    • De Clercq E. -The design of drugs for HIV and HCV - Nat. Rev. Drug Discov., 6, 1001-1017, 2007.
    • (2007) Nat. Rev. Drug Discov , vol.6 , pp. 1001-1017
    • De Clercq, E.1
  • 18
    • 17444392445 scopus 로고    scopus 로고
    • Autoprocessing of HIV-1 protease is tightly coupled to protein folding
    • Louis J., Clore G., Gronenborn A. - Autoprocessing of HIV-1 protease is tightly coupled to protein folding. - Nat. Struct. Biol., 6, 868-875, 1999.
    • (1999) Nat. Struct. Biol , vol.6 , pp. 868-875
    • Louis, J.1    Clore, G.2    Gronenborn, A.3
  • 19
    • 0036133364 scopus 로고    scopus 로고
    • Reservoirs of human immunodeficiency virus type 1: The main obstacles to viral eradication
    • Pomerantz R. - Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication. - Clin. Infect. Dis., 34, 91-97, 2002.
    • (2002) Clin. Infect. Dis , vol.34 , pp. 91-97
    • Pomerantz, R.1
  • 20
    • 33947720523 scopus 로고    scopus 로고
    • Development in motion: Helper T cells at work
    • Reiner S. - Development in motion: helper T cells at work. - Cell, 129, 33-36, 2007.
    • (2007) Cell , vol.129 , pp. 33-36
    • Reiner, S.1
  • 21
    • 39349090097 scopus 로고    scopus 로고
    • Back-to-basics push as HIV prevention struggles
    • Cohen J. - Back-to-basics push as HIV prevention struggles. - Science, 319, 888, 2008.
    • (2008) Science , vol.319 , pp. 888
    • Cohen, J.1
  • 22
    • 0037133126 scopus 로고    scopus 로고
    • Targeting to macrophages: Role of physicochemical properties of particulate carriers - liposomes and microspheres - on the phagocytosis by macrophages
    • Ahsan F., Rivas I., Khan M., Suarez A. - Targeting to macrophages: role of physicochemical properties of particulate carriers - liposomes and microspheres - on the phagocytosis by macrophages. - J. Control. Release, 79, 29-40, 2002.
    • (2002) J. Control. Release , vol.79 , pp. 29-40
    • Ahsan, F.1    Rivas, I.2    Khan, M.3    Suarez, A.4
  • 23
    • 0032971372 scopus 로고    scopus 로고
    • + T cell demographics and dynamics in lymphatic tissues
    • + T cell demographics and dynamics in lymphatic tissues. - Annu. Rev. Immunol., 17, 1999.
    • (1999) Annu. Rev. Immunol , vol.17
    • Haase, A.1
  • 24
    • 0036176509 scopus 로고    scopus 로고
    • The challenge of viral reservoirs in HIV-1 infection
    • Blankson J., Persaud D., Siliciano R. - The challenge of viral reservoirs in HIV-1 infection. - Annu. Rev. Med., 53, 557-593, 2002.
    • (2002) Annu. Rev. Med , vol.53 , pp. 557-593
    • Blankson, J.1    Persaud, D.2    Siliciano, R.3
  • 25
    • 0036289210 scopus 로고    scopus 로고
    • Macrophages and HIV infection: Therapeutic approaches toward this strategic virus reservoir
    • Aquaro S., Calio R., Balzarini J., Bellocchi M., Garaci E., Perno C. - Macrophages and HIV infection: therapeutic approaches toward this strategic virus reservoir. - Antiviral Res., 55, 209-225, 2002.
    • (2002) Antiviral Res , vol.55 , pp. 209-225
    • Aquaro, S.1    Calio, R.2    Balzarini, J.3    Bellocchi, M.4    Garaci, E.5    Perno, C.6
  • 26
    • 0037238708 scopus 로고    scopus 로고
    • The influence of cytokines, chemokines, and their receptors on HIV-1 replication in monocytes and macrophages
    • Kedzierska K., Crowe S., Turville S., Cunningham A. - The influence of cytokines, chemokines, and their receptors on HIV-1 replication in monocytes and macrophages. - Rev. Med. Virol., 13, 39-56, 2003.
    • (2003) Rev. Med. Virol , vol.13 , pp. 39-56
    • Kedzierska, K.1    Crowe, S.2    Turville, S.3    Cunningham, A.4
  • 27
    • 0036668679 scopus 로고    scopus 로고
    • Follicular dendritic cell contributions to HIV pathogenesis
    • Burton G., Keele B., Estes J., Thacker T., Gartner S. - Follicular dendritic cell contributions to HIV pathogenesis - Immunology, 14, 275-284, 2002.
    • (2002) Immunology , vol.14 , pp. 275-284
    • Burton, G.1    Keele, B.2    Estes, J.3    Thacker, T.4    Gartner, S.5
  • 29
    • 33646825160 scopus 로고    scopus 로고
    • Drug delivery across the blood-brain barrier: Why is it difficult? how to measure and improve it? - Expert Opin
    • Su Y., Sinko P. - Drug delivery across the blood-brain barrier: why is it difficult? how to measure and improve it? - Expert Opin. Drug Deliv., 3, 419-435, 2006.
    • (2006) Drug Deliv , vol.3 , pp. 419-435
    • Su, Y.1    Sinko, P.2
  • 30
    • 0032571761 scopus 로고    scopus 로고
    • Love blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat
    • Wu D., Clement J. - Love blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat. - Brain Res., 791, 313-316, 1998.
    • (1998) Brain Res , vol.791 , pp. 313-316
    • Wu, D.1    Clement, J.2
  • 31
    • 14344264538 scopus 로고    scopus 로고
    • P-glycoprotein and multidrug resistance-associated proteins limit the brain uptake of saquinavir in mice
    • Park S., Sinko P. - P-glycoprotein and multidrug resistance-associated proteins limit the brain uptake of saquinavir in mice. - J. Pharmacol. Exp. Ther., 312, 1249-1256, 2005.
    • (2005) J. Pharmacol. Exp. Ther , vol.312 , pp. 1249-1256
    • Park, S.1    Sinko, P.2
  • 32
    • 0036229852 scopus 로고    scopus 로고
    • Drugs as P-glycoprotein substrates, inhibitors, and inducers
    • Kim R. - Drugs as P-glycoprotein substrates, inhibitors, and inducers. - Drug Metab. Rev., 34, 47-54, 2002.
    • (2002) Drug Metab. Rev , vol.34 , pp. 47-54
    • Kim, R.1
  • 33
    • 9644289511 scopus 로고    scopus 로고
    • The use of cell-penetrating peptides for drug delivery
    • Temsamani J., Vidal P - The use of cell-penetrating peptides for drug delivery - Drug Discov. Today, 9, 1012-1019, 2004.
    • (2004) Drug Discov. Today , vol.9 , pp. 1012-1019
    • Temsamani, J.1    Vidal, P.2
  • 34
    • 35248880092 scopus 로고    scopus 로고
    • TAT transduction: The molecular mechanism and therapeutic prospects
    • Gump J., Dowdy S. - TAT transduction: the molecular mechanism and therapeutic prospects. - Trends Mol. Med., 13, 443-448, 2007.
    • (2007) Trends Mol. Med , vol.13 , pp. 443-448
    • Gump, J.1    Dowdy, S.2
  • 35
    • 27844435285 scopus 로고    scopus 로고
    • Standing in the way of eradication: HIV-1 infection and treatment in the male genital tract
    • Shehu-Xhilaga M., De Krester D., Dejucq-Rainsford N., Hedger M. - Standing in the way of eradication: HIV-1 infection and treatment in the male genital tract. - Curr. HIV Res., 3, 345-359, 2005.
    • (2005) Curr. HIV Res , vol.3 , pp. 345-359
    • Shehu-Xhilaga, M.1    De Krester, D.2    Dejucq-Rainsford, N.3    Hedger, M.4
  • 36
    • 85031363222 scopus 로고    scopus 로고
    • Thomson Healthcare Inc.- Mayo Clinic.com: Fosamprenavir (Oral Route)-http://www.mayoclinic.com/health/drug-information/DR601699 - Accessed [June 19, 2008].
    • Thomson Healthcare Inc.- Mayo Clinic.com: Fosamprenavir (Oral Route)-(http://www.mayoclinic.com/health/drug-information/DR601699 - Accessed [June 19, 2008].
  • 37
    • 4644305654 scopus 로고    scopus 로고
    • Chapman T., Plosker G., Perry C. - Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection. - Drugs, 64, 2101-2124, 2004.
    • Chapman T., Plosker G., Perry C. - Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection. - Drugs, 64, 2101-2124, 2004.
  • 38
    • 33344460707 scopus 로고    scopus 로고
    • Fosamprenavir: Clinical pharmacokinetics and drug interactions of the amprenavir prodrug
    • Wire M., Shelton M., Studenberg S. - Fosamprenavir: clinical pharmacokinetics and drug interactions of the amprenavir prodrug. - Clin. Pharmacokinet., 45, 137-168, 2006.
    • (2006) Clin. Pharmacokinet , vol.45 , pp. 137-168
    • Wire, M.1    Shelton, M.2    Studenberg, S.3
  • 42
    • 9144240623 scopus 로고    scopus 로고
    • Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients
    • Wood R., Arasteh K., Stellbrink H., Teofilo E., Raffi F., Pollard R., Eron J., Yeo J., Millard J., Wire M., Naderer O. - Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients - Antimicrob. Agents Chemother., 48, 124-129, 2004.
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 124-129
    • Wood, R.1    Arasteh, K.2    Stellbrink, H.3    Teofilo, E.4    Raffi, F.5    Pollard, R.6    Eron, J.7    Yeo, J.8    Millard, J.9    Wire, M.10    Naderer, O.11
  • 44
    • 17744390345 scopus 로고    scopus 로고
    • Metabolic disposition and pharmacokinetics of [14C]-amprenavir, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, administered as a single dose to healthy male subjects
    • Sadler B., Chittick G., Polk R., Slain D., Kerkering T., Studenberg S., Lou Y., Moore K., Woolley J. - Metabolic disposition and pharmacokinetics of [14C]-amprenavir, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, administered as a single dose to healthy male subjects. - J. Clin. Pharmacol., 41, 386-396, 2001.
    • (2001) J. Clin. Pharmacol , vol.41 , pp. 386-396
    • Sadler, B.1    Chittick, G.2    Polk, R.3    Slain, D.4    Kerkering, T.5    Studenberg, S.6    Lou, Y.7    Moore, K.8    Woolley, J.9
  • 45
    • 85031351050 scopus 로고    scopus 로고
    • Wire M., Lou Y., Shelton M., et al. - Evaluation of plasma amprenavir formulations with a high fat breakfast (HFB, APV10008).-44th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington DC, USA, Oct 3 - Nov. 2, 2004.
    • Wire M., Lou Y., Shelton M., et al. - Evaluation of plasma amprenavir formulations with a high fat breakfast (HFB, APV10008).-44th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington DC, USA, Oct 3 - Nov. 2, 2004.
  • 47
    • 0037105750 scopus 로고    scopus 로고
    • Effects of formulation and dosing strategy on amprenavir concentrations in seminal plasma of human immunodeficiency virus type-1 infected men
    • Chaudry N., Eron J., Naderer O., Pereira A., Wire M., Fiscus S., Kashuba A. - Effects of formulation and dosing strategy on amprenavir concentrations in seminal plasma of human immunodeficiency virus type-1 infected men. - Clin. Infect. Dis., 35, 760-762, 2002.
    • (2002) Clin. Infect. Dis , vol.35 , pp. 760-762
    • Chaudry, N.1    Eron, J.2    Naderer, O.3    Pereira, A.4    Wire, M.5    Fiscus, S.6    Kashuba, A.7
  • 48
    • 0036811720 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate: A nucleotide reverse transcriptase inhibitor for the treatment of HIV infection
    • Fung H., Stone E., Piacenti F. - Tenofovir disoproxil fumarate: a nucleotide reverse transcriptase inhibitor for the treatment of HIV infection. - Clin. Ther., 24, 1515-1548, 2002.
    • (2002) Clin. Ther , vol.24 , pp. 1515-1548
    • Fung, H.1    Stone, E.2    Piacenti, F.3
  • 49
    • 0043124520 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate
    • Chapman T, McGavin J., Noble S. - Tenofovir disoproxil fumarate. - Drugs, 63, 1597-1608, 2003.
    • (2003) Drugs , vol.63 , pp. 1597-1608
    • Chapman, T.1    McGavin, J.2    Noble, S.3
  • 50
    • 85031352543 scopus 로고    scopus 로고
    • Gilead Sciences INC, Viread (tenofovir disoproxil fumarate) tablets: US package insert, Accessed [January 23, 2007
    • Gilead Sciences INC. - Viread (tenofovir disoproxil fumarate) tablets: US package insert.-(http://www.gilead.com/pdf/viread_pi.pdf -Accessed [January 23, 2007].
  • 51
    • 3242694930 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate: Clinical pharmacology and pharmacokinetics
    • Kearney B., Flaherty J., Shah J. - Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics. - Clin. Pharmacokinet., 43, 595-612, 2004.
    • (2004) Clin. Pharmacokinet , vol.43 , pp. 595-612
    • Kearney, B.1    Flaherty, J.2    Shah, J.3
  • 52
    • 0037229911 scopus 로고    scopus 로고
    • Tenofovir: A nucleotide analog for the management of human immunodeficiency virus infection
    • Antoniou T., Park-Wyllie L., Tseng A. - Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection. - Pharmacotherapy, 23, 29-43, 2003.
    • (2003) Pharmacotherapy , vol.23 , pp. 29-43
    • Antoniou, T.1    Park-Wyllie, L.2    Tseng, A.3
  • 53
    • 0025837774 scopus 로고
    • DE-Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines
    • Clercq E. DE-Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines. - Biochem. Pharmacol., 42, 963-972, 1991.
    • (1991) Biochem. Pharmacol , vol.42 , pp. 963-972
    • Clercq, E.1
  • 54
    • 0142126681 scopus 로고    scopus 로고
    • DE - Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections
    • Clercq E. DE - Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. - Clin. Microbiol. Rev., 16, 2003.
    • (2003) Clin. Microbiol. Rev , vol.16
    • Clercq, E.1
  • 55
    • 2342451795 scopus 로고    scopus 로고
    • DE - Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections. - Expert Rev. Anti-infect
    • Clercq E. DE - Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections. - Expert Rev. Anti-infect. Ther., 1, 21-43, 2003.
    • (2003) Ther , vol.1 , pp. 21-43
    • Clercq, E.1
  • 56
    • 0031916651 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug otthe acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(ispropyloxymethylcarbonyl)PMPA
    • Robbins B., Srinivas R., Kim C., Bischofberger N., Fridland A. - Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug otthe acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(ispropyloxymethylcarbonyl)PMPA. - Antimicrob. Agents Chemother., 42, 612-617, 1998.
    • (1998) Antimicrob. Agents Chemother , vol.42 , pp. 612-617
    • Robbins, B.1    Srinivas, R.2    Kim, C.3    Bischofberger, N.4    Fridland, A.5
  • 57
    • 0032538456 scopus 로고    scopus 로고
    • Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine
    • Suo Z., Johnson K. - Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. - J. Biol. Chem., 273, 27250-27258, 1998.
    • (1998) J. Biol. Chem , vol.273 , pp. 27250-27258
    • Suo, Z.1    Johnson, K.2
  • 58
    • 0029022494 scopus 로고
    • Kinetic interaction of the diphosphate of 9-(2-phosphonylmethoxyethyl) adenine and other anti-HIV active purine congeners with HIV reverse transcriptase and human DNA polymerases α, β and γ
    • Cherrington J., Allen S., Bischofberger N., Chen M. - Kinetic interaction of the diphosphate of 9-(2-phosphonylmethoxyethyl) adenine and other anti-HIV active purine congeners with HIV reverse transcriptase and human DNA polymerases α, β and γ. - Antivir. Chem. Chemother., 6, 217-221, 1995.
    • (1995) Antivir. Chem. Chemother , vol.6 , pp. 217-221
    • Cherrington, J.1    Allen, S.2    Bischofberger, N.3    Chen, M.4
  • 59
    • 0036233759 scopus 로고    scopus 로고
    • Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerase α, δ, and ε*
    • Birkus G., Hajek M., Kramata P., Votruba I., Holy A., Otova B. - Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerase α, δ, and ε*. - Antimicrob. Agents Chemother., 46, 1610-1613, 2002.
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 1610-1613
    • Birkus, G.1    Hajek, M.2    Kramata, P.3    Votruba, I.4    Holy, A.5    Otova, B.6
  • 60
    • 0036174438 scopus 로고    scopus 로고
    • Assessment of mitochondrial toxicity in human cells treated with tenofovir: Comparison with other nucleoside reverse transcriptase inhibitors
    • Birkus G., Hitchcock M., Cihlar T. - Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors. - Antimicrob. Agents Chemother., 46, 716-723, 2002.
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 716-723
    • Birkus, G.1    Hitchcock, M.2    Cihlar, T.3
  • 61
    • 0038012639 scopus 로고    scopus 로고
    • Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells
    • Robbins B., Wilcox C., Fridland A., Rodman J. - Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells. - Pharamacotherapy, 23, 695-701, 2003.
    • (2003) Pharamacotherapy , vol.23 , pp. 695-701
    • Robbins, B.1    Wilcox, C.2    Fridland, A.3    Rodman, J.4
  • 62
    • 33747123642 scopus 로고    scopus 로고
    • Antiviral acyclic nucleoside phosphonates structure activity studies
    • Holy A. - Antiviral acyclic nucleoside phosphonates structure activity studies. - Antiviral Res., 71, 248-253, 2006.
    • (2006) Antiviral Res , vol.71 , pp. 248-253
    • Holy, A.1
  • 63
    • 0031430945 scopus 로고    scopus 로고
    • Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs
    • Shaw J., Suekoka C., Oliyai R., Lee W., Arimilli M., Kim C., Cundy K. - Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs. - Pharm. Res., 14, 1824-1829, 1997.
    • (1997) Pharm. Res , vol.14 , pp. 1824-1829
    • Shaw, J.1    Suekoka, C.2    Oliyai, R.3    Lee, W.4    Arimilli, M.5    Kim, C.6    Cundy, K.7
  • 64
    • 0030782524 scopus 로고    scopus 로고
    • Synthesis, in vitro biological evaluation and oral bioavailability of 9-[2-(phosphonomethoxy) propyl]adenine (PMPA) prodrugs
    • Arimilli M., Kim C., Dougherty J., Mulato A., Oliyai R., Shaw J., Cundy K., Bischofberger N. - Synthesis, in vitro biological evaluation and oral bioavailability of 9-[2-(phosphonomethoxy) propyl]adenine (PMPA) prodrugs. - Antivir. Chem. Chemother., 8, 557-564, 1997.
    • (1997) Antivir. Chem. Chemother , vol.8 , pp. 557-564
    • Arimilli, M.1    Kim, C.2    Dougherty, J.3    Mulato, A.4    Oliyai, R.5    Shaw, J.6    Cundy, K.7    Bischofberger, N.8
  • 67
    • 0036326062 scopus 로고    scopus 로고
    • Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures
    • Van Gelder J., Deferme S., Naesens L., De Clercq E., Van Den Mooter G., Kinget R., Augustijns P. - Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures. - Drug Metab. Dispos., 30, 924-930, 2002.
    • (2002) Drug Metab. Dispos , vol.30 , pp. 924-930
    • Van Gelder, J.1    Deferme, S.2    Naesens, L.3    De Clercq, E.4    Van Den Mooter, G.5    Kinget, R.6    Augustijns, P.7
  • 68
    • 0028797327 scopus 로고
    • Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated
    • Cihlar T., Rosenberg I., Votruba I., Holy A. - Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated. - Antimicrob. Agents Chemother., 39, 117-124, 1995.
    • (1995) Antimicrob. Agents Chemother , vol.39 , pp. 117-124
    • Cihlar, T.1    Rosenberg, I.2    Votruba, I.3    Holy, A.4
  • 69
    • 0031710248 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults
    • Deeks S., Barditch-Crovo P., Lietman P., Hwang F., Cundy K., Rooney J., Hellmann N., Safrin S., Kahn J. - Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults. - Antimicrob. Agents Chemother., 42, 2380-2384, 1998.
    • (1998) Antimicrob. Agents Chemother , vol.42 , pp. 2380-2384
    • Deeks, S.1    Barditch-Crovo, P.2    Lietman, P.3    Hwang, F.4    Cundy, K.5    Rooney, J.6    Hellmann, N.7    Safrin, S.8    Kahn, J.9
  • 70
    • 33645895267 scopus 로고    scopus 로고
    • The distribution of the anti-HIV drug, tenofovir (PMPA), into the brain, CSF and choroid plexuses
    • Anthonypillai C., Gibbs J., Thomas S. - The distribution of the anti-HIV drug, tenofovir (PMPA), into the brain, CSF and choroid plexuses. - Cerebrospinal Fluid Res., 3, 1-10, 2006.
    • (2006) Cerebrospinal Fluid Res , vol.3 , pp. 1-10
    • Anthonypillai, C.1    Gibbs, J.2    Thomas, S.3
  • 71
    • 0029883083 scopus 로고    scopus 로고
    • Metabolism and therapeutic activity of acyclic adenine phosphonate analogs
    • Robbins B., Fridland A. - Metabolism and therapeutic activity of acyclic adenine phosphonate analogs. - Int. Antivir. News, 4, 57-59, 1996.
    • (1996) Int. Antivir. News , vol.4 , pp. 57-59
    • Robbins, B.1    Fridland, A.2
  • 75
    • 7244248649 scopus 로고    scopus 로고
    • Patterns of resistance emerging in HIV-1 from antiretroviral-experienced patients undergoing intensification therapy with tenofovir disoproxil fumarate
    • McColl D., Margot N., Wulfsohn M., Coakley D., Cheng A., Miller M. - Patterns of resistance emerging in HIV-1 from antiretroviral-experienced patients undergoing intensification therapy with tenofovir disoproxil fumarate. - J. Acquir. Immune Defic. Syndr., 37, 1340-1350, 2004.
    • (2004) J. Acquir. Immune Defic. Syndr , vol.37 , pp. 1340-1350
    • McColl, D.1    Margot, N.2    Wulfsohn, M.3    Coakley, D.4    Cheng, A.5    Miller, M.6
  • 77
    • 0032506228 scopus 로고    scopus 로고
    • Unblocking of chain-terminated primer by HIV- reverse transcriptase through a nucleotide-dependent mechanism
    • Meyer P., Matsuura S., So A., Scott W. - Unblocking of chain-terminated primer by HIV- reverse transcriptase through a nucleotide-dependent mechanism. - Proc. Natl. Acad. Sci., 95, 13471-13476, 1998.
    • (1998) Proc. Natl. Acad. Sci , vol.95 , pp. 13471-13476
    • Meyer, P.1    Matsuura, S.2    So, A.3    Scott, W.4
  • 78
    • 52049105453 scopus 로고    scopus 로고
    • Recent trends in targeted anti-cancer prodrug and conjugate design
    • Singh Y., Palombo M. Sinko. - Recent trends in targeted anti-cancer prodrug and conjugate design. - Curr. Med. Chem., 15, 1802-1826, 2008.
    • (2008) Curr. Med. Chem , vol.15 , pp. 1802-1826
    • Singh, Y.1    Palombo, M.2    Sinko3
  • 80
    • 33751385189 scopus 로고
    • Meares C, Ed, American Chemical Society, Washington DC
    • Meares C. (Ed.) - Perspectives in Bioconjugate Chemistry. - American Chemical Society, Washington DC, 1993, pp. 1-8.
    • (1993) Perspectives in Bioconjugate Chemistry , pp. 1-8
  • 81
    • 3042637099 scopus 로고    scopus 로고
    • Differentiation of gut and hepatic first pass metabolism and secretion of saquinavir in ported rabbits
    • Sinko P., Kunta J., Usansky H., Perry B. - Differentiation of gut and hepatic first pass metabolism and secretion of saquinavir in ported rabbits. - J. Pharmacol. Exp. Ther., 46, 359-366, 2004.
    • (2004) J. Pharmacol. Exp. Ther , vol.46 , pp. 359-366
    • Sinko, P.1    Kunta, J.2    Usansky, H.3    Perry, B.4
  • 82
    • 2442638219 scopus 로고    scopus 로고
    • Human organic anion-transporting polypeptide OATP-A (SLC21α3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of saquinavir in Hep G2 cells
    • Su Y., Zhang X., Sinko P. - Human organic anion-transporting polypeptide OATP-A (SLC21α3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of saquinavir in Hep G2 cells. - Mol. Pharm., 1, 49-56, 2004.
    • (2004) Mol. Pharm , vol.1 , pp. 49-56
    • Su, Y.1    Zhang, X.2    Sinko, P.3
  • 83
    • 42449083749 scopus 로고    scopus 로고
    • Differential roles of P-glycoprotein multidrug resistance associated protein 2, and CYP3A on saquinavir oral absorption in Sprague-Dawley rats
    • Usansky H., Hu P., Sinko, P. - Differential roles of P-glycoprotein multidrug resistance associated protein 2, and CYP3A on saquinavir oral absorption in Sprague-Dawley rats. - Drug Metab. Dispos., 36, 863-869, 2008.
    • (2008) Drug Metab. Dispos , vol.36 , pp. 863-869
    • Usansky, H.1    Hu, P.2    Sinko, P.3
  • 84
    • 0036839699 scopus 로고    scopus 로고
    • Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporters (MRP2)
    • Williams G., Liu A., Knipp G., Sinko P. - Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporters (MRP2). - Antimicrob. Agents Chemother., 46, 3456-3462, 2002.
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 3456-3462
    • Williams, G.1    Liu, A.2    Knipp, G.3    Sinko, P.4
  • 86
    • 0035160001 scopus 로고    scopus 로고
    • Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir
    • Rouquayrol M., Gaucher B., Greiner J., Aubertin A., Vierling P., Guedj R. - Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir. - Carbohydr. Res., 336, 161-180, 2001.
    • (2001) Carbohydr. Res , vol.336 , pp. 161-180
    • Rouquayrol, M.1    Gaucher, B.2    Greiner, J.3    Aubertin, A.4    Vierling, P.5    Guedj, R.6
  • 87
    • 9244261964 scopus 로고    scopus 로고
    • Synthesis of poly(ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay
    • Gunaseelan S., Debrah O., Wan L., Leibowitz M., Rabson A., Stein S., Sinko P. - Synthesis of poly(ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay. - Bioconj. Chem., 15, 1322-1333, 2004.
    • (2004) Bioconj. Chem , vol.15 , pp. 1322-1333
    • Gunaseelan, S.1    Debrah, O.2    Wan, L.3    Leibowitz, M.4    Rabson, A.5    Stein, S.6    Sinko, P.7
  • 88
    • 9244261790 scopus 로고    scopus 로고
    • Quantitative assessment of the cell penetrating properties of R.I.-Tat-9: Evidence for a cell type-specific barrier at the plasma membrane of epithelial cells
    • Zhang X., Wan L., Pooyan S., Su Y., Gardner C., Leibowitz M., Sinko P. - Quantitative assessment of the cell penetrating properties of R.I.-Tat-9: evidence for a cell type-specific barrier at the plasma membrane of epithelial cells. - Mol. Pharm., 1, 145-155, 2004.
    • (2004) Mol. Pharm , vol.1 , pp. 145-155
    • Zhang, X.1    Wan, L.2    Pooyan, S.3    Su, Y.4    Gardner, C.5    Leibowitz, M.6    Sinko, P.7
  • 89
    • 0034868135 scopus 로고    scopus 로고
    • Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide
    • Ramanathan S., Pooyan S., Stein S., Prasad P., Wang J., Leibowitz M., Ganapathy V., Sinko P. - Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide. - Pharm. Res., 18, 950-956, 2001.
    • (2001) Pharm. Res , vol.18 , pp. 950-956
    • Ramanathan, S.1    Pooyan, S.2    Stein, S.3    Prasad, P.4    Wang, J.5    Leibowitz, M.6    Ganapathy, V.7    Sinko, P.8
  • 90
    • 0035856813 scopus 로고    scopus 로고
    • Targeted PEG-based bioconjugates enhance the cellular uptake and transport of HIV-1 TAT nonapeptide
    • Ramanathan S., Qiu B., Pooyan S., Zhang G., Stein S., Leibowitz M., Sinko P. - Targeted PEG-based bioconjugates enhance the cellular uptake and transport of HIV-1 TAT nonapeptide. - J. Control. Release, 77, 199-212, 2001.
    • (2001) J. Control. Release , vol.77 , pp. 199-212
    • Ramanathan, S.1    Qiu, B.2    Pooyan, S.3    Zhang, G.4    Stein, S.5    Leibowitz, M.6    Sinko, P.7
  • 91
    • 33748364301 scopus 로고    scopus 로고
    • Wan L., Zhang X., Gunaseelan S., Pooyan S., Debrah O., Leibowitz M., Rabson A., Stein S., Sinko P. - Novel multi-component nanopharmaceuticals derived from poly(ethylene)glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects. - AIDS Res. Ther., 3, 12-26, 2006.
    • Wan L., Zhang X., Gunaseelan S., Pooyan S., Debrah O., Leibowitz M., Rabson A., Stein S., Sinko P. - Novel multi-component nanopharmaceuticals derived from poly(ethylene)glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects. - AIDS Res. Ther., 3, 12-26, 2006.
  • 92
    • 0026070668 scopus 로고
    • Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture
    • Schuitemaker H., Kootstra N., De Goede R., DeWolf F., Miedema F., Tersmette M. - Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. - J. Virol., 65, 356-363, 1991.
    • (1991) J. Virol , vol.65 , pp. 356-363
    • Schuitemaker, H.1    Kootstra, N.2    De Goede, R.3    DeWolf, F.4    Miedema, F.5    Tersmette, M.6
  • 93
    • 27944496941 scopus 로고    scopus 로고
    • Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
    • Weissleder R., Kelly K, Sun E., Shtatland T., Josephson L. - Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. - Nat. Biotechnol., 11, 1418-1423, 2005.
    • (2005) Nat. Biotechnol , vol.11 , pp. 1418-1423
    • Weissleder, R.1    Kelly, K.2    Sun, E.3    Shtatland, T.4    Josephson, L.5
  • 94
    • 0002088730 scopus 로고
    • Lewis C.E, McGee J.O, Eds, Oxford University Press, New York
    • Auger M., Ross J. - In: The Natural Immune System: The Macrophage, Lewis C.E., McGee J.O. (Eds.), Oxford University Press, New York, 1992, pp. 2-74
    • (1992) The Natural Immune System: The Macrophage , pp. 2-74
    • Auger, M.1    Ross, J.2
  • 96
    • 0036009630 scopus 로고    scopus 로고
    • Conjugates bearing multiple formyl-methionyl peptides display enhanced binding to but not activation of phagocytic cells
    • Pooyan S., Qiu B., Chan M., Fong D., Sinko P., Leibowitz M., Stein S. - Conjugates bearing multiple formyl-methionyl peptides display enhanced binding to but not activation of phagocytic cells. - Bioconj. Chem., 13, 216-223, 2002.
    • (2002) Bioconj. Chem , vol.13 , pp. 216-223
    • Pooyan, S.1    Qiu, B.2    Chan, M.3    Fong, D.4    Sinko, P.5    Leibowitz, M.6    Stein, S.7
  • 97
    • 0030748297 scopus 로고    scopus 로고
    • The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function
    • Prossnitz E., Ye R. -The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function. - Pharmacol. Ther., 74, 73-102, 1997.
    • (1997) Pharmacol. Ther , vol.74 , pp. 73-102
    • Prossnitz, E.1    Ye, R.2
  • 98
    • 38949216354 scopus 로고    scopus 로고
    • Optimizing size and copy number for PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarrier uptake by macrophages
    • Wan L., Zhang X., Pooyan S., Palombo M., Leibowitz M., Stein S., Sinko P. - Optimizing size and copy number for PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarrier uptake by macrophages. - Bioconj. Chem., 19, 28-38, 2008.
    • (2008) Bioconj. Chem , vol.19 , pp. 28-38
    • Wan, L.1    Zhang, X.2    Pooyan, S.3    Palombo, M.4    Leibowitz, M.5    Stein, S.6    Sinko, P.7
  • 99
    • 0038037307 scopus 로고    scopus 로고
    • Remarkably size-regulated cell invasion by artificial viruses: Saccharide-dependent self-aggregation of glycoviruses and its consequence in glycoviral gene delivery
    • Nakai T., Kanamori T., Sando S., Ayoma Y. - Remarkably size-regulated cell invasion by artificial viruses: saccharide-dependent self-aggregation of glycoviruses and its consequence in glycoviral gene delivery. - J. Am. Chem. Soc., 125, 8465-8475, 2003.
    • (2003) J. Am. Chem. Soc , vol.125 , pp. 8465-8475
    • Nakai, T.1    Kanamori, T.2    Sando, S.3    Ayoma, Y.4
  • 100
    • 2542532174 scopus 로고    scopus 로고
    • A quantum dot conjugated sugar ball and its cellular uptake: On the size effects of endocytosis in the subviral region
    • Osaki F., Kanomori T., Sando S., Sera T., Ayoma Y. - A quantum dot conjugated sugar ball and its cellular uptake: on the size effects of endocytosis in the subviral region. - J. Am. Chem. Soc., 126, 6520-6521, 2004.
    • (2004) J. Am. Chem. Soc , vol.126 , pp. 6520-6521
    • Osaki, F.1    Kanomori, T.2    Sando, S.3    Sera, T.4    Ayoma, Y.5
  • 101
    • 0031469673 scopus 로고    scopus 로고
    • The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent
    • Desai M., Labhesetwar V., Walter E., Levy R., Amidon G. - The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. - Pharm. Res., 14, 1568-1573, 1997.
    • (1997) Pharm. Res , vol.14 , pp. 1568-1573
    • Desai, M.1    Labhesetwar, V.2    Walter, E.3    Levy, R.4    Amidon, G.5
  • 102
    • 0037026269 scopus 로고    scopus 로고
    • Size-dependency of nanoparticle-mediated gene transfection with fractioned nanoparticles
    • Prabha S., Zhou W., Panyam J., Labhasetwar V. - Size-dependency of nanoparticle-mediated gene transfection with fractioned nanoparticles. - Int. J. Pharm., 244, 105-115, 2002.
    • (2002) Int. J. Pharm , vol.244 , pp. 105-115
    • Prabha, S.1    Zhou, W.2    Panyam, J.3    Labhasetwar, V.4
  • 103
    • 34848891527 scopus 로고    scopus 로고
    • Peritoneal macrophage uptake, pharmacokinetics and biodistribution of macrophage-targeted PEG-fMLF (N-formylmethionyl-leucyl-phenylalanine) nanocarriers for improving HIV drug delivery
    • Wan L., Pooyan S., Hu S., Leibowitz M., Stein S., Sinko P. - Peritoneal macrophage uptake, pharmacokinetics and biodistribution of macrophage-targeted PEG-fMLF (N-formylmethionyl-leucyl-phenylalanine) nanocarriers for improving HIV drug delivery. - Pharm. Res., 24, 2100-2119, 2007.
    • (2007) Pharm. Res , vol.24 , pp. 2100-2119
    • Wan, L.1    Pooyan, S.2    Hu, S.3    Leibowitz, M.4    Stein, S.5    Sinko, P.6


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